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外刊拾贝 被引量:47
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作者 单忠艳 Li Y +7 位作者 teng D shi X Ba J 王看然 李启富 Wang K Hu J Yang J 《国际内分泌代谢杂志》 2020年第5期314-314,339,共2页
1.根据2018年美国糖尿病学会标准诊断中国糖尿病患病率:全国横断面研究目的:评估糖尿病患病率及其危险因素。设计:基于人群的横断面研究。背景:2015-2017年中国大陆31省份全国横断面数据。调查对象:75880名18周岁及以上代表中国大陆人... 1.根据2018年美国糖尿病学会标准诊断中国糖尿病患病率:全国横断面研究目的:评估糖尿病患病率及其危险因素。设计:基于人群的横断面研究。背景:2015-2017年中国大陆31省份全国横断面数据。调查对象:75880名18周岁及以上代表中国大陆人口的成年人样本。主要观察指标:根据2018年美国糖尿病学会和世界卫生组织标准诊断中国成人不同性别、区域和种族的糖尿病患病率。通过问卷的方式记录调查对象的社会人口学信息、生活方式和疾病史。 展开更多
关键词 美国糖尿病学会 社会人口学 横断面研究 调查对象 观察指标 危险因素 糖尿病患病率 疾病史
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青藏高原高寒草地地下生物多样性:进展、问题与展望 被引量:43
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作者 刘安榕 杨腾 +6 位作者 徐炜 上官子健 王金洲 刘慧颖 时玉 褚海燕 贺金生 《生物多样性》 CAS CSCD 北大核心 2018年第9期972-987,共16页
栖息于土壤中的微生物和微型动物种类繁多、数量巨大,在对地上生物多样性的调控和在生态系统功能与服务的维系中,具有举足轻重的作用。虽然对土壤微生物以及土壤动物已经开展了广泛的调查,但是整体上对于地下生物多样性的分布格局、驱... 栖息于土壤中的微生物和微型动物种类繁多、数量巨大,在对地上生物多样性的调控和在生态系统功能与服务的维系中,具有举足轻重的作用。虽然对土壤微生物以及土壤动物已经开展了广泛的调查,但是整体上对于地下生物多样性的分布格局、驱动机制及其对全球变化的响应与适应过程,仍缺乏深刻的认识。青藏高原是全球变化的敏感区域,其中高寒草地是高原最主要的植被类型,占高原面积的60%左右,在高寒生态系统生物多样性维持中具有重要意义。近年来,已有大量研究关注于高寒草地地下生物多样性,但是缺乏系统的总结与论述。基于此,本文从细菌、真菌、古菌、线虫、节肢动物五大土壤生物类群出发,阐述了青藏高原高寒草地的地下物种丰富度、分布格局及其影响因素,重点探讨了它们对气候变化和人类活动的响应,并就未来高寒草地地下生物多样性亟需关注的关键问题进行了展望,包括:(1)地下各个生物类群的分布格局、各类群之间的联系及驱动机制;(2)地上与地下生物多样性耦联的机制;(3)地下生物多样性对生态系统功能和健康的影响;(4)地下生物多样性的调控实验研究。 展开更多
关键词 土壤微生物 土壤动物 生物多样性 物种丰富度 气候变化 人类活动
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双水平正压通气治疗慢性阻塞性肺疾病急性加重期并发Ⅱ型呼吸衰竭效果的Meta分析与试验序贯分析 被引量:35
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作者 滕文哲 陈虎 +2 位作者 石思瑶 程康耀 王茵 《中国全科医学》 CAS 北大核心 2022年第2期227-235,共9页
背景慢性阻塞性肺疾病急性加重期(AECOPD)患者发展为Ⅱ型呼吸衰竭的风险明显增加。在临床治疗中双水平正压通气(BiPAP)被广泛运用于AECOPD患者来纠正呼吸性酸中毒,延缓肺功能进一步恶化,但是BiPAP在该类患者中的治疗效果仍存在着争议。... 背景慢性阻塞性肺疾病急性加重期(AECOPD)患者发展为Ⅱ型呼吸衰竭的风险明显增加。在临床治疗中双水平正压通气(BiPAP)被广泛运用于AECOPD患者来纠正呼吸性酸中毒,延缓肺功能进一步恶化,但是BiPAP在该类患者中的治疗效果仍存在着争议。目的系统评价BiPAP对于AECOPD并发Ⅱ型呼吸衰竭患者的治疗效果。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库(CBM)、PubMed、The Cochrane Library、Springer、Medline、Web of Science等数据库中关于BiPAP治疗AECOPD并发Ⅱ型呼吸衰竭的随机对照研究(RCT),检索时限从数据库建库至2020-10-01。由两位研究者独立对所检索出的文献进行筛选、提取数据和质量评价。提取第一作者、国家、人群特征、年龄、样本量、试验组及对照组的干预方式、试验组干预频率和时长、评价指标[pH值、二氧化碳分压(PaCO_(2))、氧分压(PaO_(2))、呼吸频率(RR)、气管插管率、不良反应发生率]等信息。采用Review Manager 5.4软件对纳入文献进行Meta分析,使用哥本哈根临床试验中心开发的TSA v0.9完成试验序贯分析。结果共纳入10篇RCT,其中4篇为高质量等级文献,6篇为中等质量等级文献。试验组改善AECOPD并发Ⅱ型呼吸衰竭患者的pH值[MD=0.04,95%CI(0.03,0.04),P<0.05]、PaCO_(2)[MD=-7.22,95%CI(-8.20,-6.24),P<0.05]、PaO_(2)[MD=6.23,95%CI(5.31,7.14),P<0.05]、干预24 h内和24 h后改善AECOPD并发Ⅱ型呼吸衰竭患者的RR[MD=-3.85,95%CI(-4.36,-3.35),P<0.05]、气管插管率[RR=0.50,95%CI(0.32,0.78),P<0.05]的效果优于对照组。试验组患者腹胀发生率[RR=5.95,95%CI(1.79,19.77),P<0.05]、面部皮肤受损发生率[RR=8.04,95%CI(1.92,33.76),P<0.05]高于对照组。试验序贯分析结果得出了肯定的结论,即BiPAP治疗能明显改善AECOPD并发Ⅱ型呼吸衰竭患者的pH值、PaCO_(2)、PaO_(2)、RR和气管插管率。结论AECOPD并发Ⅱ型呼吸衰竭� 展开更多
关键词 肺疾病 慢性阻塞性 呼吸功能不全 双水平气道正压通气 系统评价 Meta分析 治疗结果
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多索茶碱联合头孢他啶治疗老年慢性肺气肿的临床观察 被引量:33
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作者 腾小宝 韩明锋 +3 位作者 时靖峰 李艳敏 张晓华 袁娜娜 《中国药房》 CAS 北大核心 2016年第24期3359-3361,共3页
目的:观察多索茶碱联合头孢他啶治疗老年慢性肺气肿的疗效和安全性。方法:回顾性收集78例老年肺气肿患者资料,按用药的不同分为单药组(31例)和联合用药组(47例)。所有患者均给予补液、吸氧、营养支持等常规治疗。在此基础上,单药组患者... 目的:观察多索茶碱联合头孢他啶治疗老年慢性肺气肿的疗效和安全性。方法:回顾性收集78例老年肺气肿患者资料,按用药的不同分为单药组(31例)和联合用药组(47例)。所有患者均给予补液、吸氧、营养支持等常规治疗。在此基础上,单药组患者给予多索茶碱注射液0.05 g,q12 h,缓慢静脉注射。联合用药组患者在单药组治疗的基础上给予注射用头孢他啶1.0 g,q12h,静脉注射。疗效欠佳者,酌情加用泼尼松片20 mg,每日2次。两组疗程均为10 d。观察两组患者的临床疗效,治疗前后肺功能[最大呼气中段流量(MMEF)、第1 s用力呼气容积占预计值百分比(FEV1%)、最大呼气峰流速(PEF)]、美国简明健康状况调查问卷(SF-36)量表(QLS)评分及不良反应发生情况。结果:联合用药组患者总有效率显著高于单药组,差异有统计学意义(P<0.05)。治疗前,两组患者MMEF、FEV1%、PEF、QLS评分比较,差异无统计学意义(P>0.05)。治疗后,两组患者MMEF、FEV_1%、PEF、QLS评分均显著高于同组治疗前,且联合用药组MMEF、FEV_1%、PEF高于单药组,差异均有统计学意义(P<0.05),但组间QLS评分比较差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上,多索茶碱联合头孢他啶治疗老年慢性肺气肿的疗效优于单用多索茶碱,可改善肺功能,且安全性较好。 展开更多
关键词 老年慢性肺气肿 肺功能 多索茶碱 头孢他啶 疗效 安全性
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腹腔镜离断式肾盂输尿管成形术治疗UPJO肾积水230例经验总结 被引量:25
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作者 韩晓敏 陈敏 +10 位作者 肖亚军 赵军 李兵 鞠文 彭景涛 程永彪 侯腾 海波 石瑛 黄超 章小平 《临床泌尿外科杂志》 2019年第5期353-357,共5页
目的:探讨腹腔镜离断式肾盂输尿管成形术治疗肾盂输尿管连接部梗阻(UPJO)肾积水的临床疗效及总结手术经验。方法:回顾性分析我院2012年10月~2018年10月收治的230例UPJO患者的临床资料。其中先天性UPJO 180例,获得性UPJO 50例,含肾盂输... 目的:探讨腹腔镜离断式肾盂输尿管成形术治疗肾盂输尿管连接部梗阻(UPJO)肾积水的临床疗效及总结手术经验。方法:回顾性分析我院2012年10月~2018年10月收治的230例UPJO患者的临床资料。其中先天性UPJO 180例,获得性UPJO 50例,含肾盂输尿管连接部(UPJ)成形术后狭窄10例,输尿管镜下钬激光碎石或经皮肾镜取石术后狭窄30例及球囊扩张术后狭窄10例。采用经腹腹腔镜行离断式肾盂输尿管成形术,术前及术中对体位、Trocar布置、游离和吻合各环节做了细节优化。术后定期随访,分别于拔除双J管后1、3、6、12个月门诊复查B超检查及尿常规,测量肾盂前后径扩张程度及肾实质厚度。结果:所有手术均成功完成,5例中转开放。平均随访时间12(6~36)个月,B超提示肾积水较术前减轻,部分患者ECT及CTU提示肾实质厚度增加,梗阻程度较前减轻,患肾功能不同程度恢复,术前腰背部不适、腹痛及发热等症状主观上明显改善。6例术后出现UPJ再狭窄,3例经输尿管镜检+双J管再置2个月后拔管梗阻缓解,2例行再次腹腔镜肾盂输尿管成形术后改善,1例失访。结论:腹腔镜离断式肾盂输尿管成形术治疗UPJO肾积水安全、有效,术后并发症发生率低,改善肾积水和肾功能结果满意。严格掌握手术适应证、耐心细致的操作和正确处理术中遇到的困难是做好腹腔镜离断式肾盂输尿管成形术的关键。 展开更多
关键词 腹腔镜 离断式肾盂输尿管成形术 肾盂输尿管连接部梗阻
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Incidence of Pleural Effusion in Patients with Pulmonary Embolism 被引量:25
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作者 Min Liu Ai Cui +7 位作者 Zhen-Guo Zhai Xiao-Juan Guo Man Li Lei-Lei teng Li-Li Xu Xiao-Juan Wang Zhen Wang Huan-Zhong shi 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第8期1032-1036,共5页
Background: No data on the incidence ofpleural effusion (PE) in Chinese patients with pulmonary embolism are available to date. The aim of the current study was to investigate the frequency of PE in a Chinese popul... Background: No data on the incidence ofpleural effusion (PE) in Chinese patients with pulmonary embolism are available to date. The aim of the current study was to investigate the frequency of PE in a Chinese population of patients with pulmonary embolism. Methods: This was a retrospective observational single-center study. All data of computed tomography pulmonary angiography (CTPA) performed over 6-year period on adult patients with clinically suspected pulmonary embolism were analyzed. Results: From January 2008 until December 2013, PE was identified in 423 of 3141 patients (13.5%) with clinically suspected pulmonary embolism who underwent CTPA, The incidence of PE in patients with pulmonary embolism (19.9%) was significantly higher than in those without embolism (9.4%) (P 〈 0.001 ). Majority of PEs in pulmonary embolism patients were small to moderate and were unilateral. The locations of emboli and the numbers of arteries involved, CT pulmonary obstruction index, and parenchymal abnormalities at CT were not associated with the development of PE, Conclusions: PEs are present in about one fifth of a Chinese population of patients with pulmonary embolism, which are usually small, unilateral, and unsuitable for diagnostic thoracentesis. 展开更多
关键词 Computed Tomography Pulmonary Angiography Pleural Effusion Pulmonary Embolism
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Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma 被引量:21
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作者 LIU Lu, JIANG Zao, teng Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, GUO Qing Ming, FANG Wen, HE shi Cheng and GUO Jin He 《World Journal of Gastroenterology》 SCIE CAS CSCD 1999年第6期492-505,共14页
AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing mal... AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appeared some well differentiated tumor cells 展开更多
关键词 liver neoplasms/therapy PHOSPHORUS 32 glass microspheres ( 32 P GMS) 31 P GMS INTERVENTIONAL THERAPY
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Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome 被引量:23
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作者 Lu Zhenzhong Yin Xiaojun +6 位作者 teng Weijun Chen Yuehua Sun Jie Zhao Jimeng Wang Anqi Bao Chunhui shi Yin 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第4期402-410,共9页
OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive in... OBJECTIVE: To compare the impacts of electroacupuncture(EA) and moxibustion(Mox) on the primary gastrointestinal symptoms and the expressions of colonic mucosa-associated neuropeptide substance P(SP) and vasoactive intestinal peptide(VIP)in patients with either diarrhea-predominant or constipation-predominant irritable bowel syndrome(IBS-D and IBS-C,respectively).METHODS: Eighty-five IBS patients were randomly allocated to the EA and Mox groups. Zusanli(ST 36)and Shangjuxu(ST 37) were selected as acupoints for electroacupuncture or warm moxibustion treatment once a day for 14 consecutive days. Before and after the treatment sessions,a Visual Analog Pain Scale and the Bristol Stool Form Scale were used to evaluate gastrointestinal symptoms. There were four dropout cases,leaving 81 participants(41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions. During colonoscopy,sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.RESULTS: Both EA and Mox treatments were effective at relieving abdominal pain in IBS-D and IBS-C patients. However,Mox was more effective at reducing diarrhea in IBS-D patients,whereas EA was more effective at improving constipation in IBS-C patients. EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa,with no significant difference shown between the two treatments.CONCLUSION: Both EA and Mox treatments are effective at ameliorating gastrointestinal symptoms by reducing SP and VIP expression in the colonic mucosa of IBS patients. 展开更多
关键词 Irritable bowel syndrome Electroacu-puncture Moxibustion Substance P Vasoactive in-testinal peptide
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双水平井蒸汽辅助重力泄油蒸汽腔扩展速度计算模型及其应用 被引量:22
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作者 周游 鹿腾 +3 位作者 武守亚 石兰香 杜宣 王峻岭 《石油勘探与开发》 SCIE EI CAS CSCD 北大核心 2019年第2期334-341,共8页
蒸汽腔发育扩展是蒸汽辅助重力泄油(SAGD)开发成败的重要特征,蒸汽腔扩展速度是评价蒸汽腔发育扩展情况的关键指标。以SAGD技术理论与传热学原理为基础,提出观察井温度法和蒸汽腔边缘法2种计算模型计算蒸汽腔水平扩展速度;根据新疆风城... 蒸汽腔发育扩展是蒸汽辅助重力泄油(SAGD)开发成败的重要特征,蒸汽腔扩展速度是评价蒸汽腔发育扩展情况的关键指标。以SAGD技术理论与传热学原理为基础,提出观察井温度法和蒸汽腔边缘法2种计算模型计算蒸汽腔水平扩展速度;根据新疆风城超稠油SAGD典型区块生产监测数据和数值模型计算结果,明确了不同阶段蒸汽腔发育形态和观察井的温度变化规律;利用观察井温度数据进行了蒸汽腔扩展速度分析,并采用不同时间蒸汽腔的扩展速度预测了蒸汽腔边缘泄油带温度分布和SAGD产量。研究表明,观察井测温曲线高温带的温度函数与测深呈线性关系,该特征段可用于计算泄油界面倾斜角、蒸汽腔扩展边缘和蒸汽腔扩展速度等关键参数,经实际生产数据验证,观察井温度法和蒸汽腔边缘法2种模型计算蒸汽腔扩展速度结果可靠,可为SAGD的高效开发提供理论支持。 展开更多
关键词 蒸汽辅助重力泄油 观察井温度 蒸汽腔 蒸汽腔扩展速度 泄油带
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Thermally Conductive Poly(lactic acid) Composites with Superior Electromagnetic Shielding Performances via 3D Printing Technology 被引量:19
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作者 teng-Bo Ma Hao Ma +4 位作者 Kun-Peng Ruan Xue-Tao shi Hua Qiu Sheng-Yuan Gao Jun-Wei Gu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2022年第3期248-255,I0006,共9页
This work proposes a facile fabrication strategy for thermally conductive graphite nanosheets/poly(lactic acid) sheets with ordered GNPs(o-GNPs/PLA) via fused deposition modeling(FDM) 3 D printing technology.Further c... This work proposes a facile fabrication strategy for thermally conductive graphite nanosheets/poly(lactic acid) sheets with ordered GNPs(o-GNPs/PLA) via fused deposition modeling(FDM) 3 D printing technology.Further combinations of o-GNPs/PLA with Ti_(3) C_(2) T_(x) films prepared by vacuum-assisted filtration were carried out by "layer-by-layer stacking-hot pressing" to be the thermally conductive Ti_(3) C_(2) T_(x)/(oGNPs/PLA) composites with superior electromagnetic interference shielding effectiveness(EMI SE).When the content of GNPs was 18.60 wt%and 4 layers of Ti_(3) C_(2) T_(x)(6.98 wt%) films were embedded,the in-plane thermal conductivity coefficient(λ_(Ⅱ)) and EMI SE(EMI SE_(Ⅱ)) values of the thermally conductive Ti_(3) C_(2) T_(x)/(o-GNPs/P LA) composites significantly increa sed to 3.44 W·m^(-1)·K^(-1) and 65 d B(3.00 mm),increased by 1223.1% and2066.7%,respectively,compared with λ_(Ⅱ)(0.26 W·m^(-1)·K^(-1)) and EMI SE_(Ⅱ)(3 d B) of neat PLA matrix.This work offers a novel and easily route for designing and manufacturing highly thermally conductive polymer composites with superior EMI SE for broader application. 展开更多
关键词 Polymer-matrix composites(PMCs) Ti_(3)C_(2)T_(x) 3D printing Thermal conductivity Electromagnetic interference(EMI)
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中医护理干预对气虚血瘀型冠心病心绞痛患者生活质量、心功能及负性情绪的影响 被引量:19
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作者 金腾 石留皓 祝雪花 《新中医》 CAS 2020年第14期139-143,共5页
目的:观察中医护理干预对气虚血瘀型冠心病心绞痛患者生活质量、心功能及负性情绪的影响。方法:将110例气虚血瘀型冠心病心绞痛患者按随机数字表法分为对照组和观察组各55例。对照组给予优质护理,观察组在对照组基础上给予中医护理。比... 目的:观察中医护理干预对气虚血瘀型冠心病心绞痛患者生活质量、心功能及负性情绪的影响。方法:将110例气虚血瘀型冠心病心绞痛患者按随机数字表法分为对照组和观察组各55例。对照组给予优质护理,观察组在对照组基础上给予中医护理。比较2组临床疗效、临床指标、中医症状积分、生活质量、心功能、负性情绪和依从性的变化。结果:观察组总有效率为92.73%,高于对照组76.36%,差异有统计学意义(P<0.05)。观察组心绞痛发作次数、疼痛评分和疼痛持续时间均显著低于对照组,差异均有统计学意义(P<0.05)。护理后,2组胸痛、胸闷、心悸气短、倦怠乏力评分较护理前降低,且观察组各项评分均低于对照组,差异均有统计学意义(P<0.05)。护理后,2组精力、生理、社会、情感、精神评分均较护理前提高,且观察组各项评分均高于对照组,差异均有统计学意义(P<0.05)。护理后,2组左室收缩末径、左室舒张末径和左房内径较治疗前降低,且观察组各项指标均低于对照组,差异均有统计学意义(P<0.05)。护理后,2组焦虑自评量表(SAS)、汉密尔顿抑郁量表(HAMD)评分较护理前降低,且观察组SAS、HAMD评分均低于对照组,差异均有统计学意义(P<0.05)。结论:中医护理干预对气虚血瘀型冠心病心绞痛患者具有较好的临床效果,可降低中医症状积分,提高生活质量,改善心功能和负性情绪。 展开更多
关键词 冠心病心绞痛 气虚血瘀型 中医护理 生活质量 心功能 负性情绪
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Predictive factors for the local recurrence and distant metastasis of phyllodes tumors of the breast: a retrospective analysis of 192 cases at a single center 被引量:18
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作者 Jing Wei Yu-Ting Tan +7 位作者 Yu-Cen Cai Zhong-Yu Yuan Dong Yang Shu-Sen Wang Rou-Jun Peng Xiao-Yu teng Dong-Geng Liu Yan-Xia shi 《Chinese Journal of Cancer》 SCIE CAS CSCD 2014年第10期492-500,共9页
The local recurrence rate of phyllodes tumors of the breast varies widely among different subtypes, and distant metastasis is associated with poor survival. This study aimed to identify factors that are predictive of ... The local recurrence rate of phyllodes tumors of the breast varies widely among different subtypes, and distant metastasis is associated with poor survival. This study aimed to identify factors that are predictive of local recurrence-free survival(LRFS), distant metastasis-free survival(DMFS), and overall survival(OS) in patients with phyllodes tumors of the breast. Clinical data of all patients with a phyllodes tumor of the breast(n = 192) treated at Sun Yat-sen University Cancer Center between March 1997 and December 2012 were reviewed. The Pearson χ2 test was used to investigate the relationship between clinical features of patients and histotypes of tumors. Univariate and multivariate Cox regression analyses were performed to identify factors that are predictive of LRFS, DMFS, and OS. In total, 31(16.1%) patients developed local recurrence, and 12(6.3%) developed distant metastasis. For the patients who developed local recurrence, the median age at the diagnosis of primary tumor was 33 years(range, 17-56 years), and the median size of primary tumor was 6.0 cm(range, 0.8-18 cm). For patients who developed distant metastasis, the median age at the diagnosis of primary tumor was 46 years(range, 24-68 years), and the median size of primary tumor was 5.0 cm(range, 0.8-18 cm). In univariate analysis, age, size, hemorrhage, and margin status were found to be predictive factors for LRFS(P = 0.009, 0.024, 0.004, and 0.001, respectively), whereas histotype, epithelial hyperplasia, margin status, and local recurrence were predictors of DMFS(P = 0.001, 0.007, 0.007, and < 0.001, respectively). In multivariate analysis, independent prognostic factors for LRFS included age [hazard ratio(HR) = 3.045, P = 0.005], tumor size(HR = 2.668, P = 0.013), histotype(HR = 1.715, P = 0.017), and margin status(HR = 4.530, P< 0.001). Histotype(DMFS: HR = 4.409, P = 0.002; OS: HR = 4.194, P = 0.003) and margin status(DMFS: HR = 2.581, P = 0.013; OS: HR = 2.507, P = 0.020) were independent predictors of both DMFS and OS. In this cohort, y 展开更多
关键词 肿瘤防治中心 预测指标 复发率 乳腺 单因素分析 临床资料 肿瘤诊断 预测因子
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外送餐引起产气荚膜梭菌食物中毒流行病学调查分析 被引量:18
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作者 于颖慧 滕臣刚 +6 位作者 刘丽华 夏威 施惠军 陆逊 王晓蕾 张梦寒 季建刚 《中国食品卫生杂志》 CSCD 北大核心 2020年第5期570-575,共6页
目的查明发生在某工厂的食源性疾病暴发的可疑食品、致病因子及危险因素等,并对事件调查过程中暴露出的问题进行探讨,为今后类似事件的防控和调查提供参考依据。方法病例定义为于2019年3月3日~3月4日期间在M工厂加班职工中发生腹痛、腹... 目的查明发生在某工厂的食源性疾病暴发的可疑食品、致病因子及危险因素等,并对事件调查过程中暴露出的问题进行探讨,为今后类似事件的防控和调查提供参考依据。方法病例定义为于2019年3月3日~3月4日期间在M工厂加班职工中发生腹痛、腹泻(≥3次/24 h)或呕吐症状之一者,运用描述性和分析性流行病学方法开展病例访谈和回顾性研究。收集病例的粪便标本、剩余食品和相关环境样品进行病原分离和采用聚合酶链式反应(PCR)检测阳性菌株的毒素基因。结果检索到病例106名,罹患率为73.6%(106/144),临床症状以腹泻(78.3%,83/106)、腹痛(78.3%,83/106)为主,部分半腹部胀气、胀痛(9.4%,10/106),无发热;流行曲线为点源暴露模式,潜伏期为2~22 h,可疑餐次为2019年3月3日的午餐;单因素分析和Logistic回归分析结果显示,发病与红烧鱼块[相对危险度(RR)=1.55,95%置信区间(95%CI):1.29~1.85]、蒜苗肉丝(RR=1.26,95%CI:1.01~1.57)和雪菜烧鸭血(RR=1.47,95%CI:1.16~1.87)有关;在3份肛拭子、3份环境样品中检出产气荚膜梭菌,菌株和2份剩余食品均检测出α毒素和产气荚膜梭菌肠毒素(CPE)基因。送餐的D企业在加工经营中存在着被细菌污染并繁殖的条件。结论本次事件是因食用某供餐企业提供的配送餐引起的产气荚膜梭菌食物中毒,外送餐做好后应迅速冷却、低温储存,不能立即进食的,在食前要充分加热。 展开更多
关键词 产气夹膜梭菌 集体供餐 食物中毒 食源性疾病 毒素基因
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Generation and Measurement of Isolated 160-Attosecond XUV Laser Pulses at 82eV 被引量:17
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作者 ZHAN Min-Jie YE Peng +6 位作者 teng Hao HE Xin-Kui ZHANG Wei ZHONG shi-Yang WANG Li-Feng YUN Chen-Xia WEI Zhi-Yi 《Chinese Physics Letters》 SCIE CAS CSCD 2013年第9期54-57,共4页
Isolated attosecond extreme-ultraviolate(XUV)pulses are generated based on high-harmonic-generation from a neon gas cell driven by carrier-envelope phase stabilized sub-5-fs Ti:sapphire laser pulses at repetition rate... Isolated attosecond extreme-ultraviolate(XUV)pulses are generated based on high-harmonic-generation from a neon gas cell driven by carrier-envelope phase stabilized sub-5-fs Ti:sapphire laser pulses at repetition rate of 1kHz.Temporal characterization of isolated attosecond XUV pulses is demonstrated to be 160-attosecond by attosecond streaking spectroscopy.The development of attosecond source and streaking spectroscopy will allow scientists to explore the electron dynamics in matter. 展开更多
关键词 SPECTROSCOPY SECOND EXTREME
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不同砂梨果实中糖酸含量及代谢相关基因表达分析 被引量:16
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作者 蒋爽 岳晓燕 +6 位作者 滕元文 王晓庆 施春晖 徐芳杰 张学英 白松龄 骆军 《果树学报》 CSCD 北大核心 2016年第S1期65-70,共6页
【目的】探讨糖酸含量对梨果实口感的影响,并找出砂梨果实发育过程中可能的糖酸代谢关键基因。【方法】使用高效液相色谱仪对4个不同类型的砂梨果实中主要糖酸含量进行分析,从梨基因组注释数据中检索并分离获得糖酸代谢密切相关的基因家... 【目的】探讨糖酸含量对梨果实口感的影响,并找出砂梨果实发育过程中可能的糖酸代谢关键基因。【方法】使用高效液相色谱仪对4个不同类型的砂梨果实中主要糖酸含量进行分析,从梨基因组注释数据中检索并分离获得糖酸代谢密切相关的基因家族,并使用‘雪青’梨转录组数据对这些基因家族在果实不同发育时期进行表达分析。【结果】‘翠冠’梨中糖含量高,‘1-8-34’梨酸含量高。口感偏酸的‘新酥’梨和‘1-8-34’果实中的总糖含量与口感偏甜的‘金二十世纪’梨差异不显著。研究共分离获得糖酸代谢密切相关的10个基因家族共44成员,其中23个成员在不同果实发育时期发生表达。2个蔗糖磷酸合成酶(SPS1和SPS2)、1个磷酸烯醇式丙酮酸羧化酶(PEPC3)和2个苹果酸脱氢酶(MDH3和MDH4)在梨果实成熟期均表现出较高表达量。【结论】梨果实口感酸的主要原因是果肉中酸含量高。SPS1,SPS2,PEPC3,MDH3和MDH4在梨果实糖酸合成中起关键作用。 展开更多
关键词 基因表达分析
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Liver transplant recipients with portal vein thrombosis:a single center retrospective study 被引量:16
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作者 Tao, Yi-Feng teng, Fei +5 位作者 Wang, Zheng-Xin Guo, Wen-Yuan shi, Xiao-Min Wang, Gui-Hua Ding, Guo-Shan Fu, Zhi-Ren 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2009年第1期34-39,共6页
BACKGROUND: Portal vein thrombosis (PVT) used to be a contraindication for liver transplantation (LT). This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to ... BACKGROUND: Portal vein thrombosis (PVT) used to be a contraindication for liver transplantation (LT). This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODS: A total of 465 adult LTs were performed from December 2002 through December 2006. Operative findings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading (Yerdel grading). Comparison of risk factors, variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. RESULTS: In the 465 LTs, 42 were operatively confirmed to have PVT (9.0%) (19 recipients with grade I, 14 with grade 2, 7 with grade 3, and 2 with grade 4). Increased age and treatment of portal hypertension were associated with PVT. Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy. In grade 3 PVT patients, the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed. Grade 4 PVT was managed by our modified cavoportal hemitransposition technique. The comparison between PVT patients and controls showed no significant difference in operative duration and blood transfusion (P > 0.05). The flow rate of the PV was lower in the PVT patients (48.881 +/- 12.788 cm/s) than in the controls (57.172 +/- 21.715 cm/s, P < 0.05). The PVT patients had such postoperative complications as renal failure and PV rethrombosis (P < 0.05). The 1-year survival rates in PVT and non-PVT patients were 78.6% and 76.4% respectively (P > 0.05); the 3-year survival rates were 58.8% and 56.4% respectively (P > 0.05). CONCLUSIONS: PVT is not contraindicated for LT if it is graded. PVT recipients may have post-tra 展开更多
关键词 portal vein thrombosis liver transplantation PROGNOSIS
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黄芩抗糖尿病作用与机制的近十年研究进展 被引量:14
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作者 徐锋 陈滕 +3 位作者 汪祖华 石慧 俸婷婷 周英 《环球中医药》 CAS 2022年第2期342-348,共7页
黄芩及其成分(黄芩苷、汉黄芩苷、黄芩素、汉黄芩素和野黄芩苷等)均有显著的抗糖尿病作用。本文从调节糖脂代谢、改善胰岛素抵抗、抗氧化、保护胰岛β细胞等方面对黄芩抗糖尿病的作用机制进行整理和总结,发现黄芩可通过影响肝脏中多种... 黄芩及其成分(黄芩苷、汉黄芩苷、黄芩素、汉黄芩素和野黄芩苷等)均有显著的抗糖尿病作用。本文从调节糖脂代谢、改善胰岛素抵抗、抗氧化、保护胰岛β细胞等方面对黄芩抗糖尿病的作用机制进行整理和总结,发现黄芩可通过影响肝脏中多种酶的活性、调节腺苷酸活化蛋白激酶和胰岛素相关信号通路、干预糖的吸收、调节脂代谢及肠道菌群和肠道代谢等,多层次、多角度地发挥调节糖脂代谢的作用。此外,黄芩还能改善糖尿病肝脏、骨骼肌和脂肪组织的胰岛素抵抗,并能调控糖尿病肝脏和胰腺组织中的氧化应激反应,以及从抗凋亡和抗炎角度保护胰岛β细胞。目前黄芩抗糖尿病的研究主要集中于黄芩的黄酮类成分,对于黄芩整体及其含有的其他大类成分抗糖尿病作用及机制的研究较少,仍需要更多的研究加以阐明,以利于黄芩的进一步开发与应用。 展开更多
关键词 黄芩 糖尿病 药效物质基础 糖脂代谢 胰岛素抵抗 抗氧化途径 保护胰岛β细胞
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小剂量地塞米松预处理对乳腺癌患者多西紫杉醇化疗致过敏及其他不良反应的影响 被引量:14
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作者 滕青华 王延虹 +2 位作者 时磊 邢鑫 王丽娟 《癌症进展》 2019年第21期2548-2551,共4页
目的观察小剂量地塞米松预处理对乳腺癌患者多西紫杉醇化疗致过敏及其他不良反应的影响。方法将140例乳腺癌患者按照治疗方法的不同分为观察组(给予小剂量地塞米松预处理)和对照组(未给予地塞米松预处理),每组70例。观察全部患者的化疗... 目的观察小剂量地塞米松预处理对乳腺癌患者多西紫杉醇化疗致过敏及其他不良反应的影响。方法将140例乳腺癌患者按照治疗方法的不同分为观察组(给予小剂量地塞米松预处理)和对照组(未给予地塞米松预处理),每组70例。观察全部患者的化疗情况,比较两组患者的过敏反应和其他不良反应的发生情况及改良疾病累计评分量表(MCIRS)评分情况。结果全部乳腺癌患者均顺利完成了6个周期的化疗。两组患者过敏反应的总发生率和MCIRS评分情况比较,差异均无统计学意义(P﹥0.05)。两组患者的中性粒细胞减少、血小板减少、血红蛋白减少、淋巴细胞减少、恶心呕吐、腹泻、疲劳、水肿或积液、胃部不适的发生率比较,差异均无统计学意义(P﹥0.05);观察组患者的肌肉痛、兴奋或失眠的发生率均明显低于对照组患者(P﹤0.01)。在中性粒细胞减少和疲劳方面,与对照组相比,观察组中MCIRS评分≤14分的患者比例较高(P﹤0.05);在其余不良反应方面,两组患者的MCIRS评分情况比较,差异均无统计学意义(P﹥0.05)。结论对于行多西紫杉醇化疗的乳腺癌患者,给予小剂量地塞米松进行预处理是安全有效的,不但不会增加过敏反应和其他不良反应,还能够降低肌肉痛、兴奋或失眠的发生率。 展开更多
关键词 乳腺癌 多西紫杉醇 地塞米松 小剂量 预处理 化疗 过敏
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Modelling and mapping soil erosion potential in China 被引量:14
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作者 teng Hong-fen HU Jie +2 位作者 ZHOU Yue ZHOU Lian-qing shi Zhou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2019年第2期251-264,共14页
Soil erosion is an important environmental threat in China.However,quantitative estimates of soil erosion in China have rarely been reported in the literature.In this study,soil loss potential in China was estimated b... Soil erosion is an important environmental threat in China.However,quantitative estimates of soil erosion in China have rarely been reported in the literature.In this study,soil loss potential in China was estimated by integrating satellite images,field samples,and ground observations based on the Revised Universal Soil Loss Equation(RUSLE).The rainfall erosivity factor was estimated from merged rainfall data using Collocated CoKriging(ColCOK)and downscaled by geographically weighted regression(GWR).The Random Forest(RF)regression approach was used as a tool for understanding and predicting the relationship between the soil erodibility factor and a set of environment factors.Our results show that the average erosion rate in China is 1.44 t ha^(–1) yr^(–1).More than 60%of the territory in China is influenced by soil erosion limitedly,with an average potential erosion rate less than 0.1 t ha^(–1) yr^(–1).Other unused land and other forested woodlands showed the highest erosion risk.Our estimates are comparable to those of runoff plot studies.Our results provide a useful tool for soil loss assessments and ecological environment protections. 展开更多
关键词 soil EROSION POTENTIAL RUSLE MAPPING MODELLING
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“十四五”土壤生物学分支学科发展战略 被引量:14
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作者 褚海燕 马玉颖 +5 位作者 杨腾 张考萍 范坤坤 李云涛 时玉 高贵锋 《土壤学报》 CAS CSCD 北大核心 2020年第5期1105-1116,共12页
土壤生物是地球生物多样性的重要组成部分。土壤生物驱动着土壤中有机质降解、元素循环、污染物转化与降解以及温室气体的产生与消耗,在全球粮食安全、环境保护以及应对气候变化等方面发挥着重要作用。土壤生物学是研究土壤生物多样性... 土壤生物是地球生物多样性的重要组成部分。土壤生物驱动着土壤中有机质降解、元素循环、污染物转化与降解以及温室气体的产生与消耗,在全球粮食安全、环境保护以及应对气候变化等方面发挥着重要作用。土壤生物学是研究土壤生物多样性与分布、土壤生物的过程与功能以及土壤生物的调控与应用的科学。21世纪以来,分子生物学技术的突破与生态学理论的广泛应用极大地推进了土壤生物学研究的发展。本文回顾了土壤生物学科的发展历程,详细介绍了土壤生物学科的发展现状,提出了土壤生物学科在理论与应用上的发展趋势,并对未来土壤生物学科的发展方向进行了展望。随着多学科交叉融合以及研究手段的进步,土壤生物学迎来了一个新的发展时期。土壤生物学研究在生物资源挖掘、时空分布格局、生态服务功能和生物调控等方面取得的重要成果,将更好地服务于土壤健康、植物健康、人类健康以及我们的星球健康。 展开更多
关键词 土壤生物学 发展现状 发展趋势 学科展望 土壤健康
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