The knowledge on the effects of CCK on the physiological function of pancreas is mainly from experiments of rats. Unlike rat pancreas, which contains receptors for CCK-A, human and porcine pancreases predominantly exp...The knowledge on the effects of CCK on the physiological function of pancreas is mainly from experiments of rats. Unlike rat pancreas, which contains receptors for CCK-A, human and porcine pancreases predominantly express CCK-B receptors. However, the physiological function of CCK-B receptors in human and porcine pancreatic acini is still unclear. This study investigated the effects of CCK on the exocrine secretion and DNA synthesis in acinar cells of porcine pancreas.展开更多
Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the d...Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the development and metastasis of colorectal cancer. This study visualized and characterized the receptors for vasoactive intestinal peptide, secretin and somatostatin in the development and metastasis of colorectal cancer with storage phosphor autoradiography. Receptors for these three peptides were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of vasoactive intestinal peptide receptors was shown in the sequence from tumor-free colon (Kd=0.93nmol),展开更多
文摘The knowledge on the effects of CCK on the physiological function of pancreas is mainly from experiments of rats. Unlike rat pancreas, which contains receptors for CCK-A, human and porcine pancreases predominantly express CCK-B receptors. However, the physiological function of CCK-B receptors in human and porcine pancreatic acini is still unclear. This study investigated the effects of CCK on the exocrine secretion and DNA synthesis in acinar cells of porcine pancreas.
文摘Increasing interest in theanalogues or antagonists inapplication of gut peptide the diagnosis and treatmentof colorectal cancer necessitates a better insight and characterization of receptors for gut peptides in the development and metastasis of colorectal cancer. This study visualized and characterized the receptors for vasoactive intestinal peptide, secretin and somatostatin in the development and metastasis of colorectal cancer with storage phosphor autoradiography. Receptors for these three peptides were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of vasoactive intestinal peptide receptors was shown in the sequence from tumor-free colon (Kd=0.93nmol),
