The genus Zanthoxylum (Rutaceae) is comprised of about 50 species in China.Zanthoxylum dissitum Hems-ley, locally called 'Shanpipa', has been used to treat pains in the loin,limbs and arthritis in Chinese folk...The genus Zanthoxylum (Rutaceae) is comprised of about 50 species in China.Zanthoxylum dissitum Hems-ley, locally called 'Shanpipa', has been used to treat pains in the loin,limbs and arthritis in Chinese folk medicine. Our previous study reported the isolation andidentification of five quinoline alkaloids . In this continuing study on the chemcial constituentsof Zanthoxylum dissitum Hemsley, a phenylalanine derivative was obtained .展开更多
Background:Glioblastoma multiforme(GBM)is the most general malignancy of the primary central nervous system that is characterized by high aggressiveness and lethality.Transmembrane protein 159(TMEM159)is an endoplasmi...Background:Glioblastoma multiforme(GBM)is the most general malignancy of the primary central nervous system that is characterized by high aggressiveness and lethality.Transmembrane protein 159(TMEM159)is an endoplasmic reticulum protein that can form oligomers with seipin.The TMEM159-seipin complex decides the site of lipid droplet(LD)formation,and the formation of LDs is a marker of GBM.However,the role of TMEM159 in the progression of GBM has not been investigated to date.Methods:In this study,we examined the genes that may be associated with patient prognosis in GBM by bioinformatics analyses,and identified the key genes that affect the development of GBM using single-cell RNA sequencing technology.The biological functions of TMEM159 in GBM cells were additionally assessed by clone formation and transwell assays as well as using a model of chick embryo chorioallantois membrane(CAM)and western blotting.The association between TMEM159 and epidermal growth factor receptor(EGFR)was finally analyzed in GBM cells.Results:A prognostic model was established and validated for predicting the prognosis.Survival curve analysis showed a critical difference in the prognosis of the high-and low-risk groups predicted by the prognostic model.The results demonstrated that TMEM159 affected the proliferation and invasion of GBM cells.The chick embryo CAM assays demonstrated that the inhibition of TMEM159 expression reduced angiogenesis in the CAM model.Conclusions:The prognostic model achieved good predictive potential for high-risk patients.The findings also revealed that TMEM159 might be an important prognostic factor for GBM,indicating that the protein may be a promising therapeutic target for suppressing the development of GBM.展开更多
A scheduling algorithm is presented aiming at the task scheduling problem in the phased array radar. Rather than assuming the scheduling interval(SI) time, which is the update interval of the radar invoking the schedu...A scheduling algorithm is presented aiming at the task scheduling problem in the phased array radar. Rather than assuming the scheduling interval(SI) time, which is the update interval of the radar invoking the scheduling algorithm, to be a fixed value,it is modeled as a fuzzy set to improve the scheduling flexibility.The scheduling algorithm exploits the fuzzy set model in order to intelligently adjust the SI time. The idle time in other SIs is provided for SIs which will be overload. Thereby more request tasks can be accommodated. The simulation results show that the proposed algorithm improves the successful scheduling ratio by 16%,the threat ratio of execution by 16% and the time utilization ratio by 15% compared with the highest task mode priority first(HPF)algorithm.展开更多
Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effect...Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effects of fibroblast injection on intervertebral disc degeneration(IDD) in a preclinical setting. Compared with the IDD group, the fibroblast treatment group demonstrated effective maintenance of IVD height, reduced endplate degeneration, and improved nuclear magnetic resonance signals and overall histological structure. In doing so, fibrotic IVDs maintained the stability and biomechanics of the vertebra. This finding is in agreement with clinical findings that human nucleus pulposus(NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy(PELD). Mechanistically, we demonstrated that injected fibroblasts not only proliferated but also induced NP cells to adopt a fibrotic phenotype via the secretion of TGF-β.Finally, to better mimic human conditions, the efficacy of autologous fibroblast injection in the treatment of IDD was further examined in a nonhuman primate cynomolgus monkey model due to their capacity for upright posture. We showed that the injection of fibroblasts could maintain the IVD height and rescue IVD signals in cynomolgus monkeys. Taken together, the results of our study reveal that autologous fibroblast injection can enhance the natural process of fibrosis during acute and subacute stages of stress-induced IDD. Fibrotic IVDs can maintain the stability, biological activity, and mechanical properties of the intervertebral space, thus providing a new direction for the treatment of intervertebral space-derived lumbar degenerative diseases.展开更多
China is switching from economic growth based on extremely rapid capital accumulation to economic growth based on structural reforms and accelerated total factor productivity growth. Meanwhile, China will also face a ...China is switching from economic growth based on extremely rapid capital accumulation to economic growth based on structural reforms and accelerated total factor productivity growth. Meanwhile, China will also face a serious excess saving problem as capital accumulation slows and, hence, needs to reduce its private saving rate. Based on this analysis, we estimated the economic impact of China＇s growth slowdown and hypothetical economic transformation on Japan, the USA and Germany using the worm input-output database. We compared the following three scenarios for China＇s final demand in 2020 and economic growth from 2015 to 2020： （i） an optimistic scenario （GDP growth rate = 6.2%, investment/GDP = 0.501）; （ii） a slowdown scenario （GDP growth rate = 4%, investment/GDP = 0.501）; and （iii） a structural reform scenario （GDP growth rate = 6.2%, investment/GDP = 0.3）. Our analysis suggests that Japan and Germany would suffer more from structural reforms in China than from a slowdown in growth. Meanwhile, for the USA, the employment decline triggered by structural reforms wouM be much smaller than the employment decline caused by a slowdown in growth.展开更多
The effect of intra-channel four-wave mixing on the performance of a 160 Gb/s OTDM RZ 100 km transmission system is analyzed. Strong dispersion management to suppress the detrimental effects of intra-channel four-wave...The effect of intra-channel four-wave mixing on the performance of a 160 Gb/s OTDM RZ 100 km transmission system is analyzed. Strong dispersion management to suppress the detrimental effects of intra-channel four-wave mixing is presented theoretically and verified experimentally. Results demonstrate that amplitude fluctuation and ghost pulses are well suppressed by strong dispersion management. Stable (>2 h) error-free (10-12 ) transmission over 100 km is achieved without forward-error correction, and the power penalty is ～3.6 dB.展开更多
In a 4×10Gb/s OTDM system (optical time-division-multiplication) system, multiplexing devices are key devices. The time interval of four channels of the 40Gb/s OTDM system is 25ps respectively. If the time interv...In a 4×10Gb/s OTDM system (optical time-division-multiplication) system, multiplexing devices are key devices. The time interval of four channels of the 40Gb/s OTDM system is 25ps respectively. If the time intervals are no accurate, will induce the system performance to degeneration. In order to make out OTDM device and carry out a transmission experiment in a 40Gb/s OTDM system, a kind of OTDM device is researched. This scheme be used to fabricate multiplex device. Also the device have been used to a 4...展开更多
A water-soluble oligo(p-phenylkene vinylene) [4,4′-(1,4-phenylene dithenylene)-bis-(N-methyl pyridinium iodide)] was synthesized by Witting reaction. The oligomer was characterized by NMR, elemental analysis, UV-visi...A water-soluble oligo(p-phenylkene vinylene) [4,4′-(1,4-phenylene dithenylene)-bis-(N-methyl pyridinium iodide)] was synthesized by Witting reaction. The oligomer was characterized by NMR, elemental analysis, UV-visible spectrum, surface photovoltage spectrum and fluorescence spectrum.展开更多
In this paper, by introducing a two-stages polarization mode dispersion (PMD) compensator after a optical fiber link with a large PMD, we compensated over 270ps first-order and 2000ps2 high-order PMD in a optical fibe...In this paper, by introducing a two-stages polarization mode dispersion (PMD) compensator after a optical fiber link with a large PMD, we compensated over 270ps first-order and 2000ps2 high-order PMD in a optical fiber link with super high PMD. Our experimental results shows that, the compensators based on the two-stages of compensator can be used to PMD compensation in a 20Gb/s OTDM system with 60 km high PMD fiber. Before compensation, 270ps DGD is became into max. 7ps after compensation. At simultane...展开更多
The experiments on pollutant movement in surf zone were conducted on the two gentle beaches(with slope of 1:100 and 1:40, respectively), for diverse wave cases. The movement contours and direction of pollutants, under...The experiments on pollutant movement in surf zone were conducted on the two gentle beaches(with slope of 1:100 and 1:40, respectively), for diverse wave cases. The movement contours and direction of pollutants, under the action of regular and random waves with diverse wave amplitudes, were provided and studied in this paper. It was shown that, due to complicated hydrodynamics in surf zone, the pollutant movement state is quite complicated and different from that in pure current zone.展开更多
To study quantitative change of cerebral blood flow (CBF) on patients with early syphilis, we have estab- lished a method on absolute measurement of rCBF by using SPECT with Ethyl Cysteinate Dimmer (ECD) as imaging ag...To study quantitative change of cerebral blood flow (CBF) on patients with early syphilis, we have estab- lished a method on absolute measurement of rCBF by using SPECT with Ethyl Cysteinate Dimmer (ECD) as imaging agent, and the method was applied to measure rCBF on patients with early syphilis. The rCBF values measured by this method are highly consistent with the values measured by other classical methods such as SPECT (123I-IMP) and PET (15O-H2O). The rCBF values for early syphilis patients and the normal control show some statistical differences. A routine quantitative absolute measurement of rCBF featured with simple procedures is therefore on the way of maturation.展开更多
文摘The genus Zanthoxylum (Rutaceae) is comprised of about 50 species in China.Zanthoxylum dissitum Hems-ley, locally called 'Shanpipa', has been used to treat pains in the loin,limbs and arthritis in Chinese folk medicine. Our previous study reported the isolation andidentification of five quinoline alkaloids . In this continuing study on the chemcial constituentsof Zanthoxylum dissitum Hemsley, a phenylalanine derivative was obtained .
基金supported by the National Natural Science Foundation of China(No.82173032)Liaoning Provincial Science and Technology Plan Project(No.2023JH2/101700156)+1 种基金the Medical and Industrial Crossover Project of Liaoning Cancer Hospital&Institute(No.LD202225)the Science and Technology Planning Project of Shenyang(No.20–205-4–003).
文摘Background:Glioblastoma multiforme(GBM)is the most general malignancy of the primary central nervous system that is characterized by high aggressiveness and lethality.Transmembrane protein 159(TMEM159)is an endoplasmic reticulum protein that can form oligomers with seipin.The TMEM159-seipin complex decides the site of lipid droplet(LD)formation,and the formation of LDs is a marker of GBM.However,the role of TMEM159 in the progression of GBM has not been investigated to date.Methods:In this study,we examined the genes that may be associated with patient prognosis in GBM by bioinformatics analyses,and identified the key genes that affect the development of GBM using single-cell RNA sequencing technology.The biological functions of TMEM159 in GBM cells were additionally assessed by clone formation and transwell assays as well as using a model of chick embryo chorioallantois membrane(CAM)and western blotting.The association between TMEM159 and epidermal growth factor receptor(EGFR)was finally analyzed in GBM cells.Results:A prognostic model was established and validated for predicting the prognosis.Survival curve analysis showed a critical difference in the prognosis of the high-and low-risk groups predicted by the prognostic model.The results demonstrated that TMEM159 affected the proliferation and invasion of GBM cells.The chick embryo CAM assays demonstrated that the inhibition of TMEM159 expression reduced angiogenesis in the CAM model.Conclusions:The prognostic model achieved good predictive potential for high-risk patients.The findings also revealed that TMEM159 might be an important prognostic factor for GBM,indicating that the protein may be a promising therapeutic target for suppressing the development of GBM.
基金supported by the National Youth Foundation(61503408)
文摘A scheduling algorithm is presented aiming at the task scheduling problem in the phased array radar. Rather than assuming the scheduling interval(SI) time, which is the update interval of the radar invoking the scheduling algorithm, to be a fixed value,it is modeled as a fuzzy set to improve the scheduling flexibility.The scheduling algorithm exploits the fuzzy set model in order to intelligently adjust the SI time. The idle time in other SIs is provided for SIs which will be overload. Thereby more request tasks can be accommodated. The simulation results show that the proposed algorithm improves the successful scheduling ratio by 16%,the threat ratio of execution by 16% and the time utilization ratio by 15% compared with the highest task mode priority first(HPF)algorithm.
基金supported by the National Natural Science Foundation of China (81871790) & (81572167)the Shanghai Hospital Development Center Foundation (SHDC12016110)
文摘Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effects of fibroblast injection on intervertebral disc degeneration(IDD) in a preclinical setting. Compared with the IDD group, the fibroblast treatment group demonstrated effective maintenance of IVD height, reduced endplate degeneration, and improved nuclear magnetic resonance signals and overall histological structure. In doing so, fibrotic IVDs maintained the stability and biomechanics of the vertebra. This finding is in agreement with clinical findings that human nucleus pulposus(NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy(PELD). Mechanistically, we demonstrated that injected fibroblasts not only proliferated but also induced NP cells to adopt a fibrotic phenotype via the secretion of TGF-β.Finally, to better mimic human conditions, the efficacy of autologous fibroblast injection in the treatment of IDD was further examined in a nonhuman primate cynomolgus monkey model due to their capacity for upright posture. We showed that the injection of fibroblasts could maintain the IVD height and rescue IVD signals in cynomolgus monkeys. Taken together, the results of our study reveal that autologous fibroblast injection can enhance the natural process of fibrosis during acute and subacute stages of stress-induced IDD. Fibrotic IVDs can maintain the stability, biological activity, and mechanical properties of the intervertebral space, thus providing a new direction for the treatment of intervertebral space-derived lumbar degenerative diseases.
基金We gratefully acknowledge financial support from the Japan Society for the Promotion of Science （Grant No. 16H06322）, the Social Science Foundation of China （Grant No. 11AJY006） and the Key Project of Chinese Ministry of Education （Grant No. 12JJD790038）.
文摘China is switching from economic growth based on extremely rapid capital accumulation to economic growth based on structural reforms and accelerated total factor productivity growth. Meanwhile, China will also face a serious excess saving problem as capital accumulation slows and, hence, needs to reduce its private saving rate. Based on this analysis, we estimated the economic impact of China＇s growth slowdown and hypothetical economic transformation on Japan, the USA and Germany using the worm input-output database. We compared the following three scenarios for China＇s final demand in 2020 and economic growth from 2015 to 2020： （i） an optimistic scenario （GDP growth rate = 6.2%, investment/GDP = 0.501）; （ii） a slowdown scenario （GDP growth rate = 4%, investment/GDP = 0.501）; and （iii） a structural reform scenario （GDP growth rate = 6.2%, investment/GDP = 0.3）. Our analysis suggests that Japan and Germany would suffer more from structural reforms in China than from a slowdown in growth. Meanwhile, for the USA, the employment decline triggered by structural reforms wouM be much smaller than the employment decline caused by a slowdown in growth.
基金supported by the Fundamental Research Funds for the Central Universities (2009YJS005)National High Technology Research and Development Projects of China (2007AA01Z258,2008AA01Z15)+3 种基金the National Natural Science Foundation of China (60807003)the Beijing Nova Program (2008A026)the Natural Science Foundation of Beijing (4062027)the National Natural Science Foundation of China (60877042,60837003)
文摘The effect of intra-channel four-wave mixing on the performance of a 160 Gb/s OTDM RZ 100 km transmission system is analyzed. Strong dispersion management to suppress the detrimental effects of intra-channel four-wave mixing is presented theoretically and verified experimentally. Results demonstrate that amplitude fluctuation and ghost pulses are well suppressed by strong dispersion management. Stable (>2 h) error-free (10-12 ) transmission over 100 km is achieved without forward-error correction, and the power penalty is ～3.6 dB.
基金Supported by National Science Foundations of ChinaNational 863 High Technology Projects of China.
文摘In a 4×10Gb/s OTDM system (optical time-division-multiplication) system, multiplexing devices are key devices. The time interval of four channels of the 40Gb/s OTDM system is 25ps respectively. If the time intervals are no accurate, will induce the system performance to degeneration. In order to make out OTDM device and carry out a transmission experiment in a 40Gb/s OTDM system, a kind of OTDM device is researched. This scheme be used to fabricate multiplex device. Also the device have been used to a 4...
基金supported by the Major Basic Research Project(Grant No.2002CB613401)the Foundation of Jilin university.
文摘A water-soluble oligo(p-phenylkene vinylene) [4,4′-(1,4-phenylene dithenylene)-bis-(N-methyl pyridinium iodide)] was synthesized by Witting reaction. The oligomer was characterized by NMR, elemental analysis, UV-visible spectrum, surface photovoltage spectrum and fluorescence spectrum.
基金Supported by National Science Foundations of ChinaNational 863 High Technology Projects of China.
文摘In this paper, by introducing a two-stages polarization mode dispersion (PMD) compensator after a optical fiber link with a large PMD, we compensated over 270ps first-order and 2000ps2 high-order PMD in a optical fiber link with super high PMD. Our experimental results shows that, the compensators based on the two-stages of compensator can be used to PMD compensation in a 20Gb/s OTDM system with 60 km high PMD fiber. Before compensation, 270ps DGD is became into max. 7ps after compensation. At simultane...
文摘The experiments on pollutant movement in surf zone were conducted on the two gentle beaches(with slope of 1:100 and 1:40, respectively), for diverse wave cases. The movement contours and direction of pollutants, under the action of regular and random waves with diverse wave amplitudes, were provided and studied in this paper. It was shown that, due to complicated hydrodynamics in surf zone, the pollutant movement state is quite complicated and different from that in pure current zone.
文摘To study quantitative change of cerebral blood flow (CBF) on patients with early syphilis, we have estab- lished a method on absolute measurement of rCBF by using SPECT with Ethyl Cysteinate Dimmer (ECD) as imaging agent, and the method was applied to measure rCBF on patients with early syphilis. The rCBF values measured by this method are highly consistent with the values measured by other classical methods such as SPECT (123I-IMP) and PET (15O-H2O). The rCBF values for early syphilis patients and the normal control show some statistical differences. A routine quantitative absolute measurement of rCBF featured with simple procedures is therefore on the way of maturation.
