Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several ...Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is common. Th展开更多
Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polar...Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance.展开更多
The relief degree of land surface （RDLS） is an important factor for describing the landform at macro-scales. This study defines a concept for RDLS and applies the concept for population distribution study of the ent...The relief degree of land surface （RDLS） is an important factor for describing the landform at macro-scales. This study defines a concept for RDLS and applies the concept for population distribution study of the entire country. Based on the concept and macro-scale digital elevation model datum and ARC/INFO software, the RDLS at a 10 km×10 km grid size of China is extracted. This paper depicts systemically the spatial distributions of RDLS through analyzing the ratio structure and altitudinal characters of RDLS in China. The conclusions are drawn as follows： the RDLS in more than 63% of the area is less than one （1） （relative altitude is less than 500 m）, reflecting the fact that most of RDLS in China is low. In general, the RDLS in the west is larger than that in the east and so is the south than that of the north in China. The RDLS decreases with the increase of longitude and latitude and the change of RDLS at the latitudes of 28°N, 35°N, 42°N, as well as at the longitudes of 85°E, 102°E, 115°E could reflect the three major ladders of China. In the vertical direction, the RDLS increases with the increase of altitude. Analysis of the correlation between RDLS and population distribution in China and its regional difference shows that the R2 value between RDLS and population density is 0.91 and RDLS is an important factor influencing the spatial distribution of population. More than 85% of the people in China live in areas where the RDLS is less than one （1）, while the population in areas with RDLS greater than 3 accounts only for 0.57% of the total. The regional difference of correlation between RDLS and population within China is significant and such correlation is significant in Central China and South China and weak in Inner Mongolia and Tibet.展开更多
The mechanical properties and microstructure of two low carbon high manganese steels with 23.8% （No. 1） and 33% （No. 2） （mass percent） of manganese were investigated. The results showed that No. 1 steel possesse...The mechanical properties and microstructure of two low carbon high manganese steels with 23.8% （No. 1） and 33% （No. 2） （mass percent） of manganese were investigated. The results showed that No. 1 steel possesses high strength and high plasticity, and No. 2 steel has a relatively high strength and extraordinary plasticity. The No. 1 steel exhibits both TRIP （transformation induced plasticity） and TWIP （twin induced plasticity） effects during the deformation; while only TWIP effect appeared under the same deformation condition for No. 2 steel. The comparison between the microstructures and mechanical properties of two steels was made, and the strengthening mechanisms were also analyzed.展开更多
Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the v...Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes.Data Sources: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the Pub Med database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key articles.Results: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery,which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR technology.Conclusions: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling,and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods.展开更多
文摘Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is common. Th
基金The authors’research efforts were supported in part by research grants from the NIH(AT004418 to TCH)the 973 Program of Ministry of Science and Technology(MOST)of China(#2011CB707900 to TCH)+1 种基金the Scoliosis Research Society(to MJL),MKM was a recipient of Howard Hughes Medical Institute Medical Research FellowshipCS was a recipient of the Pritzker Summer Research Fellowship funded through a NIH T-35 training grant(NIDDK).
文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance.
基金Knowledge Innovation Project of the CAS,No.KZCX2-YW-323
文摘The relief degree of land surface （RDLS） is an important factor for describing the landform at macro-scales. This study defines a concept for RDLS and applies the concept for population distribution study of the entire country. Based on the concept and macro-scale digital elevation model datum and ARC/INFO software, the RDLS at a 10 km×10 km grid size of China is extracted. This paper depicts systemically the spatial distributions of RDLS through analyzing the ratio structure and altitudinal characters of RDLS in China. The conclusions are drawn as follows： the RDLS in more than 63% of the area is less than one （1） （relative altitude is less than 500 m）, reflecting the fact that most of RDLS in China is low. In general, the RDLS in the west is larger than that in the east and so is the south than that of the north in China. The RDLS decreases with the increase of longitude and latitude and the change of RDLS at the latitudes of 28°N, 35°N, 42°N, as well as at the longitudes of 85°E, 102°E, 115°E could reflect the three major ladders of China. In the vertical direction, the RDLS increases with the increase of altitude. Analysis of the correlation between RDLS and population distribution in China and its regional difference shows that the R2 value between RDLS and population density is 0.91 and RDLS is an important factor influencing the spatial distribution of population. More than 85% of the people in China live in areas where the RDLS is less than one （1）, while the population in areas with RDLS greater than 3 accounts only for 0.57% of the total. The regional difference of correlation between RDLS and population within China is significant and such correlation is significant in Central China and South China and weak in Inner Mongolia and Tibet.
文摘The mechanical properties and microstructure of two low carbon high manganese steels with 23.8% （No. 1） and 33% （No. 2） （mass percent） of manganese were investigated. The results showed that No. 1 steel possesses high strength and high plasticity, and No. 2 steel has a relatively high strength and extraordinary plasticity. The No. 1 steel exhibits both TRIP （transformation induced plasticity） and TWIP （twin induced plasticity） effects during the deformation; while only TWIP effect appeared under the same deformation condition for No. 2 steel. The comparison between the microstructures and mechanical properties of two steels was made, and the strengthening mechanisms were also analyzed.
基金supported by grants from the Mission Plan Program of Beijing Municipal Administration of Hospitals(SML20152201)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding(ZYLX201712)+1 种基金the National Natural Science Foundation of China(81427803)Beijing Tsinghua Changgung Hospital Fund(12015C1039)
文摘Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes.Data Sources: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the Pub Med database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key articles.Results: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery,which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR technology.Conclusions: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling,and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods.
