Effective colorectal cancer screening relies on reliable colonoscopy findings which are themselves dependent on adequate bowel cleansing. Research has consistently demonstrated that inadequate bowel preparation advers...Effective colorectal cancer screening relies on reliable colonoscopy findings which are themselves dependent on adequate bowel cleansing. Research has consistently demonstrated that inadequate bowel preparation adversely affects the adenoma detection rate and leads gastroenterologists to recommend earlier follow up than is consistent with published guidelines. Poor preparation affects as many as 30% of colonoscopies and contributes to an increased cost of colonoscopies. Patient tolerability is strongly affected by the preparation chosen and manner in which it is administered. Poor tolerability is,in turn,associated with lower quality bowel preparations. Recently,several new developments in both agents being used for bowel preparation and in the timing of administration have brought endoscopists closer to achieving the goal of effective,reliable,safe,and tolerable regimens. Historically,large volume preparations given in a single dose were administered to patients in order to achieve adequate bowel cleansing. These were poorly tolerated,and the unpleasant taste of and significant side effects produced by these large volume regimens contributed significantly to patients' inability to reliably complete the preparation and to a reluctance to repeat the procedure. Smaller volumes,including preparations that are administered as tablets to be consumed with water,given as split doses have significantly improved both the patient experience and efficacy,and an appreciation of the importance of the preparation to colonoscopy interval have produced additional cleansing.展开更多
The dinoflagellate Noctiluca scintillans is one of the most important and abundant red tide organisms and it is distributed world-wide. It occurs in two forms. Red Noctiluca is heterotrophic and fills the role of one ...The dinoflagellate Noctiluca scintillans is one of the most important and abundant red tide organisms and it is distributed world-wide. It occurs in two forms. Red Noctiluca is heterotrophic and fills the role of one of the microzooplankton grazers in the foodweb. In contrast, green Noctiluca contains a photosynthetic symbiont Pedinomonas noctilucae （a prasinophyte）, but it also feeds on other plankton when the food supply is abundant. In this review, we document the global distribution of these two forms and include the first maps of their global distribution. Red Noctiluca occurs widely in the temperate to sub-tropical coastal regions of the world. It occurs over a wide temperature range of about 10℃ to 25℃ and at higher salinities （generally not in estuaries）. It is particularly abundant in high productivity areas such as upwelling or eutrophic areas where diatoms dominate since they are its preferred food source. Green Noctiluca is much more restricted to a temperature range of 25℃-30℃ and mainly occurs in tropical waters of Southeast Asia, Bay of Bengal （east coast of India）, in the eastern, western and northern Arabian Sea, the Red Sea, and recently it has become very abundant in the Gulf of Oman. Red and green Noctiluca do overlap in their distribution in the eastern, northern and western Arabian Sea with a seasonal shift from green Noctiluca in the cooler winter convective mixing, higher productivity season, to red Noctiluca in the more oligotrophic warmer summer season.展开更多
The previously published U-Pb and 40Ar/39Ar ages and our 21 newly-obtained 40Ar/39Ar ages suggest that the Cenozoic magmatism in eastern Tibet and Indochina occurred in two episodes, each with distinctive geochemical ...The previously published U-Pb and 40Ar/39Ar ages and our 21 newly-obtained 40Ar/39Ar ages suggest that the Cenozoic magmatism in eastern Tibet and Indochina occurred in two episodes, each with distinctive geochemical signatures, at (40—28) Ma and (16—0) Ma. The older rocks are localized along the major strike-slip faults such as the Jinsha-Red River fault system and erupted synchronously with transpression. The younger rocks are widely distributed in rift basins and coeval with the east-west extension of Tibet and eastern Asia. Combining with their geochemical data, we consider that the earlier magmatic phase was generated by continental subduction, while the later volcanic phase was caused by decompression melting of a recently meta- somatically-altered, depleted mantle source. The magmatic gap between the two igneous pulses represents an important geodynamic transition in the evolution of eastern Tibet, from the processes controlled mainly by crustal deformation to those largely dominated by mantle tectonics.展开更多
This paper demonstrates the application of a design tool called BioTRIZ. Its developers claim that it can be used to access biological strategies for solving engineering problems. Our aim is to design a roof for hot c...This paper demonstrates the application of a design tool called BioTRIZ. Its developers claim that it can be used to access biological strategies for solving engineering problems. Our aim is to design a roof for hot climates that gets free cooling through radiant coupling with the sky. The insulation in a standard roof stops the sun and convection from warming the thermal mass. But it also restricts the mass＇s longwave view of the cool sky. Different solutions to this conflict are offered by BioTRIZ. The chosen solution is to replace the standard insulation component with an open cell honeycomb. The vertical cells would allow longwave radiation to pass, while arresting convection. The solutions offered by BioTRIZ＇s technological counterpart include no such changes in structure. It is estimated that the thermal mass in the biomimetic roof would remain on average 4.5℃ cooler than in a standard roof over a year in Riyadh, Saudi Arabia.展开更多
This narrative literature review delves into the multifaceted realm of parental involvement in the rehabilitation of children with permanent hearing loss. While existing research has made strides in elucidating parent...This narrative literature review delves into the multifaceted realm of parental involvement in the rehabilitation of children with permanent hearing loss. While existing research has made strides in elucidating parental roles in this context, critical gaps persist, necessitating a comprehensive exploration to inform future endeavors. Our review synthesizes a wide array of studies, identifying these gaps and emphasizing the significance of addressing them. Themes emerging from the literature include the varying degrees of parental engagement, the impact of cultural and socio-economic factors, and the challenges faced by families navigating rehabilitation processes. The synthesis of this literature not only highlights the current state of knowledge but also provides a roadmap for future research efforts. By addressing these gaps, we aim to contribute to a more nuanced understanding of parental involvement in the rehabilitation of children with permanent hearing loss, ultimately fostering improved support systems and holistic care for affected families.展开更多
文摘Effective colorectal cancer screening relies on reliable colonoscopy findings which are themselves dependent on adequate bowel cleansing. Research has consistently demonstrated that inadequate bowel preparation adversely affects the adenoma detection rate and leads gastroenterologists to recommend earlier follow up than is consistent with published guidelines. Poor preparation affects as many as 30% of colonoscopies and contributes to an increased cost of colonoscopies. Patient tolerability is strongly affected by the preparation chosen and manner in which it is administered. Poor tolerability is,in turn,associated with lower quality bowel preparations. Recently,several new developments in both agents being used for bowel preparation and in the timing of administration have brought endoscopists closer to achieving the goal of effective,reliable,safe,and tolerable regimens. Historically,large volume preparations given in a single dose were administered to patients in order to achieve adequate bowel cleansing. These were poorly tolerated,and the unpleasant taste of and significant side effects produced by these large volume regimens contributed significantly to patients' inability to reliably complete the preparation and to a reluctance to repeat the procedure. Smaller volumes,including preparations that are administered as tablets to be consumed with water,given as split doses have significantly improved both the patient experience and efficacy,and an appreciation of the importance of the preparation to colonoscopy interval have produced additional cleansing.
基金the University Grants Council of Hong Kong and its Area of Excellence Program to PJH. KF was supported by a JSPS grant on the ecophysiology of green Noctiluca in the Gulf of Thailand. PMG received funding from NSF （No. OCE-1015980）This is contribution number 4502 from the University of Maryland Center for Environmental Studies. KY Acknowledges Support from the CAS/SAFEA International Partnership Program for Creative Research Teams （No. KZCXZYW-T001）. DMA received partial funding through the NSF/NIEHS Centers for Oceans and Human Health （No. NIEHS P50 ES012742, NSF OCE- 043072 and OCE-0911031）, and through NSF Grant （No. OCE-0850421）+1 种基金 This paper is based on work partially supported by SCOR/LOICZ Working Group 132, supported by the Scientific Committee on Oceanographic Research （SCOR） through grants from the U.S. National Science Foundation （No OCE-0938349 and OCE-0813697） from the Land-Ocean Interactions in the Coastal Zone （LOICZ） Project and the Chinese Academy of Sciences. We thank A. KANA for assistance with the GIS produced maps and LIU Hao for his assistance with the tables and references.
文摘The dinoflagellate Noctiluca scintillans is one of the most important and abundant red tide organisms and it is distributed world-wide. It occurs in two forms. Red Noctiluca is heterotrophic and fills the role of one of the microzooplankton grazers in the foodweb. In contrast, green Noctiluca contains a photosynthetic symbiont Pedinomonas noctilucae （a prasinophyte）, but it also feeds on other plankton when the food supply is abundant. In this review, we document the global distribution of these two forms and include the first maps of their global distribution. Red Noctiluca occurs widely in the temperate to sub-tropical coastal regions of the world. It occurs over a wide temperature range of about 10℃ to 25℃ and at higher salinities （generally not in estuaries）. It is particularly abundant in high productivity areas such as upwelling or eutrophic areas where diatoms dominate since they are its preferred food source. Green Noctiluca is much more restricted to a temperature range of 25℃-30℃ and mainly occurs in tropical waters of Southeast Asia, Bay of Bengal （east coast of India）, in the eastern, western and northern Arabian Sea, the Red Sea, and recently it has become very abundant in the Gulf of Oman. Red and green Noctiluca do overlap in their distribution in the eastern, northern and western Arabian Sea with a seasonal shift from green Noctiluca in the cooler winter convective mixing, higher productivity season, to red Noctiluca in the more oligotrophic warmer summer season.
基金the National Natural Science Foundation of China(Grat No.49972026) the Natural Science Foundation of Gtangdong (Grat No.990531)+1 种基金 the projects of the Chinese Acadenny of Siences(Grant Nos.KZCX2-SW-117,KZCX2-101) the Chinese National Key Project for Basic Reseacch(Grat No.Gi998040800) and US NSF.
文摘The previously published U-Pb and 40Ar/39Ar ages and our 21 newly-obtained 40Ar/39Ar ages suggest that the Cenozoic magmatism in eastern Tibet and Indochina occurred in two episodes, each with distinctive geochemical signatures, at (40—28) Ma and (16—0) Ma. The older rocks are localized along the major strike-slip faults such as the Jinsha-Red River fault system and erupted synchronously with transpression. The younger rocks are widely distributed in rift basins and coeval with the east-west extension of Tibet and eastern Asia. Combining with their geochemical data, we consider that the earlier magmatic phase was generated by continental subduction, while the later volcanic phase was caused by decompression melting of a recently meta- somatically-altered, depleted mantle source. The magmatic gap between the two igneous pulses represents an important geodynamic transition in the evolution of eastern Tibet, from the processes controlled mainly by crustal deformation to those largely dominated by mantle tectonics.
文摘This paper demonstrates the application of a design tool called BioTRIZ. Its developers claim that it can be used to access biological strategies for solving engineering problems. Our aim is to design a roof for hot climates that gets free cooling through radiant coupling with the sky. The insulation in a standard roof stops the sun and convection from warming the thermal mass. But it also restricts the mass＇s longwave view of the cool sky. Different solutions to this conflict are offered by BioTRIZ. The chosen solution is to replace the standard insulation component with an open cell honeycomb. The vertical cells would allow longwave radiation to pass, while arresting convection. The solutions offered by BioTRIZ＇s technological counterpart include no such changes in structure. It is estimated that the thermal mass in the biomimetic roof would remain on average 4.5℃ cooler than in a standard roof over a year in Riyadh, Saudi Arabia.
文摘This narrative literature review delves into the multifaceted realm of parental involvement in the rehabilitation of children with permanent hearing loss. While existing research has made strides in elucidating parental roles in this context, critical gaps persist, necessitating a comprehensive exploration to inform future endeavors. Our review synthesizes a wide array of studies, identifying these gaps and emphasizing the significance of addressing them. Themes emerging from the literature include the varying degrees of parental engagement, the impact of cultural and socio-economic factors, and the challenges faced by families navigating rehabilitation processes. The synthesis of this literature not only highlights the current state of knowledge but also provides a roadmap for future research efforts. By addressing these gaps, we aim to contribute to a more nuanced understanding of parental involvement in the rehabilitation of children with permanent hearing loss, ultimately fostering improved support systems and holistic care for affected families.
