Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Thr...Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Three-week-old male mice were fed high-fat diets (containing 60% fat) in the diet group, and commercial diets in the control group, ad libitum for 15 weeks. Circle-full-thickness cutaneous wounds were made on the dorsal skin of mice. From day 0 to day 15 after wounding, we analyzed wound healing process. We measured the blood concentration of leptin, and observed the distribution of leptin-positive cells in each wound. Results: Mean body weight, the areas of subcutaneous fat and visceral fat, and the weight of epididymal fat in the diet group were significantly greater than those in the control group at 15 weeks after feeding. The diet group did not feed on the diet after wounding;their body weight decreased remarkably to the level of the control group. The ratio of wound area, re-epithelialization, and collagen fibers did not differ between the diet and control groups on each day. The blood concentration of leptin in the diet group was significantly greater than that in the control group before wounding and until day 6 after wounding (day 0, 10 hour and day 1: p < 0.01, day 6: p < 0.05). Conclusion: The results show that the wound healing process is similar between obese and non-obese mice, and that the decrease in the leptin level in the obese mouse to that in the non-obese mouse may depend on the decrease of body weight of obese mouse.展开更多
A novel method has been established to realize the experiment of electron scattering off short-lived nuclei. The method was based on the well known ＂ion trapping＂ phenomenon in electron storage rings. In the R^D exp...A novel method has been established to realize the experiment of electron scattering off short-lived nuclei. The method was based on the well known ＂ion trapping＂ phenomenon in electron storage rings. In the R^D experiments at Kyoto University, stable nucleus, 133^Cs, was employed as the target nucleus. The luminosity of scattering experiment was nearly 1026 cm^-2s^-1 at electron beam current around 75 mA. The angular distribution of elastically scattered electrons from trapped Cs ions was measured and the result was well fitted by theoretical calculation. It was indicated that higher luminosity can be reached with larger electron beam current.展开更多
The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d（γ,π-pp） reaction. Charged pions an...The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d（γ,π-pp） reaction. Charged pions and protons in the final state were detected with the Neutral Kaon Spectrometer （NKS2）. Photon energies were obtained from the reaction of d（γ,π-pp）. The derived photon energy was consistent with the design of the tagger system and the previous measurement using electron-positron pair production. The consistency demonstrates the performance of NKS2 and the capability of the photon energy calibration using d（γ,π-pp）.展开更多
It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a ...It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a splint. Three-week-old male mice (C57BL/6N) were fed high-fat diets (60% of calories from fat) in the obesity group, and commercial diets in the control group for 15 weeks. Two circular (4 mm in diameter) full-thickness wounds were made on the dorsal skin. Body weights and serum leptin levels were significantly higher in the obesity group than in the control group until day 15 after wounding. Fasting blood glucose levels before wounding were lower in the obesity group than in a hyperglycemic rodent model. The macrophage infiltration into subcutaneous fat before wounding in the obesity group was negligible. The ratios of the wound area were not significantly different between the two groups. No significant differences were observed in the number of neutrophils or macrophages or new blood vessels and ratio of myofibroblasts or collagen fibers between the two groups. Our results demonstrated that cutaneous wound healing was not delayed in the obesity group without hyperglycemia and macrophage infiltration into the subcutaneous fat and with high serum leptin levels.展开更多
The reactions γd→π-pp and γd→npπ+π-have been studied in an energy range from 0.8 to 1.1 GeV at the tagged photon facility of Laboratory of Nuclear Science,Tohoku University. Charged pions and protons in the fin...The reactions γd→π-pp and γd→npπ+π-have been studied in an energy range from 0.8 to 1.1 GeV at the tagged photon facility of Laboratory of Nuclear Science,Tohoku University. Charged pions and protons in the final state were measured by using the Neutral Kaon Spectrometer (NKS2). The analysis of the γd→π-pp was mainly used to check the acceptance of the NKS2 and to calibrate the tagged photon energy. The photoproduction of the Δ++Δ-was identified in the γd→npπ+π-reaction. Since the data analyses are still in progress,we issue an interim report and preliminary results.展开更多
文摘Purpose: Not all obese people have hyperglycemia. We wondered about the healing progress in obese people without hyperglycemia. The purpose of this study is to observe the cutaneous wound healing process. Methods: Three-week-old male mice were fed high-fat diets (containing 60% fat) in the diet group, and commercial diets in the control group, ad libitum for 15 weeks. Circle-full-thickness cutaneous wounds were made on the dorsal skin of mice. From day 0 to day 15 after wounding, we analyzed wound healing process. We measured the blood concentration of leptin, and observed the distribution of leptin-positive cells in each wound. Results: Mean body weight, the areas of subcutaneous fat and visceral fat, and the weight of epididymal fat in the diet group were significantly greater than those in the control group at 15 weeks after feeding. The diet group did not feed on the diet after wounding;their body weight decreased remarkably to the level of the control group. The ratio of wound area, re-epithelialization, and collagen fibers did not differ between the diet and control groups on each day. The blood concentration of leptin in the diet group was significantly greater than that in the control group before wounding and until day 6 after wounding (day 0, 10 hour and day 1: p < 0.01, day 6: p < 0.05). Conclusion: The results show that the wound healing process is similar between obese and non-obese mice, and that the decrease in the leptin level in the obese mouse to that in the non-obese mouse may depend on the decrease of body weight of obese mouse.
文摘A novel method has been established to realize the experiment of electron scattering off short-lived nuclei. The method was based on the well known ＂ion trapping＂ phenomenon in electron storage rings. In the R^D experiments at Kyoto University, stable nucleus, 133^Cs, was employed as the target nucleus. The luminosity of scattering experiment was nearly 1026 cm^-2s^-1 at electron beam current around 75 mA. The angular distribution of elastically scattered electrons from trapped Cs ions was measured and the result was well fitted by theoretical calculation. It was indicated that higher luminosity can be reached with larger electron beam current.
基金Supported by a Grant-in-Aid (16GS0201) for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan
文摘The energy of tagged photons, which were provided from the internal photon tagging system of the Laboratory of Nuclear Science, Tohoku University, has been calibrated using the d（γ,π-pp） reaction. Charged pions and protons in the final state were detected with the Neutral Kaon Spectrometer （NKS2）. Photon energies were obtained from the reaction of d（γ,π-pp）. The derived photon energy was consistent with the design of the tagger system and the previous measurement using electron-positron pair production. The consistency demonstrates the performance of NKS2 and the capability of the photon energy calibration using d（γ,π-pp）.
文摘It was unclear that wound healing was delayed in obesity without hyperglycemia. The purpose of this study was to compare the wound healing process between obese and non-obese mice without hyperglycemia by attaching a splint. Three-week-old male mice (C57BL/6N) were fed high-fat diets (60% of calories from fat) in the obesity group, and commercial diets in the control group for 15 weeks. Two circular (4 mm in diameter) full-thickness wounds were made on the dorsal skin. Body weights and serum leptin levels were significantly higher in the obesity group than in the control group until day 15 after wounding. Fasting blood glucose levels before wounding were lower in the obesity group than in a hyperglycemic rodent model. The macrophage infiltration into subcutaneous fat before wounding in the obesity group was negligible. The ratios of the wound area were not significantly different between the two groups. No significant differences were observed in the number of neutrophils or macrophages or new blood vessels and ratio of myofibroblasts or collagen fibers between the two groups. Our results demonstrated that cutaneous wound healing was not delayed in the obesity group without hyperglycemia and macrophage infiltration into the subcutaneous fat and with high serum leptin levels.
文摘The reactions γd→π-pp and γd→npπ+π-have been studied in an energy range from 0.8 to 1.1 GeV at the tagged photon facility of Laboratory of Nuclear Science,Tohoku University. Charged pions and protons in the final state were measured by using the Neutral Kaon Spectrometer (NKS2). The analysis of the γd→π-pp was mainly used to check the acceptance of the NKS2 and to calibrate the tagged photon energy. The photoproduction of the Δ++Δ-was identified in the γd→npπ+π-reaction. Since the data analyses are still in progress,we issue an interim report and preliminary results.
