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Future Physics Programme of BESⅢ 被引量:543
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作者 M.Ablikim M.N.Achasov +147 位作者 P.Adlarson S.Ahmed M.Albrecht M.Alekseev A.Amoroso F.F.An Q.An Y.Bai O.Bakina R.Baldini Ferroli Y.Ban K.Begzsuren J.V.Bennett N.Berger M.Bertani D.Bettoni F.Bianchi J Biernat J.Bloms I.Boyko R.A.Briere L.Calibbi H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.Chai J.F.Chang W.L.Chang J.Charles G.Chelkov Chen G.Chen H.S.Chen J.C.Chen M.L.Chen S.J.Chen Y.B.Chen H.Y.Cheng W.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai J.P.Dai X.C.Dai A.Dbeyssi D.Dedovich Z.Y.Deng A.Denig Denysenko M.Destefanis S.Descotes-Genon F.De Mori Y.Ding C.Dong J.Dong L.Y.Dong M.Y.Dong Z.L.Dou S.X.Du S.I.Eidelman J.Z.Fan J.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng M.Fritsch C.D.Fu Y.Fu Q.Gao X.L.Gao Y.Gao Y.Gao Y.G.Gao Z.Gao B.Garillon I.Garzia E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu Y.T.Gu A.Q.Guo F.K.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov S.Han X.Q.Hao F.A.Harris K.L.He F.H.Heinsius T.Held Y.K.Heng Y.R.Hou Z.L.Hou H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang J.S.Huang X.T.Huang X.Z.Huang Z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.Ji Q.P.Ji X.B.Ji X.L.Ji H.L.Jiang X.S.Jiang X.Y.Jiang J.B.Jiao Z.Jiao D.P.Jin S.Jin Y.Jin T.Johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L. 《Chinese Physics C》 SCIE CAS CSCD 2020年第4期I0001-I0004,1-102,共106页
There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B fac... There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYZ states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity. 展开更多
关键词 MESON HADRON optimization
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英国“8·9”大停电事故分析及对中国电网的启示 被引量:324
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作者 孙华东 许涛 +4 位作者 郭强 李亚楼 林伟芳 易俊 李文锋 《中国电机工程学报》 EI CSCD 北大核心 2019年第21期6183-6191,共9页
2019年8月9日,英国电网发生大规模停电事故。事故造成英国包括伦敦在内的部分重要城市出现停电现象,影响人口约100万。该文首先介绍英国电网的基本概况以及本次大停电中涉及的关键设施;然后依据英国国家电网公司提供的事故调查报告梳理... 2019年8月9日,英国电网发生大规模停电事故。事故造成英国包括伦敦在内的部分重要城市出现停电现象,影响人口约100万。该文首先介绍英国电网的基本概况以及本次大停电中涉及的关键设施;然后依据英国国家电网公司提供的事故调查报告梳理了事故各阶段的发展过程,总结了事故原因;最后结合我国电网实际情况,分析了本次事故的启示。 展开更多
关键词 英国电网 大停电 安全稳定
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Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years 被引量:241
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作者 Hao Zhou Xiu Xu +25 位作者 Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne yi Zheng Jisheng Han Zhongsheng sun Yong-hui Jiang yi Wang LATENT-NHC Study Team 《Neuroscience Bulletin》 SCIE CAS CSCD 2020年第9期961-971,共11页
This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multis... This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. 展开更多
关键词 Autism spectrum disorder PREVALENCE COMORBIDITY Autism Spectrum Rating Scale China
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煤矿区煤层气开发利用新技术现状及发展趋势 被引量:139
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作者 刘见中 孙海涛 +1 位作者 雷毅 曹偈 《煤炭学报》 EI CAS CSCD 北大核心 2020年第1期258-267,共10页
“十二五”以来,我国煤矿区煤层气开发利用技术取得了巨大的进步,虽然我国煤矿数量由近20000对直线下降到了不足5800对,但煤层气产量仍由2010年的88亿m 3提高到了2018年的184亿m 3,利用率亦提升了10%,科技对产业的贡献巨大;但是也出现... “十二五”以来,我国煤矿区煤层气开发利用技术取得了巨大的进步,虽然我国煤矿数量由近20000对直线下降到了不足5800对,但煤层气产量仍由2010年的88亿m 3提高到了2018年的184亿m 3,利用率亦提升了10%,科技对产业的贡献巨大;但是也出现了单井排采产量低、气源分散性高等新的问题。因此,全面梳理了近10 a煤矿区地面抽采技术装备、井下抽采技术装备和煤矿区高、低浓度煤层气利用技术装备的科技创新及应用效果等,阐述了煤矿区煤层气开发利用在三级瓦斯地质分析技术、碎软低渗煤层地面井分段压裂顶板技术、煤层群分层控压联合排采技术、采动区地面L型顶板水平井技术、井下千米定向长钻孔技术、碎软煤层井下护孔钻进技术、智能化钻机远控钻孔技术、井下水力化压裂/割缝增渗技术等煤层气抽采技术及其配套装备最新进展和中高浓度煤层气深冷液化、低浓度煤层气分级压缩提浓、超低浓度煤层气蓄热氧化利用等煤层气利用装备的最新进展及技术指标。在此基础上,针对我国目前面临的深部开采、西部煤炭资源开发及高强度集约化开采等新特点,分类整理了束缚煤层气产业发展的技术瓶颈和发展趋势,提出了煤炭开采与煤层气开发协同规划和联合开发的技术思路等。 展开更多
关键词 煤矿区 煤层气 开发 利用 发展趋势
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抗疫情助推我国数字化转型:机遇与挑战 被引量:119
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作者 吴静 张凤 +2 位作者 孙翊 朱永彬 刘昌新 《中国科学院院刊》 CSSCI CSCD 北大核心 2020年第3期306-311,共6页
近年来,我国数字经济蓬勃发展,赋能实体经济提质增效,成为经济增长的新动能。在2020年的新冠肺炎疫情中,新一代信息技术在疫情防控、生产生活物资保障、复工复产等各环节得到广泛应用,助力科学防控、精准施控,也为我国经济社会全面数字... 近年来,我国数字经济蓬勃发展,赋能实体经济提质增效,成为经济增长的新动能。在2020年的新冠肺炎疫情中,新一代信息技术在疫情防控、生产生活物资保障、复工复产等各环节得到广泛应用,助力科学防控、精准施控,也为我国经济社会全面数字化转型带来新的机遇。文章聚焦当前疫情影响下我国政府、产业、企业、社会的数字化转型机遇,分析了疫情中数字化转型存在的问题与挑战,提出了加快我国经济社会全面数字化转型的政策建议,具体包括:(1)加快推进政府数字化转型,提高政府治理现代化水平;(2)深化新一代信息技术在垂直细分领域的融合发展,丰富应用场景;(3)推动产业互联网建设,促进各产业数字化水平均衡发展;(4)加强数字化转型中的数据治理,保障数据的高效安全使用。 展开更多
关键词 数字化转型 数字经济 新冠肺炎
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基于区块链的分布式能源交易方案设计综述 被引量:97
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作者 李彬 覃秋悦 +5 位作者 祁兵 孙毅 李德智 石坤 杨斌 奚培锋 《电网技术》 EI CSCD 北大核心 2019年第3期961-972,共12页
以绿色新能源为主体的分布式能源成为能源交易市场中的重要组成部分,为了提高能源利用率、多渠道扩展分布式能源本地消纳,分布式能源获得合法就近售电资质,其能源生产和消费结构呈无中心、多节点状。现有能源运营模式由于具有集中式管... 以绿色新能源为主体的分布式能源成为能源交易市场中的重要组成部分,为了提高能源利用率、多渠道扩展分布式能源本地消纳,分布式能源获得合法就近售电资质,其能源生产和消费结构呈无中心、多节点状。现有能源运营模式由于具有集中式管理的特点,难以简单套用于分布式能源。区块链技术具有可追溯性、交易公开、数据透明的优势,其分散化特性与分布式能源无中心特点相符合,故提出一种基于区块链的分布式能源交易方案。分析现有分布式能源交易的方式及其弊端,研究区块链技术对于分布式能源P2P交易的适用性,在连续双边拍卖(continuousdoubleauction,CDA)、竞争均衡价格(competitive equilibrium price,CEP)、节点信誉值等基础上确立支撑分布式能源P2P交易的分布式能源结算机制,制定符合中国政策的分布式能源区块链支付模式,提出包括系统架构、交易流程在内的基于区块链技术的分布式能源交易方案,对比传统电力交易系统和基于区块链的分布式能源交易系统的性能,思考如何改进目前区块链的不足之处并展望能源市场未来,实现传统电力交易市场向分布式能源交易的延伸性发展。最后,针对区块链技术在实体应用过程中的挑战分析目前电力市场与区块链技术结合所存在的冲突及问题,并提出相应的建议方案。 展开更多
关键词 区块链 分布式能源交易 能源P2P交易 结算机制 电力交易市场
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高比例电力电子电力系统宽频带振荡研究综述 被引量:85
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作者 陈露洁 徐式蕴 +4 位作者 孙华东 毕经天 宋瑞华 易俊 郭强 《中国电机工程学报》 EI CSCD 北大核心 2021年第7期2297-2309,共13页
随着电力电子设备在电力系统中所占比例的日益提高,电力系统的动态特性发生了巨大变化,多样化设备在多时间尺度下的交互作用,使得频率覆盖次同步、超同步、高频带的电力系统宽频带振荡问题逐渐凸显。该文将首先总结高比例电力电子电力... 随着电力电子设备在电力系统中所占比例的日益提高,电力系统的动态特性发生了巨大变化,多样化设备在多时间尺度下的交互作用,使得频率覆盖次同步、超同步、高频带的电力系统宽频带振荡问题逐渐凸显。该文将首先总结高比例电力电子电力系统宽频带振荡的新特征,对谐振类和控制振荡类宽频振荡问题进行说明,然后对电力电子设备、同步发电机及电力网络间交互作用的研究成果进行总结与归纳,对模态分析法、阻抗分析法等电力系统宽频带振荡分析方法的基本原理和适用性进行说明,最后提出高比例电力电子电力系统宽频带振荡领域未来的研究方向。 展开更多
关键词 电力电子设备 宽频带振荡 振荡特征 动态交互作用 分析方法 振荡抑制
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缩短创伤骨科择期手术患者围手术期禁食水时间的前瞻性队列研究 被引量:76
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作者 李庭 周雁 +13 位作者 孙旭 孙志坚 姜矞恒 鲁雪梅 彭贵凌 张春玲 姜耀 孙胜男 伊辰 安岩 王含 韩冰 王庚 吴新宝 《中华创伤骨科杂志》 CAS CSCD 北大核心 2018年第4期312-317,共6页
目的评价缩短创伤骨科择期手术患者围手术期禁食水时间的可行性。方法对2016年11月至2017年1月收治的190例创伤骨科择期手术患者进行前瞻性研究,将患者以病房为单位分为试验组(69例)和对照组(121例)。试验组术前6h禁食,术前2h口... 目的评价缩短创伤骨科择期手术患者围手术期禁食水时间的可行性。方法对2016年11月至2017年1月收治的190例创伤骨科择期手术患者进行前瞻性研究,将患者以病房为单位分为试验组(69例)和对照组(121例)。试验组术前6h禁食,术前2h口服麦芽糊精果糖饮品,之后禁饮;术后患者一旦清醒,即可进水,进水2h后恢复正常饮食。对照组术前1d夜间12点以后禁食水,术后臂丛神经阻滞麻醉患者不限制进水,其他患者术后6h后进水,无不适反应后恢复饮食。记录并比较两组患者术前禁饮、禁食时间及术后恢复进水、进食时间,比较两组患者术前、术后主观舒适度(焦虑、口渴、饥饿、恶心、疲劳、头晕、虚汗及胃部不适)及血糖,观察患者不良反应的发生情况。结果试验组患者术前禁饮时间[(4.5±2.9)h]较对照组[(14.3±3.9)h]缩短,术前禁食时间[(17.6±3.0)h]较对照组[(16.1±3.8)h]长,术后首次进水和进食时间[1(0,3)h和2(1,4)h]较对照组[(6(6,6)h和6(6,6)h]缩短,差异均有统计学意义(P〈0.05)。试验组患者围手术期焦虑、口渴、饥饿、恶心、疲劳、头晕和胃部不适情况优于对照组,差异均有统计学意义(P〈0.05)。两组患者人院时血糖比较差异无统计学意义(P〉0.05),术前试验组明显高于对照组(P〈0.05),但术后试验组血糖逐渐下降,两组比较差异无统计学意义(P〉0.05)。两组患者均无严重不良反应发生。结论缩短创伤骨科择期手术患者围手术期禁食水时间安全、可行,并且有助于减轻患者焦虑、口渴、饥饿、恶心、疲劳、头晕及胃部不适症状。 展开更多
关键词 围手术期医护 创伤和损伤 禁水 禁食
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Knowledge domain and emerging trends in Alzheimer’s disease: a scientometric review based on CiteSpace analysis 被引量:75
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作者 Shuo Liu Ya-Ping sun +1 位作者 Xu-Ling Gao yi Sui 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第9期1643-1650,共8页
Alzheimer’s disease is the most common cause of dementia.It is an increasingly serious global health problem and has a significant impact on individuals and society.However,the precise cause of Alzheimer’s disease i... Alzheimer’s disease is the most common cause of dementia.It is an increasingly serious global health problem and has a significant impact on individuals and society.However,the precise cause of Alzheimer’s disease is still unknown.In this study,11,748 Web-of-Science-indexed manuscripts regarding Alzheimer’s disease,all published from 2015 to 2019,and their 693,938 references were analyzed.A document co-citation network map was drawn using CiteSpace software.Research frontiers and development trends were determined by retrieving subject headings with apparent changing word frequency trends,which can be used to forecast future research developments in Alzheimer’s disease. 展开更多
关键词 NERVE REGENERATION Alzheimer’sdisease NEUROPROTECTION mapping knowledge domain Web of Science CiteSpace neural REGENERATION
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Growth inhibition and apoptosis induction Sulindac on Human gastric cancer cells 被引量:64
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作者 Yun-Lin Wu~1 Bo sun~1 Xue-Jun Zhang~2 Sheng-Nian Wang~2 Heng-yi He~2 Min-Min Qiao~1 Jie Zhong~1 Jia-Yu Xu~1 1 Department of Gastroenterology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China2 Institude of Biochemistry and Cell Biology,Shanghai Institues for Biological Sciences,Chinese Academy of Sciences.Shanghai 200025,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第6期796-800,共5页
AIM: To evaluate the effects of sulindac in inducing growth inhibition and apoptosis of human gastric cancer cells in comparison with human hepatocellular carcinoma (HCC) cells. METHODS: The human gastric cancer cell ... AIM: To evaluate the effects of sulindac in inducing growth inhibition and apoptosis of human gastric cancer cells in comparison with human hepatocellular carcinoma (HCC) cells. METHODS: The human gastric cancer cell lines MKN45 and MKN28 and human hepatocellular carcinoma cell lines HepG(2) and SMMC7721 were used for the study. Anti-proliferative effect was measured by MTT assay, and apoptosis was determined by Hoechst-33258 staining, electronography and DNA fragmentation. The protein of cyclooxygenase-2 (COX-2) and Bcl-2 were detected by Western dot blotting. RESULTS: Sulindac could initiate growth inhibition and apoptosis of MKN45, MKN28, HepG(2) and SMMC7721 cells in a dose-and time-dependent manner. Growth inhibitory activity and apoptosis were more sensitive in HepG(2) cells than in SMMC7721 cells, MKN45 and MKN28 cells. After 24 hours incubation with sulindac at 2mmol x L(-1) and 4mmol x L(-1), the level of COX-2 and Bcl-2 protein were lowered in MKN45, SMMC7721 and HepG(2) cells but not in MKN28 cells. CONCLUSION: Sulindac could inhibit the growth of gastric cancer cells and HCC cells effectively in vitro by apoptosis induction, which was associated with regression of COX-2 and Bcl-2 expression. The growth inhibition and apoptosis of HCC cells were greater than that of human gastric cancer cells. The different effects of apoptosis in gastric cancer cells may be related to the differentiation of the cells. 展开更多
关键词 Anti-Inflammatory Agents Non-Steroidal Apoptosis Carcinoma Hepatocellular Cell Division Cells Cultured Comparative Study Humans Liver Neoplasms Research Support Non-U.S. Gov't Stomach Neoplasms SULINDAC
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2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents 被引量:62
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作者 Cheng Wang Yaqi Li +86 位作者 ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun sun Jinghui sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu yi Xu Hui Yan Shiwei Yang Qijian yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu 《Science Bulletin》 SCIE EI CAS CSCD 2018年第23期1558-1564,共7页
Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of eme... Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. 展开更多
关键词 CPCS CHILDREN ADOLESCENT SYNCOPE
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面向电力大数据的用户负荷特性和可调节潜力综合聚类方法 被引量:64
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作者 孙毅 毛烨华 +2 位作者 李泽坤 张旭东 李飞 《中国电机工程学报》 EI CSCD 北大核心 2021年第18期6259-6270,共12页
深度探索用户负荷特性及可调节潜力是电力大数据背景下电力市场精细化发展的迫切需求。该文提出一种考虑用户负荷特性和可调节潜力的用户用电行为综合分类方法,适用于电力系统负荷数据量大、用户用电行为影响因素较多的情况。首先,通过... 深度探索用户负荷特性及可调节潜力是电力大数据背景下电力市场精细化发展的迫切需求。该文提出一种考虑用户负荷特性和可调节潜力的用户用电行为综合分类方法,适用于电力系统负荷数据量大、用户用电行为影响因素较多的情况。首先,通过面向电力大数据的用户用电行为影响因素多维分析,提出考虑用户负荷特性和可调节潜力的用电行为综合分析实施架构。其次,为实现考虑用户用电行为多维影响因素作用下的精准聚类,该文设计一种融合K-means和SOM进行二次聚类以及BP神经网络进行反向调整修正的综合聚类方法。最后,通过选取爱尔兰地区实测负荷数据及用户用电行为相关影响因素数据,验证该文所提分类方法的有效性和实用性,同时也证明该方法对于多场景下所具有的泛化能力。 展开更多
关键词 电力大数据 负荷特性 特征降维 神经网络 可调节潜力
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新能源多场站短路比定义及指标 被引量:62
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作者 孙华东 徐式蕴 +9 位作者 许涛 郭强 贺静波 赵兵 于琳 张怡 李文锋 周莹坤 张彦涛 朱艺颖 《中国电机工程学报》 EI CSCD 北大核心 2021年第2期497-505,共9页
随着新能源在电力系统中占比不断增加、接入形式的多样化,局部地区出现了新能源并入弱交流电网的场景,这是出现宽频带振荡、过电压等问题的影响因素之一,因此,亟需提出理论科学、工程实用的新能源接入规模的量化评估指标。该文首先基于... 随着新能源在电力系统中占比不断增加、接入形式的多样化,局部地区出现了新能源并入弱交流电网的场景,这是出现宽频带振荡、过电压等问题的影响因素之一,因此,亟需提出理论科学、工程实用的新能源接入规模的量化评估指标。该文首先基于短路比的物理本质,提出计及场站间相互影响的新能源多场站短路比(multiple renewable energy stations short circuit ratio,MRSCR)定义及计算方法,并根据系统阻抗比与短路比间的关联关系,给出针对不同阻抗比范围的计算解析表达式。其次,对新能源多场站临界短路比进行定性分析,并基于典型电网参数计算结果从工程应用的角度提出MRSCR临界指标。最后,依托电力系统分析综合程序(power system analysis synthesis program,PSASP)开发MRSCR计算模块,通过时域仿真算例验证所提出MRSCR对多新能源场站接入系统电压强度表征作用的有效性。 展开更多
关键词 多新能源场站接入系统 新能源多场站短路比 阻抗比 系统电压强度 新能源接入规模
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Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats 被引量:56
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作者 Xiao-Qing sun Xiao-Bing Fu Rong-Zhan yi Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第4期555-558,共4页
AIM To explore the kinetic changes in plasma D(-)- lactate and lipopolyssccharide(LPS)levels,and investigate whether D(-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/ reperfus... AIM To explore the kinetic changes in plasma D(-)- lactate and lipopolyssccharide(LPS)levels,and investigate whether D(-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/ reperfusion,burn,and acute necrotizing pancreatitis (ANP). METHODS Three models were developed in rats:① gut ischemia/ reperfusion obtained by one hour of superior mesenteric artery occlusion followed by reperfusion;② severe burn injury created by 30% of total body surface area(TBSA)full-thickness scald burn;and ③ ANP induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct. Plasma levels of D(-)-lactate in systemic circulation and LPS in portal circulation were measured by enzymatic- spectrophotometric method and limulus amebocyte lysate (LAL)test kit,respectively.Tissue samples of intestine were taken for histological analysis. RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D(-)- lactate and LPS levels,and there was a significant correlation between the plasma D(-)-lactate and LPS(r =0.719,P<0.05).The plasma concentrations of D(-)- lactate and LPS increased significantly at 6h postburn, and there was also a remarkable correlation between them (r = 0.877,P < 0.01).D(-)-lactate and LPS levels elevated significantly at 2h after ANP,with a similar significant correlation between the two levels(r = 0.798, P < 0.01 ).The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups. CONCLUSION The changes of plasma D(-)-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood.The measurement of plasma D(-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. 展开更多
关键词 gut/injury ischemia-reperfusion/ blood burn/blood acute necrotizing pancreatitis/blood D(-)-lactate/blood lipopolysaccharide/blood intestinal permeability
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The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma 被引量:59
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作者 Ling-Long Tang Yu-Pei Chen +37 位作者 Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen ying sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin yi Xiao-Dong Zhu Jun Ma 《Cancer Communications》 SCIE 2021年第11期1195-1227,共33页
Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and m... Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. 展开更多
关键词 Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis STAGING Risk RADIOTHERAPY CHEMOTHERAPY Surgery IMMUNOTHERAPY
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联邦学习研究综述 被引量:58
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作者 周传鑫 孙奕 +1 位作者 汪德刚 葛桦玮 《网络与信息安全学报》 2021年第5期77-92,共16页
联邦学习由于能够在多方数据源聚合的场景下协同训练全局最优模型,近年来迅速成为安全机器学习领域的研究热点。首先,归纳了联邦学习定义、算法原理和分类;接着,深入分析了其面临的主要威胁与挑战;然后,重点对通信效率、隐私安全、信任... 联邦学习由于能够在多方数据源聚合的场景下协同训练全局最优模型,近年来迅速成为安全机器学习领域的研究热点。首先,归纳了联邦学习定义、算法原理和分类;接着,深入分析了其面临的主要威胁与挑战;然后,重点对通信效率、隐私安全、信任与激励机制3个方向的典型研究方案对比分析,指出其优缺点;最后,结合边缘计算、区块链、5G等新兴技术对联邦学习的应用前景及研究热点进行展望。 展开更多
关键词 联邦学习 隐私保护 区块链 边缘计算
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Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial 被引量:57
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作者 DUAN Zhong-ping JIA Zhen-hua +9 位作者 ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong sun Yan ZHANG Shu-qin WANG Yong-yan WU yi-ling 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第18期2925-2933,共9页
Background The 2009 influenza A (H1N1) virus infection is associated with the high risk of severe complications and is spreading more rapidly throughout the world than other reported seasonal influenzas. This study ... Background The 2009 influenza A (H1N1) virus infection is associated with the high risk of severe complications and is spreading more rapidly throughout the world than other reported seasonal influenzas. This study aimed to evaluate the efficacy and safety of the nature herbal medicine Lianhuaqingwen capsule (LHC) in patients infected with influenza A (H1N1) virus. Methods A total of 244 patients aged 16-65 years confirmed with influenza A (H1N1) virus infection by the real time RT-PCR were randomized to one of two treatment groups of 122 patients each. Each group assigned to receive either LHC or Oseltamivir for five days and observation for seven days. The patients were enrolled within 36 hours of illness onset if they had an axillary temperature of ≥37.4℃ and with at least one of the following symptoms: nasal obstruction, runny nose, cough, sore throat, fatigue, headache, myalgia, chills and sweating. The primary end point was the duration of illness. Results Of 244 patients, 240 (98.36%) patients with a median age 21 years completed the study between October 24, 2009 and November 23, 2009. There were no significant overall differences between LHC treated and Oseltamivir treated patients in the median duration of illness (LHC 69 hours vs. Oseltamivir 85 hours P 〉0.05) or the median duration of viral shedding (LHC 103 hours vs. Oseltamivir 96 hours, P 〉0.05). However, it was worthwhile to note that LHC significantly reduced the severity of illness and the duration of symptoms including fever, cough, sore throat, and fatigue (P〈0.05). Both study medications were well tolerated. No drug related serious adverse events occurred during the study. Conclusions Compared with Oseltamivir, LHC achieved a similar therapeutic effectiveness reduction of the duration of illness and duration of viral shedding. Therefore, LHC might be an alternative therapeutic measure for influenza A (H1N1) virus infections. 展开更多
关键词 influenza A (H1N1 Lianhuaqingwen capsule clinical randomized controlled trial
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我国实施大规模需求响应的关键问题剖析与展望 被引量:56
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作者 李彬 陈京生 +5 位作者 李德智 石坤 杨斌 祁兵 孙毅 奚培锋 《电网技术》 EI CSCD 北大核心 2019年第2期694-704,共11页
随着"互联网+智慧能源"的推进和电气信息技术的深度融合,电力需求响应业务也被赋予了诸如新能源消纳、辅助服务等新的使命,并面临着从紧急态向常态化的转型。目前我国电力需求响应试点项目建设已为需求响应业务发展积累了丰... 随着"互联网+智慧能源"的推进和电气信息技术的深度融合,电力需求响应业务也被赋予了诸如新能源消纳、辅助服务等新的使命,并面临着从紧急态向常态化的转型。目前我国电力需求响应试点项目建设已为需求响应业务发展积累了丰富经验,但在大规模复制推广方面还存在一些瓶颈。基于国内外需求响应发展现状,结合我国已经发布的相关政策、技术标准以及现有试点城市的建设情况,从政策机制保障、信息化支撑、平台部署及组织实施层面剖析当前所存在的问题,并结合实际工作情况尝试给出若干未来发展建议。 展开更多
关键词 自动需求响应 互操作 信息模型 推广应用 智慧能源
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Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study 被引量:54
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作者 Zhi Peng Tianshu Liu +32 位作者 Jia Wei Airong Wang yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang yi Ba Lin Shen 《Cancer Communications》 SCIE 2021年第11期1173-1182,共10页
Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 i... Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. 展开更多
关键词 antibody-drug conjugate gastric cancer HER2-overexpressing phase II clinical trial RC48 third-line therapy
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区块链技术发展及应用:现状与挑战 被引量:54
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作者 孙毅 范灵俊 洪学海 《中国工程科学》 CSCD 北大核心 2018年第2期27-32,共6页
本文介绍了区块链技术发展和行业应用的现状,对区块链未来大规模应用会面临的技术挑战进行了剖析,综述了区块链体系结构、共识算法、隐私保护、智能合约、跨链通信等关键问题的研究现状,从技术、人才和监管三个方面对我国进一步发展区... 本文介绍了区块链技术发展和行业应用的现状,对区块链未来大规模应用会面临的技术挑战进行了剖析,综述了区块链体系结构、共识算法、隐私保护、智能合约、跨链通信等关键问题的研究现状,从技术、人才和监管三个方面对我国进一步发展区块链技术及应用的政策提出了建议。 展开更多
关键词 高通量区块链 共识算法 智能合约 跨链通信
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