Life cycle assessment (LCA) is one of the most widely used methods of decision support. However, few studies have examined whether stakeholders prefer midpoint or endpoint approaches. In this regard, the present study...Life cycle assessment (LCA) is one of the most widely used methods of decision support. However, few studies have examined whether stakeholders prefer midpoint or endpoint approaches. In this regard, the present study examines the attitudes toward urban solid waste management, environmental issues, and scenario evaluations by using midpoint and endpoint interpretations of LCA results. This study introduces three types of social groups that typically respond to environmental conflicts: the individualist, hierarchist, and egalitarian groups. Although residents are likely to recognize global impacts as the most important issue, their view is likely to change depending on system and avoided emissions. Consistent with the Seoul Metropolitan Area’s new policy designed to increase the incineration ratio, almost half of all respondents preferred the scenario. Noteworthy is that the respondents’ preference for midpoint and endpoint decision-making tools is not consistent with that in previous studies. Most of the respondents indicated that the midpoint approach would be better in evaluating environmental systems.展开更多
DNA damage response(DDR)is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs.Hence,small molecules that inhibit DDR are expected to enhance the an...DNA damage response(DDR)is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs.Hence,small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy.Through a recent chemical library screen,we identified shikonin as an inhibitor that strongly suppressed DDR activated by various chemotherapeutic drugs in cancer cell lines derived from different origins.Mechanistically,shikonin inhibited the activation of ataxia telangiectasia mutated(ATM),and to a lesser degree ATM and RAD3-related(ATR),two master upstream regulators of the DDR signal,through inducing degradation of ATM and ATR-interacting protein(ATRIP),an obligate associating protein of ATR,respectively.As a result of DDR inhibition,shikonin enhanced the anti-cancer effect of chemotherapeutic drugs in both cell cultures and in mouse models.While degradation of ATRIP is proteasome dependent,that of ATM depends on caspase-and lysosome-,but not proteasome.Overexpression of ATM significantly mitigated DDR inhibition and cell death induced by shikonin and chemotherapeutic drugs.These novel findings reveal shikonin as a pan DDR inhibitor and identify ATM as a primary factor in determining the chemo sensitizing effect of shikonin.Our data may facilitate the development of shikonin and its derivatives as potential chemotherapy sensitizers through inducing ATM degradation.展开更多
This study suggested environmental and economic evaluations by developing a scenario according to the various treatment options of food waste in Korea. In particular, the study evaluated the possibility about the comb...This study suggested environmental and economic evaluations by developing a scenario according to the various treatment options of food waste in Korea. In particular, the study evaluated the possibility about the combined treatment of food waste and human excrement after using food waste disposers (FWDs). The scenario including only composting (133 kg CO2 equiv./ton-household organic waste) or only FWDs (125 kg CO2 equiv./ton-household organic waste) was superior to the other scenarios in the environmental aspect and the scenario including only composting (101 USD/ton-household organic waste) was superior to the other scenarios in the economic aspect. However, the study discovered that 52% of greenhouse gas emission was reduced when sewage pretreatment was conducted in houses after using FWDs and also when biogas was collected on site and utilized in the private power station. Furthermore, the energy saving effect due to recovery of biogas has found to be larger in the environment aspect than in the economic aspect.展开更多
A credible accounting of national and regional inventories for the greenhouse gas （GHG） reduction has emerged as one of the most significant current discussions. This article assessed the regional GHG emissions by t...A credible accounting of national and regional inventories for the greenhouse gas （GHG） reduction has emerged as one of the most significant current discussions. This article assessed the regional GHG emissions by three categories of the waste sector in Daejeon Metropolitan City （DMC）, Korea, examined the potential for DMC to reduce GHG emission, and discussed the methodology modified from Intergovernmental Panel on Climate Change and Korea national guidelines. During the last five years, DMC＇s overall GHG emissions were 239 thousand tons C02 eq./year from eleven public environmental infrastructure facilities, with a population of 1.52 million. Of the three categories, solid waste treatment/disposal contributes 68%, whilst wastewater treatment and others contribute 22% and 10% respectively. Among GHG unit emissions per ton of waste treatment, the biggest contributor was waste incineration of 694 kg CO2 eq./ton, followed by waste disposal of 483 kg CO2 eq./ton, biological treatment of solid waste of 209 kg CO2 eq./ton, wastewater treatment of 0.241 kg CO2 eq./m3, and public water supplies of 0.067 kg CO2 eq./m3. Furthermore, it is suggested that the potential in reducing GHG emissions from landfill process can be as high as 47.5% by increasing landfill gas recovery up to 50%. Therefore, it is apparent that reduction strategies for the main contributors of GHG emissions should take precedence over minor contributors and lead to the best practice for managing GHGs abatement.展开更多
文摘Life cycle assessment (LCA) is one of the most widely used methods of decision support. However, few studies have examined whether stakeholders prefer midpoint or endpoint approaches. In this regard, the present study examines the attitudes toward urban solid waste management, environmental issues, and scenario evaluations by using midpoint and endpoint interpretations of LCA results. This study introduces three types of social groups that typically respond to environmental conflicts: the individualist, hierarchist, and egalitarian groups. Although residents are likely to recognize global impacts as the most important issue, their view is likely to change depending on system and avoided emissions. Consistent with the Seoul Metropolitan Area’s new policy designed to increase the incineration ratio, almost half of all respondents preferred the scenario. Noteworthy is that the respondents’ preference for midpoint and endpoint decision-making tools is not consistent with that in previous studies. Most of the respondents indicated that the midpoint approach would be better in evaluating environmental systems.
基金supported by Guangdong Basic and Applied Basic Research Foundation(2021A1515011244,China)to Jinshan Tangthe National 111 Project of China(No.B13038,China)to Xinsheng Yao。
文摘DNA damage response(DDR)is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs.Hence,small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy.Through a recent chemical library screen,we identified shikonin as an inhibitor that strongly suppressed DDR activated by various chemotherapeutic drugs in cancer cell lines derived from different origins.Mechanistically,shikonin inhibited the activation of ataxia telangiectasia mutated(ATM),and to a lesser degree ATM and RAD3-related(ATR),two master upstream regulators of the DDR signal,through inducing degradation of ATM and ATR-interacting protein(ATRIP),an obligate associating protein of ATR,respectively.As a result of DDR inhibition,shikonin enhanced the anti-cancer effect of chemotherapeutic drugs in both cell cultures and in mouse models.While degradation of ATRIP is proteasome dependent,that of ATM depends on caspase-and lysosome-,but not proteasome.Overexpression of ATM significantly mitigated DDR inhibition and cell death induced by shikonin and chemotherapeutic drugs.These novel findings reveal shikonin as a pan DDR inhibitor and identify ATM as a primary factor in determining the chemo sensitizing effect of shikonin.Our data may facilitate the development of shikonin and its derivatives as potential chemotherapy sensitizers through inducing ATM degradation.
文摘This study suggested environmental and economic evaluations by developing a scenario according to the various treatment options of food waste in Korea. In particular, the study evaluated the possibility about the combined treatment of food waste and human excrement after using food waste disposers (FWDs). The scenario including only composting (133 kg CO2 equiv./ton-household organic waste) or only FWDs (125 kg CO2 equiv./ton-household organic waste) was superior to the other scenarios in the environmental aspect and the scenario including only composting (101 USD/ton-household organic waste) was superior to the other scenarios in the economic aspect. However, the study discovered that 52% of greenhouse gas emission was reduced when sewage pretreatment was conducted in houses after using FWDs and also when biogas was collected on site and utilized in the private power station. Furthermore, the energy saving effect due to recovery of biogas has found to be larger in the environment aspect than in the economic aspect.
基金supported by the Daejeon Metropolitan City and Korea Environment Corporation
文摘A credible accounting of national and regional inventories for the greenhouse gas （GHG） reduction has emerged as one of the most significant current discussions. This article assessed the regional GHG emissions by three categories of the waste sector in Daejeon Metropolitan City （DMC）, Korea, examined the potential for DMC to reduce GHG emission, and discussed the methodology modified from Intergovernmental Panel on Climate Change and Korea national guidelines. During the last five years, DMC＇s overall GHG emissions were 239 thousand tons C02 eq./year from eleven public environmental infrastructure facilities, with a population of 1.52 million. Of the three categories, solid waste treatment/disposal contributes 68%, whilst wastewater treatment and others contribute 22% and 10% respectively. Among GHG unit emissions per ton of waste treatment, the biggest contributor was waste incineration of 694 kg CO2 eq./ton, followed by waste disposal of 483 kg CO2 eq./ton, biological treatment of solid waste of 209 kg CO2 eq./ton, wastewater treatment of 0.241 kg CO2 eq./m3, and public water supplies of 0.067 kg CO2 eq./m3. Furthermore, it is suggested that the potential in reducing GHG emissions from landfill process can be as high as 47.5% by increasing landfill gas recovery up to 50%. Therefore, it is apparent that reduction strategies for the main contributors of GHG emissions should take precedence over minor contributors and lead to the best practice for managing GHGs abatement.
