目的探讨被动抬腿试验(PLR)联合左室流出道速度时间积分(VTI)评估外科ICU中急性循环衰竭(ACF)早期容量反应性的价值。方法采取前瞻性观察队列研究方法选取急性循环衰竭患者先后进行被动抬腿试验和容量负荷试验,试验前后采用经胸超声心...目的探讨被动抬腿试验(PLR)联合左室流出道速度时间积分(VTI)评估外科ICU中急性循环衰竭(ACF)早期容量反应性的价值。方法采取前瞻性观察队列研究方法选取急性循环衰竭患者先后进行被动抬腿试验和容量负荷试验,试验前后采用经胸超声心动图测量每搏量(SV),做左室流出道速度时间积分(VTI),定义试验前后SV增加(ΔSV)≥15%为有容量反应性,根据有无容量反应将患者分为有反应组和无反应组,观察两组PLR前后相关血流动力学参数的变化及其相关性,最后采用受试者工作特征曲线(ROC曲线)评价VTI预测容量反应性的价值。结果研究共计纳入60例患者,其中有容量反应35例,无容量反应性25例;有容量反应性组PLR前后平均动脉压MAP(67±19 vs 73±13 mm Hg,P=0.02)、每搏量SV(48±11 vs 56±10 ml,P=0.03)、VTI(14±4 vs 18±5 cm,P=0.04)的变化存在显著统计学差异;PLR前后与容量负荷试验前后ΔSV呈显著正相关性(r=0.8846,P<0.0001);PLR后下腔静脉塌陷指数(c IVC)、ΔVTI与ΔSV呈显著正相关性(r=0.8034,P<0.001;r=9212,P<0.001),而CVP与ΔSV无显著相关性(r=-0.1121,P=3947);PLR后ΔVTI预测容量反应性AUC(ROC曲线下面积)为0.8686±0.04(P<0.001),其中ΔVTI>8.75%预测容量反应性敏感性和特异性分别为90.63%和85.00%,阳性预测率和阴性预测率分别为90.67%和84.00%。结论 PLR联合VTI可以准确预测外科ICU中急性循环衰竭患者容量反应性,可指导临床液体治疗。展开更多
Aqueous zinc metal batteries (AZMBs) are hindered by uncontrolled dendrites and side reactions during commercialization,despite their advantages of safety and high capacity density.Herein,we propose the electrical fee...Aqueous zinc metal batteries (AZMBs) are hindered by uncontrolled dendrites and side reactions during commercialization,despite their advantages of safety and high capacity density.Herein,we propose the electrical feedback strategy to restrain the Zn dendrites resulting from the"tip effect"and optimize interfacial Zn^(2+)distribution to accelerate electrodeposition kinetics by using the lithium niobate (LNO) layer.Specifically,at the bumps of the zinc anode,the ferroelectric LNO is polarized by the locally strong electric field,which in turn counteracts the"tip effect".In this way,the dynamic polarization of LNO can repair the uneven tip electric field to achieve uniform and flat zinc deposition.In addition,owing to the interaction between Nb and Zn^(2+),a higher concentration of Zn^(2+)near the zincophilic LNO@Zn surface is obtained for the rapid electrochemical reaction kinetics of plating.Considering the aforementioned advantages,the LNO@Zn anode harvests stable cycling over 1200 h at 10 mA cm^(-2)with a superior cumulative capacity of 5800 mAh cm^(-2).Assembled with the a-MnO_(2) cathode,the full cell using LNO@Zn anode exhibits the slower capacity decay (0.054%per cycle) during 1000 cycles.This strategy provides a perspective for stabilizing zinc metal anodes through dynamic electrical response and interfacial ion redistribution effect.展开更多
Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media.However,the nontransparency and heterogeneity of media in practi...Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media.However,the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation.In this study,we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images,thereby enabling acoustic manipulation in nontransparent media.Furthermore,we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps.We achieved 3D particle manipulation in heterogeneous media(through resin baffle and ex vivo macaque and human skulls)by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves.Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery,controlled micromachine transfer,and precise treatment.展开更多
Aqueous zinc ion batteries(AZIBs)are an advanced secondary battery technology to supplement lithiumion batteries.It has been widely concerned and developed recently based on the element abundance and safety advantages...Aqueous zinc ion batteries(AZIBs)are an advanced secondary battery technology to supplement lithiumion batteries.It has been widely concerned and developed recently based on the element abundance and safety advantages.However,AZIBs still suffer from serious problems such as dendrites Zn,hydrogen evolution corrosion,and surface passivation,which hinder the further commercial application of AZIBs.Herein,an in-situ ZnCr_(2)O_(4)(ZCO)interface endows AZIBs with dendrite-free and ultra-low polarization by realizing Zn^(2+)pre-desolvation,constraining H2O-induced corrosio n,and boosting Zn^(2+)transport/deposition kinetics.The ZCO@Zn anode harvests an ultrahigh cumulative capacity of~20000 mA h cm^(-2)(cycle time:over 4000 h)at a high current density of 10 mA cm^(-2),indicating excellent reversibility of Zn deposition,Such superior performance is among the best cyclability in AZIBs.Moreover,the multifunctional ZCO interface improves the Coulombic efficiency(CE)to 99.7%for more than 2600 cycles.The outstanding electrochemical performance is also verified by the long-term cycle stability of ZCO@Zn//α-MnO_(2) full cells.Notably,the as-proposed method is efficient and low-cost enough to enable mass production.This work provides new insights into the uniform Zn electrodeposition at the scale of interfacial Zn^(2+)predesolvation and kinetics improvement.展开更多
By conducting relative permeability experiments of multi-cycle gas-water displacement and imbibition on natural cores,we discuss relative permeability hysteresis effect in underground gas storage during multi-cycle in...By conducting relative permeability experiments of multi-cycle gas-water displacement and imbibition on natural cores,we discuss relative permeability hysteresis effect in underground gas storage during multi-cycle injection and production.A correction method for relative permeability hysteresis in numerical simulation of water-invaded gas storage has been worked out using the Carlson and Killough models.A geologic model of water-invaded sandstone gas storage with medium-low permeability is built to investigate the impacts of relative permeability hysteresis on fluid distribution and production performance during multi-cycle injection and production of the gas storage.The study shows that relative permeability hysteresis effect occurs during high-speed injection and production in gas storage converted from water-invaded gas reservoir,and leads to increase of gas-water transition zone width and thickness,shrinkage of the area of high-efficiency gas storage,and decrease of the peak value variation of pore volume containing gas,and then reduces the storage capacity,working gas volume,and high-efficiency operation span of the gas storage.Numerical simulations exhibit large prediction errors of performance indexes if this hysteresis effect is not considered.Killough and Carlson methods can be used to correct the relative permeability hysteresis effect in water-invaded underground gas storage to improve the prediction accuracy.The Killough method has better adaptability to the example model.展开更多
目的探讨核糖体S6蛋白激酶1(ribosomal S6 protein kinase type 1,RSK1)在乳腺癌中的表达及其预后预测价值。方法基于Protein Atlas数据库比较乳腺癌组织及正常乳腺组织中RSK1表达差异。基于TCGA-BRCA及GEO提取RSK1 mRNA表达数据,基于TC...目的探讨核糖体S6蛋白激酶1(ribosomal S6 protein kinase type 1,RSK1)在乳腺癌中的表达及其预后预测价值。方法基于Protein Atlas数据库比较乳腺癌组织及正常乳腺组织中RSK1表达差异。基于TCGA-BRCA及GEO提取RSK1 mRNA表达数据,基于TCGA-RPPA提取RSK1蛋白表达数据,分析RSK1 mRNA及蛋白表达水平及其与乳腺癌总体预后的关系。结果数据集免疫组化分析结果显示,乳腺癌组织RSK1蛋白表达水平较正常组织低。TCGA-BRCA数据单因素和多因素Cox回归分析均显示RSK1 mRNA高表达组患者总体预后较好,分层分析结果显示女性、年龄≤60岁、Ⅰ~Ⅱ期、浸润性乳腺癌、无区域淋巴结转移(N0)以及无远处转移(M0)的高表达RSK1 mRNA患者总体预后较好。GEO 9个基于基因芯片数据集的荟萃结果与其相一致(HR=0.69,95%CI:0.56~0.86,P=0.002)。TCGA-RPPA数据显示RSK1蛋白高表达组患者总体预后较好(HR=0.49,95%CI:0.27~0.89,P=0.011),不同乳腺癌分期中,早期患者RSK1 mRNA(HR=0.61,95%CI:0.39~0.95,P=0.025)和蛋白(HR=0.43,95%CI:0.22~0.84,P=0.008)高表达组总体预后较好。结论RSK1高表达与乳腺癌患者较好的总体预后相关,RSK1可能是预测乳腺癌患者总体预后的标志物。展开更多
文摘目的探讨被动抬腿试验(PLR)联合左室流出道速度时间积分(VTI)评估外科ICU中急性循环衰竭(ACF)早期容量反应性的价值。方法采取前瞻性观察队列研究方法选取急性循环衰竭患者先后进行被动抬腿试验和容量负荷试验,试验前后采用经胸超声心动图测量每搏量(SV),做左室流出道速度时间积分(VTI),定义试验前后SV增加(ΔSV)≥15%为有容量反应性,根据有无容量反应将患者分为有反应组和无反应组,观察两组PLR前后相关血流动力学参数的变化及其相关性,最后采用受试者工作特征曲线(ROC曲线)评价VTI预测容量反应性的价值。结果研究共计纳入60例患者,其中有容量反应35例,无容量反应性25例;有容量反应性组PLR前后平均动脉压MAP(67±19 vs 73±13 mm Hg,P=0.02)、每搏量SV(48±11 vs 56±10 ml,P=0.03)、VTI(14±4 vs 18±5 cm,P=0.04)的变化存在显著统计学差异;PLR前后与容量负荷试验前后ΔSV呈显著正相关性(r=0.8846,P<0.0001);PLR后下腔静脉塌陷指数(c IVC)、ΔVTI与ΔSV呈显著正相关性(r=0.8034,P<0.001;r=9212,P<0.001),而CVP与ΔSV无显著相关性(r=-0.1121,P=3947);PLR后ΔVTI预测容量反应性AUC(ROC曲线下面积)为0.8686±0.04(P<0.001),其中ΔVTI>8.75%预测容量反应性敏感性和特异性分别为90.63%和85.00%,阳性预测率和阴性预测率分别为90.67%和84.00%。结论 PLR联合VTI可以准确预测外科ICU中急性循环衰竭患者容量反应性,可指导临床液体治疗。
基金supported by the National Natural Science Foundation of China (52172159)the Postdoctoral Fellowship Program of CPSF (GZB20230631)。
文摘Aqueous zinc metal batteries (AZMBs) are hindered by uncontrolled dendrites and side reactions during commercialization,despite their advantages of safety and high capacity density.Herein,we propose the electrical feedback strategy to restrain the Zn dendrites resulting from the"tip effect"and optimize interfacial Zn^(2+)distribution to accelerate electrodeposition kinetics by using the lithium niobate (LNO) layer.Specifically,at the bumps of the zinc anode,the ferroelectric LNO is polarized by the locally strong electric field,which in turn counteracts the"tip effect".In this way,the dynamic polarization of LNO can repair the uneven tip electric field to achieve uniform and flat zinc deposition.In addition,owing to the interaction between Nb and Zn^(2+),a higher concentration of Zn^(2+)near the zincophilic LNO@Zn surface is obtained for the rapid electrochemical reaction kinetics of plating.Considering the aforementioned advantages,the LNO@Zn anode harvests stable cycling over 1200 h at 10 mA cm^(-2)with a superior cumulative capacity of 5800 mAh cm^(-2).Assembled with the a-MnO_(2) cathode,the full cell using LNO@Zn anode exhibits the slower capacity decay (0.054%per cycle) during 1000 cycles.This strategy provides a perspective for stabilizing zinc metal anodes through dynamic electrical response and interfacial ion redistribution effect.
基金supported in part by the National Natural Science Foundation of China Grant(Grant Nos.81527901,61571431,11774370,81827807,and 81827802)Shenzhen Peacock Plan(Grant No.KQTD20170810160424889)+1 种基金Scientific Instruments Funding of Chinese Academy of Sciences(Grant No.YJKYYQ20190077)Shenzhen Key Laboratory of ultrasound imaging and therapy(Grant No.ZDSYS20180206180631473).
文摘Acoustic tweezers have great application prospects because they allow noncontact and noninvasive manipulation of microparticles in a wide range of media.However,the nontransparency and heterogeneity of media in practical applications complicate particle trapping and manipulation.In this study,we designed a 1.04 MHz 256-element 2D matrix array for 3D acoustic tweezers to guide and monitor the entire process using real-time 3D ultrasonic images,thereby enabling acoustic manipulation in nontransparent media.Furthermore,we successfully performed dynamic 3D manipulations on multiple microparticles using multifoci and vortex traps.We achieved 3D particle manipulation in heterogeneous media(through resin baffle and ex vivo macaque and human skulls)by introducing a method based on the time reversal principle to correct the phase and amplitude distortions of the acoustic waves.Our results suggest cutting-edge applications of acoustic tweezers such as acoustical drug delivery,controlled micromachine transfer,and precise treatment.
基金supported by the National Natural Science Foundation of China(52172159)the Provincial key R&D Program of Zhejiang Province(2021C01030)the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SZ-TD006)。
文摘Aqueous zinc ion batteries(AZIBs)are an advanced secondary battery technology to supplement lithiumion batteries.It has been widely concerned and developed recently based on the element abundance and safety advantages.However,AZIBs still suffer from serious problems such as dendrites Zn,hydrogen evolution corrosion,and surface passivation,which hinder the further commercial application of AZIBs.Herein,an in-situ ZnCr_(2)O_(4)(ZCO)interface endows AZIBs with dendrite-free and ultra-low polarization by realizing Zn^(2+)pre-desolvation,constraining H2O-induced corrosio n,and boosting Zn^(2+)transport/deposition kinetics.The ZCO@Zn anode harvests an ultrahigh cumulative capacity of~20000 mA h cm^(-2)(cycle time:over 4000 h)at a high current density of 10 mA cm^(-2),indicating excellent reversibility of Zn deposition,Such superior performance is among the best cyclability in AZIBs.Moreover,the multifunctional ZCO interface improves the Coulombic efficiency(CE)to 99.7%for more than 2600 cycles.The outstanding electrochemical performance is also verified by the long-term cycle stability of ZCO@Zn//α-MnO_(2) full cells.Notably,the as-proposed method is efficient and low-cost enough to enable mass production.This work provides new insights into the uniform Zn electrodeposition at the scale of interfacial Zn^(2+)predesolvation and kinetics improvement.
基金Supported by the Petro China Science and Technology Major Project(2015E-4002)。
文摘By conducting relative permeability experiments of multi-cycle gas-water displacement and imbibition on natural cores,we discuss relative permeability hysteresis effect in underground gas storage during multi-cycle injection and production.A correction method for relative permeability hysteresis in numerical simulation of water-invaded gas storage has been worked out using the Carlson and Killough models.A geologic model of water-invaded sandstone gas storage with medium-low permeability is built to investigate the impacts of relative permeability hysteresis on fluid distribution and production performance during multi-cycle injection and production of the gas storage.The study shows that relative permeability hysteresis effect occurs during high-speed injection and production in gas storage converted from water-invaded gas reservoir,and leads to increase of gas-water transition zone width and thickness,shrinkage of the area of high-efficiency gas storage,and decrease of the peak value variation of pore volume containing gas,and then reduces the storage capacity,working gas volume,and high-efficiency operation span of the gas storage.Numerical simulations exhibit large prediction errors of performance indexes if this hysteresis effect is not considered.Killough and Carlson methods can be used to correct the relative permeability hysteresis effect in water-invaded underground gas storage to improve the prediction accuracy.The Killough method has better adaptability to the example model.
