BACKGROUND The endoplasmic reticulum(ER)is closely related to a wide range of cellular functions and is a key component to maintain and restore metabolic health.Type 2 diabetes mellitus(T2DM)is a serious threat to hum...BACKGROUND The endoplasmic reticulum(ER)is closely related to a wide range of cellular functions and is a key component to maintain and restore metabolic health.Type 2 diabetes mellitus(T2DM)is a serious threat to human health,but the ER stress(ERS)-related mechanisms in T2DM have not been fully elucidated.AIM To identify potential ERS-related mechanisms and crucial biomarkers in T2DM.METHODS We conducted gene set enrichment analysis(GSEA)and gene set variation analysis(GSVA)in myoblast and myotube form GSE166502,and obtained the differentially expressed genes(DEGs).After intersecting with ERS-related genes,we obtained ERS-related DEGs.Finally,functional analyses,immune infiltration,and several networks were established.RESULTS Through GSEA and GSVA,we identified several metabolic and immune-related pathways.We obtained 227 ERS-related DEGs and constructed several important networks that help to understand the mechanisms and treatment of T2DM.Finally,memory CD4^(+)T cells accounted for the largest proportion of immune cells.CONCLUSION This study revealed ERS-related mechanisms in T2DM,which might contribute to new ideas and insights into the mechanisms and treatment of T2DM.展开更多
在现代电子战的背景下,转发式GNSS欺骗干扰已经成为一种重要的干扰方式,通过研究实施转发式GNSS欺骗干扰的选星方法,可以提高转发式欺骗干扰的干扰能力.基于转发式欺骗干扰的实现原理,提出了一种基于常用GNSS定位选星方法和卫星对位置...在现代电子战的背景下,转发式GNSS欺骗干扰已经成为一种重要的干扰方式,通过研究实施转发式GNSS欺骗干扰的选星方法,可以提高转发式欺骗干扰的干扰能力.基于转发式欺骗干扰的实现原理,提出了一种基于常用GNSS定位选星方法和卫星对位置精度因子(position dilution of precision,PDOP)的贡献值选择被转发卫星的选星方法,基于利用最小二乘算法的伪距绝对定位方法进行仿真,模拟了接收机在静态和动态条件下受到单颗卫星转发式欺骗干扰的情况.仿真结果表明,本文提出的被转发卫星选择算法分别有87.42%和100%的概率给出理论上最优的选星结果.展开更多
文摘BACKGROUND The endoplasmic reticulum(ER)is closely related to a wide range of cellular functions and is a key component to maintain and restore metabolic health.Type 2 diabetes mellitus(T2DM)is a serious threat to human health,but the ER stress(ERS)-related mechanisms in T2DM have not been fully elucidated.AIM To identify potential ERS-related mechanisms and crucial biomarkers in T2DM.METHODS We conducted gene set enrichment analysis(GSEA)and gene set variation analysis(GSVA)in myoblast and myotube form GSE166502,and obtained the differentially expressed genes(DEGs).After intersecting with ERS-related genes,we obtained ERS-related DEGs.Finally,functional analyses,immune infiltration,and several networks were established.RESULTS Through GSEA and GSVA,we identified several metabolic and immune-related pathways.We obtained 227 ERS-related DEGs and constructed several important networks that help to understand the mechanisms and treatment of T2DM.Finally,memory CD4^(+)T cells accounted for the largest proportion of immune cells.CONCLUSION This study revealed ERS-related mechanisms in T2DM,which might contribute to new ideas and insights into the mechanisms and treatment of T2DM.
文摘在现代电子战的背景下,转发式GNSS欺骗干扰已经成为一种重要的干扰方式,通过研究实施转发式GNSS欺骗干扰的选星方法,可以提高转发式欺骗干扰的干扰能力.基于转发式欺骗干扰的实现原理,提出了一种基于常用GNSS定位选星方法和卫星对位置精度因子(position dilution of precision,PDOP)的贡献值选择被转发卫星的选星方法,基于利用最小二乘算法的伪距绝对定位方法进行仿真,模拟了接收机在静态和动态条件下受到单颗卫星转发式欺骗干扰的情况.仿真结果表明,本文提出的被转发卫星选择算法分别有87.42%和100%的概率给出理论上最优的选星结果.
