The early precipitation ofγ’-Co3(Al,W)phase affects the spatial distribution and kinetic evolution of precipitates for the morphology transmission effect,but the nucleation and concomitant growth are not studied sti...The early precipitation ofγ’-Co3(Al,W)phase affects the spatial distribution and kinetic evolution of precipitates for the morphology transmission effect,but the nucleation and concomitant growth are not studied still by aging experiments due to the expeditious precipitation ofγ’phase in Co-Al-W alloy.By using the phase-field simulation with sublattice free energy,the early-stage kinetics evolution ofγ’-Co3(Al,W)phase in a medium supersaturation Co-9 Al-8 W(at.%)alloy aged from 1023 K to 1173 K is investigated.The influences of aging temperature on the evolution of morphology and composition ofγ’phase,and the kinetics of nucleation and growth to coarsening are clarified.It is found that the rates of composition evolution of W inγphase are two or three times that ofγ’phase,and the W compositions inγandγ’phases show a linear relationship with time t–1/3,which means that the coarsening takes place earlier at high temperature.In addition,the equilibrium partitioning ratios indicate Al and W partition into theγ’phase and the ratios decrease with elevated temperature.The compositional variations across theγ/γ’phase interfaces suggest that low aging temperature makes the stoichiometric ratio closer to 3:1.Moreover,the precipitation evolutions from early nucleation to growth and coarsening in Co-Al-W alloy are distinguished,and the rate constants of square and cube of average particles radius increase with temperature.In later growth stage,the relationship of the square of average particles radius and time is obeyed,while the steady-state coarsening stage follows the cube law.The time exponents of particles number density at the coarsening stage are close to–1 of Kuehmann-Voorhees(KV)theory.The study demonstrates that the early-stage evolution ofγ’phase which is undiscovered in the experiment can be captured by the phase-field simulation,and the resultant kinetics laws agree well with the experimental and theoretical results.展开更多
[Objectives]To observe the clinical efficacy of Sanying capsule combined with Xiaoying Patch in treating thyroid nodule(TN).[Methods]Two groups were treated similarly,with 200 cases in the control group undergoing bas...[Objectives]To observe the clinical efficacy of Sanying capsule combined with Xiaoying Patch in treating thyroid nodule(TN).[Methods]Two groups were treated similarly,with 200 cases in the control group undergoing basic treatment for 12 weeks and 198 cases in the observation group receiving Sanying capsule combined with Xiaoying patches for the same duration.The clinical symptoms,number of nodules,diameter of the largest nodule,and maximum reduction of nodules were observed before and after treatment.A control analysis was performed,and the underlying mechanisms were explored.[Results]The primary symptoms of the observation group exhibited a more favorable improvement than those of the control group.Additionally,the number of nodules decreased,the diameter of the largest nodule decreased,and the maximum reduction of nodules decreased in both groups following treatment.However,the observation group demonstrated a more pronounced improvement than the control group(P<0.05).[Conclusions]The combination of Sanying capsule and Xiaoying patch has been demonstrated to be an effective treatment for TN,with a high degree of reliability in terms of safety.展开更多
Hepatocellular carcinoma （HCC） is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 16 （PPM1D） was highly expressed in the majority of HCC cases （approxi...Hepatocellular carcinoma （HCC） is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 16 （PPM1D） was highly expressed in the majority of HCC cases （approximately 59%） and significantly associated with high serum a-fetoprotein （AFP） level （P = 0.044）. Kaplan- Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC- specific overall survival （HR, 2.799; 95% CI, 1.346-5.818, P = 0.006）. Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.展开更多
为研究不同烹饪方式对羊肚菌营养品质的影响,采用体外消化方法对煮制、蒸制以及烤制处理的不同粒度羊肚菌粉(粗粉、超微粉)进行消化。比较了消化后的羊肚菌粉显微形态,模拟胃、肠消化液中还原糖、蛋白质、游离氨基酸、总酚含量以及DPPH(...为研究不同烹饪方式对羊肚菌营养品质的影响,采用体外消化方法对煮制、蒸制以及烤制处理的不同粒度羊肚菌粉(粗粉、超微粉)进行消化。比较了消化后的羊肚菌粉显微形态,模拟胃、肠消化液中还原糖、蛋白质、游离氨基酸、总酚含量以及DPPH(1,1-Diphenryl-2-Picrylhydrazyl)自由基清除能力、铁离子还原能力(Ferric Ion Reducing Antioxidantpower,FRAP)、阳离子自由基清除能力2-azinobis-(3-ethylbenzthiazoline-6-sulfphonate,ABTS)。结果表明:经过体外胃、肠消化后,烤制处理的羊肚菌粉还原糖、蛋白质、多酚溶出量最高,蒸制其次,煮制最低,烤制比煮制平均依次高62.87%、58.58%、4.69倍;蒸制处理的羊肚菌,溶出的游离氨基酸含量在所有处理中最高,粗粉、细粉平均为40.40 mg/g,分别比烤制、蒸制高出18.77%,19.81%。超微粉碎不能有效提高还原糖、多酚的溶出,但可以显著提高蛋白质、游离氨基酸的溶出(P<0.05);模拟消化液的DPPH值没有显著差异,但FRAP和ABTS值差异显著(P<0.05),烤制处理的最高,其次是蒸制,煮制最低;超微粉碎不能有效提升羊肚菌模拟消化液的抗氧化水平。该研究为羊肚菌的科学食用提供了参考。展开更多
p53 is an important tumor suppressor gene.The p53 pathway is activated in response to cellular stress stimulation.However,in more than 50%of breast cancers,p53 is mutated or inactivated,which permits cancer growth.1 A...p53 is an important tumor suppressor gene.The p53 pathway is activated in response to cellular stress stimulation.However,in more than 50%of breast cancers,p53 is mutated or inactivated,which permits cancer growth.1 Although a large number of co-regulators of p53 have been identified,the integrated molecular network of p53 and the key co-factors that could transactivate p53 remain unclear.2 Myeloid Zinc Finger 1(MZF1),a member of the SCAN-ZFP(SCAN-Zinc finger protein)family,has been involved in the occurrence and development of various types of malignant tumors,including breast cancer.3 However,the exact mechanism of action remains unclear.Our study aims to investigate the cross-regulatory loop between MZF1 and p53 in breast cancer cells.展开更多
目的:探讨症状性颅内动脉粥样硬化性疾病(intracranial atherosclerotic disease,ICAD)患者前循环低灌注与缺血性卒中复发的相关性。方法:回顾性分析130例由大脑中动脉狭窄引发的症状性ICAD患者,根据急性缺血性卒中事件发生次数将其分...目的:探讨症状性颅内动脉粥样硬化性疾病(intracranial atherosclerotic disease,ICAD)患者前循环低灌注与缺血性卒中复发的相关性。方法:回顾性分析130例由大脑中动脉狭窄引发的症状性ICAD患者,根据急性缺血性卒中事件发生次数将其分为初发组(n=92)和复发组(n=38),基于残余功能达峰时间(time to maximum of the residual function,T_(max))阈值T_(max)>4 s及T_(max)>6 s定量低灌注体积。采用独立样本t检验、非参数检验、卡方检验或Fisher精确概率法对比分析两组患者大脑中动脉狭窄率、分水岭梗死发生率、T_(max)>6 s及T_(max)>4 s的低灌注体积,多因素Logistic回归探讨缺血性卒中复发相关的独立危险因素,并进行ROC曲线分析。结果:与初发组相比,复发组血管狭窄率更高(P=0.003)、分水岭梗死发生比例更高(P=0.037)、T_(max)>6 s及T_(max)>4 s的低灌注体积更高(P值均<0.001),其中T_(max)>4 s的低灌注体积是与缺血性卒中复发相关的独立危险因素(OR=1.120,低灌注体积每增加10 mL,95%CI:1.051~1.194,P<0.001),ROC曲线下面积为0.756(95%CI:0.672~0.839),灵敏度76.3%,特异度63.0%。结论:基于时间阈值T_(max)>4 s量化的低灌注体积,是前循环症状性ICAD患者卒中复发的独立危险因素,可能成为预警缺血性卒中复发的有效影像学标志物。展开更多
基金financially supported by the National Natural Science Foundation of China(No.51571122)the Fundamental Research Funds for the Central Universities(No.30916015107)。
文摘The early precipitation ofγ’-Co3(Al,W)phase affects the spatial distribution and kinetic evolution of precipitates for the morphology transmission effect,but the nucleation and concomitant growth are not studied still by aging experiments due to the expeditious precipitation ofγ’phase in Co-Al-W alloy.By using the phase-field simulation with sublattice free energy,the early-stage kinetics evolution ofγ’-Co3(Al,W)phase in a medium supersaturation Co-9 Al-8 W(at.%)alloy aged from 1023 K to 1173 K is investigated.The influences of aging temperature on the evolution of morphology and composition ofγ’phase,and the kinetics of nucleation and growth to coarsening are clarified.It is found that the rates of composition evolution of W inγphase are two or three times that ofγ’phase,and the W compositions inγandγ’phases show a linear relationship with time t–1/3,which means that the coarsening takes place earlier at high temperature.In addition,the equilibrium partitioning ratios indicate Al and W partition into theγ’phase and the ratios decrease with elevated temperature.The compositional variations across theγ/γ’phase interfaces suggest that low aging temperature makes the stoichiometric ratio closer to 3:1.Moreover,the precipitation evolutions from early nucleation to growth and coarsening in Co-Al-W alloy are distinguished,and the rate constants of square and cube of average particles radius increase with temperature.In later growth stage,the relationship of the square of average particles radius and time is obeyed,while the steady-state coarsening stage follows the cube law.The time exponents of particles number density at the coarsening stage are close to–1 of Kuehmann-Voorhees(KV)theory.The study demonstrates that the early-stage evolution ofγ’phase which is undiscovered in the experiment can be captured by the phase-field simulation,and the resultant kinetics laws agree well with the experimental and theoretical results.
基金Supported by"Shaanxi Hu Xiaojuan Famous Chinese Medicine Workshop"Construction Project of Shaanxi Provincial Administration of Traditional Chinese Medicine"Thyroid Specialized Clinic"Construction Project of Shaanxi Provincial Hospital of Traditional Chinese Medicine.
文摘[Objectives]To observe the clinical efficacy of Sanying capsule combined with Xiaoying Patch in treating thyroid nodule(TN).[Methods]Two groups were treated similarly,with 200 cases in the control group undergoing basic treatment for 12 weeks and 198 cases in the observation group receiving Sanying capsule combined with Xiaoying patches for the same duration.The clinical symptoms,number of nodules,diameter of the largest nodule,and maximum reduction of nodules were observed before and after treatment.A control analysis was performed,and the underlying mechanisms were explored.[Results]The primary symptoms of the observation group exhibited a more favorable improvement than those of the control group.Additionally,the number of nodules decreased,the diameter of the largest nodule decreased,and the maximum reduction of nodules decreased in both groups following treatment.However,the observation group demonstrated a more pronounced improvement than the control group(P<0.05).[Conclusions]The combination of Sanying capsule and Xiaoying patch has been demonstrated to be an effective treatment for TN,with a high degree of reliability in terms of safety.
基金This study was supported by grants from the National Natural Science Foundation of China （Nos. 81000880 and 81370057 to Zhi Xu）, the Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health （JQX12007 to Zhi Xu）, the clinical special project for Natural Science Foundation of Jiangsu Province （BL2012016 to Jinfei Chen）, and the Nanjing 12th Five-Year Key Scientific Project of Medicine to Jinfei Chen.
文摘Hepatocellular carcinoma （HCC） is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 16 （PPM1D） was highly expressed in the majority of HCC cases （approximately 59%） and significantly associated with high serum a-fetoprotein （AFP） level （P = 0.044）. Kaplan- Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC- specific overall survival （HR, 2.799; 95% CI, 1.346-5.818, P = 0.006）. Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.
文摘为研究不同烹饪方式对羊肚菌营养品质的影响,采用体外消化方法对煮制、蒸制以及烤制处理的不同粒度羊肚菌粉(粗粉、超微粉)进行消化。比较了消化后的羊肚菌粉显微形态,模拟胃、肠消化液中还原糖、蛋白质、游离氨基酸、总酚含量以及DPPH(1,1-Diphenryl-2-Picrylhydrazyl)自由基清除能力、铁离子还原能力(Ferric Ion Reducing Antioxidantpower,FRAP)、阳离子自由基清除能力2-azinobis-(3-ethylbenzthiazoline-6-sulfphonate,ABTS)。结果表明:经过体外胃、肠消化后,烤制处理的羊肚菌粉还原糖、蛋白质、多酚溶出量最高,蒸制其次,煮制最低,烤制比煮制平均依次高62.87%、58.58%、4.69倍;蒸制处理的羊肚菌,溶出的游离氨基酸含量在所有处理中最高,粗粉、细粉平均为40.40 mg/g,分别比烤制、蒸制高出18.77%,19.81%。超微粉碎不能有效提高还原糖、多酚的溶出,但可以显著提高蛋白质、游离氨基酸的溶出(P<0.05);模拟消化液的DPPH值没有显著差异,但FRAP和ABTS值差异显著(P<0.05),烤制处理的最高,其次是蒸制,煮制最低;超微粉碎不能有效提升羊肚菌模拟消化液的抗氧化水平。该研究为羊肚菌的科学食用提供了参考。
基金supported by grants(No.81872263 to H.W.)from the National Natural Science Foundation of China.
文摘p53 is an important tumor suppressor gene.The p53 pathway is activated in response to cellular stress stimulation.However,in more than 50%of breast cancers,p53 is mutated or inactivated,which permits cancer growth.1 Although a large number of co-regulators of p53 have been identified,the integrated molecular network of p53 and the key co-factors that could transactivate p53 remain unclear.2 Myeloid Zinc Finger 1(MZF1),a member of the SCAN-ZFP(SCAN-Zinc finger protein)family,has been involved in the occurrence and development of various types of malignant tumors,including breast cancer.3 However,the exact mechanism of action remains unclear.Our study aims to investigate the cross-regulatory loop between MZF1 and p53 in breast cancer cells.
文摘目的:探讨症状性颅内动脉粥样硬化性疾病(intracranial atherosclerotic disease,ICAD)患者前循环低灌注与缺血性卒中复发的相关性。方法:回顾性分析130例由大脑中动脉狭窄引发的症状性ICAD患者,根据急性缺血性卒中事件发生次数将其分为初发组(n=92)和复发组(n=38),基于残余功能达峰时间(time to maximum of the residual function,T_(max))阈值T_(max)>4 s及T_(max)>6 s定量低灌注体积。采用独立样本t检验、非参数检验、卡方检验或Fisher精确概率法对比分析两组患者大脑中动脉狭窄率、分水岭梗死发生率、T_(max)>6 s及T_(max)>4 s的低灌注体积,多因素Logistic回归探讨缺血性卒中复发相关的独立危险因素,并进行ROC曲线分析。结果:与初发组相比,复发组血管狭窄率更高(P=0.003)、分水岭梗死发生比例更高(P=0.037)、T_(max)>6 s及T_(max)>4 s的低灌注体积更高(P值均<0.001),其中T_(max)>4 s的低灌注体积是与缺血性卒中复发相关的独立危险因素(OR=1.120,低灌注体积每增加10 mL,95%CI:1.051~1.194,P<0.001),ROC曲线下面积为0.756(95%CI:0.672~0.839),灵敏度76.3%,特异度63.0%。结论:基于时间阈值T_(max)>4 s量化的低灌注体积,是前循环症状性ICAD患者卒中复发的独立危险因素,可能成为预警缺血性卒中复发的有效影像学标志物。
