目的观察无创正压通气(NIPPV)和经鼻高流量氧疗(HFNC)对新型冠状病毒肺炎(新冠肺炎)并发急性呼吸窘迫综合征(ARDS)患者预后的影响。方法采用回顾性研究方法,选择2020年2月至4月作者援鄂期间在华中科技大学同济医学院附属同济医院收治的...目的观察无创正压通气(NIPPV)和经鼻高流量氧疗(HFNC)对新型冠状病毒肺炎(新冠肺炎)并发急性呼吸窘迫综合征(ARDS)患者预后的影响。方法采用回顾性研究方法,选择2020年2月至4月作者援鄂期间在华中科技大学同济医学院附属同济医院收治的脉搏血氧饱和度/吸入氧浓度比值(SpO_(2)/FiO_(2),S/F)<235〔利用S/F比值代替氧合指数(PaO_(2)/FiO_(2))诊断ARDS〕的新冠肺炎患者。按氧疗模式不同将患者分为NIPPV组和HFNC组。收集患者的临床资料,包括:一般特征、呼吸频率(RR)、FiO_(2)、SpO_(2)、心率(HR)、平均动脉压(MAP),最初72 h S/F比值、入院/出院前/死亡前淋巴细胞计数(LYM)、淋巴细胞比例(LYM%)、白细胞计数(WBC)、通气前呼吸困难病程、发病至入院时间等,比较不同氧疗模式患者需要插管率、全因病死率、S/F比值和RR改善情况的差异。采用单因素分析和广义估计方程(GEE)方法分析影响S/F比值的危险因素。结果41例患者中男性比例较高(占68.3%,28例),中位年龄68(58-74)岁,28例有合并症(占68.3%),发生多器官功能障碍综合征(MODS)34例(占82.9%)。与HFNC组比较,NIPPV组合并症更多〔87.5%(21/24)比41.2%(7/17),P<0.05〕,LYM%更低〔5.3%(3.4%-7.8%)比10.0%(3.9%-19.7%),P<0.05〕,血液净化治疗率也更低〔0%(0/24)比29.4%(5/17),P<0.05〕。随时间延长,NIPPV组治疗2 h后S/F比值逐渐升高,RR逐渐下降;HFNC组S/F比值较基线有下降趋势,两组各时间点S/F比值比较差异均无统计学意义,而RR则较基线有上升趋势,治疗2 h NIPPV组RR明显高于HFNC组〔次/min:30(27-33)比24(21-27),P<0.05〕。NIPPV组与HFNC组需要插管率和病死率比较差异均无统计学意义〔66.7%(16/24)比70.6%(12/17),58.3%(14/24)比52.9%(9/17),均P>0.05〕。分析影响氧疗过程中S/F比值的因素显示:氧疗方式和入院时病程是影响患者S/F比值的因素〔β值分别为-15.827、1.202,95%可信区间(95%CI)分别为-29.102--2.552和0.247-2.15展开更多
In this essay, the authors discuss the neglected state of organizational-level turnover research in the Chinese context. They provide a brief overview of the importance of turnover research in the organizational scien...In this essay, the authors discuss the neglected state of organizational-level turnover research in the Chinese context. They provide a brief overview of the importance of turnover research in the organizational sciences, highlight the role of performance-related turnover rates research, and outline general theories and findings that appear in the Western and English-language literature. This evidence is compared with a dearth of studies using samples of Chinese organizations and in Chinese-language journals. They conclude by calling for additional theory and empirical studies on turnover rates.展开更多
文摘目的观察无创正压通气(NIPPV)和经鼻高流量氧疗(HFNC)对新型冠状病毒肺炎(新冠肺炎)并发急性呼吸窘迫综合征(ARDS)患者预后的影响。方法采用回顾性研究方法,选择2020年2月至4月作者援鄂期间在华中科技大学同济医学院附属同济医院收治的脉搏血氧饱和度/吸入氧浓度比值(SpO_(2)/FiO_(2),S/F)<235〔利用S/F比值代替氧合指数(PaO_(2)/FiO_(2))诊断ARDS〕的新冠肺炎患者。按氧疗模式不同将患者分为NIPPV组和HFNC组。收集患者的临床资料,包括:一般特征、呼吸频率(RR)、FiO_(2)、SpO_(2)、心率(HR)、平均动脉压(MAP),最初72 h S/F比值、入院/出院前/死亡前淋巴细胞计数(LYM)、淋巴细胞比例(LYM%)、白细胞计数(WBC)、通气前呼吸困难病程、发病至入院时间等,比较不同氧疗模式患者需要插管率、全因病死率、S/F比值和RR改善情况的差异。采用单因素分析和广义估计方程(GEE)方法分析影响S/F比值的危险因素。结果41例患者中男性比例较高(占68.3%,28例),中位年龄68(58-74)岁,28例有合并症(占68.3%),发生多器官功能障碍综合征(MODS)34例(占82.9%)。与HFNC组比较,NIPPV组合并症更多〔87.5%(21/24)比41.2%(7/17),P<0.05〕,LYM%更低〔5.3%(3.4%-7.8%)比10.0%(3.9%-19.7%),P<0.05〕,血液净化治疗率也更低〔0%(0/24)比29.4%(5/17),P<0.05〕。随时间延长,NIPPV组治疗2 h后S/F比值逐渐升高,RR逐渐下降;HFNC组S/F比值较基线有下降趋势,两组各时间点S/F比值比较差异均无统计学意义,而RR则较基线有上升趋势,治疗2 h NIPPV组RR明显高于HFNC组〔次/min:30(27-33)比24(21-27),P<0.05〕。NIPPV组与HFNC组需要插管率和病死率比较差异均无统计学意义〔66.7%(16/24)比70.6%(12/17),58.3%(14/24)比52.9%(9/17),均P>0.05〕。分析影响氧疗过程中S/F比值的因素显示:氧疗方式和入院时病程是影响患者S/F比值的因素〔β值分别为-15.827、1.202,95%可信区间(95%CI)分别为-29.102--2.552和0.247-2.15
文摘In this essay, the authors discuss the neglected state of organizational-level turnover research in the Chinese context. They provide a brief overview of the importance of turnover research in the organizational sciences, highlight the role of performance-related turnover rates research, and outline general theories and findings that appear in the Western and English-language literature. This evidence is compared with a dearth of studies using samples of Chinese organizations and in Chinese-language journals. They conclude by calling for additional theory and empirical studies on turnover rates.
