Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mo...Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mosquitoes through a blood meal and it is also spread through body fluids. ZIKV infection may present with symptoms like fever, myalgia, maculopapular rash as well as neurological sequelae, which include, microcephaly, epilepsy, and Guillain Barré syndrome (GBS). This put the virus on a scale of the public health burden of almost 87 countries. The potential threat of ZIKV infection is not completely eradicated in many countries in Africa, America, and the Western Pacific regions. There are no vaccines and treatments available to date. Since ZIKV causes microcephaly in utero by targeting neural progenitor cells, inducing apoptosis, and impairing neurodevelopment, this article hopes to evaluate the neurological disorders associated with the Zika virus infection while elucidating the current trends in the development of vaccines and drugs.展开更多
Two pure hydrocarbon molecules of l,3,5-tris(9-phenyl-9H-fluoren-9-yl)benzene(mTPFB)and l,3,5-tris(2-tert-butyl-9-phenyl-9H-fluoren-9-yl)benzene(tBu-mTPFB)were synthesized.Due to the conjugation blocked connection mod...Two pure hydrocarbon molecules of l,3,5-tris(9-phenyl-9H-fluoren-9-yl)benzene(mTPFB)and l,3,5-tris(2-tert-butyl-9-phenyl-9H-fluoren-9-yl)benzene(tBu-mTPFB)were synthesized.Due to the conjugation blocked connection mode and rigid/bulky substitutions,these two materials possess high triplet energy,enabling them as good hosts for blue phosphor in PhOLEDs.By studying their thermal,electrochemical,electronic absorption and photoluminescent properties,it was found that the influence of the inert tert-butyl group on material photoelectrical properties is negligible.For instance,mTPFB and tBu-mTPFB showed very similar absorption and emission profiles,with almost the same bandgap,triplet energy and energy levels.However,the encapsulation of tert-butyl on the 2-position of 9-phenylfluorene enhanced material thermal stability.Most importantly,carrier transport properties were improved dramatically,as proved by the mono carrier device.Blue phosphorescent OLEDs hosted by tBu-mTPFB showed external quantum efficiency of 15.2%and current efficiency of 23.0 cd/A,which were much higher than that of the OLEDs based on mTPFB with the analogous structure.展开更多
文摘Zika virus (ZIKV) is a flavivirus that can be identified as a small envelope with a positive-stranded RNA and an important medical pathogen, which causes deadly human diseases. The virus is carried by Aedes aegypti mosquitoes through a blood meal and it is also spread through body fluids. ZIKV infection may present with symptoms like fever, myalgia, maculopapular rash as well as neurological sequelae, which include, microcephaly, epilepsy, and Guillain Barré syndrome (GBS). This put the virus on a scale of the public health burden of almost 87 countries. The potential threat of ZIKV infection is not completely eradicated in many countries in Africa, America, and the Western Pacific regions. There are no vaccines and treatments available to date. Since ZIKV causes microcephaly in utero by targeting neural progenitor cells, inducing apoptosis, and impairing neurodevelopment, this article hopes to evaluate the neurological disorders associated with the Zika virus infection while elucidating the current trends in the development of vaccines and drugs.
基金supported by the National Natural Science Foundation of China(61474064,61504063)funding from Nanjing University of Posts and Telecommunications (NY214085,NY214177)+5 种基金the Natural Science Foundation of Jiangsu Province(BK20150836)the National Basic Research Program of China (2015CB932200)the National Synergistic Innovation Center for Advanced Materials(SICAM)Synergistic Innovation Center for Organic Electronics and Information DisplaysPriority Academic Program Development of Jiangsu Higher Education Institutions(PAPD,YX03001)funding from Key Laboratory for Organic Electronics & Information Displays
文摘Two pure hydrocarbon molecules of l,3,5-tris(9-phenyl-9H-fluoren-9-yl)benzene(mTPFB)and l,3,5-tris(2-tert-butyl-9-phenyl-9H-fluoren-9-yl)benzene(tBu-mTPFB)were synthesized.Due to the conjugation blocked connection mode and rigid/bulky substitutions,these two materials possess high triplet energy,enabling them as good hosts for blue phosphor in PhOLEDs.By studying their thermal,electrochemical,electronic absorption and photoluminescent properties,it was found that the influence of the inert tert-butyl group on material photoelectrical properties is negligible.For instance,mTPFB and tBu-mTPFB showed very similar absorption and emission profiles,with almost the same bandgap,triplet energy and energy levels.However,the encapsulation of tert-butyl on the 2-position of 9-phenylfluorene enhanced material thermal stability.Most importantly,carrier transport properties were improved dramatically,as proved by the mono carrier device.Blue phosphorescent OLEDs hosted by tBu-mTPFB showed external quantum efficiency of 15.2%and current efficiency of 23.0 cd/A,which were much higher than that of the OLEDs based on mTPFB with the analogous structure.
