BACKGROUND The coronavirus disease 2019(COVID-19)is spreading rapidly around the world.Most critically ill patients have organ injury,including acute respiratory distress syndrome,acute kidney injury,cardiac injury,or...BACKGROUND The coronavirus disease 2019(COVID-19)is spreading rapidly around the world.Most critically ill patients have organ injury,including acute respiratory distress syndrome,acute kidney injury,cardiac injury,or liver dysfunction.However,few studies on acute gastrointestinal injury(AGI)have been reported in critically ill patients with COVID-19.AIM To investigate the prevalence and outcomes of AGI in critically ill patients with COVID-19.METHODS In this retrospective study,demographic data,laboratory parameters,AGI grades,clinical severity and outcomes were collected.The primary endpoints were AGI incidence and 28-d mortality.RESULTS From February 10 to March 102020,83 critically ill patients out of 1314 patients with COVID-19 were enrolled.Seventy-two(86.7%)patients had AGI during hospital stay,of these patients,30 had AGI gradeⅠ,35 had AGI gradeⅡ,5 had AGI gradeⅢ,and 2 had AGI gradeⅣ.The incidence of AGI gradeⅡand above was 50.6%.Forty(48.2%)patients died within 28 days of admission.Multiple organ dysfunction syndrome developed in 58(69.9%)patients,and septic shock in 16(19.3%)patients.Patients with worse AGI grades had worse clinical variables,a higher incidence of septic shock and 28-d mortality.Sequential organ failure assessment(SOFA)scores(95%CI:1.374-2.860;P<0.001),white blood cell(WBC)counts(95%CI:1.037-1.379;P=0.014),and duration of mechanical ventilation(MV)(95%CI:1.020-1.340;P=0.025)were risk factors for the development of AGI gradeⅡand above.CONCLUSION The incidence of AGI was 86.7%,and hospital mortality was 48.2%in critically ill patients with COVID-19.SOFA scores,WBC counts,and duration of MV were risk factors for the development of AGI gradeⅡand above.Patients with worse AGI grades had a higher incidence of septic shock and 28-d mortality.展开更多
The tectonic environment of granitoids has always been a concern of the academic community.The Nb vs.Y and Rb vs.Nb+Y diagrams have had a substantial impact.The present work uses more than 110,000 granitoid samples(Si...The tectonic environment of granitoids has always been a concern of the academic community.The Nb vs.Y and Rb vs.Nb+Y diagrams have had a substantial impact.The present work uses more than 110,000 granitoid samples(SiO_(2)≥56%)from the globally shared database to discuss the validity and also explain why these diagrams used for discrimination between the different tectonic settings of granitoid rocks.The amount of data from the spreading center is sparse and the data are highly scattered and so,the present study focuses mainly on granites from the ocean islands and convergent margins tectonic environments.On the TAS diagram most of the ocean island data are alkaline series and trachybasalt series,and some are bimodal.In contrast,the granitoids on the convergent margin are mainly sub-alkaline.This work shows that the tectonic discrimination diagrams of granitoids remain valid,and only the boundaries need to be slightly adjusted.展开更多
基金National Natural Science Foundation of China,No.81701881Nanjing Medical Science and Technology Development Foundation,No.YKK17102.
文摘BACKGROUND The coronavirus disease 2019(COVID-19)is spreading rapidly around the world.Most critically ill patients have organ injury,including acute respiratory distress syndrome,acute kidney injury,cardiac injury,or liver dysfunction.However,few studies on acute gastrointestinal injury(AGI)have been reported in critically ill patients with COVID-19.AIM To investigate the prevalence and outcomes of AGI in critically ill patients with COVID-19.METHODS In this retrospective study,demographic data,laboratory parameters,AGI grades,clinical severity and outcomes were collected.The primary endpoints were AGI incidence and 28-d mortality.RESULTS From February 10 to March 102020,83 critically ill patients out of 1314 patients with COVID-19 were enrolled.Seventy-two(86.7%)patients had AGI during hospital stay,of these patients,30 had AGI gradeⅠ,35 had AGI gradeⅡ,5 had AGI gradeⅢ,and 2 had AGI gradeⅣ.The incidence of AGI gradeⅡand above was 50.6%.Forty(48.2%)patients died within 28 days of admission.Multiple organ dysfunction syndrome developed in 58(69.9%)patients,and septic shock in 16(19.3%)patients.Patients with worse AGI grades had worse clinical variables,a higher incidence of septic shock and 28-d mortality.Sequential organ failure assessment(SOFA)scores(95%CI:1.374-2.860;P<0.001),white blood cell(WBC)counts(95%CI:1.037-1.379;P=0.014),and duration of mechanical ventilation(MV)(95%CI:1.020-1.340;P=0.025)were risk factors for the development of AGI gradeⅡand above.CONCLUSION The incidence of AGI was 86.7%,and hospital mortality was 48.2%in critically ill patients with COVID-19.SOFA scores,WBC counts,and duration of MV were risk factors for the development of AGI gradeⅡand above.Patients with worse AGI grades had a higher incidence of septic shock and 28-d mortality.
文摘The tectonic environment of granitoids has always been a concern of the academic community.The Nb vs.Y and Rb vs.Nb+Y diagrams have had a substantial impact.The present work uses more than 110,000 granitoid samples(SiO_(2)≥56%)from the globally shared database to discuss the validity and also explain why these diagrams used for discrimination between the different tectonic settings of granitoid rocks.The amount of data from the spreading center is sparse and the data are highly scattered and so,the present study focuses mainly on granites from the ocean islands and convergent margins tectonic environments.On the TAS diagram most of the ocean island data are alkaline series and trachybasalt series,and some are bimodal.In contrast,the granitoids on the convergent margin are mainly sub-alkaline.This work shows that the tectonic discrimination diagrams of granitoids remain valid,and only the boundaries need to be slightly adjusted.
