AIM： To examine the effect of Eubacteriuro Iiroosuro （E.Iiroosuro） on colonic epithelial cell line in vitro, and to evaluate the effect of E.limosum on experimental colitis.METHODS： E.Iimosum was inoculated anaero...AIM： To examine the effect of Eubacteriuro Iiroosuro （E.Iiroosuro） on colonic epithelial cell line in vitro, and to evaluate the effect of E.limosum on experimental colitis.METHODS： E.Iimosum was inoculated anaerobically and its metabolites were obtained. The growth stimulatory effect of the E.limosum metabolites on T84 cells was evaluated by SUDH activity, and the anti-inflammatory effect by IL-6 production. The change in mRNA of toll like receptor 4 （TLR4） was evaluated by real time PCR. Colitis was induced by feeding BALB/C mice with 2.0% dextran sodium sulfate. These mice received either 5% lyophilized E.lirnosum （n=7） or control diet （n=7）. Seven days after colitis induction, clinical and histological scores, colon length, and cecal organic acid levels were determined.RESULTS： The E.Iimosum produced butyrate, acetate, propionate, and lactate at 0.25, 1.0, 0.025 and 0.07 retool/L, respectively in medium. At this concentration, each acid had no growth stimulating activity on T84 cells; however, when these acids were mixed together at the above levels, it showed significantly high activity than control. Except for lactate, these acids significantly attenuated IL-6 production at just 0.1 mmol/L. In addition, under TNF-α stimulation, butyrate attenuated the production of TLR4 mRNA. The treatment with E.limosum significantly attenuated clinical and histological scores of colitis with an increase of cecal butyrate levels, compared with the control group.CONCLUSION： E.limosum can ameliorate experimental colonic inflammation. In part, the metabolite of E.lirnosurn, butyrate, increases mucosal integrity and shows anti-inflammatory action modulation of mucosal defense system via TLR4.展开更多
Purpose:The purpose of this research is to provide evidence for decision-makers to realize the potentials of collaborations between countries/regions via the scientometric analysis of co-authoring in academic publicat...Purpose:The purpose of this research is to provide evidence for decision-makers to realize the potentials of collaborations between countries/regions via the scientometric analysis of co-authoring in academic publications.Design/methodology/approach:The approach is that Osaka University,which has set a strategy to become a global campus,is positioned to have a leading role to enhance such collaborations.This research measures co-authoring relations between Osaka University and other countries/regions to identify networks for fostering strong research collaborations.Findings:Five countries are identified as candidates for the future global campuses of Osaka University based on three factors,co-authoring relations,GDP growth,and population growth.Research limitations:The main limitation of this study is not being able to use the relations by the former positions of authors in Osaka University,because the data retrieved is limited by the query of the organization name at the first step.Practical implications:The significance of this work is to provide evidence for the university strategy to expand abroad based on the quantity and visualization of trends.Originality/value:With wider practical implementations,the approach of this research is useful in making a strategic roadmap for scientific organizations that intend to collaborate internationally.展开更多
Objective:Prostate cancer in elderly patients was formerly treated with androgen deprivation therapy.Since the latter of the 1990s new technologies were introduced into treatments,then strategies have varied.We aimed ...Objective:Prostate cancer in elderly patients was formerly treated with androgen deprivation therapy.Since the latter of the 1990s new technologies were introduced into treatments,then strategies have varied.We aimed to observe the outcomes of elderly patients treated during transition period and compare each stage with others.Methods:During 2008 and 2010,255 patients with prostate cancer older than 75 years were sequentially treated.With exception of patients with bone and/or visceral metastasis,outcomes of 199 patients with localized and locally advanced stages were examined.Complete records were obtained by the end of 2015.Results:In total,122(61%),28(14%),37(19%)and 12(6%)of patients were in stages T1c-T2a,T2b-c,T3 and T4,respectively.Patients generally presented with abnormal screening or lower urinary tract symptom.Seventy-one percent of patients received androgen deprivation therapy as monotherapy and 22% of the radiation-treated patients added androgen deprivation therapy.Patients in stage T1c-T2a and T2b-c showed a favorable prognosis.Some cancer death appeared in patients with T3 and T4 during observation periods.Twenty-seven percent of patients died from prostate cancer-independent complications:pneumonia,heart disease,and brain vascular disease.Tendency is similar to that of Japanese elderly male population.No remarkable side effects from androgen deprivation therapy were noticed.展开更多
Histogenesis of uterine leiomyosarcoma has been controversial. It is generally believed that uterine leiomyosarcomas arise de novo, rather than from any precursor lesions. We report an unusual case of spontaneous rupt...Histogenesis of uterine leiomyosarcoma has been controversial. It is generally believed that uterine leiomyosarcomas arise de novo, rather than from any precursor lesions. We report an unusual case of spontaneous rupture of leiomyosarcoma arising in pre-existing calcified uterine leiomyoma, which has been monitored over the years after menopause. This case also suggests that spontaneous intraperitoneal hemorrhage associated with malignant transformation of uterine leiomyoma, although rare, should be considered in postmenopausal women presenting with rapid growing uterine mass.展开更多
Given a simple graph G with n vertices and m edges, the spanning tree problem is to find a spanning tree for a given graph G. This problem has many applications, such as electric power systems, computer network design...Given a simple graph G with n vertices and m edges, the spanning tree problem is to find a spanning tree for a given graph G. This problem has many applications, such as electric power systems, computer network design and circuit analysis. For a simple graph, the spanning tree problem can be solved in O(log n) time with O(m+n) processors on the CRCW PRAM. In general, it is known that more efficient parallel algorithms can be developed by restricting classes of graphs. In this paper, we shall propose a parallel algorithm which runs O(log n) time with O(n/log n) processors on the EREW PRAM for constructing on proper circle trapezoid graphs.展开更多
Microduplications are normally invisible under microscopy and were not recognized before chromosomal microarray testing was available. Although it is difficult to confirm the orientation of duplicated segments by stan...Microduplications are normally invisible under microscopy and were not recognized before chromosomal microarray testing was available. Although it is difficult to confirm the orientation of duplicated segments by standard fluorescence in situ hybridization(FISH), our data indicates that fiber-FISH analysis has the potential to reveal the orientation of duplicated and triplicated segments of chromosomes. Recurrent microduplications reciprocal to microdeletions show tandem orientations of the duplicated segments, which is consistent with a non-allelic homologous recombination mechanism. Several random duplications showed tandem configurations and inverted duplications are rare. Further analysis is required to fully elucidate the basic mechanisms underlying such duplications/triplications.展开更多
As one of the UAIDs(unconventional alternative intersection designs),DLTs(displaced left-turn crossovers)have been presented to mitigate traffic congestion.Although,qualitatively and quantitatively isolated UAIDs outp...As one of the UAIDs(unconventional alternative intersection designs),DLTs(displaced left-turn crossovers)have been presented to mitigate traffic congestion.Although,qualitatively and quantitatively isolated UAIDs outperform their conventional counterparts,there is no simplified procedure to consider the DLTs coordination.Hence,this research investigates the coordination of consecutive DLTs under heterogeneous traffic conditions.To achieve the optimal coordination and provide an efficient coordination control,a bandwidth maximization progression approach was used.Seeking the optimal offset for each pair of consecutive intersections to guarantee the green bandwidth waves along the coordinated corridor,a mixed-integer linear program was adopted.The optimization problem was formulated and solved based on the standard branch-and-bound technique.As a real-world study case,data of three typical intersections located in an arterial corridor in Cairo,Egypt was used.PTV-VISSIM as a microsimulation platform was employed to simulate and evaluate the different signal timing plans.However,to represent the heterogeneous traffic characteristics as close as possible to the reality,different simulation parameters were tuned and validated carefully.The results emphasized the undoubted improvement of coordinated DLTs by different operational performance indices.The total travel time,average delay,the number of stops per vehicle were obviously improved.展开更多
文摘AIM： To examine the effect of Eubacteriuro Iiroosuro （E.Iiroosuro） on colonic epithelial cell line in vitro, and to evaluate the effect of E.limosum on experimental colitis.METHODS： E.Iimosum was inoculated anaerobically and its metabolites were obtained. The growth stimulatory effect of the E.limosum metabolites on T84 cells was evaluated by SUDH activity, and the anti-inflammatory effect by IL-6 production. The change in mRNA of toll like receptor 4 （TLR4） was evaluated by real time PCR. Colitis was induced by feeding BALB/C mice with 2.0% dextran sodium sulfate. These mice received either 5% lyophilized E.lirnosum （n=7） or control diet （n=7）. Seven days after colitis induction, clinical and histological scores, colon length, and cecal organic acid levels were determined.RESULTS： The E.Iimosum produced butyrate, acetate, propionate, and lactate at 0.25, 1.0, 0.025 and 0.07 retool/L, respectively in medium. At this concentration, each acid had no growth stimulating activity on T84 cells; however, when these acids were mixed together at the above levels, it showed significantly high activity than control. Except for lactate, these acids significantly attenuated IL-6 production at just 0.1 mmol/L. In addition, under TNF-α stimulation, butyrate attenuated the production of TLR4 mRNA. The treatment with E.limosum significantly attenuated clinical and histological scores of colitis with an increase of cecal butyrate levels, compared with the control group.CONCLUSION： E.limosum can ameliorate experimental colonic inflammation. In part, the metabolite of E.lirnosurn, butyrate, increases mucosal integrity and shows anti-inflammatory action modulation of mucosal defense system via TLR4.
文摘Purpose:The purpose of this research is to provide evidence for decision-makers to realize the potentials of collaborations between countries/regions via the scientometric analysis of co-authoring in academic publications.Design/methodology/approach:The approach is that Osaka University,which has set a strategy to become a global campus,is positioned to have a leading role to enhance such collaborations.This research measures co-authoring relations between Osaka University and other countries/regions to identify networks for fostering strong research collaborations.Findings:Five countries are identified as candidates for the future global campuses of Osaka University based on three factors,co-authoring relations,GDP growth,and population growth.Research limitations:The main limitation of this study is not being able to use the relations by the former positions of authors in Osaka University,because the data retrieved is limited by the query of the organization name at the first step.Practical implications:The significance of this work is to provide evidence for the university strategy to expand abroad based on the quantity and visualization of trends.Originality/value:With wider practical implementations,the approach of this research is useful in making a strategic roadmap for scientific organizations that intend to collaborate internationally.
文摘Objective:Prostate cancer in elderly patients was formerly treated with androgen deprivation therapy.Since the latter of the 1990s new technologies were introduced into treatments,then strategies have varied.We aimed to observe the outcomes of elderly patients treated during transition period and compare each stage with others.Methods:During 2008 and 2010,255 patients with prostate cancer older than 75 years were sequentially treated.With exception of patients with bone and/or visceral metastasis,outcomes of 199 patients with localized and locally advanced stages were examined.Complete records were obtained by the end of 2015.Results:In total,122(61%),28(14%),37(19%)and 12(6%)of patients were in stages T1c-T2a,T2b-c,T3 and T4,respectively.Patients generally presented with abnormal screening or lower urinary tract symptom.Seventy-one percent of patients received androgen deprivation therapy as monotherapy and 22% of the radiation-treated patients added androgen deprivation therapy.Patients in stage T1c-T2a and T2b-c showed a favorable prognosis.Some cancer death appeared in patients with T3 and T4 during observation periods.Twenty-seven percent of patients died from prostate cancer-independent complications:pneumonia,heart disease,and brain vascular disease.Tendency is similar to that of Japanese elderly male population.No remarkable side effects from androgen deprivation therapy were noticed.
文摘Histogenesis of uterine leiomyosarcoma has been controversial. It is generally believed that uterine leiomyosarcomas arise de novo, rather than from any precursor lesions. We report an unusual case of spontaneous rupture of leiomyosarcoma arising in pre-existing calcified uterine leiomyoma, which has been monitored over the years after menopause. This case also suggests that spontaneous intraperitoneal hemorrhage associated with malignant transformation of uterine leiomyoma, although rare, should be considered in postmenopausal women presenting with rapid growing uterine mass.
文摘Given a simple graph G with n vertices and m edges, the spanning tree problem is to find a spanning tree for a given graph G. This problem has many applications, such as electric power systems, computer network design and circuit analysis. For a simple graph, the spanning tree problem can be solved in O(log n) time with O(m+n) processors on the CRCW PRAM. In general, it is known that more efficient parallel algorithms can be developed by restricting classes of graphs. In this paper, we shall propose a parallel algorithm which runs O(log n) time with O(n/log n) processors on the EREW PRAM for constructing on proper circle trapezoid graphs.
文摘Microduplications are normally invisible under microscopy and were not recognized before chromosomal microarray testing was available. Although it is difficult to confirm the orientation of duplicated segments by standard fluorescence in situ hybridization(FISH), our data indicates that fiber-FISH analysis has the potential to reveal the orientation of duplicated and triplicated segments of chromosomes. Recurrent microduplications reciprocal to microdeletions show tandem orientations of the duplicated segments, which is consistent with a non-allelic homologous recombination mechanism. Several random duplications showed tandem configurations and inverted duplications are rare. Further analysis is required to fully elucidate the basic mechanisms underlying such duplications/triplications.
文摘As one of the UAIDs(unconventional alternative intersection designs),DLTs(displaced left-turn crossovers)have been presented to mitigate traffic congestion.Although,qualitatively and quantitatively isolated UAIDs outperform their conventional counterparts,there is no simplified procedure to consider the DLTs coordination.Hence,this research investigates the coordination of consecutive DLTs under heterogeneous traffic conditions.To achieve the optimal coordination and provide an efficient coordination control,a bandwidth maximization progression approach was used.Seeking the optimal offset for each pair of consecutive intersections to guarantee the green bandwidth waves along the coordinated corridor,a mixed-integer linear program was adopted.The optimization problem was formulated and solved based on the standard branch-and-bound technique.As a real-world study case,data of three typical intersections located in an arterial corridor in Cairo,Egypt was used.PTV-VISSIM as a microsimulation platform was employed to simulate and evaluate the different signal timing plans.However,to represent the heterogeneous traffic characteristics as close as possible to the reality,different simulation parameters were tuned and validated carefully.The results emphasized the undoubted improvement of coordinated DLTs by different operational performance indices.The total travel time,average delay,the number of stops per vehicle were obviously improved.
