目的探讨中医加速康复外科(CMERAS)理念在腹腔镜胆囊切除术(LC)围手术期中的应用。方法本试验系前瞻性研究,为系列CMERAS研究的一部分。收入2017年3月至2018年9月上海中医药大学附属曙光医院收治的胆囊息肉、胆囊结石或慢性胆囊炎患者,...目的探讨中医加速康复外科(CMERAS)理念在腹腔镜胆囊切除术(LC)围手术期中的应用。方法本试验系前瞻性研究,为系列CMERAS研究的一部分。收入2017年3月至2018年9月上海中医药大学附属曙光医院收治的胆囊息肉、胆囊结石或慢性胆囊炎患者,均接受LC,随机分为试验组和对照组两组,每组30例。试验组围手术期给予口服中药胃肠汤治疗,且试验组及对照组均按加速康复外科理念进行围手术期准备。观察术后患者胃肠道功能恢复、术后并发症、术后住院时间等情况。结果试验组LC术后排气时间[(12.5±2.2)h vs (16.1±3.4)h]、排便时间[(24.9±4.2)h vs (38.5±8.3)h]、进食时间为[(8.6±1.5)h vs(12.5±1.3)h]均显著短于对照组(P<0.05);试验组LC术后第1天胃泌素水平[(69.56±11.23)μg/mL vs (48.11±6.22)μg/mL]、胃动素水平[(198.27±36.04)μg/mL vs (124.98±20.46)μg/mL]均明显高于对照组(P<0.05);试验组术后首次下床活动时间[(4.1±1.3)h vs (7.9±1.7)h]、术后住院时间[(1.6±1.2)d vs (2.5±1.5)d]均短于对照组(P<0.05)。结论中医加速康复理念应用于LC围手术期,能加快患者胃肠道功能恢复,减少术后并发症的发生,加速患者术后康复。展开更多
目的探讨中西医结合快速康复外科(Chinese medicine enhanced recovery around surgery,CMERAS)理念在腹腔镜直肠前切除术围手术期中的应用价值。方法将符合入选标准的2017年7月-2019年7月上海中医药大学附属曙光医院普外科行腹腔镜直...目的探讨中西医结合快速康复外科(Chinese medicine enhanced recovery around surgery,CMERAS)理念在腹腔镜直肠前切除术围手术期中的应用价值。方法将符合入选标准的2017年7月-2019年7月上海中医药大学附属曙光医院普外科行腹腔镜直肠前切除术的直肠癌患者100例,采用随机数字表法分为2组,每组50例。对照组采用加速康复外科(enhanced recovery after surgery,ERAS)理念的围手术期处理方案,观察组采用CMERAS理念的围术期处理方案。2组均治疗7 d。观察2组患者手术过程中肠道清洁度及术后康复质量,包括首次排气时间、术后住院时间和并发症发生率;采用免疫比浊法检测血清CRP水平,采用化学发光免疫分析法检测血清IL-6水平,采用流式细胞仪检测患者外周血CD4、CD8和CD4/CD8,记录不良反应。结果2组手术过程中肠道清洁度比较,差异无统计学意义(Z=-1.140,P=0.254)。观察组术后首次排气时间[(29.7±4.6)h比(36.1±3.8)h,t=7.590]早于对照组,术后住院时间[(4.2±0.5)d比(4.7±0.6)d,t=4.379]少于对照组,并发症发生率[8.0%(4/50)比30.0%(15/50),χ^(2)=6.498]低于对照组(P<0.01)。术后第3天,观察组血清CRP[(11.84±4.69)mg/L比(23.63±5.04)mg/L,t=12.106]、IL-6[(34.31±5.93)ng/L比(44.39±8.81)ng/L,t=6.714]水平低于对照组(P<0.05);CD4水平[(37.74±7.28)%比(33.55±5.07)%,t=-3.344]、CD4/CD8比值[(1.36±0.27)比(1.13±0.22),t=-4.920]高于对照组(P<0.01),CD8水平[(28.04±4.68)%比(30.22±4.04)%,t=2.487]低于对照组(P<0.05)。2组患者治疗过程中均未发生不良反应。结论CMERAS理念可促进腹腔镜直肠前切除患者围手术期恢复,且安全性较好。展开更多
Guo-Qiang XuFor a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regul...Guo-Qiang XuFor a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, in-ducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 （RIPK1）, RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis ofinfammatory bowel disease （IBD） and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD.展开更多
文摘目的探讨中医加速康复外科(CMERAS)理念在腹腔镜胆囊切除术(LC)围手术期中的应用。方法本试验系前瞻性研究,为系列CMERAS研究的一部分。收入2017年3月至2018年9月上海中医药大学附属曙光医院收治的胆囊息肉、胆囊结石或慢性胆囊炎患者,均接受LC,随机分为试验组和对照组两组,每组30例。试验组围手术期给予口服中药胃肠汤治疗,且试验组及对照组均按加速康复外科理念进行围手术期准备。观察术后患者胃肠道功能恢复、术后并发症、术后住院时间等情况。结果试验组LC术后排气时间[(12.5±2.2)h vs (16.1±3.4)h]、排便时间[(24.9±4.2)h vs (38.5±8.3)h]、进食时间为[(8.6±1.5)h vs(12.5±1.3)h]均显著短于对照组(P<0.05);试验组LC术后第1天胃泌素水平[(69.56±11.23)μg/mL vs (48.11±6.22)μg/mL]、胃动素水平[(198.27±36.04)μg/mL vs (124.98±20.46)μg/mL]均明显高于对照组(P<0.05);试验组术后首次下床活动时间[(4.1±1.3)h vs (7.9±1.7)h]、术后住院时间[(1.6±1.2)d vs (2.5±1.5)d]均短于对照组(P<0.05)。结论中医加速康复理念应用于LC围手术期,能加快患者胃肠道功能恢复,减少术后并发症的发生,加速患者术后康复。
文摘目的探讨中西医结合快速康复外科(Chinese medicine enhanced recovery around surgery,CMERAS)理念在腹腔镜直肠前切除术围手术期中的应用价值。方法将符合入选标准的2017年7月-2019年7月上海中医药大学附属曙光医院普外科行腹腔镜直肠前切除术的直肠癌患者100例,采用随机数字表法分为2组,每组50例。对照组采用加速康复外科(enhanced recovery after surgery,ERAS)理念的围手术期处理方案,观察组采用CMERAS理念的围术期处理方案。2组均治疗7 d。观察2组患者手术过程中肠道清洁度及术后康复质量,包括首次排气时间、术后住院时间和并发症发生率;采用免疫比浊法检测血清CRP水平,采用化学发光免疫分析法检测血清IL-6水平,采用流式细胞仪检测患者外周血CD4、CD8和CD4/CD8,记录不良反应。结果2组手术过程中肠道清洁度比较,差异无统计学意义(Z=-1.140,P=0.254)。观察组术后首次排气时间[(29.7±4.6)h比(36.1±3.8)h,t=7.590]早于对照组,术后住院时间[(4.2±0.5)d比(4.7±0.6)d,t=4.379]少于对照组,并发症发生率[8.0%(4/50)比30.0%(15/50),χ^(2)=6.498]低于对照组(P<0.01)。术后第3天,观察组血清CRP[(11.84±4.69)mg/L比(23.63±5.04)mg/L,t=12.106]、IL-6[(34.31±5.93)ng/L比(44.39±8.81)ng/L,t=6.714]水平低于对照组(P<0.05);CD4水平[(37.74±7.28)%比(33.55±5.07)%,t=-3.344]、CD4/CD8比值[(1.36±0.27)比(1.13±0.22),t=-4.920]高于对照组(P<0.01),CD8水平[(28.04±4.68)%比(30.22±4.04)%,t=2.487]低于对照组(P<0.05)。2组患者治疗过程中均未发生不良反应。结论CMERAS理念可促进腹腔镜直肠前切除患者围手术期恢复,且安全性较好。
基金Supported by Medical Science Research Foundation of Health Bureau of Zhejiang Province,No.WKJ-ZJ-1516
文摘Guo-Qiang XuFor a long time, it was believed that apoptosis and necrosis were the main pathways for cell death, but a growing body of research has shown that there are other pathways. Among these, necroptosis, a regulatory caspase-independent, programmed cell death pathway, is supposed to be of importance in the pathogenesis of many diseases. The mechanism of regulating, in-ducing and blocking necroptosis is a complex process that involves expression and regulation of a series of molecules including receptor interacting protein kinase 1 （RIPK1）, RIPK3, and mixed lineage kinase like protein. By blocking or downregulating expression of key molecules in the necroptotic pathway, intestinal inflammation can be affected to some extent. In this paper, we introduce the concept of necroptosis, its main pathway, and its impact on the pathogenesis ofinfammatory bowel disease （IBD） and other intestinal diseases, to explore new drug targets for intestinal diseases, including IBD.
