In an environment,the food chains are balanced by the prey-predator interactions.When a predator species is provided with more than one prey population,it avails the option of prey switching between prey species accor...In an environment,the food chains are balanced by the prey-predator interactions.When a predator species is provided with more than one prey population,it avails the option of prey switching between prey species according to their availability.So,prey switching of predators mainly helps to increase the overall growth rate of a predator species.In this work,we have proposed a two prey-one predator system where the predator population adopts switching behavior between two prey species at the time of consumption.Both the prey population exhibit a strong Allee effect and the predator population is considered to be a generalist one.The proposed system is biologically well-defined as the system variables are positive and do not increase abruptly with time.The local stability analysis reveals that all the predator-free equilibria are saddle points whereas the prey-free equilibrium is always stable.The intrinsic growth rates of prey,the strong Allee parameters,and the prey refuge parameters are chosen to be the controlling parameters here.The numerical simulation reveals that in absence of one prey,the other prey refuge parameter can change the system dynamics by forming a stable or unstable limit cycle.Moreover,a situation of bi-stability,tri-stability,or even multi-stability of equilibrium points occurs in this system.As in presence of the switching effect,the predator chooses prey according to their abundance,so,increasing refuge in one prey population decreases the count of the second prey population.It is also observed that the count of predator population reaches a comparatively higher value even if they get one prey population at its fullest quantity and only a portion of other prey species.So,in the scarcity of one prey species,switching to the other prey is beneficial for the growth of the predator population.展开更多
Inpatient falls from beds in hospitals are a common problem.Such falls may result in severe injuries.This problem can be addressed by continuous monitoring of patients using cameras.Recent advancements in deep learnin...Inpatient falls from beds in hospitals are a common problem.Such falls may result in severe injuries.This problem can be addressed by continuous monitoring of patients using cameras.Recent advancements in deep learning-based video analytics have made this task of fall detection more effective and efficient.Along with fall detection,monitoring of different activities of the patients is also of significant concern to assess the improvement in their health.High computation-intensive models are required to monitor every action of the patient precisely.This requirement limits the applicability of such networks.Hence,to keep the model lightweight,the already designed fall detection networks can be extended to monitor the general activities of the patients along with the fall detection.Motivated by the same notion,we propose a novel,lightweight,and efficient patient activity monitoring system that broadly classifies the patients’activities into fall,activity,and rest classes based on their poses.The whole network comprises three sub-networks,namely a Convolutional Neural Networks(CNN)based video compression network,a Lightweight Pose Network(LPN)and a Residual Network(ResNet)Mixer block-based activity recognition network.The compression network compresses the video streams using deep learning networks for efficient storage and retrieval;after that,LPN estimates human poses.Finally,the activity recognition network classifies the patients’activities based on their poses.The proposed system shows an overall accuracy of approx.99.7% over a standard dataset with 99.63% fall detection accuracy and efficiently monitors different events,which may help monitor the falls and improve the inpatients’health.展开更多
The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray spectroscopy.Neutrons in the energy range of 1.7 to 2.7 MeV were generated using the...The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray spectroscopy.Neutrons in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)reaction.The neutron flux was measured using the standard 115In(n,n’)115mIn monitor reaction.The results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and CENDL-3.2.Theoretical calculations were performed using the nuclear reaction code TALYS.Various nuclear level density(NLD)models were tested,and their results were compared with the present findings.Realistic NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance technique.Corrections forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were performed.The experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.展开更多
Foods wherein the starch is slowly digested contribute to good health by reducing the tendency to,and for the maintenance of,diabetes,obesity and colo-rectal cancers.While foods with high amylose content have this des...Foods wherein the starch is slowly digested contribute to good health by reducing the tendency to,and for the maintenance of,diabetes,obesity and colo-rectal cancers.While foods with high amylose content have this desirable property,they usually do not have high sensory appeal and consumers are reluctant to eat them.While sensory evaluation by trained human panelists is the best way to obtain consumer preferences,these tests are expensive,time-consuming and require considerable effort and care.Instrumental measurements are easier,cheaper and invaluable for screening,but only useful if they correlate with human data for the type of food being considered.Here,we test this using cooked rice with a wide range of amylose contents.Functional properties were correlated against quantitative descriptive panelist analysis.Swelling power and breakdown viscosity correlated with all panelist sensory attributes,but no other correlations with gelatinization properties were observed.There was a strong correlation between hardness and stickiness measured by texture profile analysis(TPA)and by panelists,suggesting that TPA can be used to measure hardness and stickiness of cooked rice.We also showed that breakdown viscosity is a reliable instrumental means to provide indicative measurements of hardness and rice preference,and swelling power is a predictor of rice stickiness.展开更多
Tourism in mountainous regions is a significant source of revenue generation. However, it has also been associated with many adverse environmental consequences. This study aims at assessing the negative impacts of the...Tourism in mountainous regions is a significant source of revenue generation. However, it has also been associated with many adverse environmental consequences. This study aims at assessing the negative impacts of the incessant upsurge in tourism development on the physical environment of Mussoorie, a well-known mountain tourist destination in India. The impact indicators for the region were identified and assessed by qualitative and quantitative analysis of field observations. The observations indicated the aggravation of traffic congestion, atmospheric pollution, undisposed solid waste, water scarcity and infrastructure unavailability as the prevalent issues, especially during the peak tourist months. The extent of the consequential damage to the environment was evaluated by conducting an assessment of tourism-induced human disturbance on the natural landscape of the town. Slope, slope aspect, vegetation cover, road network and drainage network were incorporated as thedetermining landscape attributes to prepare thematic maps of landscape quality(perceivable intrinsic properties) and landscape fragility(vulnerability to anthropogenic disturbances) using GIS technique. An absorption capacity map was finally prepared to characterize the study area into regions of different conservation needs. The results identified the need for planning appropriate preservation strategies for different tourist places in the town. The study can be used by the policy makers for implementing the regulatory measures against potential disturbances due to mass-tourism.展开更多
Biomaterial research has been going on for several years,and many companies are heavily investing in new product development.However,it is a contentious field of science.Biomaterial science is a field that combines ma...Biomaterial research has been going on for several years,and many companies are heavily investing in new product development.However,it is a contentious field of science.Biomaterial science is a field that combines materials science and medicine.The replacement or restoration of damaged tissues or organs enhances the patient’s quality of life.The deciding aspect is whether or not the body will accept a biomaterial.A biomaterial used for an implant must possess certain qualities to survive a long time.When a biomaterial is used for an implant,it must have specific properties to be long-lasting.A variety of materials are used in biomedical applications.They are widely used today and can be used individually or in combination.This review will aid researchers in the selection and assessment of biomaterials.Before using a biomaterial,its mechanical and physical properties should be considered.Recent biomaterials have a structure that closely resembles that of tissue.Antiinfective biomaterials and surfaces are being developed using advanced antifouling,bactericidal,and antibiofilm technologies.This review tries to cover critical features of biomaterials needed for tissue engineering,such as bioactivity,self-assembly,structural hierarchy,applications,heart valves,skin repair,bio-design,essential ideas in biomaterials,bioactive biomaterials,bioresorbable biomaterials,biomaterials in medical practice,biomedical function for design,biomaterial properties such as biocompatibility,heat response,non-toxicity,mechanical properties,physical properties,wear,and corrosion,as well as biomaterial properties such surfaces that are antibacterial,nanostructured materials,and biofilm disrupting compounds,are all being investigated.It is technically possible to stop the spread of implant infection.展开更多
To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel r...To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been developed.For optimal performance,they require the fragment ion spectra of targeted peptides as prior knowledge.In this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples.To build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker.We then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer samples.This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)patients.Thereafter,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated.As a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control subjects.Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM.These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery.DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000.展开更多
The huge atomic heterogeneity of high-entropy materials along with a possibility to unravel the behavior of individual components at the atomic scale suggests a great promise in designing new compositionally complex s...The huge atomic heterogeneity of high-entropy materials along with a possibility to unravel the behavior of individual components at the atomic scale suggests a great promise in designing new compositionally complex systems with the desired multifunctionality.Herein,we apply multi-edge X-ray absorption spectroscopy(extended X-ray absorption fine structure(EXAFS),Xray absorption near edge structure(XANES),and X-ray magnetic circular dichroism(XMCD))to probe the structural,electronic,and magnetic properties of all individual constituents in the single-phase face-centered cubic(fcc)-structured nanocrystalline thin film of Cr_(20)Mn_(26)Fe_(18)Co_(19)Ni_(17)(at.%)high-entropy alloy on the local scale.The local crystallographic ordering and componentdependent lattice displacements were explored within the reverse Monte Carlo approach applied to EXAFS spectra collected at the K absorption edges of several constituents at room temperature.A homogeneous short-range fcc atomic environment around the absorbers of each type with very similar statistically averaged interatomic distances(2.54-2.55Å)to their nearest-neighbors and enlarged structural relaxations of Cr atoms were revealed.XANES and XMCD spectra collected at the L2,3 absorption edges of all principal components at low temperature from the oxidized and in situ cleaned surfaces were used to probe the oxidation states,the changes in the electronic structure,and magnetic behavior of all constituents at the surface and in the sub-surface volume of the film.The spin and orbital magnetic moments of Fe,Co,and Ni components were quantitatively evaluated.The presence of magnetic phase transitions and the co-existence of different magnetic phases were uncovered by conventional magnetometry in a broad temperature range.展开更多
In recent years,there has been continuous improvement in the treatment and diagnosis of cancer,which has led to a significant improvement in the survival rate of cancer patients.Treatments that include chemotherapy,ra...In recent years,there has been continuous improvement in the treatment and diagnosis of cancer,which has led to a significant improvement in the survival rate of cancer patients.Treatments that include chemotherapy,radiotherapy,surgery,or combined therapy have several side effects that may lead to premature ovarian insufficiency in females or substantial male germ cell loss.Reproductive biologists recommend that all patients who are diagnosed with a malignant tumor must undergo a consultation for fertility protection and preservation.In this review,we discuss the background knowledge,methods,and options for fertility preservation and how these new strategies help oncologists,surgeons,pediatricians,and hematologists,conserve fertility and be aware of the concepts,methods,and importance of fertility guards.This review may aid in the advancement of novel personalized methods for fertility preservation according to patients’conditions.展开更多
Landslides in the Himalayan region are primarily controlled by natural parameters,including rainfall,seismic activity,and anthropogenic parameters,such as the construction of large-scale projects like road development...Landslides in the Himalayan region are primarily controlled by natural parameters,including rainfall,seismic activity,and anthropogenic parameters,such as the construction of large-scale projects like road development,tunneling and hydroelectric power projects and climate change.The parameters which are more crucial among these are a matter of scientific study and analysis.This research,taking Solan district,Himachal Pradesh,India,as the study area,aims to assess the impact of anthropogenic activities on landslide susceptibility at a regional scale.Landslide distribution was characterized into two groups,namely Rainfall-Induced Landslide(RIL)and Human-Induced Landslide(HIL)based on triggering factors.Multiple data such as slope angle,aspect,profile curvature,distance to drainage,distance to lineament,lithology,distance to road,normalized difference vegetation index(NDVI)and land use land cover(LULC)have been considered for delineating the landslide susceptibility zonation(LSZ)map.The effect of anthropogenic activities on landslide occurrences has been examined through the distribution of landslides along national highways and land use land cover changes(LULCC).Two sets of LSZ maps with a LULC of time interval covering five years(2017&2021)were prepared to compare the temporal progression of LULC and landslide susceptibility during the five years.The results indicated the significant impact of anthropogenic activities on the landslide susceptibility.LSZ map of the year 2021 shows that 23%area falls into high and very high susceptible classes and 48%area falls into very low and low susceptibility classes.Compared to LSZ map of 2017,high and very high susceptible classes have been increased by 15%,whereas very low and low susceptible classes have been reduced by 7%.The present case study will help to understand the potential driving parameters responsible for HIL and also suggest the inclusion of LULC in landslide susceptibility analysis.The study will demonstrate new opportunities for research that could help decis展开更多
Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment options.Besides genetic mutations,epigenetic dysregulatio...Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment options.Besides genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target.Mechanisms beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under trails.Combinations of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa patients.Recent studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic therapies.Epigenetics thus promises to generate a significant amount of new knowledge of biological and medical importance.Our review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to breakthroughs.We aim to highlight the possibilities that exist and the potential therapeutic interventions.展开更多
In order to search the degradability of kraft lignin, the potential bacterial strains Bacillus subtilis（GU193980） and Klebsiella pneumoniae（GU193981） were isolated, screened and applied in axenic and co-culture co...In order to search the degradability of kraft lignin, the potential bacterial strains Bacillus subtilis（GU193980） and Klebsiella pneumoniae（GU193981） were isolated, screened and applied in axenic and co-culture conditions. Results revealed that mixed culture showed better decolorization efficiency（80%） and reduction of pollution parameters（COD 73% and BOD62%） than axenic culture. This indicated syntrophic growth of these two bacteria rather than any antagonistic effect. The HPLC analysis of degraded samples of kraft lignin has shown the reduction in peak area compared to control, suggesting that decrease in color intensity might be largely attributed to the degradation of lignin by isolated bacteria.Further, the GC-MS analysis showed that most of the compounds detected in control were diminished after bacterial treatment. Further, the seed germination test using Phaseolus aureus has supported the detoxification of bacterial decolorized kraft lignin for environmental safety. All these observations have revealed that the developed bacterial co-culture was capable for the effective degradation and decolorization of lignin containing rayon grade pulp mill wastewater for environmental safety.展开更多
Five novel europium(Ⅲ)complexes with 2-[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid(DAHB)as primary ligand and bathophenanthroline(batho),2,2’-bipyridyl(bipy),5,6-dimethyl-1,10-phenanthroline(dmph),1,10-phenanthr...Five novel europium(Ⅲ)complexes with 2-[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid(DAHB)as primary ligand and bathophenanthroline(batho),2,2’-bipyridyl(bipy),5,6-dimethyl-1,10-phenanthroline(dmph),1,10-phenanthroline(phen)as ancillary ligands were syn-thesized via solution precipitation method.The structural formulae of synthesized complexes were speculated to be Eu(DABH)_(3)·2H_(2)O(C1),Eu(DABH)_(3)·batho(C2),Eu(DABH)_(3)·bipy(C3),Eu(DABH)_(3)·dmph(C4)and Eu(DABH)_(3)·phen(C5)by elemental analysis,infrared spectroscopy and proton nuclear magnetic resonance spec-troscopy(^(1)H-NMR).The photoluminescent properties and thermal stability of the complexes were investigated by photoluminescent spectroscopy and thermogravimetric analysis(TG-DTG),respectively.The Commission Inter-nationale de I’Eclairage(CIE)color coordinates,Judd–Ofelt intensity parameter(Ω_(2)),total quantum yield,intrinsic quantum efficiency and energy transfer dynamics of com-plexes were also explored.The excitation spectra of com-plexes are extended up to visible region.These complexes exhibit characteristic photoemission of Eu^(3+)metal ion with high color purity in red region attributed to efficient energy transfer from ligand to metal ion.The replacement of water molecules from coordination sphere of europium ion by ancillary ligands results in enhancement of luminescent properties of the C2–C5 complexes,indicating that ancillary ligands act as additional light harvesting centers in sensiti-zation phenomenon.The thermal studies show that these complexes are suitable for meeting the requirement of temperature for fabrication of OLEDs devices.展开更多
This study reports on the measurements of ion and refractory black carbon(rBC)concentrations in a shallow(10.96 m)ice core sample which was drilled from the field site of the East Greenland Ice Core Project(EGRIP)in J...This study reports on the measurements of ion and refractory black carbon(rBC)concentrations in a shallow(10.96 m)ice core sample which was drilled from the field site of the East Greenland Ice Core Project(EGRIP)in July,2016.The results provide a recent record of rBC deposition in the East Greenland ice sheet from 1990 to 2016.The annual variability in oxygen(δ^(18)O)and hydrogen(δD)isotopic compositions indicated that notably warm events occurred since 2008.Peaks in rBC occurred during summer seasons,which may be attributed to the burning of biomass in boreal summer.The rBC record and analysis of historical air trajectories using the HYSPLIT model indicated that anthropogenic BC emissions from Russia,North America and Europe contributed to the majority of rBC deposition in the Greenland region,and a reduction in anthropogenic BC consumption in these areas played a dominant role in the decrease in BC concentrations since 2000.This record also suggests that the emissions from the East Asian region(China)contributed very little to the recorded BC concentrations in East Greenland ice core.The model results indicated that radiative forcing due to BC had decreased significantly since 1990,and had remained below 0.02W m^(-2) since 2000.展开更多
Development of modified plastics has been studied through the LDPE-acylated starch blend films to examine the effect of different acyl groups and degrees of substitution （DS） on properties of films. Corn starch was ...Development of modified plastics has been studied through the LDPE-acylated starch blend films to examine the effect of different acyl groups and degrees of substitution （DS） on properties of films. Corn starch was modified with acetyl and hutyryl groups and films were prepared by blending acylated starch with low density polyethylene （LDPE）. Systematic studies were done to observe the effect of acyl groups, DS and starch concentration on the properties and biodegradability of the blend films. It was observed that blend films containing 5% acetylated and butyrylated starches of high DS （2.5, 1.7） maintained 75% and 83% of tensile strength of LDPE films. Thermal analysis results indicated that acetylated and butyrylated starch blend films decomposed at 370℃ and 389℃ which were higher than the decomposition temperature of native starch film （349℃）. Scanning electron micrographs of blend films containing high DS acylated starch showed well dispersed starch particles due to improvement in dispersion between starch and LDPE. Water absorption capacity of high DS acetylated and butyrylated starch blend films （4.18% and 3.76%, respectively） was lower than that of native starch films （5%）. This study has an advantage because of blown films prepared can be integrated with the present manufacturing systems without any other requirement.展开更多
Prostate cancer(PCa)progression relies on androgen receptor(AR)action.Preventing AR’s ligand-activation is the frontline treatment for metastatic PCa.Androgen deprivation therapy(ADT)that inhibits AR ligand-binding i...Prostate cancer(PCa)progression relies on androgen receptor(AR)action.Preventing AR’s ligand-activation is the frontline treatment for metastatic PCa.Androgen deprivation therapy(ADT)that inhibits AR ligand-binding initially induces remission but eventually fails,mainly because of adaptive PCa responses that restore AR action.The vast majority of castration-resistant PCa(CRPC)continues to rely on AR activity.Novel therapeutic strategies are being explored that involve targeting other critical AR domains such as those that mediate its constitutively active transactivation function,its DNA binding ability,or its interaction with co-operating transcriptional regulators.Considerable molecular and clinical variability has been found in AR’s interaction with its ligands,DNA binding motifs,and its associated coregulators and transcription factors.Here,we review evidence that each of these levels of AR regulation can individually and differentially impact transcription by AR.In addition,we examine emerging insights suggesting that each can also impact the other,and that all three may collaborate to induce gene-specific AR target gene expression,likely via AR allosteric effects.For the purpose of this review,we refer to the modulating influence of these differential and/or interdependent contributions of ligands,cognate DNA-binding motifs and critical regulatory protein interactions on AR’s transcriptional output,which may influence the efficiency of the novel PCa therapeutic approaches under consideration,as co-regulation of AR activity.展开更多
文摘In an environment,the food chains are balanced by the prey-predator interactions.When a predator species is provided with more than one prey population,it avails the option of prey switching between prey species according to their availability.So,prey switching of predators mainly helps to increase the overall growth rate of a predator species.In this work,we have proposed a two prey-one predator system where the predator population adopts switching behavior between two prey species at the time of consumption.Both the prey population exhibit a strong Allee effect and the predator population is considered to be a generalist one.The proposed system is biologically well-defined as the system variables are positive and do not increase abruptly with time.The local stability analysis reveals that all the predator-free equilibria are saddle points whereas the prey-free equilibrium is always stable.The intrinsic growth rates of prey,the strong Allee parameters,and the prey refuge parameters are chosen to be the controlling parameters here.The numerical simulation reveals that in absence of one prey,the other prey refuge parameter can change the system dynamics by forming a stable or unstable limit cycle.Moreover,a situation of bi-stability,tri-stability,or even multi-stability of equilibrium points occurs in this system.As in presence of the switching effect,the predator chooses prey according to their abundance,so,increasing refuge in one prey population decreases the count of the second prey population.It is also observed that the count of predator population reaches a comparatively higher value even if they get one prey population at its fullest quantity and only a portion of other prey species.So,in the scarcity of one prey species,switching to the other prey is beneficial for the growth of the predator population.
基金the Deanship of Scientific Research at Majmaah University for funding this work under Project No.R-2023-667.
文摘Inpatient falls from beds in hospitals are a common problem.Such falls may result in severe injuries.This problem can be addressed by continuous monitoring of patients using cameras.Recent advancements in deep learning-based video analytics have made this task of fall detection more effective and efficient.Along with fall detection,monitoring of different activities of the patients is also of significant concern to assess the improvement in their health.High computation-intensive models are required to monitor every action of the patient precisely.This requirement limits the applicability of such networks.Hence,to keep the model lightweight,the already designed fall detection networks can be extended to monitor the general activities of the patients along with the fall detection.Motivated by the same notion,we propose a novel,lightweight,and efficient patient activity monitoring system that broadly classifies the patients’activities into fall,activity,and rest classes based on their poses.The whole network comprises three sub-networks,namely a Convolutional Neural Networks(CNN)based video compression network,a Lightweight Pose Network(LPN)and a Residual Network(ResNet)Mixer block-based activity recognition network.The compression network compresses the video streams using deep learning networks for efficient storage and retrieval;after that,LPN estimates human poses.Finally,the activity recognition network classifies the patients’activities based on their poses.The proposed system shows an overall accuracy of approx.99.7% over a standard dataset with 99.63% fall detection accuracy and efficiently monitors different events,which may help monitor the falls and improve the inpatients’health.
基金One of the authors(A.H.)sincerely acknowledges the Department of Science and Technology(DST),Government of Indiafor the INSPIRE Fellowship award(No.DST/INSPIRE Fellowship/2019/IF190924)+1 种基金partial support from the SERBwith grants No.SIR/2022/000566 and CRG/2021/000101,respectively。
文摘The excitation function of the 58Ni(n,p)58Co reaction was measured using the well-established neutron activation technique andγ-ray spectroscopy.Neutrons in the energy range of 1.7 to 2.7 MeV were generated using the 7Li(p,n)reaction.The neutron flux was measured using the standard 115In(n,n’)115mIn monitor reaction.The results of the neutron spectrum averaged cross-section of 58Ni(n,p)58Co reactions were compared with existing cross-section data available in the EXFOR data library as well as with various evaluated data libraries such as ENDF/B-VIII.0,JEFF-3.3,JENDL-4.0,and CENDL-3.2.Theoretical calculations were performed using the nuclear reaction code TALYS.Various nuclear level density(NLD)models were tested,and their results were compared with the present findings.Realistic NLDs were also obtained through the spectral distribution method(SDM).The cross-section results,along with the absolute errors,were obtained by investigating the uncertainty propagation and using the covariance technique.Corrections forγ-ray true coincidence summing,low-energy background neutrons,andγ-ray self attenuation were performed.The experimental cross-section obtained in the present study is consistent with previously published experimental data,evaluated libraries,and theoretical calculations carried out using the TALYS code.
基金We gratefully acknowledge the support of a National Science Foundation of China grant C1304013151101138 and of the 2017 Jiangsu Innovation and Entrepreneurship talents program(to R.G.G.).
文摘Foods wherein the starch is slowly digested contribute to good health by reducing the tendency to,and for the maintenance of,diabetes,obesity and colo-rectal cancers.While foods with high amylose content have this desirable property,they usually do not have high sensory appeal and consumers are reluctant to eat them.While sensory evaluation by trained human panelists is the best way to obtain consumer preferences,these tests are expensive,time-consuming and require considerable effort and care.Instrumental measurements are easier,cheaper and invaluable for screening,but only useful if they correlate with human data for the type of food being considered.Here,we test this using cooked rice with a wide range of amylose contents.Functional properties were correlated against quantitative descriptive panelist analysis.Swelling power and breakdown viscosity correlated with all panelist sensory attributes,but no other correlations with gelatinization properties were observed.There was a strong correlation between hardness and stickiness measured by texture profile analysis(TPA)and by panelists,suggesting that TPA can be used to measure hardness and stickiness of cooked rice.We also showed that breakdown viscosity is a reliable instrumental means to provide indicative measurements of hardness and rice preference,and swelling power is a predictor of rice stickiness.
基金Financial support provided to the first author from the Department of Science&Technology,Government of India under grant DST/INSPIRE FELLOWSHIP/2012/558
文摘Tourism in mountainous regions is a significant source of revenue generation. However, it has also been associated with many adverse environmental consequences. This study aims at assessing the negative impacts of the incessant upsurge in tourism development on the physical environment of Mussoorie, a well-known mountain tourist destination in India. The impact indicators for the region were identified and assessed by qualitative and quantitative analysis of field observations. The observations indicated the aggravation of traffic congestion, atmospheric pollution, undisposed solid waste, water scarcity and infrastructure unavailability as the prevalent issues, especially during the peak tourist months. The extent of the consequential damage to the environment was evaluated by conducting an assessment of tourism-induced human disturbance on the natural landscape of the town. Slope, slope aspect, vegetation cover, road network and drainage network were incorporated as thedetermining landscape attributes to prepare thematic maps of landscape quality(perceivable intrinsic properties) and landscape fragility(vulnerability to anthropogenic disturbances) using GIS technique. An absorption capacity map was finally prepared to characterize the study area into regions of different conservation needs. The results identified the need for planning appropriate preservation strategies for different tourist places in the town. The study can be used by the policy makers for implementing the regulatory measures against potential disturbances due to mass-tourism.
文摘Biomaterial research has been going on for several years,and many companies are heavily investing in new product development.However,it is a contentious field of science.Biomaterial science is a field that combines materials science and medicine.The replacement or restoration of damaged tissues or organs enhances the patient’s quality of life.The deciding aspect is whether or not the body will accept a biomaterial.A biomaterial used for an implant must possess certain qualities to survive a long time.When a biomaterial is used for an implant,it must have specific properties to be long-lasting.A variety of materials are used in biomedical applications.They are widely used today and can be used individually or in combination.This review will aid researchers in the selection and assessment of biomaterials.Before using a biomaterial,its mechanical and physical properties should be considered.Recent biomaterials have a structure that closely resembles that of tissue.Antiinfective biomaterials and surfaces are being developed using advanced antifouling,bactericidal,and antibiofilm technologies.This review tries to cover critical features of biomaterials needed for tissue engineering,such as bioactivity,self-assembly,structural hierarchy,applications,heart valves,skin repair,bio-design,essential ideas in biomaterials,bioactive biomaterials,bioresorbable biomaterials,biomaterials in medical practice,biomedical function for design,biomaterial properties such as biocompatibility,heat response,non-toxicity,mechanical properties,physical properties,wear,and corrosion,as well as biomaterial properties such surfaces that are antibacterial,nanostructured materials,and biofilm disrupting compounds,are all being investigated.It is technically possible to stop the spread of implant infection.
基金supported by the National Natural Science Foundation of China(Grant No.81972492)National Science Fund for Young Scholars(Grant No.21904107)+7 种基金Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(Grant No.LR19C050001)Hangzhou Agriculture and Society Advancement Program(Grant No.20190101A04)Westlake Startup Grantresearch funds from the National Cancer Centre Singapore and Singapore General Hospital,Singaporethe National Key R&D Program of China(Grant No.2016YFC0901704)Zhejiang Innovation Discipline Project of Laboratory Animal Genetic Engineering(Grant No.201510)the Netherlands Cancer Society(Grant No.NKI 2014-6651)The Netherlands Organization for Scientific Research(NWO)-Middelgroot(Grant No.91116017)
文摘To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been developed.For optimal performance,they require the fragment ion spectra of targeted peptides as prior knowledge.In this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples.To build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker.We then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer samples.This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)patients.Thereafter,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated.As a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control subjects.Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM.These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery.DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000.
文摘The huge atomic heterogeneity of high-entropy materials along with a possibility to unravel the behavior of individual components at the atomic scale suggests a great promise in designing new compositionally complex systems with the desired multifunctionality.Herein,we apply multi-edge X-ray absorption spectroscopy(extended X-ray absorption fine structure(EXAFS),Xray absorption near edge structure(XANES),and X-ray magnetic circular dichroism(XMCD))to probe the structural,electronic,and magnetic properties of all individual constituents in the single-phase face-centered cubic(fcc)-structured nanocrystalline thin film of Cr_(20)Mn_(26)Fe_(18)Co_(19)Ni_(17)(at.%)high-entropy alloy on the local scale.The local crystallographic ordering and componentdependent lattice displacements were explored within the reverse Monte Carlo approach applied to EXAFS spectra collected at the K absorption edges of several constituents at room temperature.A homogeneous short-range fcc atomic environment around the absorbers of each type with very similar statistically averaged interatomic distances(2.54-2.55Å)to their nearest-neighbors and enlarged structural relaxations of Cr atoms were revealed.XANES and XMCD spectra collected at the L2,3 absorption edges of all principal components at low temperature from the oxidized and in situ cleaned surfaces were used to probe the oxidation states,the changes in the electronic structure,and magnetic behavior of all constituents at the surface and in the sub-surface volume of the film.The spin and orbital magnetic moments of Fe,Co,and Ni components were quantitatively evaluated.The presence of magnetic phase transitions and the co-existence of different magnetic phases were uncovered by conventional magnetometry in a broad temperature range.
基金The study was supported by the Department of Science and Technology,India for providing the INSPIRE Fellowship(DST/INSPIRE FELLOWSHIP/IF190470).
文摘In recent years,there has been continuous improvement in the treatment and diagnosis of cancer,which has led to a significant improvement in the survival rate of cancer patients.Treatments that include chemotherapy,radiotherapy,surgery,or combined therapy have several side effects that may lead to premature ovarian insufficiency in females or substantial male germ cell loss.Reproductive biologists recommend that all patients who are diagnosed with a malignant tumor must undergo a consultation for fertility protection and preservation.In this review,we discuss the background knowledge,methods,and options for fertility preservation and how these new strategies help oncologists,surgeons,pediatricians,and hematologists,conserve fertility and be aware of the concepts,methods,and importance of fertility guards.This review may aid in the advancement of novel personalized methods for fertility preservation according to patients’conditions.
文摘Landslides in the Himalayan region are primarily controlled by natural parameters,including rainfall,seismic activity,and anthropogenic parameters,such as the construction of large-scale projects like road development,tunneling and hydroelectric power projects and climate change.The parameters which are more crucial among these are a matter of scientific study and analysis.This research,taking Solan district,Himachal Pradesh,India,as the study area,aims to assess the impact of anthropogenic activities on landslide susceptibility at a regional scale.Landslide distribution was characterized into two groups,namely Rainfall-Induced Landslide(RIL)and Human-Induced Landslide(HIL)based on triggering factors.Multiple data such as slope angle,aspect,profile curvature,distance to drainage,distance to lineament,lithology,distance to road,normalized difference vegetation index(NDVI)and land use land cover(LULC)have been considered for delineating the landslide susceptibility zonation(LSZ)map.The effect of anthropogenic activities on landslide occurrences has been examined through the distribution of landslides along national highways and land use land cover changes(LULCC).Two sets of LSZ maps with a LULC of time interval covering five years(2017&2021)were prepared to compare the temporal progression of LULC and landslide susceptibility during the five years.The results indicated the significant impact of anthropogenic activities on the landslide susceptibility.LSZ map of the year 2021 shows that 23%area falls into high and very high susceptible classes and 48%area falls into very low and low susceptibility classes.Compared to LSZ map of 2017,high and very high susceptible classes have been increased by 15%,whereas very low and low susceptible classes have been reduced by 7%.The present case study will help to understand the potential driving parameters responsible for HIL and also suggest the inclusion of LULC in landslide susceptibility analysis.The study will demonstrate new opportunities for research that could help decis
文摘Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment options.Besides genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target.Mechanisms beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under trails.Combinations of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa patients.Recent studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic therapies.Epigenetics thus promises to generate a significant amount of new knowledge of biological and medical importance.Our review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to breakthroughs.We aim to highlight the possibilities that exist and the potential therapeutic interventions.
基金financial assistance from Department of Science and Technology (DST) vide sanction order No. F. No SB/50/ BB-0042/2013 for project and UGC Kothari fellowship to Dr. Sangeeta Yadav is highly acknowledged
文摘In order to search the degradability of kraft lignin, the potential bacterial strains Bacillus subtilis（GU193980） and Klebsiella pneumoniae（GU193981） were isolated, screened and applied in axenic and co-culture conditions. Results revealed that mixed culture showed better decolorization efficiency（80%） and reduction of pollution parameters（COD 73% and BOD62%） than axenic culture. This indicated syntrophic growth of these two bacteria rather than any antagonistic effect. The HPLC analysis of degraded samples of kraft lignin has shown the reduction in peak area compared to control, suggesting that decrease in color intensity might be largely attributed to the degradation of lignin by isolated bacteria.Further, the GC-MS analysis showed that most of the compounds detected in control were diminished after bacterial treatment. Further, the seed germination test using Phaseolus aureus has supported the detoxification of bacterial decolorized kraft lignin for environmental safety. All these observations have revealed that the developed bacterial co-culture was capable for the effective degradation and decolorization of lignin containing rayon grade pulp mill wastewater for environmental safety.
基金the Junior Research Fellowship(JRF)from University Grants Commission,New Delhi,India(No.2061410096)。
文摘Five novel europium(Ⅲ)complexes with 2-[4-(dibutylamino)-2-hydroxybenzoyl]benzoic acid(DAHB)as primary ligand and bathophenanthroline(batho),2,2’-bipyridyl(bipy),5,6-dimethyl-1,10-phenanthroline(dmph),1,10-phenanthroline(phen)as ancillary ligands were syn-thesized via solution precipitation method.The structural formulae of synthesized complexes were speculated to be Eu(DABH)_(3)·2H_(2)O(C1),Eu(DABH)_(3)·batho(C2),Eu(DABH)_(3)·bipy(C3),Eu(DABH)_(3)·dmph(C4)and Eu(DABH)_(3)·phen(C5)by elemental analysis,infrared spectroscopy and proton nuclear magnetic resonance spec-troscopy(^(1)H-NMR).The photoluminescent properties and thermal stability of the complexes were investigated by photoluminescent spectroscopy and thermogravimetric analysis(TG-DTG),respectively.The Commission Inter-nationale de I’Eclairage(CIE)color coordinates,Judd–Ofelt intensity parameter(Ω_(2)),total quantum yield,intrinsic quantum efficiency and energy transfer dynamics of com-plexes were also explored.The excitation spectra of com-plexes are extended up to visible region.These complexes exhibit characteristic photoemission of Eu^(3+)metal ion with high color purity in red region attributed to efficient energy transfer from ligand to metal ion.The replacement of water molecules from coordination sphere of europium ion by ancillary ligands results in enhancement of luminescent properties of the C2–C5 complexes,indicating that ancillary ligands act as additional light harvesting centers in sensiti-zation phenomenon.The thermal studies show that these complexes are suitable for meeting the requirement of temperature for fabrication of OLEDs devices.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA19070103)the National Key Research and Development Program of China(2018YFC1406103 and 2018YFC1406104)+3 种基金the National Natural Science Foundation of China(41425003)the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(GML2019ZD0601)the Youth Innovation Promotion Association,CAS(2020419)the Scientific Research Foundation of the Key Laboratory of Cryospheric Sciences(SKLCSZZ-2020-09).
文摘This study reports on the measurements of ion and refractory black carbon(rBC)concentrations in a shallow(10.96 m)ice core sample which was drilled from the field site of the East Greenland Ice Core Project(EGRIP)in July,2016.The results provide a recent record of rBC deposition in the East Greenland ice sheet from 1990 to 2016.The annual variability in oxygen(δ^(18)O)and hydrogen(δD)isotopic compositions indicated that notably warm events occurred since 2008.Peaks in rBC occurred during summer seasons,which may be attributed to the burning of biomass in boreal summer.The rBC record and analysis of historical air trajectories using the HYSPLIT model indicated that anthropogenic BC emissions from Russia,North America and Europe contributed to the majority of rBC deposition in the Greenland region,and a reduction in anthropogenic BC consumption in these areas played a dominant role in the decrease in BC concentrations since 2000.This record also suggests that the emissions from the East Asian region(China)contributed very little to the recorded BC concentrations in East Greenland ice core.The model results indicated that radiative forcing due to BC had decreased significantly since 1990,and had remained below 0.02W m^(-2) since 2000.
文摘Development of modified plastics has been studied through the LDPE-acylated starch blend films to examine the effect of different acyl groups and degrees of substitution （DS） on properties of films. Corn starch was modified with acetyl and hutyryl groups and films were prepared by blending acylated starch with low density polyethylene （LDPE）. Systematic studies were done to observe the effect of acyl groups, DS and starch concentration on the properties and biodegradability of the blend films. It was observed that blend films containing 5% acetylated and butyrylated starches of high DS （2.5, 1.7） maintained 75% and 83% of tensile strength of LDPE films. Thermal analysis results indicated that acetylated and butyrylated starch blend films decomposed at 370℃ and 389℃ which were higher than the decomposition temperature of native starch film （349℃）. Scanning electron micrographs of blend films containing high DS acylated starch showed well dispersed starch particles due to improvement in dispersion between starch and LDPE. Water absorption capacity of high DS acetylated and butyrylated starch blend films （4.18% and 3.76%, respectively） was lower than that of native starch films （5%）. This study has an advantage because of blown films prepared can be integrated with the present manufacturing systems without any other requirement.
基金supported by DOD PCRP award W81XWH-16-1-0404(HVH)NIH NCI grant CA166440(HVH).
文摘Prostate cancer(PCa)progression relies on androgen receptor(AR)action.Preventing AR’s ligand-activation is the frontline treatment for metastatic PCa.Androgen deprivation therapy(ADT)that inhibits AR ligand-binding initially induces remission but eventually fails,mainly because of adaptive PCa responses that restore AR action.The vast majority of castration-resistant PCa(CRPC)continues to rely on AR activity.Novel therapeutic strategies are being explored that involve targeting other critical AR domains such as those that mediate its constitutively active transactivation function,its DNA binding ability,or its interaction with co-operating transcriptional regulators.Considerable molecular and clinical variability has been found in AR’s interaction with its ligands,DNA binding motifs,and its associated coregulators and transcription factors.Here,we review evidence that each of these levels of AR regulation can individually and differentially impact transcription by AR.In addition,we examine emerging insights suggesting that each can also impact the other,and that all three may collaborate to induce gene-specific AR target gene expression,likely via AR allosteric effects.For the purpose of this review,we refer to the modulating influence of these differential and/or interdependent contributions of ligands,cognate DNA-binding motifs and critical regulatory protein interactions on AR’s transcriptional output,which may influence the efficiency of the novel PCa therapeutic approaches under consideration,as co-regulation of AR activity.
