<span style="font-family:Verdana;">Gender difference in chronic hepatitis C (CHC) infection is not previously well studied. We aimed to analyze the effect of gender difference on the risk factors of CH...<span style="font-family:Verdana;">Gender difference in chronic hepatitis C (CHC) infection is not previously well studied. We aimed to analyze the effect of gender difference on the risk factors of CHC, disease progression, and outcome after oral direct acting antiviral (DAA) therapy. The study</span><span style="font-family:Verdana;"> was</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> conducted at Tropical Medicine and Gastroenterology Department, Sohag University, Egypt, in the period between 2018 and 2020. 775 patients were evaluated for hepatitis C virus (HCV) risk factors. Laboratory investigations, abdominal ultrasound and liver Shear </span><span style="font-family:Verdana;">wave elastography (SWE) were done. The patients were given antiviral therap</span><span style="font-family:Verdana;">y and followed up to assess the response and side effects of DAA therapy. 434</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(56%) of study patients were males and 341</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">(44%) were females. Catching infection from blood transfusion and intravenous (IV) injection of </span><span style="font-family:Verdana;">tarter emetic w</span></span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> significantly higher in males, while catching infection from surgical operation was significantly higher in females. Hepatic fibrosis was significantly more extensive in males. Side effects were reported more in females. Sustained virological response (SVR)</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">12 was reported in 98.6%. Females had a slightly better SVR12 than males (99.4% versus 97.9%). In conclusion males were different from females in exposure to HCV risk factors. After introduction of blood screening and stoppage of </span><span style="font-family:Verd展开更多
Heavy infection of the virus leads to overproduction of cytokines. The overproduction of cytokine (cytokines storms) is responsible for the critical cases and deaths of COVID-19. The nuclear factor kappa-B stimulates ...Heavy infection of the virus leads to overproduction of cytokines. The overproduction of cytokine (cytokines storms) is responsible for the critical cases and deaths of COVID-19. The nuclear factor kappa-B stimulates the expression of the genes, which is responsible for cytokines storm and RNA transcription. The COVID-19 virus can be controlled by inhibition of nuclear factor kappa-B. Nuclear factor kappa-B is controlled by inhibition of hydrogen peroxide and inhibitor kappa-B kinase enzyme.展开更多
文摘<span style="font-family:Verdana;">Gender difference in chronic hepatitis C (CHC) infection is not previously well studied. We aimed to analyze the effect of gender difference on the risk factors of CHC, disease progression, and outcome after oral direct acting antiviral (DAA) therapy. The study</span><span style="font-family:Verdana;"> was</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> conducted at Tropical Medicine and Gastroenterology Department, Sohag University, Egypt, in the period between 2018 and 2020. 775 patients were evaluated for hepatitis C virus (HCV) risk factors. Laboratory investigations, abdominal ultrasound and liver Shear </span><span style="font-family:Verdana;">wave elastography (SWE) were done. The patients were given antiviral therap</span><span style="font-family:Verdana;">y and followed up to assess the response and side effects of DAA therapy. 434</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(56%) of study patients were males and 341</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">(44%) were females. Catching infection from blood transfusion and intravenous (IV) injection of </span><span style="font-family:Verdana;">tarter emetic w</span></span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> significantly higher in males, while catching infection from surgical operation was significantly higher in females. Hepatic fibrosis was significantly more extensive in males. Side effects were reported more in females. Sustained virological response (SVR)</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">12 was reported in 98.6%. Females had a slightly better SVR12 than males (99.4% versus 97.9%). In conclusion males were different from females in exposure to HCV risk factors. After introduction of blood screening and stoppage of </span><span style="font-family:Verd
文摘Heavy infection of the virus leads to overproduction of cytokines. The overproduction of cytokine (cytokines storms) is responsible for the critical cases and deaths of COVID-19. The nuclear factor kappa-B stimulates the expression of the genes, which is responsible for cytokines storm and RNA transcription. The COVID-19 virus can be controlled by inhibition of nuclear factor kappa-B. Nuclear factor kappa-B is controlled by inhibition of hydrogen peroxide and inhibitor kappa-B kinase enzyme.
