AIM： To study the association of three common ABCB11 and ABCC2 polymorphisms （ABCB11： 1331T〉C→V444A; ABCC2： 3563T〉A → V1188E and 4544G 〉A → C1515Y） with intrahepatic cholestasis of pregnancy （ICP） and con...AIM： To study the association of three common ABCB11 and ABCC2 polymorphisms （ABCB11： 1331T〉C→V444A; ABCC2： 3563T〉A → V1188E and 4544G 〉A → C1515Y） with intrahepatic cholestasis of pregnancy （ICP） and contraceptive-induced cholestasis （CIC）. METHODS： ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele. RESULTS： The ABCB11 1331T〉C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls： C allele 76.2% （CI, 58.0-94.4） vs 51.3% （CI 35.8-66.7）, respectively （P = 0.0007）; and CC allele 57.1% （CI 36.0-78.3） vs 20% （CI 7.6-32.4）, respectively （P = 0.0065）. All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype. CONCLUSION： Our data support a role for the ABCB11 1331T〉C polymorphism as a susceptibility factor for the development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and 7-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC.展开更多
The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum(ER)and play a central role in translocation of nascent and newly synthesized precurso...The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum(ER)and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER.This process involves targeting of the precursors to the membrane and opening of the polypeptide conducting Sec61 channel for translocation.Apart from this central role in the intracellular transport of polypeptides,several studies of the last decade uncovered additional functions of Sec proteins in intracellular signaling:Sec62 can induce ER-phagy in the process of recovery of cells from ER stress and the Sec61 channel can also act as a passive ER calcium leak channel.Furthermore,mutations,amplifications and an overexpression of the SEC genes were linked to various diseases including kidney and liver diseases,diabetes and human cancer.Studies of the last decade could not only elucidate the functional role of Sec proteins in the pathogenesis of these diseases,but also demonstrate a relevance of Sec62 as a prognostic and predictive biomarker in head and neck cancer,prostate and lung cancer including a basis for new therapeutic strategies.In this article,we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights into the functional role and therapeutic relevance of Sec61,Sec62 and Sec63 in human diseases.展开更多
Renewable energies are highly dependent on local weather conditions, with photovoltaic energy being particularly affected by intermittent clouds. Anticipating the impact of cloud shadows on power plants is crucial, as...Renewable energies are highly dependent on local weather conditions, with photovoltaic energy being particularly affected by intermittent clouds. Anticipating the impact of cloud shadows on power plants is crucial, as clouds can cause partial shading, excessive irradiation, and operational issues. This study focuses on analyzing cloud tracking methods for short-term forecasts, aiming to mitigate such impacts. We conducted a systematic literature review, highlighting the most significant articles on cloud tracking from ground-based observations. We explore both traditional image processing techniques and advances in deep learning models. Additionally, we discuss current challenges and future research directions in this rapidly evolving field, aiming to provide a comprehensive overview of the state of the art and identify opportunities for significant advancements in the next generation of cloud tracking systems based on computer vision and deep learning.展开更多
Peroxisome proliferator-activated receptor γ(PPARγ) has been implicated in the differentiation and growth inhibition of cancer cells. We examined the effects of PPARγactivation by troglitazone on hepatocellular car...Peroxisome proliferator-activated receptor γ(PPARγ) has been implicated in the differentiation and growth inhibition of cancer cells. We examined the effects of PPARγactivation by troglitazone on hepatocellular carcinoma (HCC) cell growth, proliferation, and apoptosis in vitro and in vivo. We also studied relationships between PPARγactivation and cyclooxygenase-2 (COX-2) expression. Human HCC cell lines Huh7 and Hep3B were cultured in the presence or absence of troglitazone. Cell growth was determined via WST-1 assay, proliferation by cell cycle analysis and proliferating cell nuclear antigen (PCNA) Western blotting, and apoptosis by flow cytometry and TUNEL. Tumor growth after subcutaneous implantation of Huh7 cells in nude mice was monitored, and the effects of treatment with troglitazone were determined. In resected HCCs, PPARγexpression was less compared with the histologically normal surrounding liver. In cultures of Hep3B and Huh7 cells, basal expression of PPARγwas relatively low, but troglitazone caused dose-dependent induction of PPARγexpression. Cell cycle analysis revealed a decreased proportion of cells in S phase, with arrest at G0/G1. Concomitant downregulation of PCNA and an increase in TUNEL staining, cells were consistent with decreased proliferation and induction of apoptosis by troglitazaone. Troglitazone-mediated PPARγactivation also suppressed COX-2 expression and induced p27 in HCC cells. Administration of troglitazone to Huh7 tumor-bearing mice significantly reduced tumor growth and caused tumor regression. In conclusion, collectively, these results indicate that PPARγcould be a regulator of cell survival and growth in HCC. PPARγtherefore represents a putative molecular target for chemopreventive therapy or inhibition of liver cancer growth.展开更多
The method of obtaining zircon samples affects estimation of the global U-Pb age distribution.Researchers typically collect zircons via convenience sampling and cluster sampling.When using these techniques,weight adju...The method of obtaining zircon samples affects estimation of the global U-Pb age distribution.Researchers typically collect zircons via convenience sampling and cluster sampling.When using these techniques,weight adjustments proportional to the areas of the sampled regions improve upon unweighted estimates.Here,grid-area and modern sediment methods are used to weight the samples from a new database of 418,967 U-Pb ages.Preliminary tests involve two age models.Model-1 uses the most precise U-Pb ages as the best ages.Model-2 uses the^(206)Pb/^(238)U age as the best age if it is less than a1000 Ma cutoff,otherwise it uses the^(207)Pb/^(206)Pb age as the best age.A correlation analysis between the Model-1 and Model-2 ages indicates nearly identical distributions for both models.However,after applying acceptance criteria to include only the most precise analyses with minimal discordance,a histogram of the rejected samples shows excessive rejection of the Model-2 analyses around the1000 Ma cutoff point.Because of the excessive rejection rate for Model-2,we select Model-1 as the preferred model.After eliminating all rejected samples,the remaining analyses use only Model-1 ages for five rock-type subsets of the database:igneous,meta-igneous,sedimentary,meta-sedimentary,and modern sediments.Next,time-series plots,cross-correlation analyses,and spectral analyses determine the degree of alignment among the time-series and their periodicity.For all rock types,the U-Pb age distributions are similar for ages older than 500 Ma,but align poorly for ages younger than 500 Ma.The similarities(>500 Ma)and differences(<500 Ma)highlight how reductionism from a detailed database enhances understanding of time-dependent sequences,such as erosion,detrital transport mechanisms,lithification,and metamorphism.Time-series analyses and spectral analyses of the age distributions predominantly indicate a synchronous period-tripling sequence of^91-Myr,~273-Myr,and^819-Myr among the various rock types.展开更多
The wide-spread use of microarray technologies to study plant transcriptomes has led to important discoveries and to an accumulation of profiling data covering a wide range of different tissues, developmental stages, ...The wide-spread use of microarray technologies to study plant transcriptomes has led to important discoveries and to an accumulation of profiling data covering a wide range of different tissues, developmental stages, perturbations, and genotypes. Querying a large number of microarray experiments can provide insights that cannot be gained by analyzing single experiments. However, such a meta-analysis poses significant challenges with respect to data comparability and normalization, systematic sample annotation, and analysis tools. Genevestigator addresses these issues using a large curated expression database and a set of specifically developed analysis tools that are accessible over the internet. This combination has already proven to be useful in the area of plant research based on a large set of Arabidopsis data （Grennan, 2006）. Here, we present the release of the Genevestigator rice and barley gene expression databases that con- tain quality-controlled and well annotated microarray experiments using ontologies. The databases currently comprise experiments from pathology, plant nutrition, abiotic stress, hormone treatment, genotype, and spatial or temporal analysis, but are expected to cover a broad variety of research areas as more experimental data become available. The transcriptome meta-analysis of the model species rice and barley is expected to deliver results that can be used for functional genomics and biotechnological applications in cereals.展开更多
Background:Despitemajor advances in themedicalmanagement of Crohn’s disease(CD),a significant proportion of patients will require surgery within 5 years of diagnosis.Malnutrition is an independent risk factor for adv...Background:Despitemajor advances in themedicalmanagement of Crohn’s disease(CD),a significant proportion of patients will require surgery within 5 years of diagnosis.Malnutrition is an independent risk factor for adverse post-operative outcomes following gastrointestinal surgery.Data on the value of pre-operative total parenteral nutrition(TPN)in CD patients aremixed and there is a paucity of data in the biologic era.We aimed to define the role of pre-operative TPN in this population.Methods:This was a retrospective cohort study conducted at a tertiary referral center.CD patients who underwent major abdominal surgery were identified.Patients receiving pre-operative TPN were compared to controls.We compared the incidence of 30-day infectious and non-infectious post-operative complications between the two groups.Results:A total of 144 CD patients who underwent major abdominal surgery between March 2007 and March 2017 were included.Fifty-five patients who received pre-operative TPN were compared to 89 controls.Twenty-one(14.6%)patients developed infectious complications(18.2%in TPN group vs 12.3%in non-TPN group,P=0.34)and 23(15.9%)developed noninfectious complications(14.5%in TPN group vs 16.9%in non-TPN group,P=0.71).In a multivariate analysis,controlling for differences in baseline disease severity and malnutrition between groups,patients receiving pre-operative TPN for60 days had significantly lower odds of developing non-infectious complications(odds ratio 0.07,95%confidence interval:0.01–0.80,P=0.03).Weight loss of>10%in the past 6 months was a significant predictor of post-operative complications.Conclusions:In a subset of malnourished CD patients,TPN is safe and allows comparable operative outcomes to controls.Pre-operative TPN for60 days reduced post-operative non-infectious complications without associated increase in infectious complications.展开更多
AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were ...AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS.展开更多
Correction to:npj Computational Materials https://doi.org/10.1038/s41524-023-00966-0,published online 16 February 2023 The original version of this Article contained several typographical errors in both the PDF and th...Correction to:npj Computational Materials https://doi.org/10.1038/s41524-023-00966-0,published online 16 February 2023 The original version of this Article contained several typographical errors in both the PDF and the HTML versions.In the first paragraph of‘Introduction’,the sentence‘(The phrase was coined by Nobel laureate Francis Crick in his book What Mad Pursuit:A personal view of scientific discovery)’duplicated reference 1.The sentence and brackets have been removed in the corrected version.展开更多
Post shut‐in seismic events in enhanced geothermal systems(EGSs)occur predominantly at the outer rim of the co‐injection seismic cloud.The concept of postinjection fracture and fault closure near the injection well ...Post shut‐in seismic events in enhanced geothermal systems(EGSs)occur predominantly at the outer rim of the co‐injection seismic cloud.The concept of postinjection fracture and fault closure near the injection well has been proposed and validated as a mechanism for enhancing post shut‐in pressure diffusion that promotes seismic hazard.This phenomenon is primarily attributed to the poro‐elastic closure of fractures resulting from the reduction of wellbore pressure after injection termination.However,the thermal effects in EGSs,mainly including heat transfer and thermal stress,may not be trivial and their role in postinjection fault closure and pressure evolution needs to be explored.In this study,we performed numerical simulations to analyze the relative importance of poro‐elasticity,heat transfer,and thermo‐elasticity in promoting postinjection fault closure and pressure diffusion.The numerical model wasfirst validated against analytical solutions in terms offluid pressure diffusion and against heatedflow‐through experiments in terms of thermal processes.We then quantified and distinguished the contribution of each individual mechanism by comparing four different shut‐in scenarios simulated under different coupled conditions.Our results highlight the importance of poro‐elastic fault closure in promoting postinjection pressure buildup and seismicity,and suggest that heat transfer can further augment the fault closure‐induced pressure increase and thus potentially intensify the postinjection seismic hazard,with minimal contribution from thermo‐elasticity.展开更多
The design of mobile robots that can move without wheels or legs is an important engineering and technological problem.Self-propelling mechanisms consisting of a body that has contact with a rough surface and moveable...The design of mobile robots that can move without wheels or legs is an important engineering and technological problem.Self-propelling mechanisms consisting of a body that has contact with a rough surface and moveable internal masses are considered.Mathematical models of such systems are presented in this paper.First,a model of a vibration driven robot that moves along a rough horizontal plane with isotropic dry friction is studied.It is shown that by changing the off-resonance frequency detuning in sign,one can control the direction of motion of the system.In addition,a locomotion system which moves in an environment with anisotropic viscous friction is considered.For all models,the method of averaging to obtain an algebraic equation for the steady-state＂average＂velocity of the system is used. Prototypes were constructed to compare the theoretical results with experimental ones.展开更多
In a paper conceived about five years ago(“Globalization and Public Goods:Too Big to Tackle?”)roughly a dozen factors were linked to explain important causal paths from globalization to the potential output of publi...In a paper conceived about five years ago(“Globalization and Public Goods:Too Big to Tackle?”)roughly a dozen factors were linked to explain important causal paths from globalization to the potential output of public goods.The Russian invasion of Ukraine,the corona epidemic,and the increased hegemonic rivalry between China and the U.S.interrupted or even destroyed many of the linkages between globalization and potential public good production.About five important detrimental paths involved in the meantime.In the present article we aim at linking what is left from the previous level of globalization or emerging to form a new and simplified causal model for likely linkages between truncated or(re-)emerging globalization,and the deadly needed output of public goods.These linkages refer to rules of climate control,go to trade linkages and arbitrary tariffs and trade interventions.Regime change,regime formation,and alliance restructuring address aspects of domestic rule and international stability.Selectorate theory,regime type,and exit options for political elites provide key explanatory factors in explaining globalization and public goods productions,or their decay.Where possible we use some data and transformation experiences corroborating our arguments.In other instances need for further empirical macro research will become clear.展开更多
基金Supported by Grants from the Gebert Rüf Foundation, the Forschungskredit of the University Zurichthe Swiss National Science Foundation, Grants PP00B-108511/1 and 31-64140.00
文摘AIM： To study the association of three common ABCB11 and ABCC2 polymorphisms （ABCB11： 1331T〉C→V444A; ABCC2： 3563T〉A → V1188E and 4544G 〉A → C1515Y） with intrahepatic cholestasis of pregnancy （ICP） and contraceptive-induced cholestasis （CIC）. METHODS： ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele. RESULTS： The ABCB11 1331T〉C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls： C allele 76.2% （CI, 58.0-94.4） vs 51.3% （CI 35.8-66.7）, respectively （P = 0.0007）; and CC allele 57.1% （CI 36.0-78.3） vs 20% （CI 7.6-32.4）, respectively （P = 0.0065）. All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype. CONCLUSION： Our data support a role for the ABCB11 1331T〉C polymorphism as a susceptibility factor for the development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and 7-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC.
文摘The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the membrane of the human endoplasmic reticulum(ER)and play a central role in translocation of nascent and newly synthesized precursor polypeptides into the ER.This process involves targeting of the precursors to the membrane and opening of the polypeptide conducting Sec61 channel for translocation.Apart from this central role in the intracellular transport of polypeptides,several studies of the last decade uncovered additional functions of Sec proteins in intracellular signaling:Sec62 can induce ER-phagy in the process of recovery of cells from ER stress and the Sec61 channel can also act as a passive ER calcium leak channel.Furthermore,mutations,amplifications and an overexpression of the SEC genes were linked to various diseases including kidney and liver diseases,diabetes and human cancer.Studies of the last decade could not only elucidate the functional role of Sec proteins in the pathogenesis of these diseases,but also demonstrate a relevance of Sec62 as a prognostic and predictive biomarker in head and neck cancer,prostate and lung cancer including a basis for new therapeutic strategies.In this article,we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights into the functional role and therapeutic relevance of Sec61,Sec62 and Sec63 in human diseases.
文摘Renewable energies are highly dependent on local weather conditions, with photovoltaic energy being particularly affected by intermittent clouds. Anticipating the impact of cloud shadows on power plants is crucial, as clouds can cause partial shading, excessive irradiation, and operational issues. This study focuses on analyzing cloud tracking methods for short-term forecasts, aiming to mitigate such impacts. We conducted a systematic literature review, highlighting the most significant articles on cloud tracking from ground-based observations. We explore both traditional image processing techniques and advances in deep learning models. Additionally, we discuss current challenges and future research directions in this rapidly evolving field, aiming to provide a comprehensive overview of the state of the art and identify opportunities for significant advancements in the next generation of cloud tracking systems based on computer vision and deep learning.
文摘Peroxisome proliferator-activated receptor γ(PPARγ) has been implicated in the differentiation and growth inhibition of cancer cells. We examined the effects of PPARγactivation by troglitazone on hepatocellular carcinoma (HCC) cell growth, proliferation, and apoptosis in vitro and in vivo. We also studied relationships between PPARγactivation and cyclooxygenase-2 (COX-2) expression. Human HCC cell lines Huh7 and Hep3B were cultured in the presence or absence of troglitazone. Cell growth was determined via WST-1 assay, proliferation by cell cycle analysis and proliferating cell nuclear antigen (PCNA) Western blotting, and apoptosis by flow cytometry and TUNEL. Tumor growth after subcutaneous implantation of Huh7 cells in nude mice was monitored, and the effects of treatment with troglitazone were determined. In resected HCCs, PPARγexpression was less compared with the histologically normal surrounding liver. In cultures of Hep3B and Huh7 cells, basal expression of PPARγwas relatively low, but troglitazone caused dose-dependent induction of PPARγexpression. Cell cycle analysis revealed a decreased proportion of cells in S phase, with arrest at G0/G1. Concomitant downregulation of PCNA and an increase in TUNEL staining, cells were consistent with decreased proliferation and induction of apoptosis by troglitazaone. Troglitazone-mediated PPARγactivation also suppressed COX-2 expression and induced p27 in HCC cells. Administration of troglitazone to Huh7 tumor-bearing mice significantly reduced tumor growth and caused tumor regression. In conclusion, collectively, these results indicate that PPARγcould be a regulator of cell survival and growth in HCC. PPARγtherefore represents a putative molecular target for chemopreventive therapy or inhibition of liver cancer growth.
文摘The method of obtaining zircon samples affects estimation of the global U-Pb age distribution.Researchers typically collect zircons via convenience sampling and cluster sampling.When using these techniques,weight adjustments proportional to the areas of the sampled regions improve upon unweighted estimates.Here,grid-area and modern sediment methods are used to weight the samples from a new database of 418,967 U-Pb ages.Preliminary tests involve two age models.Model-1 uses the most precise U-Pb ages as the best ages.Model-2 uses the^(206)Pb/^(238)U age as the best age if it is less than a1000 Ma cutoff,otherwise it uses the^(207)Pb/^(206)Pb age as the best age.A correlation analysis between the Model-1 and Model-2 ages indicates nearly identical distributions for both models.However,after applying acceptance criteria to include only the most precise analyses with minimal discordance,a histogram of the rejected samples shows excessive rejection of the Model-2 analyses around the1000 Ma cutoff point.Because of the excessive rejection rate for Model-2,we select Model-1 as the preferred model.After eliminating all rejected samples,the remaining analyses use only Model-1 ages for five rock-type subsets of the database:igneous,meta-igneous,sedimentary,meta-sedimentary,and modern sediments.Next,time-series plots,cross-correlation analyses,and spectral analyses determine the degree of alignment among the time-series and their periodicity.For all rock types,the U-Pb age distributions are similar for ages older than 500 Ma,but align poorly for ages younger than 500 Ma.The similarities(>500 Ma)and differences(<500 Ma)highlight how reductionism from a detailed database enhances understanding of time-dependent sequences,such as erosion,detrital transport mechanisms,lithification,and metamorphism.Time-series analyses and spectral analyses of the age distributions predominantly indicate a synchronous period-tripling sequence of^91-Myr,~273-Myr,and^819-Myr among the various rock types.
文摘The wide-spread use of microarray technologies to study plant transcriptomes has led to important discoveries and to an accumulation of profiling data covering a wide range of different tissues, developmental stages, perturbations, and genotypes. Querying a large number of microarray experiments can provide insights that cannot be gained by analyzing single experiments. However, such a meta-analysis poses significant challenges with respect to data comparability and normalization, systematic sample annotation, and analysis tools. Genevestigator addresses these issues using a large curated expression database and a set of specifically developed analysis tools that are accessible over the internet. This combination has already proven to be useful in the area of plant research based on a large set of Arabidopsis data （Grennan, 2006）. Here, we present the release of the Genevestigator rice and barley gene expression databases that con- tain quality-controlled and well annotated microarray experiments using ontologies. The databases currently comprise experiments from pathology, plant nutrition, abiotic stress, hormone treatment, genotype, and spatial or temporal analysis, but are expected to cover a broad variety of research areas as more experimental data become available. The transcriptome meta-analysis of the model species rice and barley is expected to deliver results that can be used for functional genomics and biotechnological applications in cereals.
文摘Background:Despitemajor advances in themedicalmanagement of Crohn’s disease(CD),a significant proportion of patients will require surgery within 5 years of diagnosis.Malnutrition is an independent risk factor for adverse post-operative outcomes following gastrointestinal surgery.Data on the value of pre-operative total parenteral nutrition(TPN)in CD patients aremixed and there is a paucity of data in the biologic era.We aimed to define the role of pre-operative TPN in this population.Methods:This was a retrospective cohort study conducted at a tertiary referral center.CD patients who underwent major abdominal surgery were identified.Patients receiving pre-operative TPN were compared to controls.We compared the incidence of 30-day infectious and non-infectious post-operative complications between the two groups.Results:A total of 144 CD patients who underwent major abdominal surgery between March 2007 and March 2017 were included.Fifty-five patients who received pre-operative TPN were compared to 89 controls.Twenty-one(14.6%)patients developed infectious complications(18.2%in TPN group vs 12.3%in non-TPN group,P=0.34)and 23(15.9%)developed noninfectious complications(14.5%in TPN group vs 16.9%in non-TPN group,P=0.71).In a multivariate analysis,controlling for differences in baseline disease severity and malnutrition between groups,patients receiving pre-operative TPN for60 days had significantly lower odds of developing non-infectious complications(odds ratio 0.07,95%confidence interval:0.01–0.80,P=0.03).Weight loss of>10%in the past 6 months was a significant predictor of post-operative complications.Conclusions:In a subset of malnourished CD patients,TPN is safe and allows comparable operative outcomes to controls.Pre-operative TPN for60 days reduced post-operative non-infectious complications without associated increase in infectious complications.
文摘AIM To assess the correlation of lateral recess stenosis(LRS) of lumbar segments L4/5 and L5/S1 and the Oswestry Disability Index(ODI).METHODS Nine hundred and twenty-seven patients with history of low back pain were included in this uncontrolled study.On magnetic resonance images(MRI) the lateral recesses(LR) at lumbar levels L4/5 and L5/S1 were evaluated and each nerve root was classified into a 4-point grading scale(Grade 0-3) as normal,not deviated,deviated or compressed.Patient symptoms and disability were assessed using ODI.The Spearman's rank correlation coefficient was used for statistical analysis(P < 0.05).RESULTS Approximately half of the LR revealed stenosis(grade 1-3;52% at level L4/5 and 42% at level L5/S1) with 2.2% and 1.9% respectively reveal a nerve root compression.The ODI score ranged from 0%-91.11% with an arithmetic mean of 34.06% ± 16.89%.We observed a very weak statistically significant positive correlation between ODI and LRS at lumbar levels L4/5 and L5/S1,each bilaterally(L4/5 left:rho < 0.105,P < 0.01;L4/5 right:rho < 0.111,P < 0.01;L5/S1 left:rho 0.128,P < 0.01;L5/S1 right:rho < 0.157,P < 0.001).CONCLUSION Although MRI is the standard imaging tool for diagnosing lumbar spinal stenosis,this study showed only a weak correlation of LRS on MRI and clinical findings.This can be attributed to a number of reasons outlined in this study,underlining that imaging findings alone are not sufficient to establish a reliable diagnosis for patients with LRS.
文摘Correction to:npj Computational Materials https://doi.org/10.1038/s41524-023-00966-0,published online 16 February 2023 The original version of this Article contained several typographical errors in both the PDF and the HTML versions.In the first paragraph of‘Introduction’,the sentence‘(The phrase was coined by Nobel laureate Francis Crick in his book What Mad Pursuit:A personal view of scientific discovery)’duplicated reference 1.The sentence and brackets have been removed in the corrected version.
基金financially supported by the German Research Foundation(509134333)the Australian Research Council(DP220103222)the National Natural Science Foundation of China(11674399)。
文摘Post shut‐in seismic events in enhanced geothermal systems(EGSs)occur predominantly at the outer rim of the co‐injection seismic cloud.The concept of postinjection fracture and fault closure near the injection well has been proposed and validated as a mechanism for enhancing post shut‐in pressure diffusion that promotes seismic hazard.This phenomenon is primarily attributed to the poro‐elastic closure of fractures resulting from the reduction of wellbore pressure after injection termination.However,the thermal effects in EGSs,mainly including heat transfer and thermal stress,may not be trivial and their role in postinjection fault closure and pressure evolution needs to be explored.In this study,we performed numerical simulations to analyze the relative importance of poro‐elasticity,heat transfer,and thermo‐elasticity in promoting postinjection fault closure and pressure diffusion.The numerical model wasfirst validated against analytical solutions in terms offluid pressure diffusion and against heatedflow‐through experiments in terms of thermal processes.We then quantified and distinguished the contribution of each individual mechanism by comparing four different shut‐in scenarios simulated under different coupled conditions.Our results highlight the importance of poro‐elastic fault closure in promoting postinjection pressure buildup and seismicity,and suggest that heat transfer can further augment the fault closure‐induced pressure increase and thus potentially intensify the postinjection seismic hazard,with minimal contribution from thermo‐elasticity.
基金supported by the German Research Foundation(DFG)(Projects Zi 540-12/1 and SFB 622/B1)
文摘The design of mobile robots that can move without wheels or legs is an important engineering and technological problem.Self-propelling mechanisms consisting of a body that has contact with a rough surface and moveable internal masses are considered.Mathematical models of such systems are presented in this paper.First,a model of a vibration driven robot that moves along a rough horizontal plane with isotropic dry friction is studied.It is shown that by changing the off-resonance frequency detuning in sign,one can control the direction of motion of the system.In addition,a locomotion system which moves in an environment with anisotropic viscous friction is considered.For all models,the method of averaging to obtain an algebraic equation for the steady-state＂average＂velocity of the system is used. Prototypes were constructed to compare the theoretical results with experimental ones.
文摘In a paper conceived about five years ago(“Globalization and Public Goods:Too Big to Tackle?”)roughly a dozen factors were linked to explain important causal paths from globalization to the potential output of public goods.The Russian invasion of Ukraine,the corona epidemic,and the increased hegemonic rivalry between China and the U.S.interrupted or even destroyed many of the linkages between globalization and potential public good production.About five important detrimental paths involved in the meantime.In the present article we aim at linking what is left from the previous level of globalization or emerging to form a new and simplified causal model for likely linkages between truncated or(re-)emerging globalization,and the deadly needed output of public goods.These linkages refer to rules of climate control,go to trade linkages and arbitrary tariffs and trade interventions.Regime change,regime formation,and alliance restructuring address aspects of domestic rule and international stability.Selectorate theory,regime type,and exit options for political elites provide key explanatory factors in explaining globalization and public goods productions,or their decay.Where possible we use some data and transformation experiences corroborating our arguments.In other instances need for further empirical macro research will become clear.
