Using lattice configurations for quantum chromodynamics(QCD)generated with three domain-wall fermions at a physical pion mass,we obtain a parameter-free prediction of QCD’s renormalisation-group-invariant process-ind...Using lattice configurations for quantum chromodynamics(QCD)generated with three domain-wall fermions at a physical pion mass,we obtain a parameter-free prediction of QCD’s renormalisation-group-invariant process-independent effective charge,α^(k2).Owing to the dynamical breaking of scale invariance,evident in the emergence of a gluon mass-scale,m0=0.43(1)GeV,this coupling saturates at infrared momenta:α^(0)/π=0.97(4).Amongst other things:α^(k2)is almost identical to the process-dependent(PD)effective charge defined via the Bjorken sum rule;and also that PD charge which,employed in the one-loop evolution equations,delivers agreement between pion parton distribution functions computed at the hadronic scale and experiment.The diversity of unifying roles played byα^(k^2)suggests that it is a strong candidate for that object which represents the interaction strength in QCD at any given momentum scale;and its properties support a conclusion that QCD is a mathematically well-defined quantum field theory in four dimensions.展开更多
Coronavirus disease 2019(COVID-19)causes acute microvascular thrombosis in both venous and arterial structures which is highly associated with increased mortality.The mechanisms leading to thromboembolism are still un...Coronavirus disease 2019(COVID-19)causes acute microvascular thrombosis in both venous and arterial structures which is highly associated with increased mortality.The mechanisms leading to thromboembolism are still under investigation.Current evidence suggests that excessive complement activation with severe amplification of the inflammatory response(cytokine storm)hastens disease progression and initiates complement-dependent cytotoxic tissue damage with resultant prothrombotic complications.The concept of thromboinflammation,involving overt inflammation and activation of the coagulation cascade causing thrombotic microangiopathy and end-organ damage,has emerged as one of the core components of COVID-19 pathogenesis.The complement system is a major mediator of the innate immune response and inflammation and thus an appealing treatment target.In this review,we discuss the role of complement in the development of thrombotic microangiopathy and summarize the current data on complement inhibitors as COVID-19 therapeutics.展开更多
文摘Using lattice configurations for quantum chromodynamics(QCD)generated with three domain-wall fermions at a physical pion mass,we obtain a parameter-free prediction of QCD’s renormalisation-group-invariant process-independent effective charge,α^(k2).Owing to the dynamical breaking of scale invariance,evident in the emergence of a gluon mass-scale,m0=0.43(1)GeV,this coupling saturates at infrared momenta:α^(0)/π=0.97(4).Amongst other things:α^(k2)is almost identical to the process-dependent(PD)effective charge defined via the Bjorken sum rule;and also that PD charge which,employed in the one-loop evolution equations,delivers agreement between pion parton distribution functions computed at the hadronic scale and experiment.The diversity of unifying roles played byα^(k^2)suggests that it is a strong candidate for that object which represents the interaction strength in QCD at any given momentum scale;and its properties support a conclusion that QCD is a mathematically well-defined quantum field theory in four dimensions.
文摘Coronavirus disease 2019(COVID-19)causes acute microvascular thrombosis in both venous and arterial structures which is highly associated with increased mortality.The mechanisms leading to thromboembolism are still under investigation.Current evidence suggests that excessive complement activation with severe amplification of the inflammatory response(cytokine storm)hastens disease progression and initiates complement-dependent cytotoxic tissue damage with resultant prothrombotic complications.The concept of thromboinflammation,involving overt inflammation and activation of the coagulation cascade causing thrombotic microangiopathy and end-organ damage,has emerged as one of the core components of COVID-19 pathogenesis.The complement system is a major mediator of the innate immune response and inflammation and thus an appealing treatment target.In this review,we discuss the role of complement in the development of thrombotic microangiopathy and summarize the current data on complement inhibitors as COVID-19 therapeutics.
