The product of the ∧0/b (-B/0) differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-(-B/0→ J/ψ-K*(892)0)is measured as a function of the beauty hadron transverse mome...The product of the ∧0/b (-B/0) differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-(-B/0→ J/ψ-K*(892)0)is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B(∧0/b→ J/ψ pK-)=(3.17±0.04±0.07±0.34+0.45/-0.28)×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K*(892)0,and the fourth is due to the knowledge of f∧0/b/fd.The sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and y.The previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P+c(→ J/ψp)K-are determined.展开更多
Objectives:Pharyngocutaneous fistula(PCF)is the most common complication to follow total laryngectomy(TL)and is associated with increases in length of hospital stay and with a need for revision surgery or readmission,...Objectives:Pharyngocutaneous fistula(PCF)is the most common complication to follow total laryngectomy(TL)and is associated with increases in length of hospital stay and with a need for revision surgery or readmission,as well as with delays in return to oral diet.Patients who require salvageTL(STL)or primary(chemo)radiation therapy are at higher risk for developing PCF.Due to the quality‐of‐life burden of PCF on patients,limiting this occurrence is crucial.Methods:We conducted a retrospective cohort study of patients undergoing STL with placement of Montgomery salivary bypass tube(MSBT)^(TM)for at least 2 weeks duration between 2013 and 2017 at a single institution.Our patients all underwent free flap reconstruction.Our primary outcome of interest was development of PCF.Secondary outcomes included demographics,previous treatment,base of tongue(BOT)involvement,extent of defect,concurrent neck dissection(ND),and margin status.Univariateχ^(2) analysis was used to evaluate factors associated with PCF.Results:Forty‐four patients underwent STL with Montgomery tube placement and free flap reconstruction.Eight developed PCF(18.2%).The average age was 61.6 years;36 patients were male(81.8%),whereas eight patients were female(18.2%).There was no association between PCF and previous chemoradiation versus radiation(15.8%vs.33.3%,P<0.30),BOT involvement versus not(11.1 vs.22.2%,P<0.38),circumferential versus partial defect(18.8%vs.17.9%,P<0.94),ND versus none(10%vs.25%,P<0.20),or margin status.Conclusion:PCF complicated 18.2%of STL cases at our institution and was not associated with differences in primary treatment modality,presence of concomitant ND,extent of pharyngeal defect,BOT involvement,or positive frozen or permanent surgical margin.展开更多
Objectives:Describe the h index as a bibliometric that can be utilized to objectively evaluate scholarly impact.Identify which otolaryngology subspecialties are the most scholarly.Describe if NIH funding to one’s cho...Objectives:Describe the h index as a bibliometric that can be utilized to objectively evaluate scholarly impact.Identify which otolaryngology subspecialties are the most scholarly.Describe if NIH funding to one’s choice of medical school,residency,or fellowship has any impact on one’s scholarly output.Determine other factors predictive of an academic otolaryngologist’s productivity.Study design:Analysis of bibliometric data of academic otolaryngologists.Methods:Active grants from the National Institutes of Health(NIH)to otolaryngology departments were ascertained via the NIH Research Portfolio Online Reporting Tools Expenditures and Reports database.Faculty listings from these departments were gleaned from departmental websites.H index was calculated using the Scopus database.Results:Forty-seven otolaryngology programs were actively receiving NIH funding.There were 838 faculty members from those departments who had a mean h index of 9.61.Otology(h index 12.50)and head and neck(h index 11.96)were significantly(P<0.0001)more scholarly than the rest of subspecialists.H index was significantly correlative(P<0.0001)with degree of NIH funding at a given institution.H index was not significantly higher for those that attended medical school(P<0.18),residency(P<0.16),and fellowship(P<0.16)at institutions with NIH funding to otolaryngology departments.Conclusions:H index is a bibliometric that can be used to assess scholarly impact.Otology and head and neck are the most scholarly subspecialists within otolaryngology.NIH funding to an individual’s medical school,residency,or fellowship of origin is not correlative with one’s scholarly impact,but current institutional affiliation and choice of subspecialty are.展开更多
2017 Keqiao Fashion Week is about to raise the curtain in October On October 14th-17th,'2017 Keqiao Fashion Week'(referred to as fashion week)will be launched in Keqiao,Zhejiang.Under the guidance of China Nat...2017 Keqiao Fashion Week is about to raise the curtain in October On October 14th-17th,'2017 Keqiao Fashion Week'(referred to as fashion week)will be launched in Keqiao,Zhejiang.Under the guidance of China National Textile and Apparel Council(CNTAC),the fashion week is sponsored by People's Government of Keqiao District of Shaoxing City,and co-organized by China Textile Information Center,China Textiles Development Center。展开更多
Background &Aims: Kinetic modeling of hepatitis C virus(HCV) response to inte rferon (IFN)-based therapy provides insights into factors associated with treat ment outcomes.HCV/human immunodeficiency virus (HIV)-co...Background &Aims: Kinetic modeling of hepatitis C virus(HCV) response to inte rferon (IFN)-based therapy provides insights into factors associated with treat ment outcomes.HCV/human immunodeficiency virus (HIV)-co-infected patients show lower response rates vs. HCV-monoinfected patients. Reasons for this remain un clear. This study evaluated kinetic parameters and treatment responses in co-in fected vs monoinfected patients. Methods: Co-infected patients were randomized within a US multicenter trial (ACTG 5071) to receive pegylated-interferon (PEG -IFN) alfa-2a +ribavirin vs.IFN alfa-2a +ribavirin. Monoinfected controls w ere matched prospectively for treatment, genotype, age, sex, race, and histology .Quantitative HCV-RNA testing was performed at hours 0,6, 12, 24, 48, and 72; d ays 7, 10, 14, 28, and 56; and weeks 12,24, 48, and 72. Results: Twelve HCV/HIV -co-infected and 15 HCV-monoinfected patients underwent viral kinetic samplin g.Among HIV-positive patients the mean CD4+count was 325 cells/mm3. Seventy-f ive percent of patients were genotype 1.The HCV-RNA level was undetectable at 7 2 weeks in 25%and 40%of co-infected and monoinfected patients, respectively.P hase 1/2 declines, free virus clearance rate, and infected hepatocyte death rate were not affected by co-infection status but differed by treatment. Efficiency (e) ≥90%at 60 hours was associated with viral clearance (P =. 02). Modeling w ith pooled parameters suggests baseline viral load is a key factor in time to re sponse in this cohort. Predicted clearance time increased by 28%in co-infected patients. Conclusions: Co-infection status did not affect key kinetic paramete rs. Among kinetic parameters, efficiency was associated significantly with viral clearance. Co-infected patients may require longer treatment duration thanmono infected patients given their generally higher baseline viral loads.展开更多
BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV p...BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and HCC.We previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in Minnesota.AIM To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening program.METHODS We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV antibody.RESULTS Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV infection.Calculated age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,respectively.Seven participants developed incident HCC during follow up.CONCLUSION Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States population.Community-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients.展开更多
On September 7th,Sun Huaibin,vice president of China National Textile and Apparel Council,made a speech with the theme of''Belt and Road Initiative' and the development of China's textile industry'...On September 7th,Sun Huaibin,vice president of China National Textile and Apparel Council,made a speech with the theme of''Belt and Road Initiative' and the development of China's textile industry',to discuss the harvest and direction of China's textile industry under the background of 'Belt and Road Initiative',in the warming-up section of 2017 the the 2nd China(Zhengzhou)International Futures Forum.展开更多
基金Supported by CERN and national agencies:CAPES,CNPq,FAPERJ and FINEP(Brazil)NSFC(China)+17 种基金CNRS/IN2P3(France)BMBF,DFG,HGF and MPG(Germany)INFN(Italy)FOM and NWO(The Netherlands)MNi SW and NCN(Poland)MEN/IFA(Romania)Min ES and FANO(Russia)Min ECo(Spain)SNSF and SER(Switzerland)NASU(Ukraine)STFC(United Kingdom)NSF(USA)supported by IN2P3(France),KIT and BMBF(Germany),INFN(Italy),NWOSURF(The Netherlands),PIC(Spain),Grid PP(United Kingdom)support from EPLANET,Marie Sk lodowska-Curie ActionsERC(European Union),Conseil général de Haute-Savoie,Labex ENIGMASS and OCEVU,RégionAuvergne(France),RFBR(Russia),Xunta GalGENCAT(Spain),Royal Society and Royal Commission for the Exhibition of 1851(United Kingdom)
文摘The product of the ∧0/b (-B/0) differential production cross-section and the branching fraction of the decay ∧0/b→ J/ψ pK-(-B/0→ J/ψ-K*(892)0)is measured as a function of the beauty hadron transverse momentum, PT, and rapidity, y. The kinematic region of the measurements is pT〈20 GeV/c and 2.0 〈g〈4.5.The measurements use a data sample corresponding to an integrated luminosity of 3fb-1 collected by the LHCb detector in pp collisions at centre-of-mass energies √s=7 TeV in 2011 and √s=8 TeV in 2012. Based on previous LHCb results of the fragmentation fraction ratio,f∧0/b/fd,the branching fraction of the decay ∧0/b→ J/ψ pK-is measured to be B(∧0/b→ J/ψ pK-)=(3.17±0.04±0.07±0.34+0.45/-0.28)×10-4,where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay -B/0 →J/ψ-K*(892)0,and the fourth is due to the knowledge of f∧0/b/fd.The sum of the asymmetries in the production and decay between ∧0/b and ∧0/bis also measured as a function of PT and y.The previously published branching fraction of ∧0/b→ J/ψ pπ-,relative to that of ∧0/b→ J/ψ pK-,is updated. The branching fractions of ∧0/b→P+c(→ J/ψp)K-are determined.
文摘Objectives:Pharyngocutaneous fistula(PCF)is the most common complication to follow total laryngectomy(TL)and is associated with increases in length of hospital stay and with a need for revision surgery or readmission,as well as with delays in return to oral diet.Patients who require salvageTL(STL)or primary(chemo)radiation therapy are at higher risk for developing PCF.Due to the quality‐of‐life burden of PCF on patients,limiting this occurrence is crucial.Methods:We conducted a retrospective cohort study of patients undergoing STL with placement of Montgomery salivary bypass tube(MSBT)^(TM)for at least 2 weeks duration between 2013 and 2017 at a single institution.Our patients all underwent free flap reconstruction.Our primary outcome of interest was development of PCF.Secondary outcomes included demographics,previous treatment,base of tongue(BOT)involvement,extent of defect,concurrent neck dissection(ND),and margin status.Univariateχ^(2) analysis was used to evaluate factors associated with PCF.Results:Forty‐four patients underwent STL with Montgomery tube placement and free flap reconstruction.Eight developed PCF(18.2%).The average age was 61.6 years;36 patients were male(81.8%),whereas eight patients were female(18.2%).There was no association between PCF and previous chemoradiation versus radiation(15.8%vs.33.3%,P<0.30),BOT involvement versus not(11.1 vs.22.2%,P<0.38),circumferential versus partial defect(18.8%vs.17.9%,P<0.94),ND versus none(10%vs.25%,P<0.20),or margin status.Conclusion:PCF complicated 18.2%of STL cases at our institution and was not associated with differences in primary treatment modality,presence of concomitant ND,extent of pharyngeal defect,BOT involvement,or positive frozen or permanent surgical margin.
文摘Objectives:Describe the h index as a bibliometric that can be utilized to objectively evaluate scholarly impact.Identify which otolaryngology subspecialties are the most scholarly.Describe if NIH funding to one’s choice of medical school,residency,or fellowship has any impact on one’s scholarly output.Determine other factors predictive of an academic otolaryngologist’s productivity.Study design:Analysis of bibliometric data of academic otolaryngologists.Methods:Active grants from the National Institutes of Health(NIH)to otolaryngology departments were ascertained via the NIH Research Portfolio Online Reporting Tools Expenditures and Reports database.Faculty listings from these departments were gleaned from departmental websites.H index was calculated using the Scopus database.Results:Forty-seven otolaryngology programs were actively receiving NIH funding.There were 838 faculty members from those departments who had a mean h index of 9.61.Otology(h index 12.50)and head and neck(h index 11.96)were significantly(P<0.0001)more scholarly than the rest of subspecialists.H index was significantly correlative(P<0.0001)with degree of NIH funding at a given institution.H index was not significantly higher for those that attended medical school(P<0.18),residency(P<0.16),and fellowship(P<0.16)at institutions with NIH funding to otolaryngology departments.Conclusions:H index is a bibliometric that can be used to assess scholarly impact.Otology and head and neck are the most scholarly subspecialists within otolaryngology.NIH funding to an individual’s medical school,residency,or fellowship of origin is not correlative with one’s scholarly impact,but current institutional affiliation and choice of subspecialty are.
文摘2017 Keqiao Fashion Week is about to raise the curtain in October On October 14th-17th,'2017 Keqiao Fashion Week'(referred to as fashion week)will be launched in Keqiao,Zhejiang.Under the guidance of China National Textile and Apparel Council(CNTAC),the fashion week is sponsored by People's Government of Keqiao District of Shaoxing City,and co-organized by China Textile Information Center,China Textiles Development Center。
文摘Background &Aims: Kinetic modeling of hepatitis C virus(HCV) response to inte rferon (IFN)-based therapy provides insights into factors associated with treat ment outcomes.HCV/human immunodeficiency virus (HIV)-co-infected patients show lower response rates vs. HCV-monoinfected patients. Reasons for this remain un clear. This study evaluated kinetic parameters and treatment responses in co-in fected vs monoinfected patients. Methods: Co-infected patients were randomized within a US multicenter trial (ACTG 5071) to receive pegylated-interferon (PEG -IFN) alfa-2a +ribavirin vs.IFN alfa-2a +ribavirin. Monoinfected controls w ere matched prospectively for treatment, genotype, age, sex, race, and histology .Quantitative HCV-RNA testing was performed at hours 0,6, 12, 24, 48, and 72; d ays 7, 10, 14, 28, and 56; and weeks 12,24, 48, and 72. Results: Twelve HCV/HIV -co-infected and 15 HCV-monoinfected patients underwent viral kinetic samplin g.Among HIV-positive patients the mean CD4+count was 325 cells/mm3. Seventy-f ive percent of patients were genotype 1.The HCV-RNA level was undetectable at 7 2 weeks in 25%and 40%of co-infected and monoinfected patients, respectively.P hase 1/2 declines, free virus clearance rate, and infected hepatocyte death rate were not affected by co-infection status but differed by treatment. Efficiency (e) ≥90%at 60 hours was associated with viral clearance (P =. 02). Modeling w ith pooled parameters suggests baseline viral load is a key factor in time to re sponse in this cohort. Predicted clearance time increased by 28%in co-infected patients. Conclusions: Co-infection status did not affect key kinetic paramete rs. Among kinetic parameters, efficiency was associated significantly with viral clearance. Co-infected patients may require longer treatment duration thanmono infected patients given their generally higher baseline viral loads.
基金Supported by the Mayo Clinic Center for Clinical and Translational Science from the National Center for Advancing Translational Sciences (5UL1TR000135-10)the Mayo Clinic Hepatobiliary SPORE from the National Cancer Institute (5P50CA210964-04)+1 种基金the Mayo Clinic Center for Cell Signaling in Gastroenterology (5P30DK084567-14)Gilead Sciences,Inc.(IN-US-174-0230)
文摘BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and HCC.We previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in Minnesota.AIM To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening program.METHODS We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV antibody.RESULTS Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV infection.Calculated age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,respectively.Seven participants developed incident HCC during follow up.CONCLUSION Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States population.Community-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients.
文摘On September 7th,Sun Huaibin,vice president of China National Textile and Apparel Council,made a speech with the theme of''Belt and Road Initiative' and the development of China's textile industry',to discuss the harvest and direction of China's textile industry under the background of 'Belt and Road Initiative',in the warming-up section of 2017 the the 2nd China(Zhengzhou)International Futures Forum.