Amyotrophic lateral sclerosis (ALS) is one of the most dreadful neurodegenerative diseases leading to death within 1-5 years after symptom onset.The majority of ALS cases are sporadic(sALS),while the remaining 5-10%ar...Amyotrophic lateral sclerosis (ALS) is one of the most dreadful neurodegenerative diseases leading to death within 1-5 years after symptom onset.The majority of ALS cases are sporadic(sALS),while the remaining 5-10%are familial(fALS).Genetic discoveries have identified ALScausative mutations in more than 30 genes so far(Chia et al.,2018).Indeed,the four most common mutations observed in ALS genes in Europe are the hexanucleotide expansion repeat in Chromosome9 Open Reading Frame 72 (C9ORF72),Cu-Zn superoxide dismutase 1 (SOD1),tra nsactive response DNA Binding protein 43kDa (TARDBP)and fused in sa rcoma (FUS).展开更多
Producer gas through gasification of biomass can be used as an alternate fuel in rural areas due to high potential of biomass resources in India.Experiments were conducted to study the performance of a diesel engine(f...Producer gas through gasification of biomass can be used as an alternate fuel in rural areas due to high potential of biomass resources in India.Experiments were conducted to study the performance of a diesel engine(four stroke,single cylinder,5.25 kW) with respect to its thermal efficiency,specific fuel consumption and diesel substitution by use of diesel alone and producer gas-cum-diesel(dual fuel mode).Three types of biomass,i.e.wood chips,pigeon pea stalks and corn cobs were used for generation of producer gas.A producer gas system consisting of a downdraft gasifier,a cooling cum cleaning unit,a filtering unit and a gas air mixing device was designed,fabricated and used to power a 5.25 kW diesel engine on dual fuel mode.Performance of the engine was reported by keeping biomass moisture contents as 8%,12%,16%,and 21%,engine speed as 1 600 r/min and with variable engine loads.The average value of thermal efficiency on dual fuel mode was found slightly lower than that of diesel mode.The specific diesel consumption was found to be 60%-64% less in dual fuel mode than that in diesel mode for the same amount of energy output.The average diesel substitution of 74% was observed with wood chips followed by corn cobs(78%) and pigeon pea stalks(82%).Based on the performance studied,the producer gas may be used as a substitute or as supplementary fuel for diesel conservation,particularly for stationary engines in agricultural operations in the farm.展开更多
With an aim to improve the transient stability of a DFIG wind farm penetrated multimachine power system(MPN),an adaptive fractional integral terminal sliding mode power control(AFITSMPC)strategy has been proposed for ...With an aim to improve the transient stability of a DFIG wind farm penetrated multimachine power system(MPN),an adaptive fractional integral terminal sliding mode power control(AFITSMPC)strategy has been proposed for the unified power flow controller(UPFC),which is compensating the MPN.The proposed AFITSMPC controls the dq-axis series injected voltage,which controls the admittance model(AM)of the UPFC.As a result the power output of the DFIG stabilizes which helps in maintaining the equilibrium between the electrical and mechanical power of the nearby generators.Subsequently the rotor angular deviation of the respective generators gets recovered,which significantly stabilizes the MPN.The proposed AFITSMPC for the admittance model of the UPFC has been validated in a DFIG wind farm penetrated 2 area 4 machine power system in the MATLAB environment.The robustness and efficacy of the proposed control strategy of the UPFC,in contrast to the conventional PI control is vindicated under a number of intrinsic operating conditions,and the results analyzed are satisfactory.展开更多
An accurate short-term wind speed prediction algorithm based on the efficient kernel ridge pseudo inverse neural network （KRPINN） variants is proposed in this paper. The use of nonlinear kernel functions in pseudo i...An accurate short-term wind speed prediction algorithm based on the efficient kernel ridge pseudo inverse neural network （KRPINN） variants is proposed in this paper. The use of nonlinear kernel functions in pseudo inverse neural networks eliminates the trial and error approach of choosing the number of hidden layer neurons and their activation functions. The robustness of the proposed method has been validated in comparison with other models such as pseudo inverse radial basis function （PIRBF） and Legendre tanh activation function based neural network, i.e., PILNNT, whose input weights to the hidden layer weights are optimized using an adaptive firefly algorithm, i.e., FFA. However, since the individual kernel functions based KRPINN may not be able to produce accurate forecasts under chaotically varying wind speed conditions, a linear combination of individual kernel functions is used to build the multi kernel ridge pseudo inverse neural network （MK-RPINN） for providing improved forecasting accuracy, generalization, and stability of the wind speed prediction model. Several case studies have been presented to validate the accuracy of the short-term wind speed prediction models using the real world wind speed data from a wind farm in the Wyoming State of USA over time horizons varying from 10 minutes to 5 hours.展开更多
Forecasting wind speed is an extremely complicated and challenging problem due to its chaotic nature and its dependence on several atmospheric conditions.Although there are several intelligent techniques in the litera...Forecasting wind speed is an extremely complicated and challenging problem due to its chaotic nature and its dependence on several atmospheric conditions.Although there are several intelligent techniques in the literature for wind speed prediction,their accuracies are not yet very reliable.Therefore,in this paper,a new hybrid intelligent technique named the deep mixed kernel random vector functional-link network auto-encoder(AE)is proposed for wind speed prediction.The proposed method eliminates manual tuning of hidden nodes with random weights and biases,providing prediction model generalization and representation learning.This reduces reconstruction error due to the exact inversion of the kernel matrix,unlike the pseudo-inverse in a random vector functional-link network,and short-ens the execution time.Furthermore,the presence of a direct link from the input to the output reduces the complexity of the prediction model and improves the prediction accuracy.The kernel parameters and coefficients of the mixed kernel system are optimized using a new chaotic sine–cosine Levy flight optimization technique.The lowest errors in terms of mean absolute error(0.4139),mean absolute percentage error(4.0081),root mean square error(0.4843),standard deviation error(1.1431)and index of agreement(0.9733)prove the efficiency of the proposed model in comparison with other deep learning models such as deep AEs,deep kernel extreme learning ma-chine AEs,deep kernel random vector functional-link network AEs,benchmark models such as least square support vector machine,autoregressive integrated moving average,extreme learning machines and their hybrid models along with different state-of-the-art methods.展开更多
A Fourier kernel based time-frequency transform is a proven candidate for non-stationary signal analysis and pattern recognition because of its ability to predict time localized spectrum and global phase reference cha...A Fourier kernel based time-frequency transform is a proven candidate for non-stationary signal analysis and pattern recognition because of its ability to predict time localized spectrum and global phase reference characteristics.However,it suffers from heavy computational overhead and large execution time.The paper,therefore,uses a novel fast discrete sparse S-transform(SST)suitable for extracting time frequency response to monitor non-stationary signal parameters,which can be ultimately used for disturbance detection,and their pattern classification.From the sparse S-transform matrix,some relevant features have been extracted which are used to distinguish among different non-stationary signals by a fuzzy decision tree based classifier.This algorithm is robust under noisy conditions.Various power quality as well as chirp signals have been simulated and tested with the proposed technique in noisy conditions as well.Some real time mechanical faulty signals have been collected to demonstrate the efficiency of the proposed algorithm.All the simulation results imply that the proposed technique is very much efficient.展开更多
This paper proposes a pattern recognition based differential spectral energy protection scheme for ac microgrids using a Fourier kernel based fast sparse time-frequency representation(SST or simply the sparse S-Transf...This paper proposes a pattern recognition based differential spectral energy protection scheme for ac microgrids using a Fourier kernel based fast sparse time-frequency representation(SST or simply the sparse S-Transform).The average and differential current components are passed through a change detection filter,which senses the instant of fault inception and registers a change detection point(CDP).Subsequently,if CDP is registered for one or more phases,then half cycle data samples of the average and differential currents on either side of the CDP are passed through the proposed SST technique,which generates their respective spectral energies and a simple comparison between them detects the occurrence and type of the fault.The SST technique is also used to provide voltage and current phasors and the frequency during faults which is further utilized to estimate the fault location.The proposed technique as compared to conventional differential current protection scheme is quicker in fault detection and classification,which is least effected from bias setting,has a faster relay trip response(less than one cycle from fault incipient)and a better accuracy in fault location.The significance and accuracy of the proposed scheme have been verified extensively for faults in a standard microgrid system,subjected to a large number of operating conditions and the outputs vindicate it to be a potential candidate for real time applications.展开更多
Condition monitoring is implementation of the advanced diagnostic techniques to reduce downtime and to increase the efficiency and reliability.The research is for determining the usage of advanced techniques like Vibr...Condition monitoring is implementation of the advanced diagnostic techniques to reduce downtime and to increase the efficiency and reliability.The research is for determining the usage of advanced techniques like Vibration analysis,Oil analysis and Thermography to diagnose ensuing problems of the Plant and Machinery at an early stage and plan to take corrective and preventive actions to eliminate the forthcoming breakdown and enhancing the reliability of the system.Nowadays,the most of the industries have adopted the condition monitoring techniques as a part of support system to the basic maintenance strategies.Major condition monitoring technique they follow is Vibration Spectrum Analysis,which can detect faults at a very early stage.However implementation of other techniques like Oil analysis or Ferrography,Thermography etc.can further enhance the data interpretation as they would detect the source of abnormality at much early stage thus providing us with a longer lead time to plan and take the corrective actions.In Large Captive Power Plants and Aluminium Smelters,Integrated Condition Monitoring techniques play an important role as stoppage of primary system and its auxiliaries(boiler,steam turbine,generator,coal and ash handling plants etc.)results into the stoppage of the entire plant,which in turn leads to loss of productivity.From economical and operational point of view,it is desirable to ensure optimum level of system availability.展开更多
基金Hermann und Lilly Schilling Stiftung für Medizinische Forschung im Stifterverbond (to AH)。
文摘Amyotrophic lateral sclerosis (ALS) is one of the most dreadful neurodegenerative diseases leading to death within 1-5 years after symptom onset.The majority of ALS cases are sporadic(sALS),while the remaining 5-10%are familial(fALS).Genetic discoveries have identified ALScausative mutations in more than 30 genes so far(Chia et al.,2018).Indeed,the four most common mutations observed in ALS genes in Europe are the hexanucleotide expansion repeat in Chromosome9 Open Reading Frame 72 (C9ORF72),Cu-Zn superoxide dismutase 1 (SOD1),tra nsactive response DNA Binding protein 43kDa (TARDBP)and fused in sa rcoma (FUS).
文摘Producer gas through gasification of biomass can be used as an alternate fuel in rural areas due to high potential of biomass resources in India.Experiments were conducted to study the performance of a diesel engine(four stroke,single cylinder,5.25 kW) with respect to its thermal efficiency,specific fuel consumption and diesel substitution by use of diesel alone and producer gas-cum-diesel(dual fuel mode).Three types of biomass,i.e.wood chips,pigeon pea stalks and corn cobs were used for generation of producer gas.A producer gas system consisting of a downdraft gasifier,a cooling cum cleaning unit,a filtering unit and a gas air mixing device was designed,fabricated and used to power a 5.25 kW diesel engine on dual fuel mode.Performance of the engine was reported by keeping biomass moisture contents as 8%,12%,16%,and 21%,engine speed as 1 600 r/min and with variable engine loads.The average value of thermal efficiency on dual fuel mode was found slightly lower than that of diesel mode.The specific diesel consumption was found to be 60%-64% less in dual fuel mode than that in diesel mode for the same amount of energy output.The average diesel substitution of 74% was observed with wood chips followed by corn cobs(78%) and pigeon pea stalks(82%).Based on the performance studied,the producer gas may be used as a substitute or as supplementary fuel for diesel conservation,particularly for stationary engines in agricultural operations in the farm.
文摘With an aim to improve the transient stability of a DFIG wind farm penetrated multimachine power system(MPN),an adaptive fractional integral terminal sliding mode power control(AFITSMPC)strategy has been proposed for the unified power flow controller(UPFC),which is compensating the MPN.The proposed AFITSMPC controls the dq-axis series injected voltage,which controls the admittance model(AM)of the UPFC.As a result the power output of the DFIG stabilizes which helps in maintaining the equilibrium between the electrical and mechanical power of the nearby generators.Subsequently the rotor angular deviation of the respective generators gets recovered,which significantly stabilizes the MPN.The proposed AFITSMPC for the admittance model of the UPFC has been validated in a DFIG wind farm penetrated 2 area 4 machine power system in the MATLAB environment.The robustness and efficacy of the proposed control strategy of the UPFC,in contrast to the conventional PI control is vindicated under a number of intrinsic operating conditions,and the results analyzed are satisfactory.
文摘An accurate short-term wind speed prediction algorithm based on the efficient kernel ridge pseudo inverse neural network （KRPINN） variants is proposed in this paper. The use of nonlinear kernel functions in pseudo inverse neural networks eliminates the trial and error approach of choosing the number of hidden layer neurons and their activation functions. The robustness of the proposed method has been validated in comparison with other models such as pseudo inverse radial basis function （PIRBF） and Legendre tanh activation function based neural network, i.e., PILNNT, whose input weights to the hidden layer weights are optimized using an adaptive firefly algorithm, i.e., FFA. However, since the individual kernel functions based KRPINN may not be able to produce accurate forecasts under chaotically varying wind speed conditions, a linear combination of individual kernel functions is used to build the multi kernel ridge pseudo inverse neural network （MK-RPINN） for providing improved forecasting accuracy, generalization, and stability of the wind speed prediction model. Several case studies have been presented to validate the accuracy of the short-term wind speed prediction models using the real world wind speed data from a wind farm in the Wyoming State of USA over time horizons varying from 10 minutes to 5 hours.
文摘Forecasting wind speed is an extremely complicated and challenging problem due to its chaotic nature and its dependence on several atmospheric conditions.Although there are several intelligent techniques in the literature for wind speed prediction,their accuracies are not yet very reliable.Therefore,in this paper,a new hybrid intelligent technique named the deep mixed kernel random vector functional-link network auto-encoder(AE)is proposed for wind speed prediction.The proposed method eliminates manual tuning of hidden nodes with random weights and biases,providing prediction model generalization and representation learning.This reduces reconstruction error due to the exact inversion of the kernel matrix,unlike the pseudo-inverse in a random vector functional-link network,and short-ens the execution time.Furthermore,the presence of a direct link from the input to the output reduces the complexity of the prediction model and improves the prediction accuracy.The kernel parameters and coefficients of the mixed kernel system are optimized using a new chaotic sine–cosine Levy flight optimization technique.The lowest errors in terms of mean absolute error(0.4139),mean absolute percentage error(4.0081),root mean square error(0.4843),standard deviation error(1.1431)and index of agreement(0.9733)prove the efficiency of the proposed model in comparison with other deep learning models such as deep AEs,deep kernel extreme learning ma-chine AEs,deep kernel random vector functional-link network AEs,benchmark models such as least square support vector machine,autoregressive integrated moving average,extreme learning machines and their hybrid models along with different state-of-the-art methods.
文摘A Fourier kernel based time-frequency transform is a proven candidate for non-stationary signal analysis and pattern recognition because of its ability to predict time localized spectrum and global phase reference characteristics.However,it suffers from heavy computational overhead and large execution time.The paper,therefore,uses a novel fast discrete sparse S-transform(SST)suitable for extracting time frequency response to monitor non-stationary signal parameters,which can be ultimately used for disturbance detection,and their pattern classification.From the sparse S-transform matrix,some relevant features have been extracted which are used to distinguish among different non-stationary signals by a fuzzy decision tree based classifier.This algorithm is robust under noisy conditions.Various power quality as well as chirp signals have been simulated and tested with the proposed technique in noisy conditions as well.Some real time mechanical faulty signals have been collected to demonstrate the efficiency of the proposed algorithm.All the simulation results imply that the proposed technique is very much efficient.
文摘This paper proposes a pattern recognition based differential spectral energy protection scheme for ac microgrids using a Fourier kernel based fast sparse time-frequency representation(SST or simply the sparse S-Transform).The average and differential current components are passed through a change detection filter,which senses the instant of fault inception and registers a change detection point(CDP).Subsequently,if CDP is registered for one or more phases,then half cycle data samples of the average and differential currents on either side of the CDP are passed through the proposed SST technique,which generates their respective spectral energies and a simple comparison between them detects the occurrence and type of the fault.The SST technique is also used to provide voltage and current phasors and the frequency during faults which is further utilized to estimate the fault location.The proposed technique as compared to conventional differential current protection scheme is quicker in fault detection and classification,which is least effected from bias setting,has a faster relay trip response(less than one cycle from fault incipient)and a better accuracy in fault location.The significance and accuracy of the proposed scheme have been verified extensively for faults in a standard microgrid system,subjected to a large number of operating conditions and the outputs vindicate it to be a potential candidate for real time applications.
文摘Condition monitoring is implementation of the advanced diagnostic techniques to reduce downtime and to increase the efficiency and reliability.The research is for determining the usage of advanced techniques like Vibration analysis,Oil analysis and Thermography to diagnose ensuing problems of the Plant and Machinery at an early stage and plan to take corrective and preventive actions to eliminate the forthcoming breakdown and enhancing the reliability of the system.Nowadays,the most of the industries have adopted the condition monitoring techniques as a part of support system to the basic maintenance strategies.Major condition monitoring technique they follow is Vibration Spectrum Analysis,which can detect faults at a very early stage.However implementation of other techniques like Oil analysis or Ferrography,Thermography etc.can further enhance the data interpretation as they would detect the source of abnormality at much early stage thus providing us with a longer lead time to plan and take the corrective actions.In Large Captive Power Plants and Aluminium Smelters,Integrated Condition Monitoring techniques play an important role as stoppage of primary system and its auxiliaries(boiler,steam turbine,generator,coal and ash handling plants etc.)results into the stoppage of the entire plant,which in turn leads to loss of productivity.From economical and operational point of view,it is desirable to ensure optimum level of system availability.
