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抗表皮生长因子受体和抗血管内皮生长因子药物在非小细胞肺癌治疗中的作用 被引量:16
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作者 Corey langer Jean-Charles SORIA +1 位作者 南娟(翻译) 丁燕(校对) 《中国肺癌杂志》 CAS 2010年第9期924-936,共13页
采用以铂类药物为基础联合细胞毒性药物作为非小细胞肺癌(non-small-cell lung cancer,NSCLC)的标准化一线治疗的疗效已达到相应的平台。作用于特定通路的新型分子靶向药物逐渐成为治疗NSCLC的有效药物;某些药物的III期试验已取得阳性... 采用以铂类药物为基础联合细胞毒性药物作为非小细胞肺癌(non-small-cell lung cancer,NSCLC)的标准化一线治疗的疗效已达到相应的平台。作用于特定通路的新型分子靶向药物逐渐成为治疗NSCLC的有效药物;某些药物的III期试验已取得阳性结果。值得注意的是,有研究证实,采用抗血管内皮生长因子(vascular endothelial growth factor,VEGF)抗体贝伐珠单抗抑制VEGF通路,以及采用表皮生长因子受体(epidermal growth factor receptor,EGFR)的小分子酪氨酸激酶抑制剂厄洛替尼或单克隆抗体(西妥昔单抗)靶向作用于EGFR通路作为一线或二线治疗方案,均可延长晚期肺癌患者的生存期。可导致肿瘤细胞存活和增殖的信号处理过程不同,为靶向作用于多种信号通路为有效的抗癌治疗策略提供了依据。因此,分子靶向药物的合理联用可能达到更好的临床疗效,并可成为对标准化疗耐药或不能耐受标准化疗的患者的可替代的治疗选择。目前的挑战在于明确应探寻哪些分子实体,以及它们的最佳联合方案。本综述旨在探讨贝伐珠单抗联合厄洛替尼抑制血管生成和EGFR信号作为治疗NSCLC的有效的非化疗方案的潜在临床疗效。其它可阻滞EGFR和血管生成通路以及互补信号通路的新型药物的联合具有独特的作用机制和较轻的毒副作用,有可能为晚期NSCLC患者的个体化治疗选择提供更多的治疗方案。 展开更多
关键词 抗血管内皮生长因子 抗表皮生长因子受体 细胞毒性药物 非小细胞肺癌 一线治疗 receptor 酪氨酸激酶抑制剂 分子靶向药物
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帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析 被引量:6
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作者 周清(翻译校对) Steven F Powell +14 位作者 Delvys Rodríguez-Abreu Corey J langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第1期I0007-I0018,共12页
背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患... 背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良 展开更多
关键词 帕博利珠单抗 脑转移 化疗 非小细胞肺癌 PD-L1
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类固体非晶态材料的变形与失效 被引量:4
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作者 Falk M L langer J S +1 位作者 陈艳(译) 王云江(校) 《力学进展》 EI CSCD 北大核心 2021年第2期406-426,共21页
自20世纪70年代以来,类固体非晶态材料变形与失效的理论模型相继出现,这些模型基于应力驱动分子重排从而在局部流动缺陷处发生剪切转变这一物理图像.该图像是现代剪切转变区理论的基础,也是本综述的焦点.我们将首先概述该理论框架并给... 自20世纪70年代以来,类固体非晶态材料变形与失效的理论模型相继出现,这些模型基于应力驱动分子重排从而在局部流动缺陷处发生剪切转变这一物理图像.该图像是现代剪切转变区理论的基础,也是本综述的焦点.我们将首先概述该理论框架并给出一些应用案例,特别是块体金属玻璃应力−应变测量结果的阐释,剪切带数值模拟分析和剪切转变区运动方程在自由边界计算中的应用.在本综述的第二部分,为简单起见,将关注非晶塑性的非热模型,并基于该模型说明剪切转变区理论是如何从非平衡热力学的系统描述中发展起来的. 展开更多
关键词 塑性 非平衡热力学 剪切转变区
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Fungal diversity notes 1277-1386:taxonomic and phylogenetic contributions to fungal taxa 被引量:6
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作者 Hai-Sheng Yuan Xu Lu +88 位作者 Yu-Cheng Dai Kevin D.Hyde Yu-He Kan Ivana Kušan Shuang-Hui He Ning-Guo Liu V.Venkateswara Sarma Chang-Lin Zhao Bao-Kai Cui Nousheen Yousaf Guangyu Sun Shu-Yan Liu Fang Wu Chuan-Gen Lin Monika C.Dayarathne Tatiana Baptista Gibertoni Lucas B.Conceição Roberto Garibay-Orijel Margarita Villegas-Ríos Rodolfo Salas-Lizana Tie-Zheng Wei Jun-Zhi Qiu Ze-Fen Yu Rungtiwa Phookamsak Ming Zeng Soumitra Paloi Dan-Feng Bao Pranami DAbeywickrama De-Ping Wei Jing Yang Ishara S.Manawasinghe Dulanjalee Harishchandra Rashika S.Brahmanage Nimali Ide Silva Danushka S.Tennakoon Anuruddha Karunarathna Yusufjon Gafforov Dhandevi Pem Sheng-Nan Zhang AndréL.C.Mde Azevedo Santiago Jadson Diogo Pereira Bezerra Bálint Dima Krishnendu Acharya Julieta Alvarez-Manjarrez Ali H.Bahkali Vinod K.Bhatt Tor Erik Brandrud Timur S.Bulgakov E.Camporesi Ting Cao Yu-Xi Chen Yuan-Yuan Chen Bandarupalli Devadatha Abdallah M.Elgorban Long-Fei Fan Xing Du Liu Gao Camila Melo Gonçalves Luis F.P.Gusmão Naruemon Huanraluek Margita Jadan Ruvishika S.Jayawardena Abdul Nasir Khalid Ewald langer Diogo X.Lima Nelson Correia de Lima-Júnior Carla Rejane Sousa de Lira Jian-Kui(Jack)Liu Shun Liu Saisamorn Lumyong Zong-Long Luo Neven Matočec M.Niranjan JoséRibamar Costa Oliveira-Filho Viktor Papp Eduardo Pérez-Pazos Alan J.L.Phillips Peng-Lei Qiu Yihua Ren Rafael F.Castañeda Ruiz Kamal C.Semwal Karl Soop Carlos A.Fde Souza Cristina Maria Souza-Motta Li-Hua Sun Meng-Le Xie Yi-Jian Yao Qi Zhao Li-Wei Zhou 《Fungal Diversity》 SCIE 2020年第5期1-266,共266页
This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and s... This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and strain culture,combined with DNA sequence analyses.110 taxa are described and illustrated,including five new genera,92 new species,eight new combinations and other taxonomic contributions(one new sequenced species,one new host and three new records)which are accommodated in 40 families and 1 incertae sedis in Dothideomycetes.The new genera are Amyloceraceomyces,Catenuliconidia,Hansenopezia,Ionopezia and Magnopulchromyces.The new species are Amyloceraceomyces angustisporus,Amylocorticium ellipsosporum,Arthrinium sorghi,Catenuliconidia uniseptata,Clavulina sphaeropedunculata,Colletotrichum parthenocissicola,Coniothyrium triseptatum,Cortinarius indorusseus,C.paurigarhwalensis,C.sinensis,C.subsanguineus,C.xiaojinensis,Diaporthe pimpinel-lae,Dictyosporella guizhouensis,Diplodia torilicola,Fuscoporia marquesiana,F.semiarida,Hansenopezia decora,Helicoarcta-tus thailandicus,Hirsutella hongheensis,Humidicutis brunneovinacea,Lentaria gossypina,L.variabilis,Lycoperdon lahorense,L.pseudocurtisii,Magnopulchromyces scorpiophorus,Moelleriella gracilispora,Neodevriesia manglicola,Neodidymelliopsis salvia,N.urticae,Neoroussoella magnoliae,Neottiella gigaspora,Ophiosphaerella chiangraiensis,Phaeotremella yunnanensis,Podosphaera yulii,Rigidoporus juniperinus,Rhodofomitopsis pseudofeei,Russula benghalensis,Scleroramularia vermispora,Scytinopogon minisporus,Sporormurispora paulsenii,Thaxteriellopsis obliqus,Tomentella asiae-orientalis,T.atrobadia,T.atrocastanea,T.aureomarginata,T.brevis,T.brunneoflava,T.brunneogrisea,T.capitatocystidiata,T.changbaiensis,T.citri-nocystidiata,T.coffeae,T.conclusa,T.cystidiata,T.dimidiata,T.duplexa,T.efibulata,T.efibulis,T.farinosa,T.flavidobadia,T.fuscocrustosa,T.fuscofarinosa,T.fuscogranulosa,T.fuscopelliculosa,T.globospora,T.gloeocystidiata,T.griseocastanea,T.griseofusca,T.griseomarginata 展开更多
关键词 110 taxa AGARICOMYCETES ASCOMYCOTA BASIDIOMYCOTA Mucoromycota New combinations New genera New species Phylogeny Taxonomy
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A novel mortality risk score for emphysematous pyelonephritis:A multicenter study of the Global Research in the Emphysematous Pyelonephritis group
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作者 Hegel Trujillo-Santamaría José Iván Robles-Torres +30 位作者 Jeremy Yuen-Chun Teoh Yiloren Tanidir José Gadú Campos-Salcedo Edgar Iván Bravo-Castro Marcelo langer Wroclawski W.S.Yeoh Santosh Kumar Juan Eduardo Sanchez-Nuñez José Enrique Espinoza-Aznar Deepak Ragoori Saeed Bin Hamri Ong Teng Aik Cecil Paul Tarot-Chocooj Anil Shrestha Mohamed Amine Lakmichi Mateus Cosentino-Bellote Luis Gabriel Vázquez-Lavista Boukary Kabre Ho Yee Tiong José Gustavo Arrambide-Herrera Lauro Salvador Gómez-Guerra Umut Kutukoglu Joao Arthur Brunhara Alves-Barbosa Jorge Jaspersen Christian Acevedo Francisco Virgen-Gutiérrez Sumit Agrawal Hugo Octaviano Duarte-Santos Chai Chu Ann Daniele Castellani Vineet Gahuar 《Current Urology》 2024年第1期55-60,共6页
Background:Emphysematous pyelonephritis(EPN)is a necrotizing infection of the kidney and the surrounding tissues associated with considerable mortality.We aimed to formulate a score that classifies the risk of mortali... Background:Emphysematous pyelonephritis(EPN)is a necrotizing infection of the kidney and the surrounding tissues associated with considerable mortality.We aimed to formulate a score that classifies the risk of mortality in patients with EPN at hospital admission.Materials and methods:Patients diagnosed with EPN between 2013 and 2020 were retrospectively included.Data from 15 centers(70%)were used to develop the scoring system,and data from 7 centers(30%)were used to validate it.Univariable and mułtivariable logistic regression analyses were performed to identify independent factors related to mortality.Receiver operating characteristic curve analysis was performed to construct the sconng system and calculate the risk of mortality.A standardized regression coefficient was used to quantify the discriminating power of each factor to convert the individual coefficients into points.The area under the curve was used to quantify the scoring system performance.An 8-point scoring system for the mortality risk was created(range,0-7).Results:In total,570 patients were included(400 in the test group and 170 in the validation group).Independent predictors of mortality in the multivariable logistic regression were included in the scoring system:quick Sepsis-related Organ Failure Assessment score≥2(2 points),anemia,paranephric gas extension,leukocyte count>22,000/pL,thrombocytopenia,and hyperglycemia(1 point each).The mortality rate was<5%for scores≤3,83.3%for scores 6,and 100%for scores 7.The area under the Curve was 0.90(95%confidence interval,0.84-0.95)for test and 0.91(95%confidence interval,0.84-0.97)for the validation group.Condusions:Our score predicts the risk of mortality in patients with EPN at presentation and may help clinicians identify patients at a higher risk of death. 展开更多
关键词 Emphysematous pyelonephritis MORTALITY PROGNOSIS
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Prevention of thromboembolic events after radical prostatectomy in patients with hereditary thrombophilia due to a factor V Leiden mutation by multidisciplinary coagulation management
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作者 Randi M.Pose Sophie Knipper +6 位作者 Jonas Ekrutt Mara Kölker Pierre Tennstedt Hans Heinzer Derya Tilki Florian langer Markus Graefen 《Asian Journal of Urology》 CSCD 2024年第1期42-47,共6页
Objective:To examine the perioperative impact of factor V Leiden mutation on thromboembolic events'risk in radical prostatectomy(RP)patients.With an incidence of about 5%,factor V Leiden mutation is the most commo... Objective:To examine the perioperative impact of factor V Leiden mutation on thromboembolic events'risk in radical prostatectomy(RP)patients.With an incidence of about 5%,factor V Leiden mutation is the most common hereditary hypercoagulability among Caucasians and rarer in Asia.The increased risk of thromboembolic events is three-to seven-fold in heterozygous and to 80-fold in homozygous patients.Methods:Within our prospectively collected database,we analysed 33006 prostate cancer patients treated with RP between December 2001 and December 2020.Of those,patients with factor V Leiden mutation were identified.All patients received individualised recommendation of haemostaseologists for perioperative anticoagulation.Thromboembolic complications(deep vein thrombosis and pulmonary embolism)were assessed during hospital stay,as well as according to patient reported outcomes within the first 3 months after RP.Results:Overall,85(0.3%)patients with known factor V Leiden mutation were identified.Median age was 65(interquartile range:61-68)years.There was at least one thrombosis in 53(62.4%)patients and 31(36.5%)patients had at least one embolic event in their medical history before RP.Within all 85 patients with factor V Leiden mutation,we experienced no thromboembolic complications within the first 3 months after surgery.Conclusion:In our cohort of patients with factor V Leiden mutation,no thromboembolic events were observed after RP with an individualised perioperative coagulation management concept.This may reassure patients with this hereditary condition who are counselled for RP. 展开更多
关键词 Prostatecancer Prostatectomy Factor V Leiden mutation THROMBOEMBOLISM THROMBOPHILIA
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Defining minimal invasive surgical therapy for benign prostatic obstruction surgery: Perspectives from a global knowledge, attitude, and practice survey
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作者 Bryan Kwun-Chung Cheng Steffi Kar-Kei Yuen +14 位作者 Daniele Castellani Marcelo langer Wroclawski Hongda Zhao Mallikarjuna Chiruvella Wei-Jin Chua Ho-Yee Tiong Yiloren Tanidir Jean de la Rosette Enrique Rijo Vincent Misrai Amy Krambeck Dean S.Elterman Bhaskar K.Somani Jeremy Yuen-Chun Teoh Vineet Gauhar 《Asian Journal of Urology》 CSCD 2024年第1期55-64,共10页
Objective:To scrutinize the definitions of minimal invasive surgical therapy(MIST)and to investigate urologists’knowledge,attitudes,and practices for benign prostatic obstruction surgeries.Methods:A 36-item survey wa... Objective:To scrutinize the definitions of minimal invasive surgical therapy(MIST)and to investigate urologists’knowledge,attitudes,and practices for benign prostatic obstruction surgeries.Methods:A 36-item survey was developed with a Delphi method.Questions on definitions of MIST and attitudes and practices of benign prostatic obstruction surgeries were included.Urologists were invited globally to complete the online survey.Consensus was achieved when more than or equal to 70%responses were“agree or strongly agree”and less than or equal to 15%responses were“disagree or strongly disagree”(consensus agree),or when more than or equal to 70%responses were“disagree or strongly disagree”and less than or equal to 15%responses were“agree or strongly agree”(consensus disagree).Results:The top three qualities for defining MIST were minimal blood loss(n=466,80.3%),fast post-operative recovery(n=431,74.3%),and short hospital stay(n=425,73.3%).The top three surgeries that were regarded as MIST were Urolift®(n=361,62.2%),Rezum®(n=351,60.5%),and endoscopic enucleation of the prostate(EEP)(n=332,57.2%).Consensus in the knowledge section was achieved for the superiority of Urolift®,Rezum®,and iTIND®over transurethral resection of the prostate with regard to blood loss,recovery,day surgery feasibility,and post-operative continence.Consensus in the attitudes section was achieved for the superiority of Urolift®,Rezum®,and iTIND®over transurethral resection of the prostate with regard to blood loss,recovery,and day surgery feasibility.Consensus on both sections was achieved for EEP as the option with the better symptoms and flow improvement,lower retreatment rate,and better suitable for prostate more than 80 mL.Conclusion:Minimal blood loss,fast post-operative recovery,and short hospital stay were the most important qualities for defining MIST.Urolift®,Rezum®,and EEP were regarded as MIST by most urologists. 展开更多
关键词 Benignprostate hyperplasia Minimalinvasive surgical therapy SURGERY Bladderoutlet obstruction
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Simulated patient methodology as a“gold standard”in community pharmacy practice:Response to criticism
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作者 Christian Kunow Bernhard langer 《World Journal of Methodology》 2024年第2期172-174,共3页
The simulated patient methodology(SPM)is considered the“gold standard”as covert participatory observation.SPM is attracting increasing interest for the investigation of community pharmacy practice;however,there is c... The simulated patient methodology(SPM)is considered the“gold standard”as covert participatory observation.SPM is attracting increasing interest for the investigation of community pharmacy practice;however,there is criticism that SPM can only show a small picture of everyday pharmacy practice and therefore has limited external validity.On the one hand,a certain design and application of the SPM goes hand in hand with an increase in external validity.Even if,on the other hand,this occurs at the expense of internal validity due to the trade-off situation,the justified criticism of the SPM for investigating community pharmacy practice can be countered. 展开更多
关键词 Simulated patient methodology Community pharmacy Gold standard Covert participatory observation Internal validity External validity
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Fungal diversity notes 253-366:taxonomic and phylogenetic contributions to fungal taxa 被引量:6
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作者 Guo Jie Li Kevin D.Hyde +90 位作者 Rui Lin Zhao Sinang Hongsanan Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Pablo Alvarado Genivaldo Alves-Silva Joseph F.Ammirati Hiran A.Ariyawansa Abhishek Baghela Ali Hassan Bahkali Michael Beug D.Jayarama Bhat Dimitar Bojantchev Thitiya Boonpratuang Timur S.Bulgakov Erio Camporesi Marcela CBoro Oldriska Ceska Dyutiparna Chakraborty Jia Jia Chen K.W.Thilini Chethana Putarak Chomnunti Giovanni Consiglio Bao Kai Cui Dong Qin Dai Yu Cheng Dai Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Eske De Crop Rafael J.V.De Oliveira Carlos Alberto Fragoso de Souza JoséIde Souza Bryn T.M.Dentinger Asha J.Dissanayake Mingkwan Doilom E.Ricardo Drechsler-Santos Masoomeh Ghobad-Nejhad Sean P.Gilmore Aristóteles Góes-Neto MichałGorczak Charles H.Haitjema Kalani Kanchana Hapuarachchi Akira Hashimoto Mao Qiang He John K.Henske Kazuyuki Hirayama Maria J.Iribarren Subashini C.Jayasiri Ruvishika S.Jayawardena Sun Jeong Jeon Gustavo H.Jerônimo Ana L.Jesus E.B.Gareth Jones Ji Chuan Kang Samantha C.Karunarathna Paul M.Kirk Sirinapa Konta Eric Kuhnert Ewald langer Haeng Sub Lee Hyang Burm Lee Wen Jing Li Xing Hong Li Kare Liimatainen Diogo Xavier Lima Chuan Gen Lin Jian Kui Liu Xings Zhong Liu Zuo Yi Liu J.Jennifer Luangsa-ard Robert Lücking H.Thorsten Lumbsch Saisamorn Lumyong Eduardo M.Leaño Agostina V.Marano Misato Matsumura Eric H.C.McKenzie Suchada Mongkolsamrit Peter E.Mortimer Thi Thuong Thuong Nguyen Tuula Niskanen Chada Norphanphoun Michelle A.O’Malley Sittiporn Parnmen Julia Pawłowska Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Carmen L.A.Pires-Zottarelli Olivier Raspé 《Fungal Diversity》 SCIE 2016年第3期1-237,共237页
Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference specimens.Awide geographic and taxonomic range of fungal taxa ar... Notes on 113 fungal taxa are compiled in this paper,including 11 new genera,89 new species,one new subspecies,three new combinations and seven reference specimens.Awide geographic and taxonomic range of fungal taxa are detailed.In the Ascomycota the new genera Angustospora(Testudinaceae),Camporesia(Xylariaceae),Clematidis,Crassiparies(Pleosporales genera incertae sedis),Farasanispora,Longiostiolum(Pleosporales genera incertae sedis),Multilocularia(Parabambusicolaceae),Neophaeocryptopus(Dothideaceae),Parameliola(Pleosporales genera incertae sedis),and Towyspora(Lentitheciaceae)are introduced.Newly introduced species are Angustospora nilensis,Aniptodera aquibella,Annulohypoxylon albidiscum,Astrocystis thailandica,Camporesia sambuci,Clematidis italica,Colletotrichum menispermi,C.quinquefoliae,Comoclathris pimpinellae,Crassiparies quadrisporus,Cytospora salicicola,Diatrype thailandica,Dothiorella rhamni,Durotheca macrostroma,Farasanispora avicenniae,Halorosellinia rhizophorae,Humicola koreana,Hypoxylon lilloi,Kirschsteiniothelia tectonae,Lindgomyces okinawaensis,Longiostiolum tectonae,Lophiostoma pseudoarmatisporum,Moelleriella phukhiaoensis,M.pongdueatensis,Mucoharknessia anthoxanthi,Multilocularia bambusae,Multiseptospora thysanolaenae,Neophaeocryptopus cytisi,Ocellularia arachchigei,O.ratnapurensis,Ochronectria thailandica,Ophiocordyceps karstii,Parameliola acaciae,P.dimocarpi,Parastagonospora cumpignensis,Pseudodidymosphaeria phlei,Polyplosphaeria thailandica,Pseudolachnella brevifusiformis,Psiloglonium macrosporum,Rhabdodiscus albodenticulatus,Rosellinia chiangmaiensis,Saccothecium rubi,Seimatosporium pseudocornii,S.pseudorosae,Sigarispora ononidis and Towyspora aestuari.New combinations are provided for Eutiarosporella dactylidis(sexual morph described and illus trated)and Pseudocamarosporium pini.Descriptions,illustrations and/or reference specimens are designated for Aposphaeria corallinolutea,Cryptovalsa ampelina,Dothiorella vidmadera,Ophiocordyceps formosana,Petrakia echinata,Phragmoporthe conformis and Pse 展开更多
关键词 ASCOMYCOTA BASIDIOMYCOTA Neocallimastigomycota Oomycota.Zygomycota Phylogeny Taxonomy New genus New species
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滑动多层磁共振成像对原发性卵巢癌分期的应用研究 被引量:6
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作者 张伶 王仁法 +4 位作者 Pache G 伍尧泮 Schaefer O langer M 关键 《影像诊断与介入放射学》 2010年第3期145-148,共4页
目的分析滑动多层磁共振成像(SMS-MRI)的技术特点,并探讨SMS-MRI在原发性卵巢癌分期中的价值。方法对15例卵巢癌患者术前行SMS-MRI扫描,扫描范围包括胸腹盆腔(从胸廓入口至盆底)。SMS-MRI扫描的主要序列有常规T_2WITSE序列、SMS-TIRM序... 目的分析滑动多层磁共振成像(SMS-MRI)的技术特点,并探讨SMS-MRI在原发性卵巢癌分期中的价值。方法对15例卵巢癌患者术前行SMS-MRI扫描,扫描范围包括胸腹盆腔(从胸廓入口至盆底)。SMS-MRI扫描的主要序列有常规T_2WITSE序列、SMS-TIRM序列和SMSFLASH 2D压脂增强序列。SMS-MRI图像由两位放射科医师随机单盲阅片后进行分期诊断,并将其结果与手术病理结果对照。观察内容包括:(1)肿瘤定位(单侧或双侧);(2)局部浸润:子宫输卵管或其他盆腔组织受侵;(3)腹膜转移;(4)淋巴结转移;(5)远处转移。结果 15例均经组织病理学证实,其中浆液性囊腺癌9例,黏液性囊腺癌2例,子宫内膜样癌2例,透明细胞癌和颗粒细胞癌各1例。手术病理分期为Ⅰ期0例,Ⅱ期2例,Ⅲ期10例,Ⅳ期3例。以手术病理结果为金标准,SMS-MRI对于原发性卵巢癌总的分期准确率为100%(15/15)。SMS-MRI在卵巢癌的定位诊断、子宫输卵管局部浸润和远处转移等方面的符合率均为100%。结论结合SMS技术的MRI可在保证图像质量的情况下,在较短的时间内一次性完成体部胸腹盆腔扫描,能较准确的完成卵巢癌原发灶和转移的侦测和分期,为卵巢癌分期诊断提供了一项新的影像诊断选择。 展开更多
关键词 磁共振成像 卵巢癌 分期 滑动多层技术
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滑动多层磁共振成像在直肠间质瘤分期中的应用价值 被引量:4
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作者 熊斌 Arnd-Oliver Schaefer +2 位作者 Tobias Baumann 冯敢生 Mathias langer 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2009年第2期224-227,共4页
目的探讨滑动多层(sliding multislice,SMS)磁共振成像(MRI)在胃肠道间质瘤(gastrointestinal stromal tumours,GIST)腹部分期中的应用价值和潜力。方法2005年9月至2008年1月8例由组织学和免疫组化检测证实的直肠GIST患者,均接受盆腔静... 目的探讨滑动多层(sliding multislice,SMS)磁共振成像(MRI)在胃肠道间质瘤(gastrointestinal stromal tumours,GIST)腹部分期中的应用价值和潜力。方法2005年9月至2008年1月8例由组织学和免疫组化检测证实的直肠GIST患者,均接受盆腔静止高分辨率MRI和腹部SMS MRI检查进行治疗前分期。在盆腔静止高分辨率MRI采用T2-TSE序列检查后,利用SMS技术的T1加权增强FLASH-2D序列在1 min内检查整个腹部。分析图像,分别了解直肠GIST原发部位情况及腹部远处转移情况。结果盆腔静止高分辨率MRI检查成功确定所有患者直肠GIST的大小、范围及局部侵犯程度,肿瘤最大直径介于1.7~11.0 cm。SMS MRI检查的图像质量能够满足对可能的肝转移灶、转移淋巴结、肠系膜转移灶和骨转移灶的评价。结论腹部SMS MRI联合盆腔静止高分辨率MRI可以在一次检查中完成直肠GIST的腹部分期。 展开更多
关键词 磁共振成像 胃肠道间质瘤 肿瘤分期
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Rotational stability of plate haptic toric intraocular lenses after combined 25-gauge vitrectomy and cataract surgery 被引量:1
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作者 Lara Buhl Julian langer +3 位作者 Stefan Kassumeh Thomas C.Kreutzer Wolfgang J.Mayer Siegfried G.Priglinger 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第8期1231-1236,共6页
AIM:To evaluate the postoperative intraocular lens(IOL)rotational stability and residual refractive astigmatism following combined 25-gauge vitrectomy and cataract surgery with implantation of a plate haptic toric IOL... AIM:To evaluate the postoperative intraocular lens(IOL)rotational stability and residual refractive astigmatism following combined 25-gauge vitrectomy and cataract surgery with implantation of a plate haptic toric IOL.METHODS:In this retrospective case series,32 eyes of 32 patients underwent a combined 25-gauge vitrectomy and phacoemulsification for vitreoretinal diseases and cataract with regular corneal astigmatism of at least 1 diopter(D).A plate haptic toric IOL(AT Torbi 709M,Carl Zeiss Meditec AG)was implanted in all eyes.The outcome measures were rotational stability and refractive astigmatism up to 6mo postoperatively as well as the best corrected visual acuity(BCVA).RESULTS:Preoperative refractive astigmatism was 2.14±1.17 D,which was significantly reduced to 0.77±0.37 D six to eight weeks postoperatively and remained stable throughout the observation period(0.67±0.44 D at three months and 0.75±0.25 D at six months;for all groups:P<0.0001 compared to baseline).BCVA improved significantly from 0.36±0.33 logMAR preoperatively to 0.10±0.15 logMAR following surgery(P=0.02).Mean IOL axis deviation from the target axis was 3.4°±2.9°after six to eight weeks and significantly decreased over time(2.4°±2.6°six months after surgery;P=0.04).In one patient IOL,re-alignment was performed.CONCLUSION:Corneal astigmatism is significantly reduced following combined 25-gauge vitrectomy and cataract surgery.The plate haptic toric IOL position and axis remain stable during the observation period of six months. 展开更多
关键词 combined phaco-vitrectomy toric intraocular lens rotational stability corneal astigmatism CATARACT vitreoretinal disease
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从泰格公寓看绿色建筑规划 被引量:1
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作者 Kenneth langer 徐淑芸 《建设科技》 2004年第12期28-29,共2页
关键词 绿色建筑 建筑环境 大气污染 室内环境 公寓
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Social learning contributions to the etiology and treatment of functional abdominal pain and inflammatory bowel disease in children and adults 被引量:2
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作者 Rona L Levy Shelby L langer William E Whitehead 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第17期2397-2403,共7页
This paper reviews empirical work on cognitive and social learning contributions to the etiology and treatment of illness behavior associated with functional abdominal pain and inflammatory bowel disease. A particular... This paper reviews empirical work on cognitive and social learning contributions to the etiology and treatment of illness behavior associated with functional abdominal pain and inflammatory bowel disease. A particular emphasis is placed on randomized controlled trials, the majority of which are multi-modal in orientation, incorporating elements of cognitive behavioral therapy, social learning, and relaxation. Based on this review, we offer methodological and clinical suggestions: (1) Research investigations should include adequate sample sizes, long-term follow-up assessments, and a credible, active control group. (2) Standard gastrointestinal practice should include, when appropriate, learning opportunities for patients and family members, for example, instruction regarding the encouragement of wellness behavior. 展开更多
关键词 Functional abdominal pain Cognitivebehavioral therapy Social learning Irritable bowelsyndrome Inflammatory bowel disease Illness behavior
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局灶性肝病变动态CT与延迟CT的比较
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作者 C.Zwicker M.langer +4 位作者 R.langer F.Astinet R.Steffen R.Felix 王天才 《放射学实践》 北大核心 1992年第3期132-135,共4页
转移性肝癌的诊断对于其预后和进一步治疗具有决定性的意义。作为非损伤性手段的CT,因其良好的准确率、重复性和解剖定位,已常规应用于证实局灶性肝病变。新的外科切除方法和化疗措施要求手术前有更准确的诊断。静脉给予团剂造影剂后,... 转移性肝癌的诊断对于其预后和进一步治疗具有决定性的意义。作为非损伤性手段的CT,因其良好的准确率、重复性和解剖定位,已常规应用于证实局灶性肝病变。新的外科切除方法和化疗措施要求手术前有更准确的诊断。静脉给予团剂造影剂后,扫描时间小于或等于1秒以及高分辨力和高对比度CT,可以完成更好的动态肝脏CT扫查。 展开更多
关键词 肝病变 动态CT 延迟CT
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使用引导骨再生技术、同种脱矿冻干骨移植和迷你骨钉进行牙槽嵴增高术:种植体负载4~13年的观察
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作者 langer B langer L +3 位作者 Sullivan RM 王琳琳(译) 甘云娜(审) 邵龙泉(审) 《中国口腔医学继续教育杂志》 2011年第4期207-213,共7页
该组回顾性病例研究介绍了使用脱矿冻干自体骨移植颗粒和屏障膜对8位患者进行治疗的临床效果,其中7位患者使用了迷你骨钉或种植体来支持屏障膜。所有患者再生的垂直骨量确保了移植区可植入一枚或多枚种植体.然后.在种植体植入至少55... 该组回顾性病例研究介绍了使用脱矿冻干自体骨移植颗粒和屏障膜对8位患者进行治疗的临床效果,其中7位患者使用了迷你骨钉或种植体来支持屏障膜。所有患者再生的垂直骨量确保了移植区可植入一枚或多枚种植体.然后.在种植体植入至少55个月以后进行最终修复体修复、并负载。在4~13年的随访中,种植体周围的骨缘高度保持了稳定。 展开更多
关键词 引导骨再生技术 种植体植入 自体骨移植 牙槽嵴增高术 负载 骨钉 冻干 脱矿
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评估孕产妇和新生儿的保健服务质量:如何知道我们做的是否正确? 医疗机构评估工具综述
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作者 王晨冉(译) 徐韬(校对) +4 位作者 Brizuela V Leslie HH Sharma J langer A Tuncalp 《中国妇幼卫生杂志》 2020年第6期92-99,共8页
背景为评估并提升孕产妇和新生儿在医疗机构接受的保健服务质量,世界卫生组织(WHO)制定了一套标准,定义了31项质量说明和352项质量测量指标。本研究参照WHO的标准,对在全球范围使用的医疗机构评估工具在评估孕产妇和新生儿保健服务质量... 背景为评估并提升孕产妇和新生儿在医疗机构接受的保健服务质量,世界卫生组织(WHO)制定了一套标准,定义了31项质量说明和352项质量测量指标。本研究参照WHO的标准,对在全球范围使用的医疗机构评估工具在评估孕产妇和新生儿保健服务质量方面的能力进行综述。方法通过目的抽样,按照以下标准筛选纳入评估工具:在多国使用、在医疗机构使用、关注孕产妇和新生儿健康、收集投入和过程指标数据、在2007-2017年间应用、目前正在使用。将这些评估工具中的问题条目与WHO标准中274项与投入和过程有关的质量测量指标进行对比。结果五项调查符合纳入标准:人口和健康调查项目组制定的卫生服务供给评估(SPA);WHO制定的卫生服务可及性与反应性评估;哥伦比亚大学避免母亲死亡和残疾项目组制定的产科急救和新生儿保健需求评估;世界银行的服务提供指数(SDI)和卫生筹资成果影响评估工具包。这些工具中涵盖的WHO质量测量指标比例范围是62%(SPA)~12%(SDI)。关于卫生信息系统和病人服务体验的指标是最少被评估的内容。结论现有的医疗机构评估工具为评价孕产妇和新生儿保健服务质量提供了有价值的方法。为了减轻评估负担并增加数据的使用以提高评估质量,需要确定优先测量指标,并开发有针对性的测量模块以弥补上述不足。 展开更多
关键词 孕产妇 新生儿 保健服务 质量评估
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Medicinal uses,phytochemistry and pharmacology of Picralima nitida(Apocynaceae) in tropical diseases:A review 被引量:2
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作者 Osayemwenre Erharuyi Abiodun Falodun Peter langer 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第1期1-8,共8页
Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertensi... Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertension,jaundice,dysmenorrheal,gastrointestinal disorders and malaria.In order to reveal its full pharmacological and therapeutic potentials,die present review focuses on the current medicinal uses,phytochemistry,pharmacological and toxicological activities of this species.Literature survey on scientific journals,books as well as electronic sources have shown the isolation of alkaloids,tannins,polyphenols and steroids from different parts of the plant,pharmacological studies revealed that the extract or isolated compounds from this species posses analgesic,anti-inflammatory,hypoglyceamic,hypotensive,antiplasmodial,antimicrobial,antiulcer and antitumorigenic activities.Results from various scientific investigations to date have revealed the potential of the extract from the plant or isolated compounds for use in the treatment and prevention of various kinds of human diseases.However,further studies on the extracts and pure compounds from this species is required to completely assess its phytoc-hemical,pharmacological and toxicological profile as well as the mechanism of action behind these pharmacological activities exhibited by the compounds isolated from this species. 展开更多
关键词 Picralima nitida APOCYNACEAE PHYTOCHEMISTRY PHARMACOLOGY
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光敏剂间-四羟基苯二氢卟酚及其复合物对人T淋巴细胞白血病细胞的作用 被引量:2
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作者 郑顺贞 Karin Low +5 位作者 Matthis Wacker Arno Wiehe Sylvia Wagner Klaus langer Hagen von Briesen 邹声泉 《中华实验外科杂志》 CAS CSCD 北大核心 2010年第10期1463-1465,共3页
目的 观察光敏剂间-四羟基苯二氢卟酚(mTHPC)及其复合物HSA-mTHPC对人T淋巴细胞白血病细胞(Jurkat)的作用,探讨人血白蛋白(HSA)纳米颗粒作为mTHPC载体的可行性.方法 利用流式细胞仪测定Jurkat细胞对mTHPC及HSA-mTHPC的摄取率,通... 目的 观察光敏剂间-四羟基苯二氢卟酚(mTHPC)及其复合物HSA-mTHPC对人T淋巴细胞白血病细胞(Jurkat)的作用,探讨人血白蛋白(HSA)纳米颗粒作为mTHPC载体的可行性.方法 利用流式细胞仪测定Jurkat细胞对mTHPC及HSA-mTHPC的摄取率,通过测定不同浓度mTHPC及HSA-mTHPC孵育Jurkat细胞后的存活率、细胞膜完整性和增殖率,评价两种药物的摄取率和细胞毒性.结果 浓度1.0 mg/L,孵育4、24 h Jurkat细胞的摄取率为:mTHPC单体:98.07%、99.07% HSA-mTHPG中mTHPC:98.13%、99.19% HSA单体:2.77%、4.84%.光照后Jurkat细胞活性和增殖率呈显著剂量、时间依赖的下降,mTHPC浓度为1.0 mg/L时,4、24、48 h存活率和增殖率分别为13.27%、5.46%、4.99%和2.68%、0.91%、0.62%,HSA-mTHPC对细胞生长和增殖的抑制与mTHPC单体比较未见下降(P>0.05).光照后LDH活性呈现显著剂量、时间依赖的上升,mTHPC浓度为1.0mg/L时,4、24、48 h LDH活性分别为:80.99%、99.38%、100.67%.结论 mTHPC是一种杀伤力强的光敏剂型,能有效进入肿瘤细胞,并导致细胞损害.HSA纳米颗粒不影响细胞对mTHPC的摄取,可以作为其载体. 展开更多
关键词 光动力治疗 光敏剂 MTHPC JURKAT细胞
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新型药物释放体系 被引量:1
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作者 Robert langer 刘青 《国外医学(生物医学工程分册)》 北大核心 1991年第1期14-18,共5页
早在本世纪30年代,人们就试图将药物与一些能够降低药物溶解度的物质结合,或者在药物的外面包上一层不溶于胃酸的物质,或者将药物压成密实的片子,或者将药物制成悬浮液或乳化液,从而达到使药物长期释放的目的。虽然上述方法能使得药物... 早在本世纪30年代,人们就试图将药物与一些能够降低药物溶解度的物质结合,或者在药物的外面包上一层不溶于胃酸的物质,或者将药物压成密实的片子,或者将药物制成悬浮液或乳化液,从而达到使药物长期释放的目的。虽然上述方法能使得药物在较长时期内发挥效力,然而药物的释放量及释放速率在很大程度上受到患者的个体差异及其它“环境”效应如胃肠道pH值的影响。此外,仍需多次给药。 展开更多
关键词 药物释放体系 聚合物 控释体系
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