The Tongbai-Hong'an orogen is located in a key tectonic position linking the Qinling orogen to the west and the Dabie-Sulu orogen to the east. Because the orogen preserves a Paleozoic accretionary orogenic system ...The Tongbai-Hong'an orogen is located in a key tectonic position linking the Qinling orogen to the west and the Dabie-Sulu orogen to the east. Because the orogen preserves a Paleozoic accretionary orogenic system in the north and a latest PaleozoicMesozoic collisional orogenic system in the south, it may serve as an ideal place to study the tectonic evolution between the North and South China Blocks. The available literature data in the past 20 years indicate that the tectonic processes of the Tongbai-Hong'an orogen involved four stages during the Phanerozoic:(1) Early Paleozoic(490–420 Ma) oceanic subduction, arc magmatism and arc-continent collision created a new Andean-type active continental margin on the North China Block;(2) Late Paleozoic(340–310 Ma) oceanic subduction and accretion generated separated paired metamorphic belts: a medium P/T Wuguan-Guishan complex belt in the south of the Shandan-Songpa fault and a high P/T Xiongdian eclogite belt in the northern edge of the Mesozoic HP metamorphic terrane;(3) Latest Paleozoic-Early Mesozoic(255–200 Ma) continental subduction and collision formed the Tongbai HP terrane in the west and the Hong'an HP/UHP terrane in the east as a consequence of deep subduction towards the east and syn-subduction detachment/exhumation of the down-going slab;(4) Late Mesozoic(140–120 Ma) extension, voluminous magma intrusion and tectonic extrusion led to the final exhumation of the Tongbai-Hong'an-Dabie HP/UHP terrane and the wedge-shaped architecture of the terrane narrowing towards the west. However, many open questions still remain about the details of each evolutionary stage and earlier history of the orogen. Besides an extensive study directly on the Tongbai-Hong'an orogen in the future, integrated investigation on the "soft-collisional" Qinling orogen in the west and the "hard-collisional" Dabie-Sulu orogen in the east is required to establish a general tectonic model for the whole Qinling-TongbaiHong'an-Dabie-Sulu orogenic belt.展开更多
The orogenic belt of northern China is characterized by widely developed postorogenic Ⅰ fractionated and A-type granites in the Phanerozoic. The isotopic data display relatively high ε Nd(t) and 206Pb/ 204Pb values ...The orogenic belt of northern China is characterized by widely developed postorogenic Ⅰ fractionated and A-type granites in the Phanerozoic. The isotopic data display relatively high ε Nd(t) and 206Pb/ 204Pb values and low I Sr ratio. The low T DM model ages (<100 Ma) suggest that the Neo-Proterozoic-Phanerozoic is one of the main stages in the continental growth.展开更多
Background Seprase plays an important role in malignant cell invasion and metastasis by degrading the extracellular matrix. However, its clinical significance remains largely unknown. The objective of the current stud...Background Seprase plays an important role in malignant cell invasion and metastasis by degrading the extracellular matrix. However, its clinical significance remains largely unknown. The objective of the current study was to evaluate the expression of seprase in effusions from patients with epithelial ovarian carcinoma and its clinical values. Methods Immunohistochemistry was used to examine the expression of seprase protein in a series of 74 malignant peritoneal （n=64） and pleural （n=10） effusions from Norwegian patients with epithelial ovarian carcinoma. Additionally, 34 effusions were evaluated using the Western blotting. Nine reactive effusions, obtained from patients with benign lesions, served as a control group. Statistical analyses were carried out by Chi-square test and Kaplan-Meier method. Results In the 74 malignant effusion specimens, 57 （77.02%） were positive for seprase, while only 2 （22.22%） of the control group were positively stained （P=-0.001）. In the malignant effusions, 17 （22.97%）, 22 （29.73%）, 22 （29.73%）, 13 （17.57%） had negative, weak, moderate and strong seprase protein expression, respectively. The expression of seprase protein was predominant in cytoplasm of carcinoma cells. Increased seprase protein was negatively associated with the overall survival rate of the patients （P=0.03）. However, there was no significant correlation between protein expression and FIGO stage, age, histology, and histological grade. By Western blotting, 27 of the 34 effusions showed the presence of both 170-kD dimeric form and 97-KD monomeric form of seprase while only 1 of the 34 had 170-KD dimeric form, which was consistent with the results of immunohistochemistry （P=0.05）. Conclusions Seprase may be involved in the development of ovarian cancer, and is a potential predictive marker for the disease.展开更多
High-pressure(HP)metamorphic terrane in the Tongbai orogen comprises two HP slices(I and II)and a tectonic mélange zone in the northeast and a blueschist-greenschist zone in the southwest.HP slice I is represente...High-pressure(HP)metamorphic terrane in the Tongbai orogen comprises two HP slices(I and II)and a tectonic mélange zone in the northeast and a blueschist-greenschist zone in the southwest.HP slice I is represented by the northern and southern eclogite zones on the two sides of the Tongbaishan antiform.HP slice II is represented by retrograded eclogite-bearing metamorphic enclaves in Cretaceous gneissic granites in the Tongbai Complex.U-Pb,Lu-Hf,Rb-Sr and40Ar/39Ar multichronometric data indicate that the peak metamorphism of HP slice I took place at^255 Ma,whereas the metamorphic ages of HP slice II are as young as232–220 Ma.By contrast,the tectonic mélange zone near the suture was metamorphosed at^256 Ma.Such a diachroneity of different slices across the direction of the orogen in the Hong’an-Dabie-Sulu HP/UHP terrane is ubiquitous,and it can be interpreted by a syn-subduction detachment/exhumation model.Furthermore,the metamorphic age of HP slice I in the Tongbai orogen is older than that of the equivalent HP slice in the Hong’an orogen by^15 Ma,suggesting that the diachroneity may have also existed along the direction of the orogen.A seesaw-type subduction/exhumation model is proposed to explain this age disparity and the subduction of the South China Block becomimg shallower towards the west.展开更多
In the ANSICHT project that was jointly carried out by DBE TECHNOLOGY Gmb H,BGR,and GRS g Gmb H,two generic geological site models were used to develop a first draft of a methodology to demonstrate the safety of a hig...In the ANSICHT project that was jointly carried out by DBE TECHNOLOGY Gmb H,BGR,and GRS g Gmb H,two generic geological site models were used to develop a first draft of a methodology to demonstrate the safety of a high-level waste(HLW) repository in argillaceous formations in Germany,taking into account the regulatory requirements.The main results of the project are characterised by the developed repository concepts adapted to the geological conditions.The specific quantifications of the integrity criteria and their exemplary application with calculational proofs were used to demonstrate the integrity of the host rocks.The development of site-specific FEP(features,events,and processes) cataloges provided a complete system description for evaluation of the repository evolution.The developed work flow of the demonstration concept illustrated the complete sequence of the safety proof in a transparent way.It shows that various steps have to be performed,possibly iteratively,to provide a successful safety proof.The results form a useful tool in the pending search for a HLW repository site,especially when providing a basis for comparing safety analyses of different sites in Germany.展开更多
基金supported by the National Basic Research Program of China(Grant Nos.2015CB856104,2009CB825006)the National Natural Science Foundation of China(Grant Nos.41472064,40672047)the Geological Investigation Project of China Geological Survey(Grant No.1212010711812)
文摘The Tongbai-Hong'an orogen is located in a key tectonic position linking the Qinling orogen to the west and the Dabie-Sulu orogen to the east. Because the orogen preserves a Paleozoic accretionary orogenic system in the north and a latest PaleozoicMesozoic collisional orogenic system in the south, it may serve as an ideal place to study the tectonic evolution between the North and South China Blocks. The available literature data in the past 20 years indicate that the tectonic processes of the Tongbai-Hong'an orogen involved four stages during the Phanerozoic:(1) Early Paleozoic(490–420 Ma) oceanic subduction, arc magmatism and arc-continent collision created a new Andean-type active continental margin on the North China Block;(2) Late Paleozoic(340–310 Ma) oceanic subduction and accretion generated separated paired metamorphic belts: a medium P/T Wuguan-Guishan complex belt in the south of the Shandan-Songpa fault and a high P/T Xiongdian eclogite belt in the northern edge of the Mesozoic HP metamorphic terrane;(3) Latest Paleozoic-Early Mesozoic(255–200 Ma) continental subduction and collision formed the Tongbai HP terrane in the west and the Hong'an HP/UHP terrane in the east as a consequence of deep subduction towards the east and syn-subduction detachment/exhumation of the down-going slab;(4) Late Mesozoic(140–120 Ma) extension, voluminous magma intrusion and tectonic extrusion led to the final exhumation of the Tongbai-Hong'an-Dabie HP/UHP terrane and the wedge-shaped architecture of the terrane narrowing towards the west. However, many open questions still remain about the details of each evolutionary stage and earlier history of the orogen. Besides an extensive study directly on the Tongbai-Hong'an orogen in the future, integrated investigation on the "soft-collisional" Qinling orogen in the west and the "hard-collisional" Dabie-Sulu orogen in the east is required to establish a general tectonic model for the whole Qinling-TongbaiHong'an-Dabie-Sulu orogenic belt.
文摘The orogenic belt of northern China is characterized by widely developed postorogenic Ⅰ fractionated and A-type granites in the Phanerozoic. The isotopic data display relatively high ε Nd(t) and 206Pb/ 204Pb values and low I Sr ratio. The low T DM model ages (<100 Ma) suggest that the Neo-Proterozoic-Phanerozoic is one of the main stages in the continental growth.
基金a grant from the Norwegian Radium Hospital,Oslo University
文摘Background Seprase plays an important role in malignant cell invasion and metastasis by degrading the extracellular matrix. However, its clinical significance remains largely unknown. The objective of the current study was to evaluate the expression of seprase in effusions from patients with epithelial ovarian carcinoma and its clinical values. Methods Immunohistochemistry was used to examine the expression of seprase protein in a series of 74 malignant peritoneal （n=64） and pleural （n=10） effusions from Norwegian patients with epithelial ovarian carcinoma. Additionally, 34 effusions were evaluated using the Western blotting. Nine reactive effusions, obtained from patients with benign lesions, served as a control group. Statistical analyses were carried out by Chi-square test and Kaplan-Meier method. Results In the 74 malignant effusion specimens, 57 （77.02%） were positive for seprase, while only 2 （22.22%） of the control group were positively stained （P=-0.001）. In the malignant effusions, 17 （22.97%）, 22 （29.73%）, 22 （29.73%）, 13 （17.57%） had negative, weak, moderate and strong seprase protein expression, respectively. The expression of seprase protein was predominant in cytoplasm of carcinoma cells. Increased seprase protein was negatively associated with the overall survival rate of the patients （P=0.03）. However, there was no significant correlation between protein expression and FIGO stage, age, histology, and histological grade. By Western blotting, 27 of the 34 effusions showed the presence of both 170-kD dimeric form and 97-KD monomeric form of seprase while only 1 of the 34 had 170-KD dimeric form, which was consistent with the results of immunohistochemistry （P=0.05）. Conclusions Seprase may be involved in the development of ovarian cancer, and is a potential predictive marker for the disease.
基金supportedby the National Basic Research Program of China(2009CB825006)
文摘High-pressure(HP)metamorphic terrane in the Tongbai orogen comprises two HP slices(I and II)and a tectonic mélange zone in the northeast and a blueschist-greenschist zone in the southwest.HP slice I is represented by the northern and southern eclogite zones on the two sides of the Tongbaishan antiform.HP slice II is represented by retrograded eclogite-bearing metamorphic enclaves in Cretaceous gneissic granites in the Tongbai Complex.U-Pb,Lu-Hf,Rb-Sr and40Ar/39Ar multichronometric data indicate that the peak metamorphism of HP slice I took place at^255 Ma,whereas the metamorphic ages of HP slice II are as young as232–220 Ma.By contrast,the tectonic mélange zone near the suture was metamorphosed at^256 Ma.Such a diachroneity of different slices across the direction of the orogen in the Hong’an-Dabie-Sulu HP/UHP terrane is ubiquitous,and it can be interpreted by a syn-subduction detachment/exhumation model.Furthermore,the metamorphic age of HP slice I in the Tongbai orogen is older than that of the equivalent HP slice in the Hong’an orogen by^15 Ma,suggesting that the diachroneity may have also existed along the direction of the orogen.A seesaw-type subduction/exhumation model is proposed to explain this age disparity and the subduction of the South China Block becomimg shallower towards the west.
基金the Federal Ministry for Economic Affairs and Energy(BMWi=Bundesministerium für Wirtschaft und Energie)represented by the Project Management Agency Karlsruhe(Karlsruhe Institute of Technology,KIT)for funding the research work performed in this project
文摘In the ANSICHT project that was jointly carried out by DBE TECHNOLOGY Gmb H,BGR,and GRS g Gmb H,two generic geological site models were used to develop a first draft of a methodology to demonstrate the safety of a high-level waste(HLW) repository in argillaceous formations in Germany,taking into account the regulatory requirements.The main results of the project are characterised by the developed repository concepts adapted to the geological conditions.The specific quantifications of the integrity criteria and their exemplary application with calculational proofs were used to demonstrate the integrity of the host rocks.The development of site-specific FEP(features,events,and processes) cataloges provided a complete system description for evaluation of the repository evolution.The developed work flow of the demonstration concept illustrated the complete sequence of the safety proof in a transparent way.It shows that various steps have to be performed,possibly iteratively,to provide a successful safety proof.The results form a useful tool in the pending search for a HLW repository site,especially when providing a basis for comparing safety analyses of different sites in Germany.
