Diabetic foot ulcers are the consequence of multiple factors including peripheral neuropathy,decreased blood supply,high plantar pressures,etc.,and pose a significant risk for morbidity,limb loss and mortality.The cri...Diabetic foot ulcers are the consequence of multiple factors including peripheral neuropathy,decreased blood supply,high plantar pressures,etc.,and pose a significant risk for morbidity,limb loss and mortality.The critical aspects of the wound healing mechanism and host physiological status in patients with diabetes necessitate the selection of an appropriate treatment strategy based on the complexity and type of wound.In addition to systemic antibiotics and surgical intervention,wound care is considered to be an important component of diabetic foot ulcer management.This article will focus on the use of different wound care materials in diabetic foot.From a clinical perspective,it is important to decide on the wound care material depending on the type and grade of the ulcer.This article will also provide clinicians with a simple approach to the choice of wound care materials in diabetic foot ulcer.展开更多
The different investigation has been carried out on the biological activities of titanium dioxide nanoparticle but the effect of this nano product on the antibacterial activity of different antibiotics has not been ye...The different investigation has been carried out on the biological activities of titanium dioxide nanoparticle but the effect of this nano product on the antibacterial activity of different antibiotics has not been yet demonstrated. In this study the nano size TiO2 is synthesized using citric acid and alpha dextrose and the enhancement effect of TiO2 nanoparticle on the antibacterial activity of different antibiotics was evaluated against Methicillin-resistant Staphylococcus aureus (MRSA). During the present study, different concentrations of nano-scale TiO2 were tested to find out the best concentration that can have the most effective antibacterial property against the MRSA culture. Disk diffusion method was used to determine the antibacterial activity of these antibiotics in the absence and presence of sub inhibitory concentration of TiO2 nano particle. A clinical isolate of MRSA, isolated from Intensive Care Unit (ICU) was used as test strain. In the presence of sub-inhibitory concentration of TiO2 nanoparticle (20 μg/disc) the antibacterial activities of all antibiotics have been increased against test strain with minimum 2 mm to maximum 10mm. The highest increase in inhibitory zone for MRSA was observed against pencillin G and amikacin (each 10 mm). Conversely, in case of nalidixic acid, TiO2 nanoparticle showed a Synergic effect on the antibacterial activity of this antibiotic against test strain. These results signify that the TiO2 nanoparticle potentate the antimicrobial action of beta lactums, cephalosporins, aminoglycosides, glycopeptides, macrolids and lincosamides, tetracycline a possible utilization of nano compound in combination effect against MRSA.展开更多
Childhood-onset obesity has emerged as a major public healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and epigenetic predispositions.This has led to an exponent...Childhood-onset obesity has emerged as a major public healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and epigenetic predispositions.This has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and adolescents.The looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most countries.Unless there is a collective global effort to curb the devastation caused by the situation,the impact is poised to be pro-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this goal.This article delves into the current epidemiological landscape,explores evidence concerning potential risks and consequences,delves into the pathobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.展开更多
From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span s...From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span style="font-family:Verdana;">Curcuma</span></i> <i><span style="font-family:Verdana;">longa</span></i><span style="font-family:Verdana;"> (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial </span><span style="font-family:Verdana;">effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities.</span><span style="font-family:Verdana;"> Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.展开更多
Online Social Networks (OSN) sites allow end-users to share agreat deal of information, which may also contain sensitive information,that may be subject to commercial or non-commercial privacy attacks. Asa result, gua...Online Social Networks (OSN) sites allow end-users to share agreat deal of information, which may also contain sensitive information,that may be subject to commercial or non-commercial privacy attacks. Asa result, guaranteeing various levels of privacy is critical while publishingdata by OSNs. The clustering-based solutions proved an effective mechanismto achieve the privacy notions in OSNs. But fixed clustering limits theperformance and scalability. Data utility degrades with increased privacy,so balancing the privacy utility trade-off is an open research issue. Theresearch has proposed a novel privacy preservation model using the enhancedclustering mechanism to overcome this issue. The proposed model includesphases like pre-processing, enhanced clustering, and ensuring privacy preservation.The enhanced clustering algorithm is the second phase where authorsmodified the existing fixed k-means clustering using the threshold approach.The threshold value is determined based on the supplied OSN data of edges,nodes, and user attributes. Clusters are k-anonymized with multiple graphproperties by a novel one-pass algorithm. After achieving the k-anonymityof clusters, optimization was performed to achieve all privacy models, suchas k-anonymity, t-closeness, and l-diversity. The proposed privacy frameworkachieves privacy of all three network components, i.e., link, node, and userattributes, with improved utility. The authors compare the proposed techniqueto underlying methods using OSN Yelp and Facebook datasets. The proposedapproach outperformed the underlying state of art methods for Degree ofAnonymization, computational efficiency, and information loss.展开更多
Optimal initial non-invasive management of acute hypoxemic respiratory failure(AHRF),of both coronavirus disease 2019(COVID-19)and non-COVID-19 etiologies,has been the subject of significant discussion.Avoidance of en...Optimal initial non-invasive management of acute hypoxemic respiratory failure(AHRF),of both coronavirus disease 2019(COVID-19)and non-COVID-19 etiologies,has been the subject of significant discussion.Avoidance of endotracheal intubation reduces related complications,but maintenance of spontaneous breathing with intense respiratory effort may increase risks of patients’self-inflicted lung injury,leading to delayed intubation and worse clinical outcomes.High-flow nasal oxygen is currently recommended as the optimal strategy for AHRF management for its simplicity and beneficial physiological effects.Non-invasive ventilation(NIV),delivered as either pressure support or continuous positive airway pressure via interfaces like face masks and helmets,can improve oxygenation and may be associated with reduced endotracheal intubation rates.However,treatment failure is common and associated with poor outcomes.Expertise and knowledge of the specific features of each interface are necessary to fully exploit their potential benefits and minimize risks.Strict clinical and physiological monitoring is necessary during any treatment to avoid delays in endotracheal intubation and protective ventilation.In this narrative review,we analyze the physiological benefits and risks of spontaneous breathing in AHRF,and the characteristics of tools for delivering NIV.The goal herein is to provide a contemporary,evidence-based overview of this highly relevant topic.展开更多
A novel DOIND logic approach is proposed for domino logic, which reduces the leakage current with a minimum delay penalty. Simulation is performed at 70 nm technology node with supply voltage 1V for domino logic and D...A novel DOIND logic approach is proposed for domino logic, which reduces the leakage current with a minimum delay penalty. Simulation is performed at 70 nm technology node with supply voltage 1V for domino logic and DOIND logic based AND, OR, XOR and Half Adder circuits using the tanner EDA tool. Simulation results show that the proposed DOIND approach decreases the average leakage current by 68.83%, 66.6%, 77.86% and 74.34% for 2 input AND, OR, XOR and Half Adder respectively. The proposed approach also has 47.76% improvement in PDAP for the buffer circuit as compared to domino logic.展开更多
Objective:To determine the antioxidant and hepatoprotective potential of methanol extract of rhizome of Curcuma angustifolia(MECA)against carbon tetrachloride(CCl4)-induced hepatic damage in vitro and in vivo.Methods:...Objective:To determine the antioxidant and hepatoprotective potential of methanol extract of rhizome of Curcuma angustifolia(MECA)against carbon tetrachloride(CCl4)-induced hepatic damage in vitro and in vivo.Methods:DPPH,ABTS and reducing power assays were performed to estimate the antioxidant effect of MECA.In vitro cytotoxicity of MECA against HepG2 cells was evaluated,whereas serum biochemical parameters and levels of antioxidative enzymes were measured in vivo and in vitro.Additionally,histopathological studies were estimated in order to investigate the hepatoprotective efficacy of MECA.Furthermore,GC-MS analysis of the extract was performed to identify the chemical components.Results:MECA exhibited strong antioxidant activity and attenuated CCl4-induced decrease in the viability of HepG2 cells.Additionally,MECA significantly restored the ALT,AST,ALP,TP and albumin level in comparison with the CCl4 group.After pre-treatment with MECA,effects of SOD,CAT and GSH were increased as well as lipid peroxidation amount decreased on CCl4-induced hepatotoxicity in in vitro and in vivo model.Furthermore,histopathological observation confirmed that MECA reduced liver injury induced by CCl4 in rats.GC-MS analysis confirmed the presence of bioactive constituents such as α-tocopherol(12.27%),phytol(7.61%),squalene(3.71%),β-sitosterol(2.19%),eugenol(2.59%),curcumenol(1.20%),β-elemene(1.00%)and eucalyptol(0.89%).Conclusions:MECA contains antioxidant and hepatoprotective constituents such asα-tocopherol,phytol,squalene and eugenol and exerts hepatoprotective effect both in vitro and in vivo.展开更多
BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomi...BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant tre展开更多
The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream regions.Trace metals flowed with river water can lead to serious impact on ecological system an...The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream regions.Trace metals flowed with river water can lead to serious impact on ecological system and human health.Nevertheless,the documentation on trace elements of Himalayan rivers is inadequately documented.The current study deals with the spatial and temporal variability of the major and trace elements of Ganga river water in epirhithron,metarhithron and hyporhithron zone belonging to Himalayan segment.Water samples from nineteen monitoring locations were collected in pre-monsoon(May-June),monsoon(AugustSeptember)and post-monsoon(December)seasons and subjected to be assessed for 20 elements(Ag,Al,Ba,Cd,Ca,Cr,Cu,Fe,Ga,K,Mn,Mg,Na,Ni,Pb,Sr,Th,U,Zn,and Zr)using ICP-OES(Inductively Coupled Plasma-Optical Emission Spectrometer).Different water pollution indexes such as HPI(Heavy Metal Pollution Index),MI(Metal Index)and PI(Pollution Index)were used to describe current water quality status at each monitoring station under particular classified ecological zone.The studied stations in hyporhithron zone had the value of Metal Index(MI>1),indicating threshold of warning.Further,the highest values of HPI in hyporhithron zone correspond to poor water quality status.Sites with poor water quality were also found to be contaminated as per the Pollution Index(PI),exhibiting high concentrations for element(Fe).However,the epirhithron and metarhithron zone in Himalayan segment showed excellent water quality mainly contributed from natural sources.Cluster Analysis(CA)and Principal Component Analysis(PCA)were applied to identify the main influential sources for Ganga river water pollution.The Kriging interpolation method was also applied to prepare spatial distribution map of computed indexes(HPI,MI,and PI).With the help of index of local Moran’s I(LMI),identified spatial clusters and spatial outliers revealed the elevated concentration of most elements in hyporhithron zone.The dataset presented in this study wo展开更多
MC （Monte Carlo） simulation code, JA-IPU is used to study radiation damage of SiC irradiated to spallation neutron and AmBe neutron spectra. The code is based on the major physical processes of radiation damage on i...MC （Monte Carlo） simulation code, JA-IPU is used to study radiation damage of SiC irradiated to spallation neutron and AmBe neutron spectra. The code is based on the major physical processes of radiation damage on incorporation of atomic collision cascade and limited to 10 MeV neutron energy. A phenomenological relation for radiation swelling is also derived. Based on the calculation of swelling, DPA （displacement per atom）, defect production efficiency and effective threshold energy, Efff from the data of MC simulation, SiC is inferred to be a highly radiation resistant material when compared with Nb and Ni metals which are used in composition of several reactor steels. Experimental results of hill-hock density measured using AFM （atomic force microscopy）, also confirm radiation resistant behavior of SiC.展开更多
The important enhancement in the structural,dielectric and optical properties of pure polymer and CdSe incorporated polyvinyl pyrrolidone has been reported in this paper.The surface morphology of CdSe/PVP nanocomposit...The important enhancement in the structural,dielectric and optical properties of pure polymer and CdSe incorporated polyvinyl pyrrolidone has been reported in this paper.The surface morphology of CdSe/PVP nanocomposite film is studied by using scanning electron microscopy(SEM).The chemical composition of different elements has been reported using energy dispersive X-ray(EDX)spectrum.The structure of polymer nanocomposite is determined with the help of X-ray diffraction(XRD)spectrum and is observed to be hexagonal.Particle size,intercrystalline separation,interplanner spacing,lattice parameters,strain and dislocation factors are calculated using XRD results.Fourier transform infrared spectroscopy(FTIR)and Photoluminescence(PL)analysis have been studied in order to check the possible interaction between CdSe quantum dots and polyvinyl pyrrolidone(PVP)matrix.The ac conductivity of CdSe/PVP nanocomposite is found to be higher as compared to pure polymers.The highest value of conductivity observed at 60203 Hz and at 523 K is found to be 3:72105 Sm1.Comparative study of dielectric constant,dielectric losses,dissipation factor,electric modulus and impedance has been performed.The semi-circles in impedance measurement for both materials show the bulk electrical properties that result in single relaxation process in CdSe/PVP nanocomposite.展开更多
To determine whether reforestation efforts in the denuded hills have significant impacts on hydrology in the Xinjiang River watershed, the authors examined eight land-cover scenarios to compare hydrologic responses an...To determine whether reforestation efforts in the denuded hills have significant impacts on hydrology in the Xinjiang River watershed, the authors examined eight land-cover scenarios to compare hydrologic responses and to provide a conceptual basis for restoration practices. The authors analyzed a 17-year time period using remote sensing to develop land-cover classification for the watershed. Climate, soil and terrain data for the watershed were used as input in the SWAT （soil and water analysis tool） to quantify and compare the impacts on hydrologic processes. The model was calibrated to a two-year record of stream discharge measurements. The results show significant increase in forest-cover on hills （13%）. However, the hydrological response is not very significant considering the changes in forest-cover, the surface runoff and percolation ratios only changed by 2% and 1% over time. Installment of earthen irrigation ponds in the outlets of sub-basin with maximum runoff had provided the most significant hydrologic improvements and could provide irrigation water to increase crop yield on remaining cropland. The study will provide information to the local government to aid decision-making in sustainable reforestation programs resulting in better hydrologic functioning for sustainable water resource management.展开更多
Forest fires are one of the major environmental issues globally.In Nepal,substantial amounts of forest biomass and carbon are lost due to fire.Nepal’s high value lowland forests are particularly vulnerable to fire.Ho...Forest fires are one of the major environmental issues globally.In Nepal,substantial amounts of forest biomass and carbon are lost due to fire.Nepal’s high value lowland forests are particularly vulnerable to fire.However,there are limited studies on the estimation of biomass loss and carbon emissions due to fire.Thus,this research addresses the information gap in the tropical mixed broad-leaved forests of Nawalparasi District.The forests were divided into three strata:Lower Tropical Sal Mixed Broad-leaved Forest,Hill Sal Forest and Riverine Forest,and from these four community-managed forests were selected for estimating above ground biomass.Ninety-two sample plots were set out for above ground biomass estimation in burnt and non-burnt areas.Forest fire incidences from 2001 to 2017 were acquired from the MODIS fire data.Forest biomass and carbon emissions were estimated using standard allometric equations.The fuel fraction consumed during the fire was estimated through field surveys during the forest fire season.The results show that every year,over 3158 ha of forests are burnt,resulting in some 1108 tons of carbon emissions,equivalent to approximately 4066 t CO_(2),2581 t CO and 1474 t CH4.Among the forests,the Hill Sal Forest was more vulnerable to fire.Forest management strategies,therefore,should include construction of fire lines and conservation ponds along with capacity building and raising awareness among local communities and stakeholders.展开更多
Lipoma is a benign neoplasm of the soft tissue that originates in mature adipocytes. Even though it is a very common tumor, it is relatively uncommon in oral cavity. It represents about 1% to 4% of all benign tumors i...Lipoma is a benign neoplasm of the soft tissue that originates in mature adipocytes. Even though it is a very common tumor, it is relatively uncommon in oral cavity. It represents about 1% to 4% of all benign tumors in oral cavity (12). This article describes a case of a 39 years old male with an intraoral pedunculated mass in the right side of hard palate which was histopathologically proved as a simple lipoma.展开更多
In malaria-endemic regions,people often get exposed to various pathogens simultaneously,generating coinfection scenarios.In such scenarios,overlapping symptoms pose serious diagnostic challenges.The delayed diagnosis ...In malaria-endemic regions,people often get exposed to various pathogens simultaneously,generating coinfection scenarios.In such scenarios,overlapping symptoms pose serious diagnostic challenges.The delayed diagnosis may lead to an increase in disease severity and catastrophic events.Recent coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has affected various areas globally,including malaria-endemic regions.The Plasmodium and SARS-CoV-2 co-infection and its effect on health are yet unexplored.We present a case report of a previously healthy,middle-aged individual from the malaria-endemic area who suffered SARS-CoV-2 and Plasmodium falciparum co-infection.The patient developed severe disease indications in a short time period.The patient showed neurological symptoms,altered hematological as well as liver-test parameters,and subsequent death in a narrow time span.We hereby discuss the various aspects of this case regarding treatment and hematological parameters.Further,we have put forward perspectives related to the mechanism behind severity and neurological symptoms in this fatal parasite-virus co-infection case.In malaria-endemic regions,due to overlapping symptoms,suspected COVID-19 patients should also be monitored for diagnosis of malaria without any delay.The SARS-CoV-2 and Plasmodium co-infection could increase the disease severity in a short time span.In treatment,dexamethasone may not help in severe cases having malaria as well as COVID-19 positive status and needs further exploration.展开更多
Sir,Oral submucous fibrosis is a chronic inflammatory disease,which results in progressive juxta-epithelial fibrosis of the oral soft tissues and can cause increasing difficulty in chewing,swallowing,speaking and mout...Sir,Oral submucous fibrosis is a chronic inflammatory disease,which results in progressive juxta-epithelial fibrosis of the oral soft tissues and can cause increasing difficulty in chewing,swallowing,speaking and mouth opening.[1]Management of the disease,being medical or surgical,poses a great challenge because of the tendency to recur or undergo malignant transformation.展开更多
Seven zoysiagrass genotypes were evaluated for salt tolerance in a greenhouse study.The plant materials included Zoysia matrella'Diamond',Z.japonica'Palisades',three Z.matrella×Z.japonica hybrids ...Seven zoysiagrass genotypes were evaluated for salt tolerance in a greenhouse study.The plant materials included Zoysia matrella'Diamond',Z.japonica'Palisades',three Z.matrella×Z.japonica hybrids DALZ 1701,DALZ 1713,and'Innovation',and two Z.minima×Z.matrella hybrids(DALZ 1309 and'Lazer').Treatments included a control(nutrient solution)and two saline treatments representing moderate and high salt levels.The electrical conductivity(EC)was 1.3 dS m−1 for control and moderate(EC5)and high salinity(EC10)were 5.0 and 10.0 dS m−1,respectively.At the end of eight-weeks of treatment,the relative(percent control)shoot dry weight(DW)was greatest in'Diamond'in EC10,and the relative root DW was greatest in DALZ 1309 in EC5.A cluster analysis based on the relative tissue dry weight identified'Diamond',DALZ 1309,and DALZ 1713 as the most salt tolerant genotypes.Additionally,the green leaf area(GLA)index of'Diamond'and DALZ 1713 were 98.8%and 100%,respectively,indicating excellent visual appearance under high salt levels.Bi-weekly clipping DW showed that'Diamond'continued to produce biomass throughout the duration of the study under the EC10 treatment.Sodium(Na^(+))and chloride(Cl−)content in the shoot tissue of the seven turfgrass genotypes indicated that lower concentrations corresponded to greater salt tolerance indicating exclusion of Na+and Cl−from the shoot tissue.Taken together,the genotypes'Diamond'and DALZ 1713 were determined to be the most salt tolerant and recommended for use in areas with high soil or water salinity.展开更多
文摘Diabetic foot ulcers are the consequence of multiple factors including peripheral neuropathy,decreased blood supply,high plantar pressures,etc.,and pose a significant risk for morbidity,limb loss and mortality.The critical aspects of the wound healing mechanism and host physiological status in patients with diabetes necessitate the selection of an appropriate treatment strategy based on the complexity and type of wound.In addition to systemic antibiotics and surgical intervention,wound care is considered to be an important component of diabetic foot ulcer management.This article will focus on the use of different wound care materials in diabetic foot.From a clinical perspective,it is important to decide on the wound care material depending on the type and grade of the ulcer.This article will also provide clinicians with a simple approach to the choice of wound care materials in diabetic foot ulcer.
文摘The different investigation has been carried out on the biological activities of titanium dioxide nanoparticle but the effect of this nano product on the antibacterial activity of different antibiotics has not been yet demonstrated. In this study the nano size TiO2 is synthesized using citric acid and alpha dextrose and the enhancement effect of TiO2 nanoparticle on the antibacterial activity of different antibiotics was evaluated against Methicillin-resistant Staphylococcus aureus (MRSA). During the present study, different concentrations of nano-scale TiO2 were tested to find out the best concentration that can have the most effective antibacterial property against the MRSA culture. Disk diffusion method was used to determine the antibacterial activity of these antibiotics in the absence and presence of sub inhibitory concentration of TiO2 nano particle. A clinical isolate of MRSA, isolated from Intensive Care Unit (ICU) was used as test strain. In the presence of sub-inhibitory concentration of TiO2 nanoparticle (20 μg/disc) the antibacterial activities of all antibiotics have been increased against test strain with minimum 2 mm to maximum 10mm. The highest increase in inhibitory zone for MRSA was observed against pencillin G and amikacin (each 10 mm). Conversely, in case of nalidixic acid, TiO2 nanoparticle showed a Synergic effect on the antibacterial activity of this antibiotic against test strain. These results signify that the TiO2 nanoparticle potentate the antimicrobial action of beta lactums, cephalosporins, aminoglycosides, glycopeptides, macrolids and lincosamides, tetracycline a possible utilization of nano compound in combination effect against MRSA.
文摘Childhood-onset obesity has emerged as a major public healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and epigenetic predispositions.This has led to an exponential rise in the incidence of type 2 diabetes mellitus in children and adolescents.The looming wave of diabetes-related complications in early adulthood is anticipated to strain the healthcare budgets in most countries.Unless there is a collective global effort to curb the devastation caused by the situation,the impact is poised to be pro-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this goal.This article delves into the current epidemiological landscape,explores evidence concerning potential risks and consequences,delves into the pathobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.
文摘From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span style="font-family:Verdana;">Curcuma</span></i> <i><span style="font-family:Verdana;">longa</span></i><span style="font-family:Verdana;"> (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial </span><span style="font-family:Verdana;">effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities.</span><span style="font-family:Verdana;"> Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.
文摘Online Social Networks (OSN) sites allow end-users to share agreat deal of information, which may also contain sensitive information,that may be subject to commercial or non-commercial privacy attacks. Asa result, guaranteeing various levels of privacy is critical while publishingdata by OSNs. The clustering-based solutions proved an effective mechanismto achieve the privacy notions in OSNs. But fixed clustering limits theperformance and scalability. Data utility degrades with increased privacy,so balancing the privacy utility trade-off is an open research issue. Theresearch has proposed a novel privacy preservation model using the enhancedclustering mechanism to overcome this issue. The proposed model includesphases like pre-processing, enhanced clustering, and ensuring privacy preservation.The enhanced clustering algorithm is the second phase where authorsmodified the existing fixed k-means clustering using the threshold approach.The threshold value is determined based on the supplied OSN data of edges,nodes, and user attributes. Clusters are k-anonymized with multiple graphproperties by a novel one-pass algorithm. After achieving the k-anonymityof clusters, optimization was performed to achieve all privacy models, suchas k-anonymity, t-closeness, and l-diversity. The proposed privacy frameworkachieves privacy of all three network components, i.e., link, node, and userattributes, with improved utility. The authors compare the proposed techniqueto underlying methods using OSN Yelp and Facebook datasets. The proposedapproach outperformed the underlying state of art methods for Degree ofAnonymization, computational efficiency, and information loss.
文摘Optimal initial non-invasive management of acute hypoxemic respiratory failure(AHRF),of both coronavirus disease 2019(COVID-19)and non-COVID-19 etiologies,has been the subject of significant discussion.Avoidance of endotracheal intubation reduces related complications,but maintenance of spontaneous breathing with intense respiratory effort may increase risks of patients’self-inflicted lung injury,leading to delayed intubation and worse clinical outcomes.High-flow nasal oxygen is currently recommended as the optimal strategy for AHRF management for its simplicity and beneficial physiological effects.Non-invasive ventilation(NIV),delivered as either pressure support or continuous positive airway pressure via interfaces like face masks and helmets,can improve oxygenation and may be associated with reduced endotracheal intubation rates.However,treatment failure is common and associated with poor outcomes.Expertise and knowledge of the specific features of each interface are necessary to fully exploit their potential benefits and minimize risks.Strict clinical and physiological monitoring is necessary during any treatment to avoid delays in endotracheal intubation and protective ventilation.In this narrative review,we analyze the physiological benefits and risks of spontaneous breathing in AHRF,and the characteristics of tools for delivering NIV.The goal herein is to provide a contemporary,evidence-based overview of this highly relevant topic.
文摘A novel DOIND logic approach is proposed for domino logic, which reduces the leakage current with a minimum delay penalty. Simulation is performed at 70 nm technology node with supply voltage 1V for domino logic and DOIND logic based AND, OR, XOR and Half Adder circuits using the tanner EDA tool. Simulation results show that the proposed DOIND approach decreases the average leakage current by 68.83%, 66.6%, 77.86% and 74.34% for 2 input AND, OR, XOR and Half Adder respectively. The proposed approach also has 47.76% improvement in PDAP for the buffer circuit as compared to domino logic.
文摘Objective:To determine the antioxidant and hepatoprotective potential of methanol extract of rhizome of Curcuma angustifolia(MECA)against carbon tetrachloride(CCl4)-induced hepatic damage in vitro and in vivo.Methods:DPPH,ABTS and reducing power assays were performed to estimate the antioxidant effect of MECA.In vitro cytotoxicity of MECA against HepG2 cells was evaluated,whereas serum biochemical parameters and levels of antioxidative enzymes were measured in vivo and in vitro.Additionally,histopathological studies were estimated in order to investigate the hepatoprotective efficacy of MECA.Furthermore,GC-MS analysis of the extract was performed to identify the chemical components.Results:MECA exhibited strong antioxidant activity and attenuated CCl4-induced decrease in the viability of HepG2 cells.Additionally,MECA significantly restored the ALT,AST,ALP,TP and albumin level in comparison with the CCl4 group.After pre-treatment with MECA,effects of SOD,CAT and GSH were increased as well as lipid peroxidation amount decreased on CCl4-induced hepatotoxicity in in vitro and in vivo model.Furthermore,histopathological observation confirmed that MECA reduced liver injury induced by CCl4 in rats.GC-MS analysis confirmed the presence of bioactive constituents such as α-tocopherol(12.27%),phytol(7.61%),squalene(3.71%),β-sitosterol(2.19%),eugenol(2.59%),curcumenol(1.20%),β-elemene(1.00%)and eucalyptol(0.89%).Conclusions:MECA contains antioxidant and hepatoprotective constituents such asα-tocopherol,phytol,squalene and eugenol and exerts hepatoprotective effect both in vitro and in vivo.
文摘BACKGROUND Pancreatitis with infected necrosis is a severe complication of acute pancreatitis and carries with it high rates of morbidity and mortality. The management of infected pancreatic necrosis alongside concomitant colorectal cancer has never been described in literature.CASE SUMMARY A 77 years old gentleman presented to the Emergency Department of our hospital complaining of ongoing abdominal pain for 8 h. The patient had clinical features of pancreatitis with a raised lipase of 3810 U/L, A computed tomography(CT) abdomen confirmed pancreatitis with extensive peri-pancreatic edema. During the course of his admission, the patient had persistent high fevers and delirium thought secondary to infected necrosis, prompting the commencement of broad-spectrum antibiotic therapy with Piperacillin/Tazobactam. Subsequent CT abdomen confirmed extensive pancreatic necrosis(over 70%). Patient was managed with supportive therapy,nutritional support and gut rest initially and improved over the course of his admission and was discharged 42 d post admission. He represented 24 d following his discharge with fever and chills and a repeat CT abdomen scan noted gas bubbles within the necrotic pancreatic tissue thereby confirming infected necrotic pancreatitis. This CT scan also revealed asymmetric thickening of the rectal wall suspicious for malignancy. A rectal cancer was confirmed on flexible sigmoidoscopy. The patient underwent two endoscopic necrosectomies and was treated with intravenous antibiotics and was discharged after 28 d.Within 1 wk post discharge, the patient commenced a course of neoadjuvant radiotherapy and subsequently underwent concomitant chemotherapy prior to undergoing a successful Hartmann's procedure for treatment of his colorectal cancer.CONCLUSION This case highlights the efficacy of endoscopic necrosectomy, early enteral feeding and targeted antibiotic therapy for timely management of infected necrotic pancreatitis. The prompt resolution of pancreatitis permitted the patient to undergo neoadjuvant tre
基金the Doon University,Dehradun,India,for the financial support to carry out the research work。
文摘The rivers draining from the Himalayan range distribute enormous amount of fresh water to the people living in downstream regions.Trace metals flowed with river water can lead to serious impact on ecological system and human health.Nevertheless,the documentation on trace elements of Himalayan rivers is inadequately documented.The current study deals with the spatial and temporal variability of the major and trace elements of Ganga river water in epirhithron,metarhithron and hyporhithron zone belonging to Himalayan segment.Water samples from nineteen monitoring locations were collected in pre-monsoon(May-June),monsoon(AugustSeptember)and post-monsoon(December)seasons and subjected to be assessed for 20 elements(Ag,Al,Ba,Cd,Ca,Cr,Cu,Fe,Ga,K,Mn,Mg,Na,Ni,Pb,Sr,Th,U,Zn,and Zr)using ICP-OES(Inductively Coupled Plasma-Optical Emission Spectrometer).Different water pollution indexes such as HPI(Heavy Metal Pollution Index),MI(Metal Index)and PI(Pollution Index)were used to describe current water quality status at each monitoring station under particular classified ecological zone.The studied stations in hyporhithron zone had the value of Metal Index(MI>1),indicating threshold of warning.Further,the highest values of HPI in hyporhithron zone correspond to poor water quality status.Sites with poor water quality were also found to be contaminated as per the Pollution Index(PI),exhibiting high concentrations for element(Fe).However,the epirhithron and metarhithron zone in Himalayan segment showed excellent water quality mainly contributed from natural sources.Cluster Analysis(CA)and Principal Component Analysis(PCA)were applied to identify the main influential sources for Ganga river water pollution.The Kriging interpolation method was also applied to prepare spatial distribution map of computed indexes(HPI,MI,and PI).With the help of index of local Moran’s I(LMI),identified spatial clusters and spatial outliers revealed the elevated concentration of most elements in hyporhithron zone.The dataset presented in this study wo
文摘MC （Monte Carlo） simulation code, JA-IPU is used to study radiation damage of SiC irradiated to spallation neutron and AmBe neutron spectra. The code is based on the major physical processes of radiation damage on incorporation of atomic collision cascade and limited to 10 MeV neutron energy. A phenomenological relation for radiation swelling is also derived. Based on the calculation of swelling, DPA （displacement per atom）, defect production efficiency and effective threshold energy, Efff from the data of MC simulation, SiC is inferred to be a highly radiation resistant material when compared with Nb and Ni metals which are used in composition of several reactor steels. Experimental results of hill-hock density measured using AFM （atomic force microscopy）, also confirm radiation resistant behavior of SiC.
文摘The important enhancement in the structural,dielectric and optical properties of pure polymer and CdSe incorporated polyvinyl pyrrolidone has been reported in this paper.The surface morphology of CdSe/PVP nanocomposite film is studied by using scanning electron microscopy(SEM).The chemical composition of different elements has been reported using energy dispersive X-ray(EDX)spectrum.The structure of polymer nanocomposite is determined with the help of X-ray diffraction(XRD)spectrum and is observed to be hexagonal.Particle size,intercrystalline separation,interplanner spacing,lattice parameters,strain and dislocation factors are calculated using XRD results.Fourier transform infrared spectroscopy(FTIR)and Photoluminescence(PL)analysis have been studied in order to check the possible interaction between CdSe quantum dots and polyvinyl pyrrolidone(PVP)matrix.The ac conductivity of CdSe/PVP nanocomposite is found to be higher as compared to pure polymers.The highest value of conductivity observed at 60203 Hz and at 523 K is found to be 3:72105 Sm1.Comparative study of dielectric constant,dielectric losses,dissipation factor,electric modulus and impedance has been performed.The semi-circles in impedance measurement for both materials show the bulk electrical properties that result in single relaxation process in CdSe/PVP nanocomposite.
文摘To determine whether reforestation efforts in the denuded hills have significant impacts on hydrology in the Xinjiang River watershed, the authors examined eight land-cover scenarios to compare hydrologic responses and to provide a conceptual basis for restoration practices. The authors analyzed a 17-year time period using remote sensing to develop land-cover classification for the watershed. Climate, soil and terrain data for the watershed were used as input in the SWAT （soil and water analysis tool） to quantify and compare the impacts on hydrologic processes. The model was calibrated to a two-year record of stream discharge measurements. The results show significant increase in forest-cover on hills （13%）. However, the hydrological response is not very significant considering the changes in forest-cover, the surface runoff and percolation ratios only changed by 2% and 1% over time. Installment of earthen irrigation ponds in the outlets of sub-basin with maximum runoff had provided the most significant hydrologic improvements and could provide irrigation water to increase crop yield on remaining cropland. The study will provide information to the local government to aid decision-making in sustainable reforestation programs resulting in better hydrologic functioning for sustainable water resource management.
基金Acknowledgement： Authors are highly thankful to the CSIR, New Delhi （India） for providing financial assistance to carryout the present work. Authors are also thankful to the forest officials of Rajasthan for providing the necessary facilities during the field work to the tribals for giving the valuable information to the authorities of Forest Research Institute, Dehradun for permitting to consult herbarium for final identification of plants.
文摘Forest fires are one of the major environmental issues globally.In Nepal,substantial amounts of forest biomass and carbon are lost due to fire.Nepal’s high value lowland forests are particularly vulnerable to fire.However,there are limited studies on the estimation of biomass loss and carbon emissions due to fire.Thus,this research addresses the information gap in the tropical mixed broad-leaved forests of Nawalparasi District.The forests were divided into three strata:Lower Tropical Sal Mixed Broad-leaved Forest,Hill Sal Forest and Riverine Forest,and from these four community-managed forests were selected for estimating above ground biomass.Ninety-two sample plots were set out for above ground biomass estimation in burnt and non-burnt areas.Forest fire incidences from 2001 to 2017 were acquired from the MODIS fire data.Forest biomass and carbon emissions were estimated using standard allometric equations.The fuel fraction consumed during the fire was estimated through field surveys during the forest fire season.The results show that every year,over 3158 ha of forests are burnt,resulting in some 1108 tons of carbon emissions,equivalent to approximately 4066 t CO_(2),2581 t CO and 1474 t CH4.Among the forests,the Hill Sal Forest was more vulnerable to fire.Forest management strategies,therefore,should include construction of fire lines and conservation ponds along with capacity building and raising awareness among local communities and stakeholders.
文摘Lipoma is a benign neoplasm of the soft tissue that originates in mature adipocytes. Even though it is a very common tumor, it is relatively uncommon in oral cavity. It represents about 1% to 4% of all benign tumors in oral cavity (12). This article describes a case of a 39 years old male with an intraoral pedunculated mass in the right side of hard palate which was histopathologically proved as a simple lipoma.
基金supported by Council for Scientific and Industrial Research[Grant no 37(1693)/17/EMR-II]Department of Science and Technology as Ramanujan fellowship[Grant no.SB/S2/RJN-132/20/5].
文摘In malaria-endemic regions,people often get exposed to various pathogens simultaneously,generating coinfection scenarios.In such scenarios,overlapping symptoms pose serious diagnostic challenges.The delayed diagnosis may lead to an increase in disease severity and catastrophic events.Recent coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has affected various areas globally,including malaria-endemic regions.The Plasmodium and SARS-CoV-2 co-infection and its effect on health are yet unexplored.We present a case report of a previously healthy,middle-aged individual from the malaria-endemic area who suffered SARS-CoV-2 and Plasmodium falciparum co-infection.The patient developed severe disease indications in a short time period.The patient showed neurological symptoms,altered hematological as well as liver-test parameters,and subsequent death in a narrow time span.We hereby discuss the various aspects of this case regarding treatment and hematological parameters.Further,we have put forward perspectives related to the mechanism behind severity and neurological symptoms in this fatal parasite-virus co-infection case.In malaria-endemic regions,due to overlapping symptoms,suspected COVID-19 patients should also be monitored for diagnosis of malaria without any delay.The SARS-CoV-2 and Plasmodium co-infection could increase the disease severity in a short time span.In treatment,dexamethasone may not help in severe cases having malaria as well as COVID-19 positive status and needs further exploration.
文摘Sir,Oral submucous fibrosis is a chronic inflammatory disease,which results in progressive juxta-epithelial fibrosis of the oral soft tissues and can cause increasing difficulty in chewing,swallowing,speaking and mouth opening.[1]Management of the disease,being medical or surgical,poses a great challenge because of the tendency to recur or undergo malignant transformation.
基金Funding for this project is provided by USDA NIFA to Project No.2017-68007-26318through the Agriculture and Food Research Initiative,Water for Agricultural Challenge Area,and hatch project TEX07726.
文摘Seven zoysiagrass genotypes were evaluated for salt tolerance in a greenhouse study.The plant materials included Zoysia matrella'Diamond',Z.japonica'Palisades',three Z.matrella×Z.japonica hybrids DALZ 1701,DALZ 1713,and'Innovation',and two Z.minima×Z.matrella hybrids(DALZ 1309 and'Lazer').Treatments included a control(nutrient solution)and two saline treatments representing moderate and high salt levels.The electrical conductivity(EC)was 1.3 dS m−1 for control and moderate(EC5)and high salinity(EC10)were 5.0 and 10.0 dS m−1,respectively.At the end of eight-weeks of treatment,the relative(percent control)shoot dry weight(DW)was greatest in'Diamond'in EC10,and the relative root DW was greatest in DALZ 1309 in EC5.A cluster analysis based on the relative tissue dry weight identified'Diamond',DALZ 1309,and DALZ 1713 as the most salt tolerant genotypes.Additionally,the green leaf area(GLA)index of'Diamond'and DALZ 1713 were 98.8%and 100%,respectively,indicating excellent visual appearance under high salt levels.Bi-weekly clipping DW showed that'Diamond'continued to produce biomass throughout the duration of the study under the EC10 treatment.Sodium(Na^(+))and chloride(Cl−)content in the shoot tissue of the seven turfgrass genotypes indicated that lower concentrations corresponded to greater salt tolerance indicating exclusion of Na+and Cl−from the shoot tissue.Taken together,the genotypes'Diamond'and DALZ 1713 were determined to be the most salt tolerant and recommended for use in areas with high soil or water salinity.
