Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psori...Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psoriatic activity.Methanol extract(100 and 200 mg/kg b.w.) and isolated flavonoid quercetin(25 and 50 mg/kg b.w.) were tested in Swiss albino mice.Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values.The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats.In vitro antiproliferant assay on HaCaT cell lines was also carried out.Results:The isolated flavonoid quercetin from the rhizome of S.china produced significant orthokeratosis(P<0.01) in the mouse tail test.In epidermal thickness,a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin.The methanol extract(200 mg/kg) and isolated flavonoid quercetin(50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition(P<0.001) in leukocyte migration.Maximum antiproliferant activity was shown by isolated flavonoid quercetin(IC_(50),62.42± 10.20 μg/mL).Conclusions:From the above data,the flavonoid quercetin shows significant orthokeratosis,anti-inflammatory and maximum antiproliferant activities.To our knowledge,this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity.展开更多
Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic acti...Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.展开更多
With the invention of Internet-enabled devices,cloud and blockchain-based technologies,an online voting system can smoothly carry out election processes.During pandemic situations,citizens tend to develop panic about ...With the invention of Internet-enabled devices,cloud and blockchain-based technologies,an online voting system can smoothly carry out election processes.During pandemic situations,citizens tend to develop panic about mass gatherings,which may influence the decrease in the number of votes.This urges a reliable,flexible,transparent,secure,and cost-effective voting system.The proposed online voting system using cloud-based hybrid blockchain technology eradicates the flaws that persist in the existing voting system,and it is carried out in three phases:the registration phase,vote casting phase and vote counting phase.A timestamp-based authentication protocol with digital signature validates voters and candidates during the registration and vote casting phases.Using smart contracts,third-party interventions are eliminated,and the transactions are secured in the blockchain network.Finally,to provide accurate voting results,the practical Byzantine fault tolerance(PBFT)consensus mechanism is adopted to ensure that the vote has not been modified or corrupted.Hence,the overall performance of the proposed system is significantly better than that of the existing system.Further performance was analyzed based on authentication delay,vote alteration,response time,and latency.展开更多
High-temperature superconductivity in ceramic oxides is a new technology in which advances are occurring at a rapid pace. Here, the author describes some properties of a new nano crystalline ceramic Type II supercondu...High-temperature superconductivity in ceramic oxides is a new technology in which advances are occurring at a rapid pace. Here, the author describes some properties of a new nano crystalline ceramic Type II superconductor, PbSrCaCuO. Type II superconductors are usually made of metal alloys or complex oxide ceramics. The PSCCO perovskite phase structure was prepared by the conventional solid state reaction technique. In order to show the viability of the proposed method, super-conducting powder was prepared in special furnace. The sample was analyzed by X-ray Diffraction (XRD), Particle size determination, SEM and EDX. The comparison of XRD results with JCPDS files confirmed the orthorhombic structure of the sample with a ≠ b ≠ c and α = β = γ = 90°. Scanning electron microscopy (SEM) studies revealed that its particle size is in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX spectrum shows the elements of the sample. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.展开更多
With the discovery of high-TC superconducting materials like Yttrium Barium Cupric Oxide, Bismuth Strontium Calcium Copper Oxide and Thallium Calcium Barium Copper Oxide, tremendous interest has developed over the pas...With the discovery of high-TC superconducting materials like Yttrium Barium Cupric Oxide, Bismuth Strontium Calcium Copper Oxide and Thallium Calcium Barium Copper Oxide, tremendous interest has developed over the past two years in understanding these materials as well as utilizing them in a variety of applications. The thin films of these materials are expected to play an important role in the area of microelectronics, especially for interconnects in integrated circuits, Josephson junctions, magnetic field sensors and optical detectors. Here, the authors designed a new nanocrystalline ceramic type II high-TC superconductor, Gadolinium Barium Copper Oxide (GdBaCuO/GBCO). The GBCO perovskite phase structure was prepared by the conventional solid state thermochemical reaction technique involving mixing, milling, calcination and sintering. In GBCO system, the method for controlling microstructure and superconducting state is related to oxygen content consideration because small changes in oxygen concentration can often?lead to huge change in Tc. In order to show the viability of the proposed method, super-conducting powder was prepared in special furnace. The sample was analyzed by X-Ray Diffraction (XRD), an indispensible non-destructive tool for structural materials characterization and quality control which makes use of the Debye-Scherrer method. The comparison of XRD results with JCPDS files confirmed the orthorhombic structure of the sample. Micro-structural features are studied using Scanning Electron Microscopy (SEM) which revealed that its particle size is in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX plot shows the presence of all the constituents. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.展开更多
X-ray crystallography is concerned with discovering and describing the crystal structure. High-temperature superconductivity in ceramic oxides is a new technology in which advances are occurring at a rapid pace. Here,...X-ray crystallography is concerned with discovering and describing the crystal structure. High-temperature superconductivity in ceramic oxides is a new technology in which advances are occurring at a rapid pace. Here, the author describes some properties of a new nano crystalline ceramic type II superconductor, PbBaTiO. Type II superconductors are usually made of metal alloys or complex oxide ceramics. The PBT perovskite phase structure was prepared by the conventional solid state reaction technique. The sample was analyzed by X-ray Diffraction (XRD), Particle size determination, SEM and EDX. The comparison of XRD results with JCPDS files confirmed the tetragonal structure of the sample with a = b ≠ c and α = β = γ = 90°. Scanning electron microscopy (SEM) studies revealed that its particle size was in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX spectrum shows the elements of the sample. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.展开更多
Poeciloneuron pauciflorum is a narrow endemic having highly restricted distribution in the southern-western Ghats region of India. 18 accessions of P. pauciflorum collected from four different locations were analyzed ...Poeciloneuron pauciflorum is a narrow endemic having highly restricted distribution in the southern-western Ghats region of India. 18 accessions of P. pauciflorum collected from four different locations were analyzed for genetic variation using 20 random primers. Out of 141 amplicons generated, 130 of them were polymorphic (92.20% polymorphism). Contrary to the general concept of low genetic variation associated with endemic plant species, P. pauciflorum exhibits high genetic diversity as the similarity index value based on Nei & Li’s similarity coefficient ranges from 0.36 to 0.95 with mean GS = 0.72 and Shannon’s information measure (0.43). Cluster analysis showed grouping of all accessions from the State of Tamil Nadu into two major clusters with few outliers while those from the State of Kerala also clustered with them. Accessions from Kalliankadu forest segment harbors maximum diversity as indicated by various genetic diversity indices like h, I, Ht, Hs, Gst, PL and hence this site is recommended for in situ conservation of this narrow endemic. The main factors responsible for the high level of genetic diversity among accessions are probably related to the reproductive isolation and ecological breadth. The strong genetic variability among accessions indicates that the management for the conservation of the genetic diversity in P. pauciflorum should aim to preserve every accession. The present study assumes significance as it negotiates endemism and genetic variation in tree species, a global phenomenon having wide implications in species diversity and conservation.展开更多
The high temperature superconductors are ceramic materials with layers of Copper-oxide spaced by layers containing Barium and other atoms. The Yttrium compound is somewhat unique in that it has a regular crystal struc...The high temperature superconductors are ceramic materials with layers of Copper-oxide spaced by layers containing Barium and other atoms. The Yttrium compound is somewhat unique in that it has a regular crystal structure while the Lanthanum version is classified as a solid solution. The Yttrium compound is often called the 1-2-3 superconductor because of the ratios of its constituents. Lanthanum Zirconium Yttrium Barium Calcium Copper Oxide (LaZrYBaCaCuO) was prepared by the usual solid state reaction method. In order to show the viability of the proposed method, super-conducting powder was prepared in special furnace. The sample was analyzed by X-ray Diffraction (XRD), Particle size determination, SEM and EDX. The comparison of XRD results with JCPDS files confirmed the orthorhombic structure of the sample with a ≠ b ≠ c and α = β = γ = 90°. Scanning Electron Microscopy (SEM) studies revealed that its particle size is in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX spectrum shows the elements of the sample. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.展开更多
Clustering is one of the recently challenging tasks since there is an ever.growing amount of data in scientific research and commercial applications. High quality and fast document clustering algorithms are in great d...Clustering is one of the recently challenging tasks since there is an ever.growing amount of data in scientific research and commercial applications. High quality and fast document clustering algorithms are in great demand to deal with large volume of data. The computational requirements for bringing such growing amount data to a central site for clustering are complex. The proposed algorithm uses optimal centroids for K.Means clustering based on Particle Swarm Optimization(PSO).PSO is used to take advantage of its global search ability to provide optimal centroids which aids in generating more compact clusters with improved accuracy. This proposed methodology utilizes Hadoop and Map Reduce framework which provides distributed storage and analysis to support data intensive distributed applications. Experiments were performed on Reuter's and RCV1 document dataset which shows an improvement in accuracy with reduced execution time.展开更多
In recent years,much research has been focused on separating acoustic sources from their mixtures.Degenerate Unmixing Estimation Technique(DUET)is one of the widely popular meth-ods of Blind Source Separation(BSS)in u...In recent years,much research has been focused on separating acoustic sources from their mixtures.Degenerate Unmixing Estimation Technique(DUET)is one of the widely popular meth-ods of Blind Source Separation(BSS)in underdetermined scenarios.DUET is based on a signal recovery sparsity algorithm whose performance is strongly influenced by sparsity in the Time-Frequency(TF)domain.Noises and an several sources in mixtures limit the sparsity resulting in performance degradation in DUET.Here an enhanced strategy has been adopted by combin-ing DUET with adaptive noise cancellation utilising the Dual-Tree Complex Wavelet Transform(DTCWT)as a pre-processor and TF refinement utilising Synchroextracting Transform(SET)as a post-processor.This improves the sparsity of sources and energy concentrations in a TF rep-resentation.Results of the signal separation performance evaluation reveal that the proposed algorithm outperforms conventional DUET in signal separation,especially in real-time scenarios.展开更多
基金financially supported by Vels University,Tamilnadu,India
文摘Objective:To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china(S.china) Linn.Methods:Mouse tail test was used for the evaluation of anti-psoriatic activity.Methanol extract(100 and 200 mg/kg b.w.) and isolated flavonoid quercetin(25 and 50 mg/kg b.w.) were tested in Swiss albino mice.Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values.The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats.In vitro antiproliferant assay on HaCaT cell lines was also carried out.Results:The isolated flavonoid quercetin from the rhizome of S.china produced significant orthokeratosis(P<0.01) in the mouse tail test.In epidermal thickness,a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin.The methanol extract(200 mg/kg) and isolated flavonoid quercetin(50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition(P<0.001) in leukocyte migration.Maximum antiproliferant activity was shown by isolated flavonoid quercetin(IC_(50),62.42± 10.20 μg/mL).Conclusions:From the above data,the flavonoid quercetin shows significant orthokeratosis,anti-inflammatory and maximum antiproliferant activities.To our knowledge,this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity.
文摘Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.
文摘With the invention of Internet-enabled devices,cloud and blockchain-based technologies,an online voting system can smoothly carry out election processes.During pandemic situations,citizens tend to develop panic about mass gatherings,which may influence the decrease in the number of votes.This urges a reliable,flexible,transparent,secure,and cost-effective voting system.The proposed online voting system using cloud-based hybrid blockchain technology eradicates the flaws that persist in the existing voting system,and it is carried out in three phases:the registration phase,vote casting phase and vote counting phase.A timestamp-based authentication protocol with digital signature validates voters and candidates during the registration and vote casting phases.Using smart contracts,third-party interventions are eliminated,and the transactions are secured in the blockchain network.Finally,to provide accurate voting results,the practical Byzantine fault tolerance(PBFT)consensus mechanism is adopted to ensure that the vote has not been modified or corrupted.Hence,the overall performance of the proposed system is significantly better than that of the existing system.Further performance was analyzed based on authentication delay,vote alteration,response time,and latency.
文摘High-temperature superconductivity in ceramic oxides is a new technology in which advances are occurring at a rapid pace. Here, the author describes some properties of a new nano crystalline ceramic Type II superconductor, PbSrCaCuO. Type II superconductors are usually made of metal alloys or complex oxide ceramics. The PSCCO perovskite phase structure was prepared by the conventional solid state reaction technique. In order to show the viability of the proposed method, super-conducting powder was prepared in special furnace. The sample was analyzed by X-ray Diffraction (XRD), Particle size determination, SEM and EDX. The comparison of XRD results with JCPDS files confirmed the orthorhombic structure of the sample with a ≠ b ≠ c and α = β = γ = 90°. Scanning electron microscopy (SEM) studies revealed that its particle size is in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX spectrum shows the elements of the sample. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.
文摘With the discovery of high-TC superconducting materials like Yttrium Barium Cupric Oxide, Bismuth Strontium Calcium Copper Oxide and Thallium Calcium Barium Copper Oxide, tremendous interest has developed over the past two years in understanding these materials as well as utilizing them in a variety of applications. The thin films of these materials are expected to play an important role in the area of microelectronics, especially for interconnects in integrated circuits, Josephson junctions, magnetic field sensors and optical detectors. Here, the authors designed a new nanocrystalline ceramic type II high-TC superconductor, Gadolinium Barium Copper Oxide (GdBaCuO/GBCO). The GBCO perovskite phase structure was prepared by the conventional solid state thermochemical reaction technique involving mixing, milling, calcination and sintering. In GBCO system, the method for controlling microstructure and superconducting state is related to oxygen content consideration because small changes in oxygen concentration can often?lead to huge change in Tc. In order to show the viability of the proposed method, super-conducting powder was prepared in special furnace. The sample was analyzed by X-Ray Diffraction (XRD), an indispensible non-destructive tool for structural materials characterization and quality control which makes use of the Debye-Scherrer method. The comparison of XRD results with JCPDS files confirmed the orthorhombic structure of the sample. Micro-structural features are studied using Scanning Electron Microscopy (SEM) which revealed that its particle size is in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX plot shows the presence of all the constituents. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.
文摘X-ray crystallography is concerned with discovering and describing the crystal structure. High-temperature superconductivity in ceramic oxides is a new technology in which advances are occurring at a rapid pace. Here, the author describes some properties of a new nano crystalline ceramic type II superconductor, PbBaTiO. Type II superconductors are usually made of metal alloys or complex oxide ceramics. The PBT perovskite phase structure was prepared by the conventional solid state reaction technique. The sample was analyzed by X-ray Diffraction (XRD), Particle size determination, SEM and EDX. The comparison of XRD results with JCPDS files confirmed the tetragonal structure of the sample with a = b ≠ c and α = β = γ = 90°. Scanning electron microscopy (SEM) studies revealed that its particle size was in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX spectrum shows the elements of the sample. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.
文摘Poeciloneuron pauciflorum is a narrow endemic having highly restricted distribution in the southern-western Ghats region of India. 18 accessions of P. pauciflorum collected from four different locations were analyzed for genetic variation using 20 random primers. Out of 141 amplicons generated, 130 of them were polymorphic (92.20% polymorphism). Contrary to the general concept of low genetic variation associated with endemic plant species, P. pauciflorum exhibits high genetic diversity as the similarity index value based on Nei & Li’s similarity coefficient ranges from 0.36 to 0.95 with mean GS = 0.72 and Shannon’s information measure (0.43). Cluster analysis showed grouping of all accessions from the State of Tamil Nadu into two major clusters with few outliers while those from the State of Kerala also clustered with them. Accessions from Kalliankadu forest segment harbors maximum diversity as indicated by various genetic diversity indices like h, I, Ht, Hs, Gst, PL and hence this site is recommended for in situ conservation of this narrow endemic. The main factors responsible for the high level of genetic diversity among accessions are probably related to the reproductive isolation and ecological breadth. The strong genetic variability among accessions indicates that the management for the conservation of the genetic diversity in P. pauciflorum should aim to preserve every accession. The present study assumes significance as it negotiates endemism and genetic variation in tree species, a global phenomenon having wide implications in species diversity and conservation.
文摘The high temperature superconductors are ceramic materials with layers of Copper-oxide spaced by layers containing Barium and other atoms. The Yttrium compound is somewhat unique in that it has a regular crystal structure while the Lanthanum version is classified as a solid solution. The Yttrium compound is often called the 1-2-3 superconductor because of the ratios of its constituents. Lanthanum Zirconium Yttrium Barium Calcium Copper Oxide (LaZrYBaCaCuO) was prepared by the usual solid state reaction method. In order to show the viability of the proposed method, super-conducting powder was prepared in special furnace. The sample was analyzed by X-ray Diffraction (XRD), Particle size determination, SEM and EDX. The comparison of XRD results with JCPDS files confirmed the orthorhombic structure of the sample with a ≠ b ≠ c and α = β = γ = 90°. Scanning Electron Microscopy (SEM) studies revealed that its particle size is in the nanometer range. It also confirmed the calculated value of particle size from Debye Scherrer’s formula. EDX spectrum shows the elements of the sample. X-ray instrumental peak broadening analysis was used to evaluate the size and lattice strain by the Williamson-Hall Plot method.
文摘Clustering is one of the recently challenging tasks since there is an ever.growing amount of data in scientific research and commercial applications. High quality and fast document clustering algorithms are in great demand to deal with large volume of data. The computational requirements for bringing such growing amount data to a central site for clustering are complex. The proposed algorithm uses optimal centroids for K.Means clustering based on Particle Swarm Optimization(PSO).PSO is used to take advantage of its global search ability to provide optimal centroids which aids in generating more compact clusters with improved accuracy. This proposed methodology utilizes Hadoop and Map Reduce framework which provides distributed storage and analysis to support data intensive distributed applications. Experiments were performed on Reuter's and RCV1 document dataset which shows an improvement in accuracy with reduced execution time.
文摘In recent years,much research has been focused on separating acoustic sources from their mixtures.Degenerate Unmixing Estimation Technique(DUET)is one of the widely popular meth-ods of Blind Source Separation(BSS)in underdetermined scenarios.DUET is based on a signal recovery sparsity algorithm whose performance is strongly influenced by sparsity in the Time-Frequency(TF)domain.Noises and an several sources in mixtures limit the sparsity resulting in performance degradation in DUET.Here an enhanced strategy has been adopted by combin-ing DUET with adaptive noise cancellation utilising the Dual-Tree Complex Wavelet Transform(DTCWT)as a pre-processor and TF refinement utilising Synchroextracting Transform(SET)as a post-processor.This improves the sparsity of sources and energy concentrations in a TF rep-resentation.Results of the signal separation performance evaluation reveal that the proposed algorithm outperforms conventional DUET in signal separation,especially in real-time scenarios.
