Autoimmune uveitis is a group of intraocular inflammatory diseases that arise without known infectious etiology.Uveitis is one of the leading causes of blindness in the developed world and is responsible for up to 15%...Autoimmune uveitis is a group of intraocular inflammatory diseases that arise without known infectious etiology.Uveitis is one of the leading causes of blindness in the developed world and is responsible for up to 15%of severe visual handicap.The disease affects population of working age and has a significant impact on public health.Patients often show detectable immune responses to unique retinal proteins such as retinal arrestin and interphotoreceptor retinoid binding protein(IRBP),which are involved in visual function,and particular HLA haplotypes have been associated with disease,supporting the autoimmune nature(1).Although anecdotal evidence suggested a link between microbial infections and uveitis,our understanding of the etiology of disease.展开更多
文摘Autoimmune uveitis is a group of intraocular inflammatory diseases that arise without known infectious etiology.Uveitis is one of the leading causes of blindness in the developed world and is responsible for up to 15%of severe visual handicap.The disease affects population of working age and has a significant impact on public health.Patients often show detectable immune responses to unique retinal proteins such as retinal arrestin and interphotoreceptor retinoid binding protein(IRBP),which are involved in visual function,and particular HLA haplotypes have been associated with disease,supporting the autoimmune nature(1).Although anecdotal evidence suggested a link between microbial infections and uveitis,our understanding of the etiology of disease.
