Solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor is a rare epithelial neoplasm that represents 0.3% to 2.7% of exocrine pancreatic tumors. These tumors occur mainly in young women and have a good p...Solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor is a rare epithelial neoplasm that represents 0.3% to 2.7% of exocrine pancreatic tumors. These tumors occur mainly in young women and have a good prognosis. We present a case of a 19-year-old female patient who presented to the emergency for abdominal pain. Physical examination reveals a left hypochondrium mass. Ultrasound imaging showed an encapsulated caudal pancreatic mass with cystic components. The patient underwent tumor excision and lymph node removal. Macroscopically, the tumor was encapsulated and measuring 12 × 8 × 7 cm. It has a solid-cystic and hemorrhagic appearance inside. Histologically, the tumor had two components: solid and papillary. Tumor tissue showed monomorphic tumor cells radiating around blood vessels. Perineural invasion and vascular emboli were not seen. Three lymph nodes without metastases were observed. The diagnosis of solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor was retained. Solid-pseudo-papillary tumor of the pancreas is rare and not always suspected by the physician. The clinical and imaging patterns are not specific. Anatomopathological examination confirmed the diagnosis. The patient underwent curative surgery.展开更多
Introduction: Demons-Meigs syndrome combines a benign tumor of the ovary with ascites and pleural effusion. It is a rare disease and the pathophysiological mechanism is not yet well understood. The aim of our study is...Introduction: Demons-Meigs syndrome combines a benign tumor of the ovary with ascites and pleural effusion. It is a rare disease and the pathophysiological mechanism is not yet well understood. The aim of our study is to report a case of Demons-Meigs syndrome, to determine its different characteristics and to make clinicians aware of the malignant predictive value of CA 125 in front of an ovarian tumor. Observation: The patient was 42 years old and had no previous history. She presented with intense abdominal pain of sudden onset, prompting a medical consultation. On clinical examination, the abdomen was distended with signs of peritoneal effusion and right pleural effusion. Ultrasound revealed a well-circumscribed, ovarian mass with an internal fluid component and hypervascularization on Doppler. The CA 125 level was elevated (293.9 U/ml). Exploratory laparotomy revealed two bilateral, firm, solid ovarian tumors without vegetation or peritoneal lesions. Macroscopically, one of the tumors was well circumscribed, lobulated with a smooth outer surface. It measured 20 × 17 × 8 cm and weighed 1400 g. The other tumor measured 19 × 11 × 5 cm, weighed 1090 g and had the same characteristics as the other tumor. Histologically, both tumors were a proliferation of fibroblastic spindle cells organized in short intersecting or storiform bundles, without cyto-nuclear atypia or excess mitoses. The diagnosis retained was bilateral ovarian fibroma in the context of a Demons-Meigs syndrome. Conclusion: Demons-Meigs syndrome is a rare entity. The concomitant elevation of the CA 125 level is not always an indicator of ovarian cancer. The curative treatment is surgical based on tumor removal ensuring the disappearance of peritoneal and pleural effusions.展开更多
Introduction: Meningiomas are tumors formed by arachnoid cells, typically attached to the inner surface of the dura mater. Malignant forms are rare and no case has been reported in the Malagasy literature. The objecti...Introduction: Meningiomas are tumors formed by arachnoid cells, typically attached to the inner surface of the dura mater. Malignant forms are rare and no case has been reported in the Malagasy literature. The objective of our study is to report two Malagasy cases of malignant meningioma and to discuss the epidemiological and anatomical-clinical particularities of this tumor. Observation: The first patient, a 41-year-old woman, presented with a rapidly progressive intracranial hypertension syndrome. The patient had undergone surgery two years earlier for a grade II meningioma and had no family history of meningioma, neurofibromatosis, or personal history of brain irradiation or head trauma. Her brain scan showed a heterogeneous polylobed left parieto-occipital mass with a meningeal implantation base. The anatomopathological examination of the samples revealed a malignant meningioma. The second patient was a 33-year-old man, operated for grade I meningioma eleven months before admission, with no other personal or family history. The patient was hospitalized for tumor recurrence with signs of intracranial hypertension. The brain computed tomography (CT) scan showed a heterogeneous extra-axial tumor in right temporo-parietal lobe. Surgical excision was performed. On histological examination, a proliferation of tumor cells of meningothelial appearance with papillary architecture was observed, leading to the diagnosis of malignant meningioma. Conclusion: Malignant meningioma is a rare and serious entity. The clinical manifestations are nonspecific and imaging may mimic a low-grade meningioma. The diagnosis of certainty is histological and is based on essentially morphological criteria. The latter condition the overall survival of the patient and the therapeutic conduct.展开更多
Tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis complex. This illness is a major public health challenge in Madagascar and around the world. The disease can develop in the lungs an...Tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis complex. This illness is a major public health challenge in Madagascar and around the world. The disease can develop in the lungs and other organs. Digestive tuberculosis is rare, accounting for 10% of extrapulmonary forms. Symptoms are not specific. Diagnosis is based on anatomical pathology examination. The purpose of this study is to determine the epidemiological and anatomopathological characteristics of abdominal tuberculosis. Our study was a retrospective, descriptive study conducted at the Pathological Anatomy and Cytology Unit of the University Hospital Center of Joseph Ravoahangy Andrianavalona over a 10-year period from January 1, 2012 to December 31, 2021. Digestive localization accounted for 17 cases, which are 1.85% of extra-pulmonary localizations. The mean age of patients was 33 years with extremes of 9 and 66 years. The sex ratio was 4.67. Pain was the main symptom, accounting for 76.47% of cases. Histological aspects were caseo-follicular in 82.35% (n = 14) of cases, follicular in 11.76% (n = 2) and caseous in 5.89% (n = 1). Patients were treated with isoniazid, rifampicin, pyrazinamide, and ethambutol. Surgery has sometimes been required. Tuberculosis is a public health problem in Madagascar. Digestive localization of the disease is mainly observed in young adults especially among men. Clinical signs are not specific, and diagnosis is based on anatomopathology. Treatment is medical but sometimes surgery may be necessary.展开更多
Meningiomas in children are rare. They represent only 1% to 3% of all intracranial tumors. It was a case report of a childhood girl meningioma, which is from the rare tumor and presenting by seizures, evolving in an a...Meningiomas in children are rare. They represent only 1% to 3% of all intracranial tumors. It was a case report of a childhood girl meningioma, which is from the rare tumor and presenting by seizures, evolving in an apyretic context. She had no notion of irradiation or particular personal history apart from wearing glasses since the age of 5 years. She weighed 70 kg (BMI = 31). Biological examinations were normal. The brain scan showed a left frontal extra-axial tumor process measuring 76 × 60 × 55 mm. Tumor resection was performed. Macroscopically, the surgical specimen was found to be 8 firm, lobulated, yellowish-white fragments measuring 14 × 11 × 2 cm and weighing 150 g in total. The histological examination showed a proliferation of meningothelial cells, with a tendency to stratify and to roll up on each other in an onion bulb shape, without excess of mitoses and without cortical infiltration, evoking a meningioma. Meningioma in children remains a rare tumor. In our case, seizures were the only revealing signs of this disease. Cerebral computed tomography oriented the diagnosis. Anatomopathological examination was essential for confirmation.展开更多
Gastrointestinal lymphoma is a non-Hodgkin’s lymphoma that develops from MALT (Mucosa Associated Lymphoid Tissue). It is a rare entity representing 1% of tumors of the gastrointestinal tract. In Madagascar, few studi...Gastrointestinal lymphoma is a non-Hodgkin’s lymphoma that develops from MALT (Mucosa Associated Lymphoid Tissue). It is a rare entity representing 1% of tumors of the gastrointestinal tract. In Madagascar, few studies have been performed on these lymphomas. Our objective is to report a series of digestive lymphoma in order to evaluate the epidemiological and anatomical-clinical aspects. This was a retrospective, cross-sectional, descriptive bicentric study conducted at the Department of Pathology at the Soavinandriana Hospital Center (CENHOSOA) and the Department of Pathology at the University Hospital Center of Andrainjato over a period of 4 years from January 1<sup>st</sup>, 2016 to December 31<sup>st</sup>, 2019. During the study period, we collected 14 cases of primary digestive lymphoma representing 16% of all lymphomas. We noted a female predominance with a sex ratio of 0.75. The mean age of the patients was 35.64 years with extremes of 3 and 78 years. The clinical signs were dominated by occlusive syndrome (57.14%), abdominal pain (21.44%), digestive hemorrhage (7.14%), intestinal invagination (7.14%) and lingual swelling (7.14%). Regarding the location, the ileum was the most frequently affected (42.85%), followed by the stomach (14.29%), the ileo-caecal area (14.29%), the sigmoid (14.29%), the colon (7.14%) and we also noted a lingual location (7.14%). The most frequent histological type was diffuse large B cell lymphoma (42.86%) followed by MALT lymphoma (35.71%), Burkitt’s lymphoma (14.29%) and diffuse small cell lymphoma (unclassified) (7.14%). We did not observe a significant association (p > 0.05) between the site involvement and the histological subtypes. Among the 14 cases, 3 were confirmed by immunohistochemistry. Primary lymphomas of the gastrointestinal tract include several anatomic entities with different presentation and prognosis. Pathological examination is essential for diagnosis. Immunohistochemical examination is a valuable aid for immunophenotyping despite its difficult access in 展开更多
Ovarian fibroma is a tumor of the stroma and sex cords of the ovary. It is rare and represents 1% to 4% of benign ovarian tumors. It is sometimes associated with Demons-Meigs syndrome, raising suspicion of malignancy ...Ovarian fibroma is a tumor of the stroma and sex cords of the ovary. It is rare and represents 1% to 4% of benign ovarian tumors. It is sometimes associated with Demons-Meigs syndrome, raising suspicion of malignancy at the clinical and paraclinical stages. We report a case of bilateral ovarian fibroma diagnosed in the Pathological Anatomy Department of CHU Anosiala. A 46-year-old woman presented with abdominal pain and pollakiuria. Clinical examination revealed a palpable abdominopelvic mass lateralized to the right. Ultrasound suspected leiomyoma. Foci of microcalcifications were observed. The patient underwent bilateral adnexectomy. The histological study confirmed the diagnosis of bilateral ovarian fibroma. This is the first case of ovarian fibroma reported at the CHU Anosiala.展开更多
Clear cell carcinoma of the thyroid is rare. We report a case observed in a 17-year-old woman with a nodule in the left lobe of the thyroid. Cervical ultrasound showed a single nodule of the left lobe of the thyroid, ...Clear cell carcinoma of the thyroid is rare. We report a case observed in a 17-year-old woman with a nodule in the left lobe of the thyroid. Cervical ultrasound showed a single nodule of the left lobe of the thyroid, measuring 28 × 14 × 21 mm with microcalcifications, classified TIRADS 4. Pathological and immunohistochemical examination of the excisional specimen concluded with clear cell carcinoma. The epidemiological and histological aspects were discussed.展开更多
Gastrointestinal stromal tumor (GIST) is a rare tumor of the digestive tract, but it is the most common of the mesenchymal tumors. The location is often gastric and small intestine. GIST of the appendix is extremely r...Gastrointestinal stromal tumor (GIST) is a rare tumor of the digestive tract, but it is the most common of the mesenchymal tumors. The location is often gastric and small intestine. GIST of the appendix is extremely rare. We report one case in a 48-year-old man. He complained of severe pain in the right iliac region. The clinical presentation was typically like acute appendicitis. Abdominal ultrasound was performed and suspected an appendicular abscess. Surgical excision of the appendix was performed and histological diagnosis was “gastrointestinal stromal tumor of the appendix”.展开更多
<div style="text-align:justify;"> <span style="font-family:Verdana;">Schistosomiasis is a chronic disease, and remains a major public health problem. It holds second place among parasit...<div style="text-align:justify;"> <span style="font-family:Verdana;">Schistosomiasis is a chronic disease, and remains a major public health problem. It holds second place among parasitic endemics in the world. Schistosoma can infect various organs through the blood vessels. The genital form affects at least 16 million women in endemic areas, and the uterine cervix is the most common site. Two cases of cervical cancer associated with schistosomiasis of the cervix are presented. The aim of this study is to discuss the epidemiological, clinical and histopathological features. Both of the patients lived in Mahanjaga, aged respectively 57 and 43 years old. They complained of uterine bleeding disorder and presented cauliflower lesions with ulceration of the uterine cervix that extended to the vagina in one case. They were undergone cervical biopsies. The diagnosis was, in both cases, invasive, well-differentiated squamous cell carcinoma with cervical schistosomiasis.</span> </div>展开更多
文摘Solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor is a rare epithelial neoplasm that represents 0.3% to 2.7% of exocrine pancreatic tumors. These tumors occur mainly in young women and have a good prognosis. We present a case of a 19-year-old female patient who presented to the emergency for abdominal pain. Physical examination reveals a left hypochondrium mass. Ultrasound imaging showed an encapsulated caudal pancreatic mass with cystic components. The patient underwent tumor excision and lymph node removal. Macroscopically, the tumor was encapsulated and measuring 12 × 8 × 7 cm. It has a solid-cystic and hemorrhagic appearance inside. Histologically, the tumor had two components: solid and papillary. Tumor tissue showed monomorphic tumor cells radiating around blood vessels. Perineural invasion and vascular emboli were not seen. Three lymph nodes without metastases were observed. The diagnosis of solid-pseudopapillary tumor of the pancreas (SPT) or Frantz’s tumor was retained. Solid-pseudo-papillary tumor of the pancreas is rare and not always suspected by the physician. The clinical and imaging patterns are not specific. Anatomopathological examination confirmed the diagnosis. The patient underwent curative surgery.
文摘Introduction: Demons-Meigs syndrome combines a benign tumor of the ovary with ascites and pleural effusion. It is a rare disease and the pathophysiological mechanism is not yet well understood. The aim of our study is to report a case of Demons-Meigs syndrome, to determine its different characteristics and to make clinicians aware of the malignant predictive value of CA 125 in front of an ovarian tumor. Observation: The patient was 42 years old and had no previous history. She presented with intense abdominal pain of sudden onset, prompting a medical consultation. On clinical examination, the abdomen was distended with signs of peritoneal effusion and right pleural effusion. Ultrasound revealed a well-circumscribed, ovarian mass with an internal fluid component and hypervascularization on Doppler. The CA 125 level was elevated (293.9 U/ml). Exploratory laparotomy revealed two bilateral, firm, solid ovarian tumors without vegetation or peritoneal lesions. Macroscopically, one of the tumors was well circumscribed, lobulated with a smooth outer surface. It measured 20 × 17 × 8 cm and weighed 1400 g. The other tumor measured 19 × 11 × 5 cm, weighed 1090 g and had the same characteristics as the other tumor. Histologically, both tumors were a proliferation of fibroblastic spindle cells organized in short intersecting or storiform bundles, without cyto-nuclear atypia or excess mitoses. The diagnosis retained was bilateral ovarian fibroma in the context of a Demons-Meigs syndrome. Conclusion: Demons-Meigs syndrome is a rare entity. The concomitant elevation of the CA 125 level is not always an indicator of ovarian cancer. The curative treatment is surgical based on tumor removal ensuring the disappearance of peritoneal and pleural effusions.
文摘Introduction: Meningiomas are tumors formed by arachnoid cells, typically attached to the inner surface of the dura mater. Malignant forms are rare and no case has been reported in the Malagasy literature. The objective of our study is to report two Malagasy cases of malignant meningioma and to discuss the epidemiological and anatomical-clinical particularities of this tumor. Observation: The first patient, a 41-year-old woman, presented with a rapidly progressive intracranial hypertension syndrome. The patient had undergone surgery two years earlier for a grade II meningioma and had no family history of meningioma, neurofibromatosis, or personal history of brain irradiation or head trauma. Her brain scan showed a heterogeneous polylobed left parieto-occipital mass with a meningeal implantation base. The anatomopathological examination of the samples revealed a malignant meningioma. The second patient was a 33-year-old man, operated for grade I meningioma eleven months before admission, with no other personal or family history. The patient was hospitalized for tumor recurrence with signs of intracranial hypertension. The brain computed tomography (CT) scan showed a heterogeneous extra-axial tumor in right temporo-parietal lobe. Surgical excision was performed. On histological examination, a proliferation of tumor cells of meningothelial appearance with papillary architecture was observed, leading to the diagnosis of malignant meningioma. Conclusion: Malignant meningioma is a rare and serious entity. The clinical manifestations are nonspecific and imaging may mimic a low-grade meningioma. The diagnosis of certainty is histological and is based on essentially morphological criteria. The latter condition the overall survival of the patient and the therapeutic conduct.
文摘Tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis complex. This illness is a major public health challenge in Madagascar and around the world. The disease can develop in the lungs and other organs. Digestive tuberculosis is rare, accounting for 10% of extrapulmonary forms. Symptoms are not specific. Diagnosis is based on anatomical pathology examination. The purpose of this study is to determine the epidemiological and anatomopathological characteristics of abdominal tuberculosis. Our study was a retrospective, descriptive study conducted at the Pathological Anatomy and Cytology Unit of the University Hospital Center of Joseph Ravoahangy Andrianavalona over a 10-year period from January 1, 2012 to December 31, 2021. Digestive localization accounted for 17 cases, which are 1.85% of extra-pulmonary localizations. The mean age of patients was 33 years with extremes of 9 and 66 years. The sex ratio was 4.67. Pain was the main symptom, accounting for 76.47% of cases. Histological aspects were caseo-follicular in 82.35% (n = 14) of cases, follicular in 11.76% (n = 2) and caseous in 5.89% (n = 1). Patients were treated with isoniazid, rifampicin, pyrazinamide, and ethambutol. Surgery has sometimes been required. Tuberculosis is a public health problem in Madagascar. Digestive localization of the disease is mainly observed in young adults especially among men. Clinical signs are not specific, and diagnosis is based on anatomopathology. Treatment is medical but sometimes surgery may be necessary.
文摘Meningiomas in children are rare. They represent only 1% to 3% of all intracranial tumors. It was a case report of a childhood girl meningioma, which is from the rare tumor and presenting by seizures, evolving in an apyretic context. She had no notion of irradiation or particular personal history apart from wearing glasses since the age of 5 years. She weighed 70 kg (BMI = 31). Biological examinations were normal. The brain scan showed a left frontal extra-axial tumor process measuring 76 × 60 × 55 mm. Tumor resection was performed. Macroscopically, the surgical specimen was found to be 8 firm, lobulated, yellowish-white fragments measuring 14 × 11 × 2 cm and weighing 150 g in total. The histological examination showed a proliferation of meningothelial cells, with a tendency to stratify and to roll up on each other in an onion bulb shape, without excess of mitoses and without cortical infiltration, evoking a meningioma. Meningioma in children remains a rare tumor. In our case, seizures were the only revealing signs of this disease. Cerebral computed tomography oriented the diagnosis. Anatomopathological examination was essential for confirmation.
文摘Gastrointestinal lymphoma is a non-Hodgkin’s lymphoma that develops from MALT (Mucosa Associated Lymphoid Tissue). It is a rare entity representing 1% of tumors of the gastrointestinal tract. In Madagascar, few studies have been performed on these lymphomas. Our objective is to report a series of digestive lymphoma in order to evaluate the epidemiological and anatomical-clinical aspects. This was a retrospective, cross-sectional, descriptive bicentric study conducted at the Department of Pathology at the Soavinandriana Hospital Center (CENHOSOA) and the Department of Pathology at the University Hospital Center of Andrainjato over a period of 4 years from January 1<sup>st</sup>, 2016 to December 31<sup>st</sup>, 2019. During the study period, we collected 14 cases of primary digestive lymphoma representing 16% of all lymphomas. We noted a female predominance with a sex ratio of 0.75. The mean age of the patients was 35.64 years with extremes of 3 and 78 years. The clinical signs were dominated by occlusive syndrome (57.14%), abdominal pain (21.44%), digestive hemorrhage (7.14%), intestinal invagination (7.14%) and lingual swelling (7.14%). Regarding the location, the ileum was the most frequently affected (42.85%), followed by the stomach (14.29%), the ileo-caecal area (14.29%), the sigmoid (14.29%), the colon (7.14%) and we also noted a lingual location (7.14%). The most frequent histological type was diffuse large B cell lymphoma (42.86%) followed by MALT lymphoma (35.71%), Burkitt’s lymphoma (14.29%) and diffuse small cell lymphoma (unclassified) (7.14%). We did not observe a significant association (p > 0.05) between the site involvement and the histological subtypes. Among the 14 cases, 3 were confirmed by immunohistochemistry. Primary lymphomas of the gastrointestinal tract include several anatomic entities with different presentation and prognosis. Pathological examination is essential for diagnosis. Immunohistochemical examination is a valuable aid for immunophenotyping despite its difficult access in
文摘Ovarian fibroma is a tumor of the stroma and sex cords of the ovary. It is rare and represents 1% to 4% of benign ovarian tumors. It is sometimes associated with Demons-Meigs syndrome, raising suspicion of malignancy at the clinical and paraclinical stages. We report a case of bilateral ovarian fibroma diagnosed in the Pathological Anatomy Department of CHU Anosiala. A 46-year-old woman presented with abdominal pain and pollakiuria. Clinical examination revealed a palpable abdominopelvic mass lateralized to the right. Ultrasound suspected leiomyoma. Foci of microcalcifications were observed. The patient underwent bilateral adnexectomy. The histological study confirmed the diagnosis of bilateral ovarian fibroma. This is the first case of ovarian fibroma reported at the CHU Anosiala.
文摘Clear cell carcinoma of the thyroid is rare. We report a case observed in a 17-year-old woman with a nodule in the left lobe of the thyroid. Cervical ultrasound showed a single nodule of the left lobe of the thyroid, measuring 28 × 14 × 21 mm with microcalcifications, classified TIRADS 4. Pathological and immunohistochemical examination of the excisional specimen concluded with clear cell carcinoma. The epidemiological and histological aspects were discussed.
文摘Gastrointestinal stromal tumor (GIST) is a rare tumor of the digestive tract, but it is the most common of the mesenchymal tumors. The location is often gastric and small intestine. GIST of the appendix is extremely rare. We report one case in a 48-year-old man. He complained of severe pain in the right iliac region. The clinical presentation was typically like acute appendicitis. Abdominal ultrasound was performed and suspected an appendicular abscess. Surgical excision of the appendix was performed and histological diagnosis was “gastrointestinal stromal tumor of the appendix”.
文摘<div style="text-align:justify;"> <span style="font-family:Verdana;">Schistosomiasis is a chronic disease, and remains a major public health problem. It holds second place among parasitic endemics in the world. Schistosoma can infect various organs through the blood vessels. The genital form affects at least 16 million women in endemic areas, and the uterine cervix is the most common site. Two cases of cervical cancer associated with schistosomiasis of the cervix are presented. The aim of this study is to discuss the epidemiological, clinical and histopathological features. Both of the patients lived in Mahanjaga, aged respectively 57 and 43 years old. They complained of uterine bleeding disorder and presented cauliflower lesions with ulceration of the uterine cervix that extended to the vagina in one case. They were undergone cervical biopsies. The diagnosis was, in both cases, invasive, well-differentiated squamous cell carcinoma with cervical schistosomiasis.</span> </div>
