Orobanchaceae is the largest family of parasiticplants,containing autotrophic and parasiticplants with all degrees of parasitism.This makes it byfar the best family for studying the origin and evolution of plant paras...Orobanchaceae is the largest family of parasiticplants,containing autotrophic and parasiticplants with all degrees of parasitism.This makes it byfar the best family for studying the origin and evolution of plant parasitism.Here we provide three high-quality genomes of orobanchaceous plants,the autotrophic Lindenbergia luchunensis and the holoparasitic plants Phelipanche aegyptiaca and Orobanche cumana.Phylogenomic analysis of these three genomes together with those previously published and the transcriptomes of other orobanchaceous species createda robust phylogeneticframework forOrobanchaceae.We found that an ancient whole-genome duplication(WGD;about 73.48million years ago),which occurred earlierthan theoriginof Orobanchaceae,mighthave contributed totheemergence of parasitism.However,no WGD events occurred in any lineage of orobanchaceous parasites except for Striga after divergence from their autotrophic common ancestor,suggesting that,in contrast with previous speculations,WGD is not associated with the emergence of holoparasitism.We detected evident convergent gene loss in all parasites within Orobanchaceae and between Orobanchaceae and dodder Cuscuta australis.The gene families in the orobanchaceous parasites showed a clear pattern of recent gains and expansions.The expanded gene families are enriched in functions related to the development of the haustorium,suggesting that recent gene family expansions may have facilitated the adaptation of orobanchaceous parasites to different hosts.This study illustrates a stepwise pattern in the evolution of parasitism in the orobanchaceous parasites and will facilitate future studieson parasitism and the control of parasitic plants in agriculture.展开更多
The LDL Principle has recently been invoked to describe the observation that lowering the LDL cholesterol (by whatever means) results in a lowering of atherosclerotic cardiovascular events. The scientific basis of the...The LDL Principle has recently been invoked to describe the observation that lowering the LDL cholesterol (by whatever means) results in a lowering of atherosclerotic cardiovascular events. The scientific basis of the LDL Principle dates back to the discovery that the LDL receptor is the prime determinant of the circulating LDL-c concentration. Since that time, major advances have been made at both the basic and clinical science level in our understanding of the pathogenesis and reversal of atherosclerosis. The incorporation of atherogenic lipoproteins plus inflammatory mediators into plaque formation permits the targeted intervention into preventing plaque rupture. In addition, genetic studies identifying individuals with unique phenotypes of either abnormally high or low LDL-c concentrations have provided insight into possible therapeutic modalities that have recently provided the physician with the tools necessary to apply the LDL Principle to achieve reversal of atherosclerosis. The epidemic of atherosclerotic cardiovascular disease has resulted in numerous randomized controlled intervention trials in an attempt to identify approaches to reduce ASCD morbidity and mortality. Recently published data indicate that circulating LDL-c levels of 50 mg/dl or less are not only physiologic at birth but also effective in greatly reducing cardiovascular disease. In addition, the recent availability of two PCSK9 inhibitors provides the primary care physician with the possibility of achieving this low level of LDL-c even in statin intolerant patients. The widespread availability of the coronary artery calcium scan plus the inclusion of traditional cardiovascular risk factors in risk assessment has enabled the physician to readily identify asymptomatic individuals at high risk for cardiovascular events. Aggressively applying the LDL Principle to these individuals has the potential of greatly reducing cardiovascular mortality. This review will document the scientific basis for this principle and provide the arguments in favo展开更多
<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""><strong> </strong>The lack of a financ</span><span style="white...<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""><strong> </strong>The lack of a financ</span><span style="white-space:normal;font-family:;" "="">e</span><span style="white-space:normal;font-family:;" "=""> policy to cover heart coronary artery disease CT imaging led to an epidemic of heart disease, the most common cause of death in the United States. The difficulty for many adults to pay $150 for CT heart imaging was the impetus for public health reform through legislative intervention. <b>Methods:</b> The key to finance policy reform was the organization of the medical environment involved in asymptomatic heart disease. Using the ecosystem paradigm for organizational alignment, the legislative goal was financing the $150 heart image to identify and medically prevent symptomatic heart disease, obviating future surgical costs of >$100,000. <b>Results:</b> Assisted by stakeholders for public health reform, a 3-year initiative to pass a legislative bill mandating health insurance coverage of $150 heart imaging was signed into law. Understanding the legislative process was necessary for successful advancement of public health and eliminating unnecessary costs of an established conservative ecosystem. <b>Conclusions:</b> Texas was the first state to achieve this legislative goal and New Mexico soon followed. If political environments, regardless of country follow</span><span style="white-space:normal;font-family:;" "="">ing</span><span style="white-space:normal;font-family:;" "=""> this road map of public health reform, a significant beneficial impact upon heart disease, its cost, and healthier public would result.</span>展开更多
基金This work was supported by the National Natural Science Foundation of China(32000179 Y.X.)the Strategic Priority Research Program of Chinese Academy of Sciences(XDPB16 J.W.)+2 种基金the CAS"Light of West China"Program(G.S.)the Special Research Assistant of Chinese Academy of Sciences(Y.X.and J.Z.)the Postdoctoral Directional Training Foundation of Yunnan Province(Y.X.).
文摘Orobanchaceae is the largest family of parasiticplants,containing autotrophic and parasiticplants with all degrees of parasitism.This makes it byfar the best family for studying the origin and evolution of plant parasitism.Here we provide three high-quality genomes of orobanchaceous plants,the autotrophic Lindenbergia luchunensis and the holoparasitic plants Phelipanche aegyptiaca and Orobanche cumana.Phylogenomic analysis of these three genomes together with those previously published and the transcriptomes of other orobanchaceous species createda robust phylogeneticframework forOrobanchaceae.We found that an ancient whole-genome duplication(WGD;about 73.48million years ago),which occurred earlierthan theoriginof Orobanchaceae,mighthave contributed totheemergence of parasitism.However,no WGD events occurred in any lineage of orobanchaceous parasites except for Striga after divergence from their autotrophic common ancestor,suggesting that,in contrast with previous speculations,WGD is not associated with the emergence of holoparasitism.We detected evident convergent gene loss in all parasites within Orobanchaceae and between Orobanchaceae and dodder Cuscuta australis.The gene families in the orobanchaceous parasites showed a clear pattern of recent gains and expansions.The expanded gene families are enriched in functions related to the development of the haustorium,suggesting that recent gene family expansions may have facilitated the adaptation of orobanchaceous parasites to different hosts.This study illustrates a stepwise pattern in the evolution of parasitism in the orobanchaceous parasites and will facilitate future studieson parasitism and the control of parasitic plants in agriculture.
文摘The LDL Principle has recently been invoked to describe the observation that lowering the LDL cholesterol (by whatever means) results in a lowering of atherosclerotic cardiovascular events. The scientific basis of the LDL Principle dates back to the discovery that the LDL receptor is the prime determinant of the circulating LDL-c concentration. Since that time, major advances have been made at both the basic and clinical science level in our understanding of the pathogenesis and reversal of atherosclerosis. The incorporation of atherogenic lipoproteins plus inflammatory mediators into plaque formation permits the targeted intervention into preventing plaque rupture. In addition, genetic studies identifying individuals with unique phenotypes of either abnormally high or low LDL-c concentrations have provided insight into possible therapeutic modalities that have recently provided the physician with the tools necessary to apply the LDL Principle to achieve reversal of atherosclerosis. The epidemic of atherosclerotic cardiovascular disease has resulted in numerous randomized controlled intervention trials in an attempt to identify approaches to reduce ASCD morbidity and mortality. Recently published data indicate that circulating LDL-c levels of 50 mg/dl or less are not only physiologic at birth but also effective in greatly reducing cardiovascular disease. In addition, the recent availability of two PCSK9 inhibitors provides the primary care physician with the possibility of achieving this low level of LDL-c even in statin intolerant patients. The widespread availability of the coronary artery calcium scan plus the inclusion of traditional cardiovascular risk factors in risk assessment has enabled the physician to readily identify asymptomatic individuals at high risk for cardiovascular events. Aggressively applying the LDL Principle to these individuals has the potential of greatly reducing cardiovascular mortality. This review will document the scientific basis for this principle and provide the arguments in favo
文摘<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""><strong> </strong>The lack of a financ</span><span style="white-space:normal;font-family:;" "="">e</span><span style="white-space:normal;font-family:;" "=""> policy to cover heart coronary artery disease CT imaging led to an epidemic of heart disease, the most common cause of death in the United States. The difficulty for many adults to pay $150 for CT heart imaging was the impetus for public health reform through legislative intervention. <b>Methods:</b> The key to finance policy reform was the organization of the medical environment involved in asymptomatic heart disease. Using the ecosystem paradigm for organizational alignment, the legislative goal was financing the $150 heart image to identify and medically prevent symptomatic heart disease, obviating future surgical costs of >$100,000. <b>Results:</b> Assisted by stakeholders for public health reform, a 3-year initiative to pass a legislative bill mandating health insurance coverage of $150 heart imaging was signed into law. Understanding the legislative process was necessary for successful advancement of public health and eliminating unnecessary costs of an established conservative ecosystem. <b>Conclusions:</b> Texas was the first state to achieve this legislative goal and New Mexico soon followed. If political environments, regardless of country follow</span><span style="white-space:normal;font-family:;" "="">ing</span><span style="white-space:normal;font-family:;" "=""> this road map of public health reform, a significant beneficial impact upon heart disease, its cost, and healthier public would result.</span>
