Nature inspired optimization algorithms have made substantial step towards solving of various engineering and scientific real-life problems.Success achieved for those evolution-ary optimization techniques are due to s...Nature inspired optimization algorithms have made substantial step towards solving of various engineering and scientific real-life problems.Success achieved for those evolution-ary optimization techniques are due to simplicity and flexibility of algorithm structures.In this paper,optimal set of filter coefficients are searched by the evolutionary optimiza-tion technique called Opposition-based Differential Evolution(ODE)for solving infinite impulse response(IIR)system identification problem.Opposition-based numbering con-cept is embedded into the primary foundation of Differential Evolution(DE)technique metaphorically to enhance the convergence speed and the performance for finding the optimal solution.The population is generated with the evaluation of a solution and its opposite solution by fitness function for choosing potent solutions for each iteration cycle.With this competent population,faster convergence speed and better solution quality are achieved.Detailed and balanced search in multidimensional problem space is accomplished with judiciously chosen control parameters for mutation,crossover and selection adopted in the basic DE technique.When tested against standard benchmark examples,for same order and reduced order models,the simulation results establish the ODE as a competent candidate to others in terms of accuracy and convergence speed.展开更多
PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (<i>Psidium</i> <i>guajava</i> L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (b...PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (<i>Psidium</i> <i>guajava</i> L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (breast cancer patients’ saliva) origin. The zymogram and ELISA were developed of different samples following standard methods. The isolation and identification of the new MMP-2 inhibitor(s) for its molecular characterization is under investigation.展开更多
Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal...Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.展开更多
文摘Nature inspired optimization algorithms have made substantial step towards solving of various engineering and scientific real-life problems.Success achieved for those evolution-ary optimization techniques are due to simplicity and flexibility of algorithm structures.In this paper,optimal set of filter coefficients are searched by the evolutionary optimiza-tion technique called Opposition-based Differential Evolution(ODE)for solving infinite impulse response(IIR)system identification problem.Opposition-based numbering con-cept is embedded into the primary foundation of Differential Evolution(DE)technique metaphorically to enhance the convergence speed and the performance for finding the optimal solution.The population is generated with the evaluation of a solution and its opposite solution by fitness function for choosing potent solutions for each iteration cycle.With this competent population,faster convergence speed and better solution quality are achieved.Detailed and balanced search in multidimensional problem space is accomplished with judiciously chosen control parameters for mutation,crossover and selection adopted in the basic DE technique.When tested against standard benchmark examples,for same order and reduced order models,the simulation results establish the ODE as a competent candidate to others in terms of accuracy and convergence speed.
文摘PBS (Phosphate Buffed Saline), pH 7.4 extract of Guava leaves (<i>Psidium</i> <i>guajava</i> L.) inhibits the active MMP-2 like molecule both of plant origin as well as active MMP-2 of human (breast cancer patients’ saliva) origin. The zymogram and ELISA were developed of different samples following standard methods. The isolation and identification of the new MMP-2 inhibitor(s) for its molecular characterization is under investigation.
文摘Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.
