Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT...Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.展开更多
Bacterial small RNAs （sRNAs） are an emerging class of regulatory RNAs of about 40-500 nucleotides in length and, by binding to their target mRNAs or proteins, get involved in many biological processes such as sensin...Bacterial small RNAs （sRNAs） are an emerging class of regulatory RNAs of about 40-500 nucleotides in length and, by binding to their target mRNAs or proteins, get involved in many biological processes such as sensing environmental changes and regulating gene expres- sion. Thus, identification of bacterial sRNAs and their targets has become an important part of sRNA biology. Current strategies for discovery of sRNAs and their targets usually involve bioinformatics prediction followed by experimental validation, emphasizing a key role for bioinformatics prediction. Here, therefore, we provided an overview on prediction methods, focusing on the merits and limita- tions of each class of models. Finally, we will present our thinking on developing related bioinformafics models in future.展开更多
Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical coupling....Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical coupling.Various types of piezoelectric actuators have sprung up and gained widespread use in various applications in terms of compelling attributes,such as high precision,flexibility of stoke,immunity to electromagnetic interference,and structural scalability.This paper systematically reviews the piezoelectric materials,operating principles,representative schemes,characteristics,and potential applications of each mainstream type of piezoelectric actuator.Herein,we intend to provide a more scientific and nuanced perspective to classify piezoelectric actuators into direct and indirect categories with several subcategories.In addition,this review outlines the pros and cons and the future development trends for all kinds of piezoelectric actuators by exploring the relations and mechanisms behind them.The rich content and detailed comparison can help build an in-depth and holistic understanding of piezoelectric actuators and pave the way for future research and the selection of practical applications.展开更多
Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptos...Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment.展开更多
Blue perovskite light-emitting diodes(PeLEDs)are essential in pixels of perovskite displays,while their progress lags far behind their red and green counterparts.Here,we focus on recent advances of blue PeLEDs and sys...Blue perovskite light-emitting diodes(PeLEDs)are essential in pixels of perovskite displays,while their progress lags far behind their red and green counterparts.Here,we focus on recent advances of blue PeLEDs and systematically review the noteworthy strategies,which are categorized into compositional engineering,dimensional control,and size confinement,on optimizing microstructures,energy landscapes,and charge behaviors of wide-bandgap perovskite emitters(bandgap>2.5 eV).Moreover,the stability of perovskite blue emitters and related devices is discussed.In the end,we propose a technical roadmap for the fabrication of state-of-the-art blue PeLEDs to chase and achieve comparable performance with the other two primary-color devices.展开更多
A method is proposed to characterize the fast neutron scattering cross-section ( s f) quantitatively by the combina-tion of inelastic gamma rays and captured gamma rays, so as to realize the gas saturation evaluation ...A method is proposed to characterize the fast neutron scattering cross-section ( s f) quantitatively by the combina-tion of inelastic gamma rays and captured gamma rays, so as to realize the gas saturation evaluation of CO_(2)-injected heavy oilreservoirs based on the three-de tector pulsed neutron logging technology. Factors influencing of the evaluation effect of thismethod are analyzed and the effectiveness of this method is verified by a simulation example. By using the Monte Carlo simu-lation method and the physical model of bulk-volume rock, the relationship between s f and CO_(2) saturation is studied, and thesaturation interpretation model is established. The influences of formation temperature and pressure, heavy oil density, bore-hole fluid and reservoir methane content on the evaluation results of CO_(2) saturation are analyzed. The results show that thecharacterization of s f by the combination of secondary gamma information can eliminate the influence of formation lithology,borehole fluid and methane content are the main factors affecting the quantitative monitoring of CO_(2) saturation, and the ef-fects of formation temperature and pressure and heavy oil density are negligible. The simulation example verified the feasibilityof the method for evaluating the CO_(2) saturation of CO_(2)-injected heavy oil reservoirs.展开更多
基金This work was supported by the National Key R&D Program of China(2016YFC1307301)the National Natural Science Foundation of China(81820108012)This study was partially funded by Boehringer Ingelheim China.
文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.
基金supported by grants from National Key Basic Research and Development Program (Grant No.2010CB912801)National Natural Science Foundation of China (Grant No. 31071157 and 31271404)
文摘Bacterial small RNAs （sRNAs） are an emerging class of regulatory RNAs of about 40-500 nucleotides in length and, by binding to their target mRNAs or proteins, get involved in many biological processes such as sensing environmental changes and regulating gene expres- sion. Thus, identification of bacterial sRNAs and their targets has become an important part of sRNA biology. Current strategies for discovery of sRNAs and their targets usually involve bioinformatics prediction followed by experimental validation, emphasizing a key role for bioinformatics prediction. Here, therefore, we provided an overview on prediction methods, focusing on the merits and limita- tions of each class of models. Finally, we will present our thinking on developing related bioinformafics models in future.
基金supported by the National Natural Science Foundation of China(Grant No.62004166)Natural Science Foundation of Ningbo,China(Grant No.202003N4062)+3 种基金Natural Science Foundation of Zhejiang Province,China(Grant No.LY23F040002)National Postdoctoral Program for Innovative Talents,China(Grant No.BX20200279)Natural Science Basic Research Program of Shaanxi Province,China(Grant No.2020JQ-199)Fundamental Research Funds for the Central Universities,China(Grant No.31020190QD027).
文摘Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical coupling.Various types of piezoelectric actuators have sprung up and gained widespread use in various applications in terms of compelling attributes,such as high precision,flexibility of stoke,immunity to electromagnetic interference,and structural scalability.This paper systematically reviews the piezoelectric materials,operating principles,representative schemes,characteristics,and potential applications of each mainstream type of piezoelectric actuator.Herein,we intend to provide a more scientific and nuanced perspective to classify piezoelectric actuators into direct and indirect categories with several subcategories.In addition,this review outlines the pros and cons and the future development trends for all kinds of piezoelectric actuators by exploring the relations and mechanisms behind them.The rich content and detailed comparison can help build an in-depth and holistic understanding of piezoelectric actuators and pave the way for future research and the selection of practical applications.
基金supported by grants from the National Natural Science Foundation(Grant No.81972859 to WT)CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2019-I2M-1-003 to WT)the State Key Laboratory of Molecular Oncology Grant(Grant No.SKLMO-2021-03 to WT).
文摘Objective:The identification of biomarkers for predicting chemoradiotherapy efficacy is essential to optimize personalized treatment.This study determined the effects of genetic variations in genes involved in apoptosis,pyroptosis,and ferroptosis on the prognosis of patients with locally advanced rectal cancer receiving postoperative chemoradiotherapy(CRT).Methods:The Sequenom MassARRAY was used to detect 217 genetic variations in 40 genes from 300 patients with rectal cancer who received postoperative CRT.The associations between genetic variations and overall survival(OS)were evaluated using hazard ratios(HRs)and 95%confidence intervals(CIs)computed using a Cox proportional regression model.Functional experiments were performed to determine the functions of the arachidonate 5-lipoxygenase(ALOX5)gene and the ALOX5 rs702365 variant.Results:We detected 16 genetic polymorphisms in CASP3,CASP7,TRAILR2,GSDME,CASP4,HO-1,ALOX5,GPX4,and NRF2 that were significantly associated with OS in the additive model(P<0.05).There was a substantial cumulative effect of three genetic polymorphisms(CASP4 rs571407,ALOX5 rs2242332,and HO-1 rs17883419)on OS.Genetic variations in the CASP4 and ALOX5 gene haplotypes were associated with a higher OS.We demonstrated,for the first time,that rs702365[G]>[C]represses ALOX5 transcription and corollary experiments suggested that ALOX5 may promote colon cancer cell growth by mediating an inflammatory response.Conclusions:Polymorphisms in genes regulating cell death may play essential roles in the prognosis of patients with rectal cancer who are treated with postoperative CRT and may serve as potential genetic biomarkers for individualized treatment.
基金The authors disclose support for the research of this work from the Beijing Natural Science Foundation(JQ21005)the National Key R&D Program of China(2021YFB3800100,2021YFB3800101)+1 种基金China Postdoctoral Science Foundation(2022M720376)Beijing Postdoctoral Research Foundation.
文摘Blue perovskite light-emitting diodes(PeLEDs)are essential in pixels of perovskite displays,while their progress lags far behind their red and green counterparts.Here,we focus on recent advances of blue PeLEDs and systematically review the noteworthy strategies,which are categorized into compositional engineering,dimensional control,and size confinement,on optimizing microstructures,energy landscapes,and charge behaviors of wide-bandgap perovskite emitters(bandgap>2.5 eV).Moreover,the stability of perovskite blue emitters and related devices is discussed.In the end,we propose a technical roadmap for the fabrication of state-of-the-art blue PeLEDs to chase and achieve comparable performance with the other two primary-color devices.
基金Supported by the National Natural Science Foundation of China(41974127,41974155)China University of Petroleum(East China)Graduate Student Innovation Project Funding Project(YCX2020008)。
文摘A method is proposed to characterize the fast neutron scattering cross-section ( s f) quantitatively by the combina-tion of inelastic gamma rays and captured gamma rays, so as to realize the gas saturation evaluation of CO_(2)-injected heavy oilreservoirs based on the three-de tector pulsed neutron logging technology. Factors influencing of the evaluation effect of thismethod are analyzed and the effectiveness of this method is verified by a simulation example. By using the Monte Carlo simu-lation method and the physical model of bulk-volume rock, the relationship between s f and CO_(2) saturation is studied, and thesaturation interpretation model is established. The influences of formation temperature and pressure, heavy oil density, bore-hole fluid and reservoir methane content on the evaluation results of CO_(2) saturation are analyzed. The results show that thecharacterization of s f by the combination of secondary gamma information can eliminate the influence of formation lithology,borehole fluid and methane content are the main factors affecting the quantitative monitoring of CO_(2) saturation, and the ef-fects of formation temperature and pressure and heavy oil density are negligible. The simulation example verified the feasibilityof the method for evaluating the CO_(2) saturation of CO_(2)-injected heavy oil reservoirs.
