Diabetes mellitus, a type of chronic metabolic disease, is occurring more frequently and causes severe threats to human health. In vivo, exercise can stimulate skeletal muscle cells to secrete and release myokines int...Diabetes mellitus, a type of chronic metabolic disease, is occurring more frequently and causes severe threats to human health. In vivo, exercise can stimulate skeletal muscle cells to secrete and release myokines into blood circulation, which will participate in metabolism and act on multiple organs or systems. Recently, the relationship between myokines and diabetes mellitus was a hot research topic, and myokines may be potential targets for the diagnosis, monitoring, prevention and treatment of diabetes mellitus. In this review, we elucidated the multiple effects of common myokines in the pathogenesis and therapy of diabetes mellitus, which will provide a theoretical foundation of the mechanism in the positive effects of exercises on humans.展开更多
基金supported by the Ministry of Science and Technology of China(2018YFA0703200 and 2022YFB3603800)the National Natural Science Foundation of China(21875259,52233010,51725304,61890943 and 22021002)+4 种基金the Chinese Academy of Sciences Project for Young Scientists in Basic Research(YSBR-053)the Youth Innovation Promotion Association of the Chinese Academy of Sciencesthe National Program for Support of Top-notch Young ProfessionalsBeijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202012)the Key Research Program of the Chinese Academy of Sciences(XDPB13)。
文摘Diabetes mellitus, a type of chronic metabolic disease, is occurring more frequently and causes severe threats to human health. In vivo, exercise can stimulate skeletal muscle cells to secrete and release myokines into blood circulation, which will participate in metabolism and act on multiple organs or systems. Recently, the relationship between myokines and diabetes mellitus was a hot research topic, and myokines may be potential targets for the diagnosis, monitoring, prevention and treatment of diabetes mellitus. In this review, we elucidated the multiple effects of common myokines in the pathogenesis and therapy of diabetes mellitus, which will provide a theoretical foundation of the mechanism in the positive effects of exercises on humans.
