To investigate the immune responses to the attenuated Mycoplasma hyopneumoniae 168 strain vaccine, 8-15 d old piglets were immunized with M. hyopneurnoniae 168 strain vaccine by intrapulmonic route. And the specific I...To investigate the immune responses to the attenuated Mycoplasma hyopneumoniae 168 strain vaccine, 8-15 d old piglets were immunized with M. hyopneurnoniae 168 strain vaccine by intrapulmonic route. And the specific IgG antibody in serum, lymphoproliferation, IFNT, and specific secretory IgA （SIgA） antibody in bronchoalveolar lavage fluid were detected on 30 and 60 d post-immunization （DPI）, respectively. On 60 DPI, all the pigs except for those in health control group were challenged with a field M. hyopneumoniae strain JS. Necropsy was performed on 30 d post-challenge （DPC）. The results showed that IFN7 and specific SIgA were stimulated on surface of respiratory tract after immunization. And peripheral blood mononuclear cells could also be proliferated about 1.81 and 2.12 fold on 30 and 60 DPI when stimulated by M. hyopneumoniae protein in vitro. However, no serum IgG antibody against M. hyopneumoniae was detected during the whole immune phage. After challenge, vaccinated pigs were observed with only very slight histological lesion in individual lobes. None of vaccinated pigs showed any clinical signs. While the unvaccinated pigs from challenge control group showed varying degrees of clinical sign and severe macroscopical lesion of mycoplasmal pneumonia of swine （MPS）. The result suggested that the attenuated M. hyopneumoniae 168 strain vaccine inoculated by intrapulmonic route could activate the systemic cellular immunity, the local mucosal immunity and IFNγ secretion in respiratory tract to against M. hyopneumoniae infection in piglets.展开更多
目的探讨"LEER"模式加速康复外科(ERAS)理念在胰十二指肠切除术中的临床应用价值。方法回顾性分析2017年9月至2019年5月乐山市人民医院收治的62例行胰十二指肠切除术的患者基本临床资料。37例围术期采用传统方案(传统组),25...目的探讨"LEER"模式加速康复外科(ERAS)理念在胰十二指肠切除术中的临床应用价值。方法回顾性分析2017年9月至2019年5月乐山市人民医院收治的62例行胰十二指肠切除术的患者基本临床资料。37例围术期采用传统方案(传统组),25例围术期采用"LEER"模式ERAS方案(ERAS组)。"LEER"模式为:少痛(less pain)、早动(early move)、早食(early eat)、安心(reassuring)。结果 ERAS组相比于传统组,术后疼痛评分更低[(3.12±0.78) vs (4.59±1.01),t=6.459,P<0.05],术后胃肠道功能恢复更快[(3.28±0.46)d vs (3.76±1.01)d,t=2.205,P<0.05],术后下床活动时间[(1.96±0.79)d vs (2.62±0.64)d,t=3.635,P<0.05]及术后拔除引流管时间[(3.28±0.46)d vs (6.05±1.39)d,t=7.056,P<0.05]更早,胰漏发生率更低[20.00%(5/25) vs 51.35%(19/37),χ^2=6.181,P<0.05],住院时间更短[(11.52±1.39)d vs (15.76±2.51)d,t=7.671,P<0.05],住院费用更低[(61 610.92±4 272.13)元 vs (70 167.70±3 736.14)元,t=8.348,P<0.05]。两组手术时间、术中出血量及其他并发症无统计学差异(P>0.05)。结论"LEER"模式加速康复外科理念应用于胰十二指肠切除术安全有效,可加快术后康复,缩短住院时间,减少医疗费用。展开更多
The honeybee （Apis mellifera） is a social insect with strong sensory capacity and diverse behavioral repertoire and is recognized as a good model organism for studying the neurobiological basis of learning and memor...The honeybee （Apis mellifera） is a social insect with strong sensory capacity and diverse behavioral repertoire and is recognized as a good model organism for studying the neurobiological basis of learning and memory. In this study, we analyzed the changes in microRNA （miRNA） and messenger RNA （mRNA） following maze-based visual learning using next-generation small RNA sequencing and Solexa/lllumina Digital Gene Expression tag profiling （DGE）. For small RNA sequencing, we obtained 13 367 770 and 13 132 655 clean tags from the maze and control groups, respectively. A total of 40 differentially expressed known miRNAs were detected between these two samples, and all of them were up-regulated in the maze group compared to the control group. For DGE, 5 681 320 and 5 939 855 clean tags were detected from the maze and control groups, respectively. There were a total of 388 differentially expressed genes between these two samples, with 45 genes up-regulated and 343 genes down-regulated in the maze group, compared to the control group. Additionally, the expression levels of 10 differentially expressed genes were confirmed by quantitative reverse transcription polymerase chain reaction （qRT-PCR） and the expression trends of eight of them were consistent with the DGE result, although the degree of change was lower in amplitude. The integrative analysis of miRNA and mRNA expression showed that, among the 40 differentially expressed known miRNAs and 388 differentially expressed genes, 60 pairs of miRNA/mRNA were identified as co-expressed in our present study. These results suggest that both miRNA and mRNA may play a pivotal role in the process of learning and memory in honeybees. Our sequencing data provide comprehensive miRNA and gene expression information for maze-based visual learning, which will facilitate understanding of the molecular mechanisms of honeybee learning and memory.展开更多
The Full-disk vector Magneto Graph(FMG)instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179?spectral line.This paper describes how to choose this single wavelength positi...The Full-disk vector Magneto Graph(FMG)instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179?spectral line.This paper describes how to choose this single wavelength position,the relevant data-processing and the magnetic field calibrations based on the measured polarization signals at one single wavelength position.It is found that solar radial Doppler velocity,which can cause the spectral line to shift,is a disadvantageous factor for the linear calibration at one wavelength position.Observations at two symmetric wavelength positions may significantly reduce the wavelength shift effect(~75%),but simulations show that such polarization signals located at the solar limbs(e.g.,beyond the longitude range of±30°)are not free from the effect completely.In future work,we plan to apply machine learning techniques to calibrate vector magnetic fields,or employ full Stokes parameter profile inversion techniques to obtain accurate vector magnetic fields,in order to complement the linear calibration at the single wavelength position.展开更多
Background Potentially lethal ventricular arrhythmias （PLVAs） occur frequently in survivors after acute myocardial infarction and are increasingly recognized in other forms of structural heart diseases.This study in...Background Potentially lethal ventricular arrhythmias （PLVAs） occur frequently in survivors after acute myocardial infarction and are increasingly recognized in other forms of structural heart diseases.This study investigated the prevalence and prognostic significance of PLVAs in patients with chronic heart failure （CHF）.Methods Data concerning demographics,etiology of heart failure,NYHA functional class,biochemical variables,electrocardiographic and echocardiographic findings,and medical treatments were collected by reviewing hospital medical records from 1080 patients with NYHA Ⅱ-Ⅳ and a left ventricular （LV） ejection fraction ≤45%.PLVAs were defined as multi-focal ventricular ectopy （〉30 beats/h on Holter monitoring）,bursts of ventricular premature beats,and nonsustained ventricular tachycardia.All-cause mortality,sudden death,and rehospitalization due to worsening heart failure,or cardiac transplantation during 5-year follow-up after discharge were recorded.Results The occurrence rate of PLVAs in CHF was 30.2%,and increased with age; 23.4% in patients 〈45 years old,27.8% in those between 45-65 years old,and 33.5% in patients 〉65 years old （P=0.033）.Patients with PLVAs had larger LV size and lower ejection fraction （both P 〈0.01） and higher all-cause mortality （P=0.014） during 5-year follow-up than those without PLVAs.Age （OR 1.041,95% Cl 1.004-1.079,P=0.03） and LV end-diastolic dimension （OR 1.068,95% Cl 1.013-1.126,P=0.015） independently predicted the occurrence of PLVAs.And PLVA was an independent factor for all-cause mortality （RR 1.702,95% Cl 1.017-2.848,P=0.031） and sudden death （RR 1.937,95% CI 1.068-3.516,P=0.030） in patients with CHF.Conclusion PLVAs are common and exert a negative impact on Iona-term clinical outcome in patients with CHF.展开更多
Extraintestinal manifestations of inflammatory bowel disease(IBD) are a systemic illness that may affect up to half of all patients. Among the extraintestinal manifestations of IBD, those involving the lungs are relat...Extraintestinal manifestations of inflammatory bowel disease(IBD) are a systemic illness that may affect up to half of all patients. Among the extraintestinal manifestations of IBD, those involving the lungs are relatively rare and often overlooked. However, there is a wide array of such manifestations, spanning from airway disease to lung parenchymal disease, thromboembolic disease, pleural disease, enteric-pulmonary fistulas, pulmonary function test abnormalities, and adverse drug reactions. The spectrum of IBD manifestations in the chest is broad, and the manifestations may mimic other diseases. Although infrequent, physicians dealing with IBD must be aware of these conditions, which are sometimes life-threatening, to avoid further health impairment of the patients and to alleviate their symptoms by prompt recognition and treatment. Knowledge of these manifestations in conjunction with pertinent clinical data is essential for establishing the correct diagnosis and treatment. The treatment of IBD-related respiratory disorders depends on the specific pattern of involvement, and in most patients, steroids are required in the initial management. Corticosteroids, both systemic and aerosolized, are the mainstay therapeutic approach, while antibiotics must also be administered inthe case of infectious and suppurative processes, whose sequelae sometimes require surgical intervention.展开更多
The volume of the metallic lithium anode in allsolid-state Li metal batteries increases significantly due to the lithium dendrite formation during the battery cycling,and the rough surface of lithium metal also reduce...The volume of the metallic lithium anode in allsolid-state Li metal batteries increases significantly due to the lithium dendrite formation during the battery cycling,and the rough surface of lithium metal also reduces Li-ion transport in Li/electrolyte interface.In this work,we developed a solid polymer composite by adding the lowcost Si_(3)N_(4)particles to protect the lithium anode in allsolid-state batteries.The Fourier transform infrared spectroscopy(FTIR)data show that the surface of 10 wt%Si_(3)N_(4)particles interacts with the polyethylene oxide(PEO)and lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)salt;the interaction restricts the anion mobility and improves the ionic conductivity(1×10^(-4)S·cm^(-1))and lithium-ion transference number(0.28)of the composite electrolyte.The lithium metal anode is well protected by the composite electrolyte in all-solid-state cells,including symmetric and Li/LiFePO_(4)cells.The lithium dendrite growth suppression by this composite electrolyte indicates the possible application of these low-cost composite electrolytes for lithium metal protection.展开更多
Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because ...Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].展开更多
As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SD...As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload.展开更多
The clinical efficacy of acupuncture-moxibustion(AM)mainly depends on acupoints,but the relationship between the acupoints and AM remains unclear.Improving clinical efficacy and clarifying the mechanisms of AM is crit...The clinical efficacy of acupuncture-moxibustion(AM)mainly depends on acupoints,but the relationship between the acupoints and AM remains unclear.Improving clinical efficacy and clarifying the mechanisms of AM is critical.We found that the specificity and sensitivity of acupoints,the skill of operation,and reasonable amount of stimulation can significantly improve the efficacy of AM.In addition,some studies have shown that Neural-Endocrine-Immune network and metabolites are involved in this process,clarifying the therapeutic mechanism of acupoints.Therefore,how to effectively use acupoints to improve the clinical efficacy of AM is one of the key issues in need of an urgent solution.In summary,this article reviewed the Chinese and English databases on the clinical efficacy and underlying mechanisms of acupoints to clarify the relationship between acupoints and AM efficacy and ultimately improve clinical efficacy through effective and rational use of acupoints.展开更多
基金supported by the Natural Science Foundation of Jiangsu Province, China (BK2007711)the China Postdoctoral Fundation (20070421022)the Three Agricultural Projects Fundation of Jiangsu Province, China (SX2007082)
文摘To investigate the immune responses to the attenuated Mycoplasma hyopneumoniae 168 strain vaccine, 8-15 d old piglets were immunized with M. hyopneurnoniae 168 strain vaccine by intrapulmonic route. And the specific IgG antibody in serum, lymphoproliferation, IFNT, and specific secretory IgA （SIgA） antibody in bronchoalveolar lavage fluid were detected on 30 and 60 d post-immunization （DPI）, respectively. On 60 DPI, all the pigs except for those in health control group were challenged with a field M. hyopneumoniae strain JS. Necropsy was performed on 30 d post-challenge （DPC）. The results showed that IFN7 and specific SIgA were stimulated on surface of respiratory tract after immunization. And peripheral blood mononuclear cells could also be proliferated about 1.81 and 2.12 fold on 30 and 60 DPI when stimulated by M. hyopneumoniae protein in vitro. However, no serum IgG antibody against M. hyopneumoniae was detected during the whole immune phage. After challenge, vaccinated pigs were observed with only very slight histological lesion in individual lobes. None of vaccinated pigs showed any clinical signs. While the unvaccinated pigs from challenge control group showed varying degrees of clinical sign and severe macroscopical lesion of mycoplasmal pneumonia of swine （MPS）. The result suggested that the attenuated M. hyopneumoniae 168 strain vaccine inoculated by intrapulmonic route could activate the systemic cellular immunity, the local mucosal immunity and IFNγ secretion in respiratory tract to against M. hyopneumoniae infection in piglets.
文摘目的探讨"LEER"模式加速康复外科(ERAS)理念在胰十二指肠切除术中的临床应用价值。方法回顾性分析2017年9月至2019年5月乐山市人民医院收治的62例行胰十二指肠切除术的患者基本临床资料。37例围术期采用传统方案(传统组),25例围术期采用"LEER"模式ERAS方案(ERAS组)。"LEER"模式为:少痛(less pain)、早动(early move)、早食(early eat)、安心(reassuring)。结果 ERAS组相比于传统组,术后疼痛评分更低[(3.12±0.78) vs (4.59±1.01),t=6.459,P<0.05],术后胃肠道功能恢复更快[(3.28±0.46)d vs (3.76±1.01)d,t=2.205,P<0.05],术后下床活动时间[(1.96±0.79)d vs (2.62±0.64)d,t=3.635,P<0.05]及术后拔除引流管时间[(3.28±0.46)d vs (6.05±1.39)d,t=7.056,P<0.05]更早,胰漏发生率更低[20.00%(5/25) vs 51.35%(19/37),χ^2=6.181,P<0.05],住院时间更短[(11.52±1.39)d vs (15.76±2.51)d,t=7.671,P<0.05],住院费用更低[(61 610.92±4 272.13)元 vs (70 167.70±3 736.14)元,t=8.348,P<0.05]。两组手术时间、术中出血量及其他并发症无统计学差异(P>0.05)。结论"LEER"模式加速康复外科理念应用于胰十二指肠切除术安全有效,可加快术后康复,缩短住院时间,减少医疗费用。
基金Acknowledgments This work was supported by the Earmarked Fund for the China Agricultural Research System （No. CARS- 45-KXJ12） and the National Natural Science Foundation of China （No. 31260524）. The deep sequencing and bio-information analysis work were carried out in the Beijing Genome Institute （http：//www.genomics.cn/ index.php）. We thank Hong Zhu for invaluable guidance and assistance in the maze experiments and dissection of samples, Dr. Aung Si and Dr. Andrew B. Barron for helpful suggestions that improved the manuscript, Fei Zhang and Zhen-Xiu Zeng for help with beekeeping, Xu Han and Shu-Yun Li for their help in maze experiments.
文摘The honeybee （Apis mellifera） is a social insect with strong sensory capacity and diverse behavioral repertoire and is recognized as a good model organism for studying the neurobiological basis of learning and memory. In this study, we analyzed the changes in microRNA （miRNA） and messenger RNA （mRNA） following maze-based visual learning using next-generation small RNA sequencing and Solexa/lllumina Digital Gene Expression tag profiling （DGE）. For small RNA sequencing, we obtained 13 367 770 and 13 132 655 clean tags from the maze and control groups, respectively. A total of 40 differentially expressed known miRNAs were detected between these two samples, and all of them were up-regulated in the maze group compared to the control group. For DGE, 5 681 320 and 5 939 855 clean tags were detected from the maze and control groups, respectively. There were a total of 388 differentially expressed genes between these two samples, with 45 genes up-regulated and 343 genes down-regulated in the maze group, compared to the control group. Additionally, the expression levels of 10 differentially expressed genes were confirmed by quantitative reverse transcription polymerase chain reaction （qRT-PCR） and the expression trends of eight of them were consistent with the DGE result, although the degree of change was lower in amplitude. The integrative analysis of miRNA and mRNA expression showed that, among the 40 differentially expressed known miRNAs and 388 differentially expressed genes, 60 pairs of miRNA/mRNA were identified as co-expressed in our present study. These results suggest that both miRNA and mRNA may play a pivotal role in the process of learning and memory in honeybees. Our sequencing data provide comprehensive miRNA and gene expression information for maze-based visual learning, which will facilitate understanding of the molecular mechanisms of honeybee learning and memory.
基金supported by the Strategic Priority Research Program on Space Science, the Chinese Academy of Sciences (Grant Nos. XDA15320302, XDA15052200 and XDA15320102)the National Natural Science Foundation of China (Grant Nos. 11773038, 11703042, U1731241, 11427901, 11427803, 11473039 and U1831107)the 13th Fiveyear Informatization Plan of the Chinese Academy of Sciences (Grant No. XXH13505-04)
文摘The Full-disk vector Magneto Graph(FMG)instrument will carry out polarization observations at one wavelength position of the Fe I 5324.179?spectral line.This paper describes how to choose this single wavelength position,the relevant data-processing and the magnetic field calibrations based on the measured polarization signals at one single wavelength position.It is found that solar radial Doppler velocity,which can cause the spectral line to shift,is a disadvantageous factor for the linear calibration at one wavelength position.Observations at two symmetric wavelength positions may significantly reduce the wavelength shift effect(~75%),but simulations show that such polarization signals located at the solar limbs(e.g.,beyond the longitude range of±30°)are not free from the effect completely.In future work,we plan to apply machine learning techniques to calibrate vector magnetic fields,or employ full Stokes parameter profile inversion techniques to obtain accurate vector magnetic fields,in order to complement the linear calibration at the single wavelength position.
文摘Background Potentially lethal ventricular arrhythmias （PLVAs） occur frequently in survivors after acute myocardial infarction and are increasingly recognized in other forms of structural heart diseases.This study investigated the prevalence and prognostic significance of PLVAs in patients with chronic heart failure （CHF）.Methods Data concerning demographics,etiology of heart failure,NYHA functional class,biochemical variables,electrocardiographic and echocardiographic findings,and medical treatments were collected by reviewing hospital medical records from 1080 patients with NYHA Ⅱ-Ⅳ and a left ventricular （LV） ejection fraction ≤45%.PLVAs were defined as multi-focal ventricular ectopy （〉30 beats/h on Holter monitoring）,bursts of ventricular premature beats,and nonsustained ventricular tachycardia.All-cause mortality,sudden death,and rehospitalization due to worsening heart failure,or cardiac transplantation during 5-year follow-up after discharge were recorded.Results The occurrence rate of PLVAs in CHF was 30.2%,and increased with age; 23.4% in patients 〈45 years old,27.8% in those between 45-65 years old,and 33.5% in patients 〉65 years old （P=0.033）.Patients with PLVAs had larger LV size and lower ejection fraction （both P 〈0.01） and higher all-cause mortality （P=0.014） during 5-year follow-up than those without PLVAs.Age （OR 1.041,95% Cl 1.004-1.079,P=0.03） and LV end-diastolic dimension （OR 1.068,95% Cl 1.013-1.126,P=0.015） independently predicted the occurrence of PLVAs.And PLVA was an independent factor for all-cause mortality （RR 1.702,95% Cl 1.017-2.848,P=0.031） and sudden death （RR 1.937,95% CI 1.068-3.516,P=0.030） in patients with CHF.Conclusion PLVAs are common and exert a negative impact on Iona-term clinical outcome in patients with CHF.
文摘Extraintestinal manifestations of inflammatory bowel disease(IBD) are a systemic illness that may affect up to half of all patients. Among the extraintestinal manifestations of IBD, those involving the lungs are relatively rare and often overlooked. However, there is a wide array of such manifestations, spanning from airway disease to lung parenchymal disease, thromboembolic disease, pleural disease, enteric-pulmonary fistulas, pulmonary function test abnormalities, and adverse drug reactions. The spectrum of IBD manifestations in the chest is broad, and the manifestations may mimic other diseases. Although infrequent, physicians dealing with IBD must be aware of these conditions, which are sometimes life-threatening, to avoid further health impairment of the patients and to alleviate their symptoms by prompt recognition and treatment. Knowledge of these manifestations in conjunction with pertinent clinical data is essential for establishing the correct diagnosis and treatment. The treatment of IBD-related respiratory disorders depends on the specific pattern of involvement, and in most patients, steroids are required in the initial management. Corticosteroids, both systemic and aerosolized, are the mainstay therapeutic approach, while antibiotics must also be administered inthe case of infectious and suppurative processes, whose sequelae sometimes require surgical intervention.
基金the Shandong Province Key Research and Development Plan(No.2019GGX102016)。
文摘The volume of the metallic lithium anode in allsolid-state Li metal batteries increases significantly due to the lithium dendrite formation during the battery cycling,and the rough surface of lithium metal also reduces Li-ion transport in Li/electrolyte interface.In this work,we developed a solid polymer composite by adding the lowcost Si_(3)N_(4)particles to protect the lithium anode in allsolid-state batteries.The Fourier transform infrared spectroscopy(FTIR)data show that the surface of 10 wt%Si_(3)N_(4)particles interacts with the polyethylene oxide(PEO)and lithium bis(trifluoromethanesulfonyl)imide(LiTFSI)salt;the interaction restricts the anion mobility and improves the ionic conductivity(1×10^(-4)S·cm^(-1))and lithium-ion transference number(0.28)of the composite electrolyte.The lithium metal anode is well protected by the composite electrolyte in all-solid-state cells,including symmetric and Li/LiFePO_(4)cells.The lithium dendrite growth suppression by this composite electrolyte indicates the possible application of these low-cost composite electrolytes for lithium metal protection.
基金the National Natural Science Foundation of China(81520108016,81661148045,and 31471084 to Yu-Feng Zang81671774 and 81630031 to Chao-Gan Yan+11 种基金81571228 to Tao Wu61571047 to Xia Wu81701664 to Jian Wang,81471654 to Biao Huang81701671 to Wei-Guo Liu82001898 to Xi-Ze Jia81771820,81371519 and 81571654 to Wei Luo)Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang,BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan,NIH(2R01AG006457 to Fay B.Horak1RC4NS073008-01 and P50NS062684 to Tara Madhyastha)NINDS Intramural Research Program to Mark HallettStart-up Funds for Leading Talents at Beijing Normal UniversityNational Basic Science Data Center‘‘Chinese Data-sharing Warehouse for In-vivo Imaging Brain”(NBSDC-DB-15)to Xi-Nian ZuoGrant NU20-04-00294 of the Agency for Health Research,Czech Republic to Lenka Krajcovicova and Irena Rektorova。
文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].
基金supported by Chinese Academy of Sciences (CAS)supported by the National Natural Science Foundation of China (Grant Nos. 11427803, U1731241, U1731114 and U1531106)the CAS Strategic Pioneer Program on Space Science (Grant Nos. XDA04076100, XDA15052200, XDA15320103 and XDA15320301)
文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload.
基金supported by the Shanghai Municipal Population and Family Planning Commission“Excellent Youth Talent Training Program”(No.2018YQ11)the Clinical Research Plan of SHDC(Shanghai Hospital Development Center)(No.16CR4023A)+1 种基金the National Basic Research Program of China(973 program,No.2015CB554501)the National Natural Science Foundation of China(No.81674074,No.81873377)。
文摘The clinical efficacy of acupuncture-moxibustion(AM)mainly depends on acupoints,but the relationship between the acupoints and AM remains unclear.Improving clinical efficacy and clarifying the mechanisms of AM is critical.We found that the specificity and sensitivity of acupoints,the skill of operation,and reasonable amount of stimulation can significantly improve the efficacy of AM.In addition,some studies have shown that Neural-Endocrine-Immune network and metabolites are involved in this process,clarifying the therapeutic mechanism of acupoints.Therefore,how to effectively use acupoints to improve the clinical efficacy of AM is one of the key issues in need of an urgent solution.In summary,this article reviewed the Chinese and English databases on the clinical efficacy and underlying mechanisms of acupoints to clarify the relationship between acupoints and AM efficacy and ultimately improve clinical efficacy through effective and rational use of acupoints.
