电化学一氧化氮传感器能够实时监测颅内一氧化氮浓度,对于了解大脑中一氧化氮的功能至关重要.然而,在大脑中使用的传统刚性传感电极面临着灵敏度低和植入后神经炎症引起一氧化氮浓度异常的问题.在这里,我们报道了一种结合物理和化学吸...电化学一氧化氮传感器能够实时监测颅内一氧化氮浓度,对于了解大脑中一氧化氮的功能至关重要.然而,在大脑中使用的传统刚性传感电极面临着灵敏度低和植入后神经炎症引起一氧化氮浓度异常的问题.在这里,我们报道了一种结合物理和化学吸附能力、具有高灵敏度和准确性的电化学一氧化氮传感器.其对一氧化氮的物理和化学吸附能力分别来自于电极的高比表面积和丰富的羧基官能团.此外,柔软的电极可以与脑组织的力学性能相匹配,实现了一个高度适应的电极/组织界面.由此设计的颅内一氧化氮传感器表现出迄今为止所报道文献中最高的灵敏度,为3245 pA nmol^(-1)L,检测限为0.1 nmol L^(-1).电极在植入后未观察到显著的炎症反应以及过量的一氧化氮表达,提高了检测的准确性.该传感器成功捕捉了大脑中的一氧化氮波动,并实现了对多个脑区的同时检测,促进了对大脑中一氧化氮生理病理作用的研究.展开更多
Mental health has gradually become a focus of attention, especially with the significant increase in stress-related psychological disorders such as anxiety and depression [1,2]. This has led to an increasing demand fo...Mental health has gradually become a focus of attention, especially with the significant increase in stress-related psychological disorders such as anxiety and depression [1,2]. This has led to an increasing demand for effective methods to assess mental health.However, current methods for assessing psychological stress are mostly limited to subjective surveys and clinical questionnaires。展开更多
基金financially supported by the National Natural Science Foundation of China (22175086, 22005137, 22205098, and 82201992)the Natural Science Foundation of Jiangsu Province (BK20200321 and BK20210681)+5 种基金the Postdoctoral Research Foundation of Jiangsu Province (2021K007A)China Postdoctoral Science Foundation (2021M700067)the National Postdoctoral Program for Innovative Talents (BX20200161)the Program for Innovative Talents and Entrepreneurs in Jiangsu (JSSCTD202138)the Fundamental Research Funds for the Central Universities (021314380234)the Natural Science Foundation of Nanjing University of Chinese Medicine (XPT82201992)。
文摘电化学一氧化氮传感器能够实时监测颅内一氧化氮浓度,对于了解大脑中一氧化氮的功能至关重要.然而,在大脑中使用的传统刚性传感电极面临着灵敏度低和植入后神经炎症引起一氧化氮浓度异常的问题.在这里,我们报道了一种结合物理和化学吸附能力、具有高灵敏度和准确性的电化学一氧化氮传感器.其对一氧化氮的物理和化学吸附能力分别来自于电极的高比表面积和丰富的羧基官能团.此外,柔软的电极可以与脑组织的力学性能相匹配,实现了一个高度适应的电极/组织界面.由此设计的颅内一氧化氮传感器表现出迄今为止所报道文献中最高的灵敏度,为3245 pA nmol^(-1)L,检测限为0.1 nmol L^(-1).电极在植入后未观察到显著的炎症反应以及过量的一氧化氮表达,提高了检测的准确性.该传感器成功捕捉了大脑中的一氧化氮波动,并实现了对多个脑区的同时检测,促进了对大脑中一氧化氮生理病理作用的研究.
基金supported by the National Natural Science Foundation of China (22175086 and 22005137)the Natural Science Foundation of Jiangsu Province (BK20200321)the Program for Innovative Talents and Entrepreneurs in Jiangsu Province(JSSCTD202138)。
文摘Mental health has gradually become a focus of attention, especially with the significant increase in stress-related psychological disorders such as anxiety and depression [1,2]. This has led to an increasing demand for effective methods to assess mental health.However, current methods for assessing psychological stress are mostly limited to subjective surveys and clinical questionnaires。
