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数字孪生模型构建理论及应用 被引量:239
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作者 陶飞 张贺 +13 位作者 戚庆林 徐俊 孙铮 胡天亮 刘晓军 刘庭煜 关俊涛 陈畅宇 孟凡伟 张辰源 李志远 魏永利 朱铭浩 肖斌 《计算机集成制造系统》 EI CSCD 北大核心 2021年第1期1-15,共15页
数字孪生作为实现数字化转型和促进智能化升级的重要使能途径,一直备受各行各业关注,已从理论研究走向了实际应用阶段。数字孪生是以多维虚拟模型和融合数据双驱动,通过虚实闭环交互,来实现监控、仿真、预测、优化等实际功能服务和应用... 数字孪生作为实现数字化转型和促进智能化升级的重要使能途径,一直备受各行各业关注,已从理论研究走向了实际应用阶段。数字孪生是以多维虚拟模型和融合数据双驱动,通过虚实闭环交互,来实现监控、仿真、预测、优化等实际功能服务和应用需求,其中数字孪生模型构建是实现数字孪生落地应用的前提。针对如何构建数字孪生模型问题,首先提出了数字孪生模型"四化四可八用"构建准则。基于所提出的构建准则,从"建—组—融—验—校—管"6个方面探索建立了一套数字孪生模型构建理论体系。并基于所提出的数字孪生模型构建准则和理论体系,结合笔者团队承担的国家重点研发计划项目"基于数字孪生的智能生产过程精确建模理论与方法",以数字孪生车间为例,从车间要素实体建模、生产过程动态建模、生产系统仿真建模3个方面对数字孪生车间模型构建理论与技术开展了研究和实践。相关工作期望能为数字孪生构建和进一步落地应用提供理论参考。 展开更多
关键词 数字孪生 智能制造 数字孪生车间 建模 构建准则 理论体系
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The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer 被引量:154
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作者 Feng-Hua Wang Lin Shen +19 位作者 Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long guan Rui-Hua Xu 《Cancer Communications》 SCIE 2019年第1期75-105,共31页
China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and ... China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. 展开更多
关键词 Chinese Society of Clinical Oncology(CSCO) Gastric cancer Diagnosis Surgery NEOADJUVANT ADJUVANT RADIOTHERAPY Chemotherapy Targeted therapy IMMUNOTHERAPY
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中国常见恶性肿瘤患者营养状况调查 被引量:126
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作者 宋春花 王昆华 +47 位作者 郭增清 付振明 王畅 翁敏 曹晶晶 周福祥 林源 李苏宜 巴一 袁凯涛 刘明 胡雯 周岚 马虎 姚庆华 丛明华 李涛 陈子华 陈公琰 赵青川 李增宁 冯长艳 贺英 吴静 杨家君 宋新霞 余亚英 马文君 罗素霞 郑瑾 陈俊强 罗琪 王巍 乔秋阁 施咏梅 齐玉梅 冯永东 姜海平 邱红 管文贤 陈甲信 黄河 余震 方玉 崔久嵬 许红霞 李薇 石汉平 《中国科学:生命科学》 CSCD 北大核心 2020年第12期1437-1452,共16页
营养不良对恶性肿瘤患者的不利影响贯穿其整个病程.肿瘤患者的营养状况如何未见大样本报道,而且已有报道差异很大,本研究旨在调查中国常见恶性肿瘤患者营养不良状况及营养治疗现状.本次观察性多中心研究采用两阶段随机抽样方法抽取全国2... 营养不良对恶性肿瘤患者的不利影响贯穿其整个病程.肿瘤患者的营养状况如何未见大样本报道,而且已有报道差异很大,本研究旨在调查中国常见恶性肿瘤患者营养不良状况及营养治疗现状.本次观察性多中心研究采用两阶段随机抽样方法抽取全国22个主要省市80家三甲医院共47488例16种常见恶性肿瘤住院患者,以患者主观整体评估(Patient-Generated Subjective Global Assessment,PG-SGA)评估患者营养状况,以定量评估区分营养不良严重程度:0~1分无营养不良,2~3分、4~8分、≥9分分别定义为可疑/轻度、中度、重度营养不良.方差分析比较不同特征肿瘤患者PG-SGA评分.肿瘤患者中、重度营养不良的发病率为58.2%(中度32.1%、重度26.1%),22.2%为可疑/轻度营养不良,只有19.6%的患者无营养不良.营养不良的发病存在瘤种、年龄、性别、肿瘤分期、治疗情况及地区差异:胰腺癌患者PG-SGA评分最高(9.58±5.74),乳腺癌患者PG-SGA评分最低(3.51±3.49);<45岁年龄组患者PG-SGA评分最低(4.84±4.50),≥70岁年龄组患者PG-SGA评分最高(7.82±5.10);女性肺癌(5.87vs.5.60,P=0.006)和胃癌(8.36 vs.7.81,P<0.001)PG-SGA评分高于男性;TNM分期较高的患者其PG-SGA评分也较高,其中胰腺癌Ⅲ、Ⅳ期患者PG-SGA评分最高,乳腺癌Ⅰ~Ⅲ期患者PG-SGA评分均低于4分(3.05±2.83);接受手术治疗的患者PG-SGA评分最高(6.22±4.74),而目前还没有接受任何治疗的患者评分最低(5.61±4.68);华中区域PG-SGA评分最低(4.82±4.16),华东区域PG-SGA评分最高(7.31±5.53).此外,在某些肿瘤类型中,不同医疗保险类型、受教育水平、职业、居住地、民族的患者PG-SGA评分也有显著差异,农民、小学及以下低教育水平患者营养状况最差.68.78%的肿瘤患者没有获得任何营养治疗,重度营养不良(PG-SGA≥9)肿瘤患者的无营养治疗比例仍然高达55.03%.以上结果说明,中国常见恶性肿瘤患者营养不良发生率 展开更多
关键词 营养不良 营养治疗 恶性肿瘤 现况调查
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A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root 被引量:54
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作者 Tian-qi Zhang Zhou-Geng Xu +1 位作者 guan-Dong Shang Jia-Wei Wang 《Molecular Plant》 SCIE CAS CSCD 2019年第5期648-660,共13页
Cells of eukaryotic multicellular organisms have inherent heterogeneity.Recent advances in single-cell gene expression studies enable us to explore transcriptional regulation in dynamic development processes and highl... Cells of eukaryotic multicellular organisms have inherent heterogeneity.Recent advances in single-cell gene expression studies enable us to explore transcriptional regulation in dynamic development processes and highly heterogeneous cell populations.In this study,using a high-throughput single-cell RNA-sequencing assay,we found that the cells in Arabidopsis root are highly heterogeneous in their transcriptomes.A total of 24 putative cell clusters and the cluster-specific marker genes were identified.The spatial distribution and temporal ordering of the individual cells at different developmental stages illustrate their hierarchical structures and enable the reconstruction of continuous differentiation trajectory of root development.Moreover,we found that each root cell cluster exhibits distinct patterns of ion assimilation and hormonal responses.Collectively,our study reveals a high degree of heterogeneity of root cells and identifies the expression signatures of intermediate states during root cell differentiation at single-cell resolution.We also established a web server(http://wanglab.sippe.ac.cn/rootatlas/)to facilitate the use of the datasets generated in this study. 展开更多
关键词 ARABIDOPSIS ROOT scRNA-seq cell ATLAS differentiation trajectory MERISTEM
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Advances in coatings on biodegradable magnesium alloys 被引量:47
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作者 Zheng-Zheng Yin Wei-Chen qi +4 位作者 Rong-Chang Zeng Xiao-Bo Chen Chang-Dong Gu Shao-Kang guan Yu-Feng Zheng 《Journal of Magnesium and Alloys》 SCIE 2020年第1期42-65,共24页
The clinic applications of bioabsorbable magnesium(Mg)and its alloys have been significantly restricted owing to their poor corrosion resistance.Besides elemental alloying,surface modification and functionality is a m... The clinic applications of bioabsorbable magnesium(Mg)and its alloys have been significantly restricted owing to their poor corrosion resistance.Besides elemental alloying,surface modification and functionality is a major approach to increasing corrosion resistance for magnesium alloys.This article reviews the cutting-edge advances and progress of biodegradable surface coatings upon Mg alloys over the last decades,aims to build up a knowledge framework of surface modification on biodegradable Mg alloys.A considerable number of conversion,deposition,mechanical and functional coatings and their preparation methods are discussed.The emphasis has been placed on the composition of chemical conversion and deposited coatings to overcome the disadvantages of adhesion,corrosion resistance and biocompatibility of a single coating for biomedical materials.The issues have been addressed on the integration of the structural and functional factors of the composite coatings. 展开更多
关键词 Magnesium alloy Biomaterial Corrosion resistance Coating BIODEGRADABILITY
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Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy 被引量:44
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作者 Yan-Ping Mao Ling-Long Tang +7 位作者 Lei Chen Ying Sun Zhen-Yu qi guan-Qun Zhou Li-Zhi Liu Li Li Ai-Hua Lin Jun Ma 《Chinese Journal of Cancer》 SCIE CAS CSCD 2016年第12期673-682,共10页
Background: The prognostic values of staging parameters require continual re?assessment amid changes in diag?nostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of ... Background: The prognostic values of staging parameters require continual re?assessment amid changes in diag?nostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non?meta?static nasopharyngeal carcinoma(NPC) in the intensity?modulated radiotherapy(IMRT) era.Methods: We reviewed the data from 749 patients with newly diagnosed, biopsy?proven, non?metastatic NPC in our cancer center(South China, an NPC endemic area) between January 2003 and December 2007. All patients under?went magnetic resonance imaging(MRI) before receiving IMRT. The actuarial survival rates were estimated using the Kaplan–Meier method, and survival curves were compared using the log?rank test. Multivariate analyses with the Cox proportional hazards model were used to test for the independent prognostic factors by backward eliminating insigniicant explanatory variables.Results: The 5?year occurrence rates of local failure, regional failure, locoregional failure, and distant failure were 5.4, 3.0, 7.4, and 17.4%, respectively. The 5?year survival rates were as follows: local relapse?free survival, 94.6%; nodal relapse?free survival, 97.0%; distant metastasis?free survival, 82.6%; disease?free survival, 75.1%; and overall survival, 82.0%. Multivariate Cox regression analysis revealed that orbit involvement was the only signiicant prognostic fac?tor for local failure(P = 0.011). Parapharyngeal tumor extension, retropharyngeal lymph node involvement, and the laterality, longest diameter, and Ho's location of the cervical lymph nodes were signiicant prognostic factors for both distant failure and disease failure(all P < 0.05). Intracranial extension had signiicant prognostic value for distant failure(P = 0.040).Conclusions: The key failure pattern for NPC was distant metastasis in the IMRT era. With changes in diagnostic and therapeutic technologies as well as treatment modalities, the signiicant prognostic parameters for local control have also been altered substantially. 展开更多
关键词 Nasopharyngeal carcinoma Intensity-modulated radiotherapy PROGNOSIS Failure pattern Tumor staging
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The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) 被引量:43
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作者 Xiang-Qun Cui Yong-Heng Zhao +52 位作者 Yao-Quan Chu Guo-Ping Li qi Li Li-Ping Zhang Hong-Jun Su Zheng-qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-Li Luo Xin-qi Xu Zhen-Chao Zhang Gen-Rong Liu Hao-Tong Zhang De-Hua Yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Yan Li Ye-Ping Li guan-QunLiu Zhi-Gang Liu Huo-Ming Shi Zheng-Hong Tang qing-Sheng Tao Xiang-Yan Yuan Chao Zhai Jing Zhang Yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2012年第9期1197-1242,共46页
The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effecti... The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects. 展开更多
关键词 techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction
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常态化新冠肺炎防控策略与机制的思考 被引量:42
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作者 罗银波 吴杨 +4 位作者 刘漫 陈琦 刘家发 官旭华 童叶青 《公共卫生与预防医学》 2020年第6期1-5,共5页
自2019年12月底新冠肺炎疫情暴发以来,湖北省积极采取“隔离、救治、检测、封控”等一系列防控措施,实现了本土疫情的基本阻断。但随着境外疫情的发展及国内局部地区聚集疫情的发生,全省既面临着新冠肺炎输入性病例的威胁,又面临恢复正... 自2019年12月底新冠肺炎疫情暴发以来,湖北省积极采取“隔离、救治、检测、封控”等一系列防控措施,实现了本土疫情的基本阻断。但随着境外疫情的发展及国内局部地区聚集疫情的发生,全省既面临着新冠肺炎输入性病例的威胁,又面临恢复正常生产、生活秩序的迫切需要,这对常态化防控工作提出了更高的要求。因此,要深刻认识到常态化防控的意义以及全省疫情防控形势,总结经验与教训,坚持“政府主导、群专结合、以专为主”的防控策略,落实常态化防控监测和局部疫情快速应急处置相结合的工作要求,建立常态化新冠肺炎多点触发预警机制,强化应急物资储备,开展全省疫情防控培训和演练,为秋冬疫情来临做好充分的准备工作;改革疾病预防和公共卫生体系,全面提升防控和救治能力,推进公共卫生治理现代化。 展开更多
关键词 新型冠状病毒肺炎 常态化防控 监测 体系改革
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The first data release(DR1) of the LAMOST regular survey 被引量:29
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作者 A-Li Luo Yong-Heng Zhao +134 位作者 Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li guang-Wei Li Hai-Ning Li Jian Li qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang qi Yong-Jun qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-qiang Su Hong-Jun Su Zheng-Hong Tang qing-Sheng Tao Yuan Tian Dan Wang Da-qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-guan Wang Shu-qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-qin Yang Ming Yang Zheng-qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2015年第8期1095-1124,共30页
The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of ... The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. 展开更多
关键词 techniques: spectroscopic survey—data release—catalog
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The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2023 被引量:27
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作者 Feng-Hua Wang Xiao-Tian Zhang +33 位作者 Lei Tang qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong qiu Yu-Jing Zhang Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen qiu Wen-Long guan Sheng-Xiang Rao Jia-Fu Ji Yan Xin Wei-qi Sheng Hui-Mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-qiao Zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu 《Cancer Communications》 SCIE 2024年第1期127-172,共46页
The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-... The 2023 update of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision medicine.These updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer patients.Key revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric cancer.For advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,along with updated management strategies for human epidermal growth factor receptor 2(HER2)-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)patients.Additionally,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric cancer.The 2023 CSCO Clinical Guidelines for Gastric Cancer updates are based on both Chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of China,while maintaining a commitment to scientific rigor,impartiality,and timely revisions. 展开更多
关键词 Chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery NEOADJUVANT ADJUVANT RADIOTHERAPY chemotherapy targeted therapy IMMUNOTHERAPY
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Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation 被引量:30
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作者 ZHANG Wen SONG Jun-Ke +6 位作者 ZHANG Xue ZHOU qi-Meng HE Guo-Rong XU Xiao-Na Yan Rong ZHOU Wen-Xia DU guan-Hua 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2018年第3期184-193,共10页
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The pr... Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to determine the brain protective effects of SAA against cerebral ischemia reperfusion injury in rats, and to figure out whether SAA could protect the blood brain barrier (BBB) through matrix metallopeptidase 9 (MMP-9) inhibition. A focal cerebral ischemia reperfusion model was induced by middle cerebral artery occlusion (MCAO) for 1.5-h followed by 24-h reperfusion. SAA was administered intravenously at doses of 5, 10, and 20 mg.kg-l. SAA significantly reduced the infarct volumes and neurological deficit scores. Immunohistochemical analyses showed that SAA treatments could also improve the morphology of neurons in hippocampus CA1 and CA3 regions and increase the number of neurons. Western blotting analyses showed that SAA downregulated the levels of MMP-9 and upregulated the levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) to attenuate BBB injury. SAA treatment significantly prevented MMP-9-induced degradation of ZO-1, claudin-5 and occludin proteins. SAA also prevented cerebral NF-κB p65 activation and reduced inflammation response. Our results suggested that SAA could be a promising agent to attenuate cerebral ischemia reperfusion injury through MMP-9 inhibition and anti-inflammation activities. 展开更多
关键词 Salvianolic acid A ISCHEMIA MCAO Blood brain barrier NF-κB MMP-9
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Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products 被引量:29
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作者 Xi Chen Chao Gao +15 位作者 Haijin Li Lei Huang qi Sun Yanye Dong Chunliang Tian Shengpu Gao Hailin Dong Danping guan Xiaoyun Hu Shujian Zhao Liang Li Lin Zhu qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang 《Cell Research》 SCIE CAS CSCD 2010年第10期1128-1137,共10页
Recent baby formula milk powder contamination incidents have shown that the classic markers or standards in milk quality control are insufficient in identifying "manipulated" poor-quality milk. In the present study,... Recent baby formula milk powder contamination incidents have shown that the classic markers or standards in milk quality control are insufficient in identifying "manipulated" poor-quality milk. In the present study, we demonstrated for the first time that cow milk contains large amounts of microRNAs (miRNAs) and that the unique expression profile of milk-specific miRNAs can serve as a novel indicator and possible new standard for the quafity control of raw milk and milk-related commercial products, such as fluid milk and powdered formula milk. First, using Solexa sequencing, we systematically screened miRNA expression in raw milk and identified a total of 245 miR- NAs in raw milk. Unlike other classic biomarkers whose expression levels are nearly identical at different periods of lactation, individual miRNAs can be significantly altered during lactation process, implicating that miRNAs may be a more accurate indicator to reflect the quality alteration of milk. Second, using TaqMan probe-based miRNA quantitative RT-PCR, we further identified seven miRNAs that have a relatively consistent expression throughout the lactation process, and more importantly, the expression profile of these seven milk-specific miRNAs can serve as an ideal biomarker for discriminating poor-quality or "manipulated" milk from pure raw milk, as well as for the quality control of commercial milk products, such as fluid milk and powdered formula milk. Together, our findings provide a basis for understanding the physiological role of milk miRNAs and a new potential standard for determining the quality of raw milk or milk-related commercial products. 展开更多
关键词 MICRORNA MILK fluid milk powdercd milk
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Role of vasoactive intestinal peptide and nitric oxide in the modulation of electroacupucture on gastric motility in stressed rats 被引量:27
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作者 Guo-Ming Shen Mei-qi Zhou +2 位作者 guan-Sun Xu Ying Xu Gang Yin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第38期6156-6160,共5页
AIM: To investigate the effects and mechanisms of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in the modulation of electroacupucture (EA) on gastric motility in restrained-cold stressed rats. METHODS: An... AIM: To investigate the effects and mechanisms of vasoactive intestinal peptide (VIP) and nitric oxide (NO) in the modulation of electroacupucture (EA) on gastric motility in restrained-cold stressed rats. METHODS: An animal model of gastric motility disorder was established by restrained-cold stress. Gastric myoelectric activities were recorded by electrogastroent erography (EGG). VIP and NO concentrations in plasma and gastric mucosal and bulb tissues were detected by radioimmunoassay (RIA). VIP expression in the gastric walls was assayed using avidin-biotin-peroxidase complex (ABC) and image analysis. RESULTS: In cold restrained stressed rats, EGG was disordered and irregular. The frequency and amplitude of gastric motility were higher than that in control group (P < 0.01). VIP and NO contents of plasma, gastric mucosal and bulb tissues were obviously decreased (P < 0.01). Following EA at “Zusanli” (ST36), the frequency and amplitude of gastric motility were obviously lowered (P < 0.01), while the levels of VIP and NO in plasma, gastric mucosal and bulb tissues increased strikingly (P < 0.01, P < 0.05) and expression of VIP in antral smooth muscle was elevated significantly (P < 0.01) in comparison with those of model group. CONCLUSION: VIP and NO participate in the modulatory effect of EA on gastric motility. EA at “Zusanli” acupoint (ST36) can improve gastric motility of the stressed rats by increasing the levels of VIP and NO. 展开更多
关键词 Vasoactive intestinal peptide Nitric oxide Gastric motility ELECTROACUPUNCTURE
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医患沟通技能评价表在住院医师规范化培训中的应用 被引量:27
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作者 谷士贤 张爱京 +3 位作者 霍刚 张祺 王冠 韩庆烽 《中华医学教育杂志》 2018年第3期435-438,454,共5页
目的探讨医患沟通培训课程对提升住院医师医患沟通能力的效果。方法选取北京大学第三医院181名住院医师为研究对象,采取自身前后对照的研究方法,在医患沟通课程培训前后,采用《医患沟通技能评价表》及自制问卷对这些住院医师进行调... 目的探讨医患沟通培训课程对提升住院医师医患沟通能力的效果。方法选取北京大学第三医院181名住院医师为研究对象,采取自身前后对照的研究方法,在医患沟通课程培训前后,采用《医患沟通技能评价表》及自制问卷对这些住院医师进行调查。结果医患沟通培训前后,住院医师在沟通启动、信息收集、信息给予、理解患者及结束问诊5个维度比较,差异具有统计学意义(均P〈0.001)。问卷调查结果表明,住院医师对授课教师、教学学时、授课方式及授课内容的满意度较高。结论今后仍然需要在沟通启动和信息收集2个医患沟通技能方面不断改进教学,以提升住院医师医患沟通能力,构建和谐医患关系。 展开更多
关键词 医患沟通 住院医师 培训 研究
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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients 被引量:24
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作者 ZHENG Ying CAI guang-yan +59 位作者 CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN qin-kai JIA Shun-lian GONG Zhi-feng guan guang-ju XIA Tian ZHONG Liang-bao 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第12期2276-2280,共5页
Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease (CKD) patients are limited.The aim of the present study was to investigate the prevalence,awareness,treatment,and co... Background Data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease (CKD) patients are limited.The aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in China.Methods The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China (except Hong Kong,Macao,and Taiwan).Trained physicians collected demographic and clinical data and measured blood pressure (BP) using a standardized protocol.Hypertension was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive medications.BP 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension control.In multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD patients.Results The analysis included 8927 non-dialysis CKD patients.The prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,respectively.Of hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,respectively.With successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased (P〈0.001).When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively (P〈0.05).Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages (P〈0.05).Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was suboptimal.With successive CKD stages,the risk of uncontrolled hypertension increased. 展开更多
关键词 non-dialysis chronic kidney disease chronic kidney disease stages HYPERTENSION EPIDEMIOLOGY
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Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity 被引量:24
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作者 SHANG Xian Wen LIU Ai Ling +9 位作者 ZHANG qian HU Xiao qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA guan Sheng 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第2期125-132,共8页
Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558,... Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant’s height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. 展开更多
关键词 Sugar-sweetened Beverages OBESITY CHILDREN
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药用植物锁阳的研究进展 被引量:22
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作者 任梦云 杨光 +5 位作者 杜乐山 刘方 张盾 沈奇 关潇 张银东 《生物学杂志》 CAS CSCD 北大核心 2018年第5期95-98,共4页
锁阳(Cynomorium songaricum Rupr)为锁阳科(Cynomoriaceae)锁阳属(Cynomorium songaricum)多年生、全寄生草本植物,具补肾助阳、益精血、润肠通便之功效,是一种珍稀濒危药用植物,目前常用于中、蒙、藏药中。综述了锁阳的生物学特征、... 锁阳(Cynomorium songaricum Rupr)为锁阳科(Cynomoriaceae)锁阳属(Cynomorium songaricum)多年生、全寄生草本植物,具补肾助阳、益精血、润肠通便之功效,是一种珍稀濒危药用植物,目前常用于中、蒙、藏药中。综述了锁阳的生物学特征、遗传多样性、化学成分及药理作用、以及人工栽培技术等方面的研究进展,在此基础上提出了今后研究重点与热点,即着重研究锁阳生物活性成分的药理作用机制,构建一套完整的锁阳药材质量评估体系,其次应深入研究锁阳种质资源、资源保护与再生,加强锁阳的人工繁育技术,以期为锁阳的合理利用与保护提供理论参考。 展开更多
关键词 锁阳 药理活性 生物学特征 遗传多样性 资源保护
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复杂多孔介质主流通道定量判识标准 被引量:22
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作者 李熙喆 卢德唐 +7 位作者 罗瑞兰 孙玉平 沈伟军 胡勇 刘晓华 齐亚东 关春晓 郭辉 《石油勘探与开发》 SCIE EI CAS CSCD 北大核心 2019年第5期943-949,共7页
为判识油气储集层中复杂多孔介质的主流通道类型,利用试井解释获取的综合渗透率与岩心测试(或测井解释)得到的基质渗透率的比值定义了“主流通道指数”,同时基于流量等效原理建立了相应的数学模型,提出了主流通道分类方法,实现了储集层... 为判识油气储集层中复杂多孔介质的主流通道类型,利用试井解释获取的综合渗透率与岩心测试(或测井解释)得到的基质渗透率的比值定义了“主流通道指数”,同时基于流量等效原理建立了相应的数学模型,提出了主流通道分类方法,实现了储集层流动通道类型的定量表征,并通过典型气藏实例分析验证了该方法的有效性。研究表明,“主流通道指数”能够定量划分流动通道类型:该指数小于3,基质孔隙为主要流动通道;该指数为3~20,流动通道以裂缝为主、基质孔隙为辅;该指数大于20可视裂缝为唯一渗流通道。典型气藏的动态分析显示,“主流通道指数”可用于评价多孔介质流动通道类型,进而指导气藏分类开发、规避气藏开发风险。 展开更多
关键词 多孔介质 基质孔隙 裂缝 流动通道 主流通道指数 定量判识标准
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Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography 被引量:21
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作者 Yang Deng qi-Wen Zhong +11 位作者 Ai-qi Zhang Xiao-Juan Cai Ming-Zhi Lu Shao-Chong Zhang Li-Shi Su Hui Chen Ying Lin Li-Mei Sun guan-Di Chen Li-Ting Zhong Chen-Jin Jin Wei Chi 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第5期802-808,共7页
AIM: To investigate microvascular changes in eyes with central retinal vein occlusion(CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these chang... AIM: To investigate microvascular changes in eyes with central retinal vein occlusion(CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity(BCVA) and retinal thickness. METHODS: Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the results of optical coherence tomography angiography(OCTA) automatic measurements of the vessel density in the superficial(SCP) and deep retinal capillary plexus(DCP), the foveal avascular zone(FAZ) area, the FAZ perimeter(PERIM), the vessel density within a 300-μm wide ring surrounding the FAZ(FD-300), the acircularity index(AI), the choriocapillaris flow area, and retinal thickness were recorded before and at one month after treatment and compared with the results observed in age-and sexmatched healthy subjects. RESULTS: The vessel density in the SCP and DCP, the FD-300, and the flow area of the choriocapillaris were allsignificantly lower in CRVO eyes than in healthy eyes, while the AI and retinal thickness were significantly higher(all P<0.05). After treatment, retinal thickness was significantly decreased, and the mean BCVA had markedly improved from 20/167 to 20/65(P=0.0092). The flow area of the choriocapillaris was also significantly improved, which may result from the reduction of shadowing effect caused by the attenuation of macular edema. However, there were no significant changes in SCP and DCP vessel density after treatment. The flow area of the choriocapillaris at baseline was negatively correlated with retinal thickness.CONCLUSION: OCTA enables the non-invasive, layerspecific and quantitative assessment of microvascular changes both before and after treatment, and can therefore be used as a valuable imaging tool for the evaluation of the follow-up in CRVO patients. 展开更多
关键词 central retinal VEIN OCCLUSION optical coherence tomography ANGIOGRAPHY MACULAR EDEMA conbercept vessel density flow area foveal AVASCULAR zone
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新冠肺炎疫情暴发期间基层医务人员心理健康调查分析 被引量:21
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作者 周延 周浩 +4 位作者 赵魏情 齐兴菊 关牧曦 李健 胡理强 《中国研究型医院》 2020年第2期27-31,共5页
目的:调查分析新冠肺炎疫情暴发期间基层医务人员的心理健康,为更好地开展心理辅导提供理论与实践依据。方法:选取2020.1.24至2020.2.20贵阳地区基层医务人员,采用焦虑自评表(SAS)和抑郁自评表(SDS)评估新冠肺炎疫情暴发期间基层医务人... 目的:调查分析新冠肺炎疫情暴发期间基层医务人员的心理健康,为更好地开展心理辅导提供理论与实践依据。方法:选取2020.1.24至2020.2.20贵阳地区基层医务人员,采用焦虑自评表(SAS)和抑郁自评表(SDS)评估新冠肺炎疫情暴发期间基层医务人员的焦虑和抑郁状态,并对其影响因素进行调查分析。结果:本次共发放问卷95份,回收有效问卷83份,参与率为87.4%,平均年龄(31.39±9.22)岁,其中男22.9%。调查问卷分析后发现新冠肺炎疫情暴发期间基层医务人员的 SAS和SDS得分与国内常模比较(37.99±8.78 vs.33.80±5.90,P<0.001;47.09±8.73 vs.41.88±10.57,P<0.001),均高于中国正常人群常模。13.25%基层医务人员有焦虑症状,轻、中、重度发生率分别为12.04%、1.20%和0%;20.48%基层医务人员有抑郁症状,轻、中、重度发生率分别为19.27%、0%和1.204%。基层医务人员的性别、年龄、民族、婚姻、工作年限、职业、文化程度、经济收入因素与焦虑、抑郁情绪无关。结论:新冠肺炎疫情暴发期间基层医务人员的焦虑、抑郁发生率明显高于正常人群,应加强对这一特定人群心理状态的评价与重视,并及时进行相应的人文关怀和心理干预,为其在工作中的身心健康打下良好基础。 展开更多
关键词 焦虑 抑郁 新冠肺炎 基层医务人员
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