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Directly accessing octave-spanning dissipative Kerr soliton frequency combs in an AlN microresonator 被引量:16
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作者 HAIZHONG WENG JIA LIU +7 位作者 ADNAN ALI AFRIDI JING LI JIANGNAN DAI XIANG MA YI ZHANG qiaoyin lu JOHN F.DONEGAN WEIHUA GUO 《Photonics Research》 SCIE EI CAS CSCD 2021年第7期1351-1357,共7页
Self-referenced dissipative Kerr solitons (DKSs) based on optical microresonators offer prominent characteristics allowing for various applications from precision measurement to astronomical spectrometer calibration. ... Self-referenced dissipative Kerr solitons (DKSs) based on optical microresonators offer prominent characteristics allowing for various applications from precision measurement to astronomical spectrometer calibration. To date,direct octave-spanning DKS generation has been achieved only in ultrahigh-Q silicon nitride microresonators under optimized laser tuning speed or bi-directional tuning. Here we propose a simple method to easily access the octave-spanning DKS in an aluminum nitride (AlN) microresonator. In the design,two modes that belong to different families but with the same polarization are nearly degenerate and act as a pump and an auxiliary resonance,respectively. The presence of the auxiliary resonance can balance the thermal dragging effect,crucially simplifying the DKS generation with a single pump and leading to an enhanced soliton access window. We experimentally demonstrate the long-lived DKS operation with a record single-soliton step (10.4 GHz or83 pm) and an octave-spanning bandwidth (1100–2300 nm) through adiabatic pump tuning. Our scheme also allows for direct creation of the DKS state with high probability and without elaborate wavelength or power schemes being required to stabilize the soliton behavior. 展开更多
关键词 SOLITON SPANNING DISSIPATIVE
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Narrow-linewidth thermally tuned multi-channel interference widely tunable semiconductor laser with thermal tuning power below 50 mW 被引量:3
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作者 QUANAN CHEN CHUN JIANG +5 位作者 KUANKUAN WANG MIAO ZHANG XIANG MA YE LIU qiaoyin lu WEIHUA GUO 《Photonics Research》 SCIE EI CSCD 2020年第5期671-676,共6页
A thermally tuned multi-channel interference widely tunable semiconductor laser is designed and demonstrated,for the first time to our knowledge,that realizes a tuning range of more than 45 nm,side-mode suppression ra... A thermally tuned multi-channel interference widely tunable semiconductor laser is designed and demonstrated,for the first time to our knowledge,that realizes a tuning range of more than 45 nm,side-mode suppression ratios up to 56 d B,and Lorentzian linewidth below 160 k Hz.Al Ga In As multiple quantum wells(MQWs)were used to reduce linewidth,which have a lower linewidth enhancement factor compared with In Ga As P MQWs.To decrease the power consumption of micro-heaters,air gaps were fabricated below the arm phase sections.For a 75μm long suspended thermal tuning waveguide,about 6.3 m W micro-heater tuning power is needed for a 2πround-trip phase change.Total micro-heater tuning power required is less than 50 m W across the whole tuning range,which is lower than that of the reported thermally tuned tunable semiconductor lasers. 展开更多
关键词 tuning TUNABLE POWER
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Directly modulated active distributed reflector distributed feedback lasers over wide temperature range operation(-40 to 85℃) 被引量:1
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作者 Gonghai Liu Gongyuan Zhao +2 位作者 Gong Zhang qiaoyin lu Weihua Guo 《Chinese Optics Letters》 SCIE EI CAS CSCD 2020年第6期45-49,共5页
We experimentally demonstrated that the distributed feedback(DFB) lasers with the active distributed reflector achieved a 25.8 Gb/s operation over a wide temperature range of -40 to 85℃. The DFB lasers can achieve ad... We experimentally demonstrated that the distributed feedback(DFB) lasers with the active distributed reflector achieved a 25.8 Gb/s operation over a wide temperature range of -40 to 85℃. The DFB lasers can achieve additional feedback from an active distributed reflector with accurately controlled phase, and single-mode yields are not related to the position of cleave. The threshold currents of the fabricated laser are 6 mA and 20 mA at -40℃ and 85℃, respectively. The side mode suppression ratio of the fabricated laser is above 50 dB at all temperatures. Transmissions of 25.8 Gb/s after 10 km single-mode fibers with clear eye openings and less than 0.8 dB power penalty over a wide temperature range have been demonstrated as well. 展开更多
关键词 distributed feedback laser wide temperature range active distributed reflector directly modulated laser
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Design of a single-mode directly modulated orbital angular momentum laser 被引量:1
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作者 Xiang Ma Shuang Zheng +3 位作者 Jia Liu Quanan Chen qiaoyin lu Weihua Guo 《Chinese Optics Letters》 SCIE EI CAS CSCD 2021年第8期12-17,共6页
We propose a design of single-mode orbital angular momentum(OAM) beam laser with high direct-modulation bandwidth. It is a microcylinder/microring cavity interacted with two types of second-order gratings: the complex... We propose a design of single-mode orbital angular momentum(OAM) beam laser with high direct-modulation bandwidth. It is a microcylinder/microring cavity interacted with two types of second-order gratings: the complex top grating containing the real part and the imaginary part modulations and the side grating. The side grating etched on the periphery of the microcylinder/microring cavity can select a whispering gallery mode with a specific azimuthal mode number, while the complex top grating can scatter the lasing mode with travelling-wave pattern vertically. With the cooperation of the gratings, the laser works with a single mode and emits radially polarized OAM beams. With an asymmetrical pad metal on the top of the cavity, the OAM on-chip laser can firstly be directly modulated with electrical pumping. Due to the small active volume, the laser with low threshold current is predicted to have a high direct modulation bandwidth about 29 GHz with the bias current of ten times the threshold from the simulation. The semiconductor OAM laser can be rather easily realized at different wavelengths such as the O band, C band, and L band. 展开更多
关键词 orbital angular momentum diffraction and gratings vertical emitting lasers microcavity devices semiconductor lasers single mode directly modulated laser
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Circ0075829在神经母细胞瘤组织中表达并抑制细胞增殖和迁移
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作者 任冬 刘悄吟 +12 位作者 鲁洁 王生才 李艳红 于永波 杨业然 常艳 张雪溪 孙念 刘薇 张杰 倪鑫 金雅琼 郭永丽 《中国小儿血液与肿瘤杂志》 CAS 2021年第5期261-269,共9页
目的探讨circ0075829对人神经母细胞瘤(NB)细胞生物学行为的影响。方法通过Sanger测序和RNase R消化实验检测circ0075829环化位点序列及环化情况;应用实时荧光定量PCR(qRT-PCR)检测NB组织样本和细胞系中circ0075829表达水平;应用siRNA... 目的探讨circ0075829对人神经母细胞瘤(NB)细胞生物学行为的影响。方法通过Sanger测序和RNase R消化实验检测circ0075829环化位点序列及环化情况;应用实时荧光定量PCR(qRT-PCR)检测NB组织样本和细胞系中circ0075829表达水平;应用siRNA和慢病毒分别敲减和过表达circ0075829;采用细胞克隆形成技术和实时无标记细胞分析技术(RTCA)观察NB细胞增殖和迁移情况。全自动蛋白质印迹定量(Wes)法验证circ0075829对MAPK通路(ERK、JNK、p38)的作用。结果在NB细胞系SH-SY5Y和SK-N-BE2中可鉴定到circ0075829表达;敲减circ0075829后SH-SY5Y和SK-N-BE2细胞系增殖和迁移能力增强;反之,过表达circ0075829使细胞增殖和迁移能力减弱。MAPK通路中,敲减circ0075829激活ERK磷酸化活性,对p38和JNK磷酸化活性无明显影响。Circ0075829表达量与INSS分期(P<0.05)和危险度分期(P<0.01)呈负相关,与患者总生存期(OS)呈正相关(P=0.002)。结论本研究表明,circ0075829可抑制NB细胞增殖和迁移;其高表达与临床表型良好相关;可能通过激活ERK MAPK通路起作用,是NB潜在的生物学标志物和治疗靶点。 展开更多
关键词 环状RNA Circ0075829 神经母细胞瘤 增殖 迁移
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TUBB基因p.M73V变异所致复合型脑皮质发育不良伴其他脑发育畸形6型患儿1例的遗传学分析
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作者 薛慧琴 唐巧茵 +4 位作者 郭荣 曹桂芝 冯宇 孙夏瑜 卢洪涌 《中华医学遗传学杂志》 CAS CSCD 2023年第12期1541-1545,共5页
目的探讨1例多发畸形患儿的遗传学病因。方法以2021年2月就诊于山西省儿童医院的1例患儿作为研究对象。收集患儿的临床信息,并对其进行全外显子组测序(WES),对候选变异进行Sanger测序家系验证以及致病性分析。结果患儿全身皮肤无异常,... 目的探讨1例多发畸形患儿的遗传学病因。方法以2021年2月就诊于山西省儿童医院的1例患儿作为研究对象。收集患儿的临床信息,并对其进行全外显子组测序(WES),对候选变异进行Sanger测序家系验证以及致病性分析。结果患儿全身皮肤无异常,但存在右耳缺如、半椎体畸形,心室间隔缺损、动脉导管与卵圆孔未闭、左肾集合系统分离等。磁共振成像显示双侧侧脑室不规则增大、大脑皮层与颞侧脑膜间距增加。测序发现其携带TUBB基因NM_178014.4:c.217A>G(p.Met73Val)新发杂合变异,根据美国医学遗传学与基因组学学会(ACMG)相关指南判定为可能致病。结合其临床表型以及基因检测结果,患儿被确诊为复合型脑皮质发育不良伴其他脑发育畸形6型(CDCBM6)。结论CDCBM是一类罕见的具有遗传异质性的严重疾病,其中TUBB基因缺陷所致的CDCBM6更为罕见。本研究的结果扩展了TUBB基因的变异谱和表型谱,为总结CDCBM6的基因型-表型对应关系提供了重要的参考。 展开更多
关键词 TUBB基因 复合型脑皮质发育不良伴其他脑发育畸形 先天性对称皮肤褶皱综合征
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