The controllable growth of metal nanoparticles on nanomaterials is becoming an effective strategy for developing nanocomposites with designated performance.Herein,a simple and mild strategy for the in situ growth of P...The controllable growth of metal nanoparticles on nanomaterials is becoming an effective strategy for developing nanocomposites with designated performance.Herein,a simple and mild strategy for the in situ growth of Pt–Pd bimetallic nanoparticles on covalent organic frameworks(COFs)to regulate the nanozyme activity was designed for colorimetric detection of hydrogen peroxide(H2O2)and glutathione(GSH).The COFs not only offer sufficient loading sites for the uniform dispersion of Pt–Pd bimetallic nanoparticles,but also increase the adsorption of substrate to promote the catalytic reaction.With the bimetallic synergistic effect of Pt–Pd nanoparticles,the prepared multifunctional nanozyme(Pt–Pd/COFs nanozyme)simultaneously exhibited superior peroxidase(POD)-like activity and oxidase(OXD)-like activity.Using the multifunctional nanozyme,a colorimetric sensing system was constructed for sensitive detection of H2O2 and GSH,with the wide linear ranges of 5–1000µmol/L and 1–40µmol/L,and the detection limits were 1.14μmol/L and 0.43μmol/L,respectively.It was successfully used for the detection of real samples in environmental water and serum,providing a simple method for disease diagnosis and environmental monitoring.展开更多
基金financially supported by the National Natural Science Foundation of China(22076041,22076042)the Key Research and Development Program of Hubei Province,China(2023BAB134).
文摘The controllable growth of metal nanoparticles on nanomaterials is becoming an effective strategy for developing nanocomposites with designated performance.Herein,a simple and mild strategy for the in situ growth of Pt–Pd bimetallic nanoparticles on covalent organic frameworks(COFs)to regulate the nanozyme activity was designed for colorimetric detection of hydrogen peroxide(H2O2)and glutathione(GSH).The COFs not only offer sufficient loading sites for the uniform dispersion of Pt–Pd bimetallic nanoparticles,but also increase the adsorption of substrate to promote the catalytic reaction.With the bimetallic synergistic effect of Pt–Pd nanoparticles,the prepared multifunctional nanozyme(Pt–Pd/COFs nanozyme)simultaneously exhibited superior peroxidase(POD)-like activity and oxidase(OXD)-like activity.Using the multifunctional nanozyme,a colorimetric sensing system was constructed for sensitive detection of H2O2 and GSH,with the wide linear ranges of 5–1000µmol/L and 1–40µmol/L,and the detection limits were 1.14μmol/L and 0.43μmol/L,respectively.It was successfully used for the detection of real samples in environmental water and serum,providing a simple method for disease diagnosis and environmental monitoring.
