Previous studies suggested that smoking and passive smoking could increase the risk of breast cancer, but the results were inconsistent, especially for Chinese females. Thus, we systematically searched cohort and case...Previous studies suggested that smoking and passive smoking could increase the risk of breast cancer, but the results were inconsistent, especially for Chinese females. Thus, we systematically searched cohort and case-control studies investigating the associations of active and passive smoking with breast cancer risk among Chinese females in four English databases(PubMed, Embase, ScienceDirect, and Wiley) and three Chinese databases(CNKI, WanFang, and VIP). Fifty-one articles(3 cohort studies and 48 casecontrol studies) covering 17 provinces of China were finally included in this systematic review. Among Chinese females, there was significant association between passive smoking and this risk of breast cancer [odds ratio(OR): 1.62; 95% confidence interval(CI): 1.39–1.85; I2 = 75.8%, P < 0.001; n = 26] but no significant association between active smoking and the risk of breast cancer(OR: 1.04; 95% CI: 0.89–1.20; I2 = 13.9%, P = 0.248; n = 31). The OR of exposure to husband's smoking and to smoke in the workplace was 1.27(95% CI: 1.07–1.50) and 1.66(95% CI: 1.07–2.59), respectively. The OR of light and heavy passive smoking was 1.11 and 1.41, respectively, for women exposed to their husband's smoke(< 20 and ≥ 20 cigarettes per day), and 1.07 and 1.87, respectively, for those exposed to smoke in the workplace(< 300 and ≥ 300 min of exposure per day). These results imply that passive smoking is associated with an increased risk of breast cancer, and the risk seems to increase as the level of passive exposure to smoke increases among Chinese females. Women with passive exposure to smoke in the workplace have a higher risk of breast cancer than those exposed to their husband's smoking.展开更多
Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with chemosensitivity.Hence,targeting metabolic enzymes remains an attractive appro...Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with chemosensitivity.Hence,targeting metabolic enzymes remains an attractive approach for treating tumors.展开更多
Purpose:This research examined road traffic injury mortality and morbidity disparities across of country development status,and discussed the possibility of reducing country disparities by various actions to accelerat...Purpose:This research examined road traffic injury mortality and morbidity disparities across of country development status,and discussed the possibility of reducing country disparities by various actions to accelerate the pace of achieving Sustainable Development Goals target 3.6 e to halve the number of global deaths and injuries from road traffic accidents by 2020.Methods:Data for road traffic mortality,morbidity,and socio-demographic index(SDI)were extracted by country from the estimates of the Global Burden of Disease study,and the implementation of the three types of national actions(legislation,prioritized vehicle safety standards,and trauma-related post-crash care service)were extracted from the Global Status Report on Road Safety byWorld Health Organization.We fitted joinpoint regression analysis to identify and quantify the significant rate changes from 2011 to 2017.Results:Age-adjusted road traffic mortality decreased substantially for all the five SDI categories from 2011 to 2017(by 7.52%e16.08%).Age-adjusted road traffic mortality decreased significantly as SDI increased in the study time period,while age-adjusted morbidity generally increased as SDI increased.Subgroup analysis by road user yielded similar results,but with two major differences during the study period of 2011 to 2017:(1)pedestrians in the high SDI countries experienced the lowest mortality(1.68e1.90 per 100,000 population)and morbidity(110.45e112.72 per 100,000 population for incidence and 487.48e491.24 per 100,000 population for prevalence),and(2)motor vehicle occupants in the high SDI countries had the lowest mortality(4.07e4.50 per 100,000 population)but the highest morbidity(428.74e467.78 per 100,000 population for incidence and 1025.70e1116.60 per 100,000 population for prevalence).Implementation of the three types of national actions remained nearly unchanged in all five SDI categories from 2011 to 2017 and was consistently stronger in the higher SDI countries than in the lower SDI countries.Lower income nations comprise the he展开更多
Ekphrasis refers the vividly use of language to describe the visual details in literature.David Mitchell’s Cloud Atlas has abundant literary ekphrasis of spaces.David Mitchell combines visual descriptions of environm...Ekphrasis refers the vividly use of language to describe the visual details in literature.David Mitchell’s Cloud Atlas has abundant literary ekphrasis of spaces.David Mitchell combines visual descriptions of environments with characters’emotions to convey themes.Utilizing the lens of visual culture and through the eyes of various protagonists,this essay examines two kinds of active gazers,namely“flâneurs”and“flâneuses”,as well as the“imperial gazers”in flowing spaces and colonial spaces respectively.This essay adopts the methods of urban studies and colonial criticism to explore Mitchell’s portrayal visual spaces in Cloud Atlas.展开更多
The effect of Mo and Al addition on the microstructure as well as creep rupture properties at760.C/850 MPa was investigated by transmission electron microscopy(TEM)in a Ni-based single-crystal(SC)alloy with the compos...The effect of Mo and Al addition on the microstructure as well as creep rupture properties at760.C/850 MPa was investigated by transmission electron microscopy(TEM)in a Ni-based single-crystal(SC)alloy with the composition of Ni-6.5Al-8.0Mo-2.4Cr-6.2Ta-4.9Co-1.5Re-(0.01-0.05)Y(wt%).The microstructure analysis shows that 0.5 wt%Al addition induces rapid decrease in creep rupture life,and this can be attributed to the formation of dense stacking faults cutting intoγ'precipitates,which can be explained by the increase in Orowan stress caused by the narrowerγchannel width and the decrease in stacking faults energy.Besides,1.5 wt%Mo addition increases the anti-phase boundary energy and decreases the stacking faults energy,resulting in fewer stacking faults and thus a slight decrease in the creep rupture life.展开更多
The acidic tumor microenvironment provides an energy source driving malignant tumor progression.Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells.The expression of the vitamin D ...The acidic tumor microenvironment provides an energy source driving malignant tumor progression.Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells.The expression of the vitamin D receptor(VDR)is closely related to the initiation and development of colorectal carcinoma(CRC),but its regulatory mechanism in CRC stem cells is still unclear.Our study revealed that acidosis reduced VDR expression by downregulating peroxisome proliferator-activated receptor delta(PPARD)expression.Overexpression of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in acidosis.The nuclear export signal in VDR was sensitive to acidosis,and VDR was exported from the nucleus.Chromatin immunoprecipitation(ChIP)and assay for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq)analyses showed that VDR transcriptionally repressed SRY-box 2(SOX2)by binding to the vitamin D response elements in the promoter of SOX2,impairing tumor growth and drug resistance.We demonstrated that a change in the acidic microenvironment combined with overexpression of VDR substantially restricted the occurrence and development of CRC in vivo.These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling,resulting in a lack of efficacy of vitamin D in antineoplastic process.展开更多
BACKGROUND Since the acute fibrinous and organizing pneumonia(AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no...BACKGROUND Since the acute fibrinous and organizing pneumonia(AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no standard therapy for this disease and the treatment methods remain controversial. Both steroid and immunosuppressive agents, such as cyclophosphamide or mycophenolate mofetil, have been reported to be effective in some studies, but with many side effects, especially in patients of advanced age. CASE SUMMARY We herein report an 81-year-old female patient who was admitted to our hospital due to dry cough, and breathlessness for 1 mo. She was treated with broadspectrum antibiotics and anti-fungal therapy, but without improvement in both symptoms and radiological findings, and her respiratory status worsened, and she required bed rest almost the whole day. Computed tomography-guided percutaneous needle lung biopsy was performed and histopathology examination confirmed the diagnosis of AFOP. She was then successfully treated with a steroid monotherapy, which resulted in a satisfactory clinical outcome without serious complications. CONCLUSION We conclude that complete remission of AFOP can be achieved by steroid monotherapy in patients of advanced age.展开更多
Hereditary spastic paraplegia(HSP) is a rare neurodegenerative disease due to a length-dependent distal axonopathy of the corticospinal tract(Fink, 2006). HSP has highly clinical heterogeneity and is classified into p...Hereditary spastic paraplegia(HSP) is a rare neurodegenerative disease due to a length-dependent distal axonopathy of the corticospinal tract(Fink, 2006). HSP has highly clinical heterogeneity and is classified into pure and complex forms according to the description by Harding(1983).展开更多
Multi-scale contributions are involved in the South China Sea(SCS)summer monsoon(SCSSM)onset process.The relative roles of intraseasonal oscillation and above-seasonal component in the year-to-year variation of the SC...Multi-scale contributions are involved in the South China Sea(SCS)summer monsoon(SCSSM)onset process.The relative roles of intraseasonal oscillation and above-seasonal component in the year-to-year variation of the SCSSM onset are evaluated in this study.The 30-90-day and above-90-day components are major contributors to the year-to-year variation of the SCSSM onset,and the former contributes greater portion,while the 8-30-day component has little contribution to the onset.In the early onset cases,the 30-90-day westerly winds move and extend eastward from the tropical Indian Ocean(TIO)to the SCS monsoon region relatively earlier,and replace the easterly winds over the SCS with the cooperation of the 30-90-day cyclone moving southward from northern East Asia.The westerly anomalies of the above-90-day component in spring jointly contribute to the early SCSSM onset.In the late onset cases,the late eastward expansion of 30-90-day westerly wind over the TIO,accompanied by the late occurrence and weakening of the 30-90-day anticyclone over the SCS,and its late withdraw from the SCS,as well as the persistent easterly anomalies of above-90-day component,suppress the SCSSM onset.However,the SCSSM outbreaks in the obvious weakening stage of 30-90-day easterly anomalies.The easterlies-to-westerlies transition of the 30-90-day 850-hPa zonal wind over the SCS in spring is closely associated with sea surface temperature in the tropical western Pacific in preceding winter and spring,while the interannual variation of the above-90-day zonal wind in April-May is closely related to the decaying stage of the El Niño-Southern Oscillation events.展开更多
On the basis of fracture mechanics earthquake rupture model, the relations between source parameters and τ0, the value of tectonic ambient shear stress in the place where the earthquake occurs, have been derived. Thu...On the basis of fracture mechanics earthquake rupture model, the relations between source parameters and τ0, the value of tectonic ambient shear stress in the place where the earthquake occurs, have been derived. Thus, we can calculate a large number of values of tectonic ambient shear stress or values of background stress in the place where the earthquake occurs. If nuclear explosions are treated as earthquakes in the calculation, we find that τ0 values of nuclear explosions have about 20 MPa, which is obviously higher than average τ0 values of earthquakes with the same magnitude. This result can be used to discriminate nuclear explosions from earthquakes.展开更多
Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations"(Its abbreviation is "Monthly Report").……
Let α be a nonzero endomorphism of a ring R, n be a positive integer and T_n（R, α） be the skew triangular matrix ring. We show that some properties related to nilpotent elements of R are inherited by T_n（R, α）....Let α be a nonzero endomorphism of a ring R, n be a positive integer and T_n（R, α） be the skew triangular matrix ring. We show that some properties related to nilpotent elements of R are inherited by T_n（R, α）. Meanwhile, we determine the strongly prime radical, generalized prime radical and Behrens radical of the ring R[x; α]/（x^n）, where R[x; α] is the skew polynomial ring.展开更多
IllustrationAll the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events o...IllustrationAll the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The "Monthly Report" is monthly compiled by the Ninth Section of Institute of Geophysics, CSB.展开更多
IllustrationAll the data in this catalog are chosen from the 2Preliminary Seismological Report of Chine-se Seismic Stations2 (Its abbreviation is 2Monthly Report2). The catalog includes the events of M34.7 in and near...IllustrationAll the data in this catalog are chosen from the 2Preliminary Seismological Report of Chine-se Seismic Stations2 (Its abbreviation is 2Monthly Report2). The catalog includes the events of M34.7 in and near China and M36 all over the world. The 2Monthly Report2 is monthly compiled by the Ninth Section of Institute of Geophysics, CSB.The origin times of earthquakes in the catalog adopt coordinated universal time (UTC) in accordance with international convention. The location of every epicenter is expressed by its latitude and longitude, at the same time by the corresponding geographical region proposed by Flinn and Engdahl. The regional names are only for references and do not imply any political significance. The number of stations used and standard deviation are also given in order to illus-trate the precision of location.The surface wave magnitude MS is measured from the records of intermediate period broad band SK seismographs and adopting the surface wave magnitude formula of Beijing Station of 1965: MS= lg(AH/T)+1.66lgD +3.5 (1°<D<130°), in which AH is the resultant displacement ampli-tude of the maximum surface wave of horizontal components. MS7 is measured from records of the long-period seismographs of 763 type and adopting the surface wave magnitude formula re-commended by IASPEI in 1967. MS7=lg(AV/T)+1.66lgD +3.3 (20°<D<160°), in which AV is the maximum ground displacement of surface wave in vertical component, mb is short-period body-wave magnitude. ML is local magnitude. In order to avoid confusion, no conversion is made among the various magnitudes. For convenience of use and comparison, the surface wave mag-nitude MSZ (NEIS) and mb (NEIS) measured by NEIS recorded on short period seismographs are also listed.展开更多
In the centre of the famous Chinese painting, Qingrning Shanghe Tu, an arch-shaped timber bridge, Hongqiao, stands like a rainbow over the river Bianhe. Unfortunately, Hongqiao was damaged during floods from the Yello...In the centre of the famous Chinese painting, Qingrning Shanghe Tu, an arch-shaped timber bridge, Hongqiao, stands like a rainbow over the river Bianhe. Unfortunately, Hongqiao was damaged during floods from the Yellow River, and we can only see her beautiful form in Qingming Shanghe Tu. While, the geometrical dimensions, structural principle, as well as the construction methods of the bridge are still an interesting mystery. In the present paper, the author uncovers the structural principle and the geometric dimensions of the bridge as well as its history background. Furthermore, the author introduces two new structural systems, Lap-Beam and 1.5-Layer space frame, which are inspired by the structural principle of the Hongqiao.展开更多
Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events ...Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The "Monthly Report" is monthly compiled bv the Ninth Section of Institute of Geophysics, CSB.……展开更多
Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chine-se Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the... Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chine-se Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The "Monthly Report" is monthly compiled by the Ninth Section of Institute of Geophysics, CSB. The origin times of earthquakes in the catalog adopt coordinated universal time (UTC) in accordance with international convention. The location of every epicenter is expressed by its latitude and longitude, at the same time by the corresponding geographical region proposed by Flinn and Engdahl. The regional names are only for references and do not imply any political significance. The number of stations used and standard deviation are also given in order to illus-trate the precision of location.……展开更多
The present paper represents comparison of continuum shells and latticed shells with qualitative analysis. For shells, the mechanical characteristics in the two perpendicular directions are continuous and related to e...The present paper represents comparison of continuum shells and latticed shells with qualitative analysis. For shells, the mechanical characteristics in the two perpendicular directions are continuous and related to each other, and any change in thickness will result in change in stiffness in any direction. In latticed shells, members are discrete and stiffnesses in two mutually perpendicular directions are discontinuous and independent of each other. Therefore, sensitivity of geometrical imperfection for buckling of latticed shells should be different from that of continuum shells. The author proposes a shape optimization method for maximum buckling load of a latticed shell. A single layer latticed dome is taken as a numerical example, and the results show that the buckling load parameter for full area loading case increases 32.75% compared to that of its initial shape. Furthermore, the numerical example demonstrates that an optimum latticed shell with maximum buckling load, unlike an optimum continuum shell, may not be sensitive to its geometrical imperfection.展开更多
IllustrationAll the data in this catalog are chosen from the (Preliminary Seismological Report of Chinese Seismic Stations( (Its abbreviation is (Monthly Report(). The catalog includes the events of M(4.7 in and near ...IllustrationAll the data in this catalog are chosen from the (Preliminary Seismological Report of Chinese Seismic Stations( (Its abbreviation is (Monthly Report(). The catalog includes the events of M(4.7 in and near China and M(6 all over the world. The (Monthly Report( is monthly compiled by the Ninth Section of Institute of Geophysics, CSB.展开更多
基金supported partly by grants from the National Natural Science Foundation of China (No. 81172762)program for Changjiang Scholars and Innovation Research Team in University in China (No. IRT1076)+4 种基金National Scientific and Technological Project (No. 2011ZX09307-001-04)Tianjin Science Committee Foundation (No. 09ZCZDSF04800 and No. 09ZCZDSF04700)Tianjin Science and Technology Committee Foundation (No. 12ZCDZSY16000 and No. 11ZCGYSY02200)Major State Basic Research Program for China (973 Program No. 2009CB918903)
文摘Previous studies suggested that smoking and passive smoking could increase the risk of breast cancer, but the results were inconsistent, especially for Chinese females. Thus, we systematically searched cohort and case-control studies investigating the associations of active and passive smoking with breast cancer risk among Chinese females in four English databases(PubMed, Embase, ScienceDirect, and Wiley) and three Chinese databases(CNKI, WanFang, and VIP). Fifty-one articles(3 cohort studies and 48 casecontrol studies) covering 17 provinces of China were finally included in this systematic review. Among Chinese females, there was significant association between passive smoking and this risk of breast cancer [odds ratio(OR): 1.62; 95% confidence interval(CI): 1.39–1.85; I2 = 75.8%, P < 0.001; n = 26] but no significant association between active smoking and the risk of breast cancer(OR: 1.04; 95% CI: 0.89–1.20; I2 = 13.9%, P = 0.248; n = 31). The OR of exposure to husband's smoking and to smoke in the workplace was 1.27(95% CI: 1.07–1.50) and 1.66(95% CI: 1.07–2.59), respectively. The OR of light and heavy passive smoking was 1.11 and 1.41, respectively, for women exposed to their husband's smoke(< 20 and ≥ 20 cigarettes per day), and 1.07 and 1.87, respectively, for those exposed to smoke in the workplace(< 300 and ≥ 300 min of exposure per day). These results imply that passive smoking is associated with an increased risk of breast cancer, and the risk seems to increase as the level of passive exposure to smoke increases among Chinese females. Women with passive exposure to smoke in the workplace have a higher risk of breast cancer than those exposed to their husband's smoking.
基金This research was supported by the National Natural Science Foundation of China(82022052,82173128,81930065,82073377,81772587)Natural Science Foundation of Guangdong Province(2018B030306049,2021A1515012439)Science and Technology Program of Guangdong(2019B020227002)+1 种基金Science and Technology Program of Guangzhou(201904020046)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-036).
文摘Metabolic enzymes have an indispensable role in metabolic reprogramming,and their aberrant expression or activity has been associated with chemosensitivity.Hence,targeting metabolic enzymes remains an attractive approach for treating tumors.
基金supported by the National Natural Science Foundation of China(No.82073672).
文摘Purpose:This research examined road traffic injury mortality and morbidity disparities across of country development status,and discussed the possibility of reducing country disparities by various actions to accelerate the pace of achieving Sustainable Development Goals target 3.6 e to halve the number of global deaths and injuries from road traffic accidents by 2020.Methods:Data for road traffic mortality,morbidity,and socio-demographic index(SDI)were extracted by country from the estimates of the Global Burden of Disease study,and the implementation of the three types of national actions(legislation,prioritized vehicle safety standards,and trauma-related post-crash care service)were extracted from the Global Status Report on Road Safety byWorld Health Organization.We fitted joinpoint regression analysis to identify and quantify the significant rate changes from 2011 to 2017.Results:Age-adjusted road traffic mortality decreased substantially for all the five SDI categories from 2011 to 2017(by 7.52%e16.08%).Age-adjusted road traffic mortality decreased significantly as SDI increased in the study time period,while age-adjusted morbidity generally increased as SDI increased.Subgroup analysis by road user yielded similar results,but with two major differences during the study period of 2011 to 2017:(1)pedestrians in the high SDI countries experienced the lowest mortality(1.68e1.90 per 100,000 population)and morbidity(110.45e112.72 per 100,000 population for incidence and 487.48e491.24 per 100,000 population for prevalence),and(2)motor vehicle occupants in the high SDI countries had the lowest mortality(4.07e4.50 per 100,000 population)but the highest morbidity(428.74e467.78 per 100,000 population for incidence and 1025.70e1116.60 per 100,000 population for prevalence).Implementation of the three types of national actions remained nearly unchanged in all five SDI categories from 2011 to 2017 and was consistently stronger in the higher SDI countries than in the lower SDI countries.Lower income nations comprise the he
基金this paper is funded by The 13th Postgraduate Education Innovation Fund of Wuhan Institute of Technology(WIT),Research on Ekphrasis of To the Light House(Project Number:CX2021396).
文摘Ekphrasis refers the vividly use of language to describe the visual details in literature.David Mitchell’s Cloud Atlas has abundant literary ekphrasis of spaces.David Mitchell combines visual descriptions of environments with characters’emotions to convey themes.Utilizing the lens of visual culture and through the eyes of various protagonists,this essay examines two kinds of active gazers,namely“flâneurs”and“flâneuses”,as well as the“imperial gazers”in flowing spaces and colonial spaces respectively.This essay adopts the methods of urban studies and colonial criticism to explore Mitchell’s portrayal visual spaces in Cloud Atlas.
基金financially supported by the National Natural Science Foundation of China (No.51101004)。
文摘The effect of Mo and Al addition on the microstructure as well as creep rupture properties at760.C/850 MPa was investigated by transmission electron microscopy(TEM)in a Ni-based single-crystal(SC)alloy with the composition of Ni-6.5Al-8.0Mo-2.4Cr-6.2Ta-4.9Co-1.5Re-(0.01-0.05)Y(wt%).The microstructure analysis shows that 0.5 wt%Al addition induces rapid decrease in creep rupture life,and this can be attributed to the formation of dense stacking faults cutting intoγ'precipitates,which can be explained by the increase in Orowan stress caused by the narrowerγchannel width and the decrease in stacking faults energy.Besides,1.5 wt%Mo addition increases the anti-phase boundary energy and decreases the stacking faults energy,resulting in fewer stacking faults and thus a slight decrease in the creep rupture life.
基金supported by grants from the National Natural Science Foundation of China(81930065,81802971)Science and Technology Program of Guangdong(2019B020227002)+3 种基金Science and Technology Program of Guangzhou(201904020046,201803040019,201704020228)CAMS Innovation Fund for Medical Sciences(2019-I2M-5-036)China Postdoctoral Science Foundation(2018M643301),China Postdoctoral Innovative Talent Support ProgramNatural Science Foundation of Guangdong(2018A0303130282,2019A1515011109).
文摘The acidic tumor microenvironment provides an energy source driving malignant tumor progression.Adaptation of cells to an acidic environment leads to the emergence of cancer stem cells.The expression of the vitamin D receptor(VDR)is closely related to the initiation and development of colorectal carcinoma(CRC),but its regulatory mechanism in CRC stem cells is still unclear.Our study revealed that acidosis reduced VDR expression by downregulating peroxisome proliferator-activated receptor delta(PPARD)expression.Overexpression of VDR effectively suppressed the stemness and oxaliplatin resistance of cells in acidosis.The nuclear export signal in VDR was sensitive to acidosis,and VDR was exported from the nucleus.Chromatin immunoprecipitation(ChIP)and assay for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq)analyses showed that VDR transcriptionally repressed SRY-box 2(SOX2)by binding to the vitamin D response elements in the promoter of SOX2,impairing tumor growth and drug resistance.We demonstrated that a change in the acidic microenvironment combined with overexpression of VDR substantially restricted the occurrence and development of CRC in vivo.These findings reveal a new mechanism by which acidosis could affect the stemness of CRC cells by regulating the expression of SOX2 and show that abnormal VDR expression leads to ineffective activation of vitamin D signaling,resulting in a lack of efficacy of vitamin D in antineoplastic process.
文摘BACKGROUND Since the acute fibrinous and organizing pneumonia(AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no standard therapy for this disease and the treatment methods remain controversial. Both steroid and immunosuppressive agents, such as cyclophosphamide or mycophenolate mofetil, have been reported to be effective in some studies, but with many side effects, especially in patients of advanced age. CASE SUMMARY We herein report an 81-year-old female patient who was admitted to our hospital due to dry cough, and breathlessness for 1 mo. She was treated with broadspectrum antibiotics and anti-fungal therapy, but without improvement in both symptoms and radiological findings, and her respiratory status worsened, and she required bed rest almost the whole day. Computed tomography-guided percutaneous needle lung biopsy was performed and histopathology examination confirmed the diagnosis of AFOP. She was then successfully treated with a steroid monotherapy, which resulted in a satisfactory clinical outcome without serious complications. CONCLUSION We conclude that complete remission of AFOP can be achieved by steroid monotherapy in patients of advanced age.
基金supported by the research foundation for distinguished scholar of Zhejiang University to Zhi-Ying Wu (188020-193810101/089, Hangzhou)Fundamental Research Funds for the Central Universities (2019XZZX00101-04)。
文摘Hereditary spastic paraplegia(HSP) is a rare neurodegenerative disease due to a length-dependent distal axonopathy of the corticospinal tract(Fink, 2006). HSP has highly clinical heterogeneity and is classified into pure and complex forms according to the description by Harding(1983).
基金Program of National Science Foundation of China(42175018,42088101)Program of Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies(2020B1212060025)。
文摘Multi-scale contributions are involved in the South China Sea(SCS)summer monsoon(SCSSM)onset process.The relative roles of intraseasonal oscillation and above-seasonal component in the year-to-year variation of the SCSSM onset are evaluated in this study.The 30-90-day and above-90-day components are major contributors to the year-to-year variation of the SCSSM onset,and the former contributes greater portion,while the 8-30-day component has little contribution to the onset.In the early onset cases,the 30-90-day westerly winds move and extend eastward from the tropical Indian Ocean(TIO)to the SCS monsoon region relatively earlier,and replace the easterly winds over the SCS with the cooperation of the 30-90-day cyclone moving southward from northern East Asia.The westerly anomalies of the above-90-day component in spring jointly contribute to the early SCSSM onset.In the late onset cases,the late eastward expansion of 30-90-day westerly wind over the TIO,accompanied by the late occurrence and weakening of the 30-90-day anticyclone over the SCS,and its late withdraw from the SCS,as well as the persistent easterly anomalies of above-90-day component,suppress the SCSSM onset.However,the SCSSM outbreaks in the obvious weakening stage of 30-90-day easterly anomalies.The easterlies-to-westerlies transition of the 30-90-day 850-hPa zonal wind over the SCS in spring is closely associated with sea surface temperature in the tropical western Pacific in preceding winter and spring,while the interannual variation of the above-90-day zonal wind in April-May is closely related to the decaying stage of the El Niño-Southern Oscillation events.
文摘On the basis of fracture mechanics earthquake rupture model, the relations between source parameters and τ0, the value of tectonic ambient shear stress in the place where the earthquake occurs, have been derived. Thus, we can calculate a large number of values of tectonic ambient shear stress or values of background stress in the place where the earthquake occurs. If nuclear explosions are treated as earthquakes in the calculation, we find that τ0 values of nuclear explosions have about 20 MPa, which is obviously higher than average τ0 values of earthquakes with the same magnitude. This result can be used to discriminate nuclear explosions from earthquakes.
文摘 Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations"(Its abbreviation is "Monthly Report").……
文摘Let α be a nonzero endomorphism of a ring R, n be a positive integer and T_n（R, α） be the skew triangular matrix ring. We show that some properties related to nilpotent elements of R are inherited by T_n（R, α）. Meanwhile, we determine the strongly prime radical, generalized prime radical and Behrens radical of the ring R[x; α]/（x^n）, where R[x; α] is the skew polynomial ring.
文摘IllustrationAll the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The "Monthly Report" is monthly compiled by the Ninth Section of Institute of Geophysics, CSB.
文摘IllustrationAll the data in this catalog are chosen from the 2Preliminary Seismological Report of Chine-se Seismic Stations2 (Its abbreviation is 2Monthly Report2). The catalog includes the events of M34.7 in and near China and M36 all over the world. The 2Monthly Report2 is monthly compiled by the Ninth Section of Institute of Geophysics, CSB.The origin times of earthquakes in the catalog adopt coordinated universal time (UTC) in accordance with international convention. The location of every epicenter is expressed by its latitude and longitude, at the same time by the corresponding geographical region proposed by Flinn and Engdahl. The regional names are only for references and do not imply any political significance. The number of stations used and standard deviation are also given in order to illus-trate the precision of location.The surface wave magnitude MS is measured from the records of intermediate period broad band SK seismographs and adopting the surface wave magnitude formula of Beijing Station of 1965: MS= lg(AH/T)+1.66lgD +3.5 (1°<D<130°), in which AH is the resultant displacement ampli-tude of the maximum surface wave of horizontal components. MS7 is measured from records of the long-period seismographs of 763 type and adopting the surface wave magnitude formula re-commended by IASPEI in 1967. MS7=lg(AV/T)+1.66lgD +3.3 (20°<D<160°), in which AV is the maximum ground displacement of surface wave in vertical component, mb is short-period body-wave magnitude. ML is local magnitude. In order to avoid confusion, no conversion is made among the various magnitudes. For convenience of use and comparison, the surface wave mag-nitude MSZ (NEIS) and mb (NEIS) measured by NEIS recorded on short period seismographs are also listed.
文摘In the centre of the famous Chinese painting, Qingrning Shanghe Tu, an arch-shaped timber bridge, Hongqiao, stands like a rainbow over the river Bianhe. Unfortunately, Hongqiao was damaged during floods from the Yellow River, and we can only see her beautiful form in Qingming Shanghe Tu. While, the geometrical dimensions, structural principle, as well as the construction methods of the bridge are still an interesting mystery. In the present paper, the author uncovers the structural principle and the geometric dimensions of the bridge as well as its history background. Furthermore, the author introduces two new structural systems, Lap-Beam and 1.5-Layer space frame, which are inspired by the structural principle of the Hongqiao.
文摘Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chinese Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The "Monthly Report" is monthly compiled bv the Ninth Section of Institute of Geophysics, CSB.……
文摘 Illustration All the data in this catalog are chosen from the "Preliminary Seismological Report of Chine-se Seismic Stations" (Its abbreviation is "Monthly Report"). The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The "Monthly Report" is monthly compiled by the Ninth Section of Institute of Geophysics, CSB. The origin times of earthquakes in the catalog adopt coordinated universal time (UTC) in accordance with international convention. The location of every epicenter is expressed by its latitude and longitude, at the same time by the corresponding geographical region proposed by Flinn and Engdahl. The regional names are only for references and do not imply any political significance. The number of stations used and standard deviation are also given in order to illus-trate the precision of location.……
文摘The present paper represents comparison of continuum shells and latticed shells with qualitative analysis. For shells, the mechanical characteristics in the two perpendicular directions are continuous and related to each other, and any change in thickness will result in change in stiffness in any direction. In latticed shells, members are discrete and stiffnesses in two mutually perpendicular directions are discontinuous and independent of each other. Therefore, sensitivity of geometrical imperfection for buckling of latticed shells should be different from that of continuum shells. The author proposes a shape optimization method for maximum buckling load of a latticed shell. A single layer latticed dome is taken as a numerical example, and the results show that the buckling load parameter for full area loading case increases 32.75% compared to that of its initial shape. Furthermore, the numerical example demonstrates that an optimum latticed shell with maximum buckling load, unlike an optimum continuum shell, may not be sensitive to its geometrical imperfection.
文摘IllustrationAll the data in this catalog are chosen from the (Preliminary Seismological Report of Chinese Seismic Stations( (Its abbreviation is (Monthly Report(). The catalog includes the events of M(4.7 in and near China and M(6 all over the world. The (Monthly Report( is monthly compiled by the Ninth Section of Institute of Geophysics, CSB.
