We propose a 3D model feature line extraction method using templates for guidance. The 3D model is first projected into a depth map, and a set of candidate feature points are extracted. Then, a conditional random fiel...We propose a 3D model feature line extraction method using templates for guidance. The 3D model is first projected into a depth map, and a set of candidate feature points are extracted. Then, a conditional random fields (CRF) model is established to match the sketch points and the candidate feature points. Using sketch strokes, the candidate feature points can then be connected to obtain the feature lines, and using a CRF-matching model, the 2D image shape similarity features and 3D model geometric features can be effectively integrated. Finally, a relational metric based on shape and topological similarity is proposed to evaluate the matching results, and an iterative matching process is applied to obtain the globally optimized model feature lines. Experimental results showed that the proposed method can extract sound 3D model feature lines which correspond to the initial sketch template.展开更多
BACKGROUND Fuzi(Radix aconiti lateralis)-Gancao(Radix glycyrrhizae)is one of the most classical drug pairs of traditional Chinese medicine.In clinical practice,decoctions containing Fuzi-Gancao(F-G)are often used in t...BACKGROUND Fuzi(Radix aconiti lateralis)-Gancao(Radix glycyrrhizae)is one of the most classical drug pairs of traditional Chinese medicine.In clinical practice,decoctions containing Fuzi-Gancao(F-G)are often used in the treatment of liver diseases such as hepatitis and liver failure.AIM To investigate the metabolomics of F-G in CCl4 induced acute liver injury in rats and its regulatory effect on the bile acid profile.METHODS The pharmacodynamic effect of F-G on CCl4 induced acute liver injury in rats was evaluated,and an ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method for the simultaneous determination of 92 metabolites from multiple pathways was established to explore the protective metabolic mechanism of F-G in serum on the liver.RESULTS Twenty-four differential metabolites were identified in serum samples.The primary bile acid biosynthetic metabolic pathway was the major common pathway in the model group and F-G group.Subsequently,a UPLC-MS/MS method for simultaneous determination of 11 bile acids,including cholic acid,ursodeoxycholic acid,glycochenodeoxycholic acid,glycochenodeoxycholic acid,taurocholic acid,glycocholic acid,chenodeoxycholic acid,deoxycholic acid,taurochenodeoxycholic acid,taurocholic acid,and glycinic acid,was established to analyze the regulatory mechanism of F-G in serum.F-G decreased the contents of these 11 bile acids in serum in a dose-dependent manner compared with those in the model control group.CONCLUSION F-G could protect hepatocytes by promoting the binding of free bile acids to glycine and taurine,and reducing the accumulation of free bile acids in the liver.F-G could also regulate the compensatory degree of taurine,decreasing the content of taurine-conjugated bile acids to protect hepatocytes.展开更多
This paper presents a synthesis method for 3D models using Petri net. Feature structure units from the example model are extracted, along with their constraints, through structure analysis, to create a new model using...This paper presents a synthesis method for 3D models using Petri net. Feature structure units from the example model are extracted, along with their constraints, through structure analysis, to create a new model using an inference method based on Petri net. Our method has two main advantages: first, 3D model pieces are delineated as the feature structure units and Petri net is used to record their shape features and their constraints in order to outline the model, including extending and deforming operations; second, a construction space generating algorithm is presented to convert the curve drawn by the user into local shape controlling parameters, and the free form deformation (FFD) algorithm is used in the inference process to deform the feature structure units. Experimental results showed that the proposed method can create large-scale complex scenes or models and allow users to effectively control the model result.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 61272219, 61100110, and 61021062)the National High-Tech R&D Program (863) of China (No. 2007AA01Z334)+1 种基金the Program for New Century Excellent Talents in University (No. NCET-0404605)the Science and Technology Program of Jiangsu Province, China (Nos. BE2010072, BE2011058, and BY2012190)
文摘We propose a 3D model feature line extraction method using templates for guidance. The 3D model is first projected into a depth map, and a set of candidate feature points are extracted. Then, a conditional random fields (CRF) model is established to match the sketch points and the candidate feature points. Using sketch strokes, the candidate feature points can then be connected to obtain the feature lines, and using a CRF-matching model, the 2D image shape similarity features and 3D model geometric features can be effectively integrated. Finally, a relational metric based on shape and topological similarity is proposed to evaluate the matching results, and an iterative matching process is applied to obtain the globally optimized model feature lines. Experimental results showed that the proposed method can extract sound 3D model feature lines which correspond to the initial sketch template.
基金by Scientific Research Projects for Higher Education in Inner Mongolia Autonomous Region,No.NJZZ21027Support Plan for the Innovation and Entrepreneurship Initiation Plan for Overseas Students in Inner Mongolia Autonomous Region,No.MOHRSS2020122Doctoral Start-up Fund of the Affiliated Hospital of Inner Mongolia University for the Nationalities,No.MDFY2020001.
文摘BACKGROUND Fuzi(Radix aconiti lateralis)-Gancao(Radix glycyrrhizae)is one of the most classical drug pairs of traditional Chinese medicine.In clinical practice,decoctions containing Fuzi-Gancao(F-G)are often used in the treatment of liver diseases such as hepatitis and liver failure.AIM To investigate the metabolomics of F-G in CCl4 induced acute liver injury in rats and its regulatory effect on the bile acid profile.METHODS The pharmacodynamic effect of F-G on CCl4 induced acute liver injury in rats was evaluated,and an ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)method for the simultaneous determination of 92 metabolites from multiple pathways was established to explore the protective metabolic mechanism of F-G in serum on the liver.RESULTS Twenty-four differential metabolites were identified in serum samples.The primary bile acid biosynthetic metabolic pathway was the major common pathway in the model group and F-G group.Subsequently,a UPLC-MS/MS method for simultaneous determination of 11 bile acids,including cholic acid,ursodeoxycholic acid,glycochenodeoxycholic acid,glycochenodeoxycholic acid,taurocholic acid,glycocholic acid,chenodeoxycholic acid,deoxycholic acid,taurochenodeoxycholic acid,taurocholic acid,and glycinic acid,was established to analyze the regulatory mechanism of F-G in serum.F-G decreased the contents of these 11 bile acids in serum in a dose-dependent manner compared with those in the model control group.CONCLUSION F-G could protect hepatocytes by promoting the binding of free bile acids to glycine and taurine,and reducing the accumulation of free bile acids in the liver.F-G could also regulate the compensatory degree of taurine,decreasing the content of taurine-conjugated bile acids to protect hepatocytes.
基金supported by the National Natural Science Foundation of China (Nos. 61272219, 61100110, and 61021062)the National High-Tech R&D Program of China (No. 2007AA01Z334)+2 种基金the Program for New Century Excellent Talents in University (No. NCET04-04605)the Science and Technology Program of Jiangsu Province (Nos. BE2010072, BE2011058, and BY2012190)the Graduate Training Innovative Projects Foundation of Jiangsu Province (No. CXLX12_ 0054), China
文摘This paper presents a synthesis method for 3D models using Petri net. Feature structure units from the example model are extracted, along with their constraints, through structure analysis, to create a new model using an inference method based on Petri net. Our method has two main advantages: first, 3D model pieces are delineated as the feature structure units and Petri net is used to record their shape features and their constraints in order to outline the model, including extending and deforming operations; second, a construction space generating algorithm is presented to convert the curve drawn by the user into local shape controlling parameters, and the free form deformation (FFD) algorithm is used in the inference process to deform the feature structure units. Experimental results showed that the proposed method can create large-scale complex scenes or models and allow users to effectively control the model result.
