Background:Acupuncture has been proven to improve the pregnancy rate in infertile women.Endometriosis is a common cause of infertility.So far,there are no studies of the efficacy of acupuncture on endometriosis-associ...Background:Acupuncture has been proven to improve the pregnancy rate in infertile women.Endometriosis is a common cause of infertility.So far,there are no studies of the efficacy of acupuncture on endometriosis-associated infertility(EAI).Therefore,we will conduct a randomized controlled trial(RCT)to investigate whether acupuncture could have higher pregnancy rates in patients with EAI compared with sham acupuncture.The study protocol is reported in this paper.Methods/design:The current trial is a multicenter randomized controlled study undergoing in Shanghai,China.About 224 eligible patients with EAI will be randomly assigned into the acupuncture group and the sham acupuncture group in a 1:1 ratio.In the acupuncture group,patients will be treated with acupuncture on Guanyuan(CV4),Zhongji(CV3),Zigong(EX-CA1),Xuehai(SP10),Zusanli(ST36),Sanyinjiao(SP6),and Taichong(LR3),twice a week,for 3 menstrual cycles,and 12 menstrual cycles will be followed up.The Park sham device will be used to perform non-transdermal acupuncture in the sham acupuncture group.The operation points will be located at 1.5 cm away beside these acupoints in the acupuncture group.The intervention period is the same as that in the acupuncture group.The primary outcome will be pregnancy rate.Secondary outcomes will include ultrasound results,cancer antigen 125(CA125),antiMullerian hormone(AMH),sex hormones,and the Endometriosis Health Profile-5(EHP-5).Outcomes will be collected at baseline,the end of treatment,and follow-up visits at 3,6,and 12 menstrual cycles.All data,including major adverse events,will be recorded in electronic case report forms and analyzed using SPSS V.25.0.Discussion:This study will help to evaluate whether acupuncture is effective in increasing the pregnancy rate of infertile women with endometriosis.展开更多
In the underwater waveguide,the conventional adaptive subspace detector(ASD),derived by using the generalized likelihood ratio test(GLRT)theory,suffers from a significant degradation in detection performance when the ...In the underwater waveguide,the conventional adaptive subspace detector(ASD),derived by using the generalized likelihood ratio test(GLRT)theory,suffers from a significant degradation in detection performance when the samplings of training data are deficient.This paper proposes a dimension-reduced approach to alleviate this problem.The dimension reduction includes two steps:firstly,the full array is divided into several subarrays;secondly,the test data and the training data at each subarray are transformed into the modal domain from the hydrophone domain.Then the modal-domain test data and training data at each subarray are processed to formulate the subarray statistic by using the GLRT theory.The final test statistic of the dimension-reduced ASD(DR-ASD)is obtained by summing all the subarray statistics.After the dimension reduction,the unknown parameters can be estimated more accurately so the DR-ASD achieves a better detection performance than the ASD.In order to achieve the optimal detection performance,the processing gain of the DR-ASD is deduced to choose a proper number of subarrays.Simulation experiments verify the improved detection performance of the DR-ASD compared with the ASD.展开更多
基金Supported by Shanghai Sailing Program:22YF1444200the National Natural Science Foundation of China:81403429Clinical Research Project of Shanghai Municipal Health Commission:202240054。
文摘Background:Acupuncture has been proven to improve the pregnancy rate in infertile women.Endometriosis is a common cause of infertility.So far,there are no studies of the efficacy of acupuncture on endometriosis-associated infertility(EAI).Therefore,we will conduct a randomized controlled trial(RCT)to investigate whether acupuncture could have higher pregnancy rates in patients with EAI compared with sham acupuncture.The study protocol is reported in this paper.Methods/design:The current trial is a multicenter randomized controlled study undergoing in Shanghai,China.About 224 eligible patients with EAI will be randomly assigned into the acupuncture group and the sham acupuncture group in a 1:1 ratio.In the acupuncture group,patients will be treated with acupuncture on Guanyuan(CV4),Zhongji(CV3),Zigong(EX-CA1),Xuehai(SP10),Zusanli(ST36),Sanyinjiao(SP6),and Taichong(LR3),twice a week,for 3 menstrual cycles,and 12 menstrual cycles will be followed up.The Park sham device will be used to perform non-transdermal acupuncture in the sham acupuncture group.The operation points will be located at 1.5 cm away beside these acupoints in the acupuncture group.The intervention period is the same as that in the acupuncture group.The primary outcome will be pregnancy rate.Secondary outcomes will include ultrasound results,cancer antigen 125(CA125),antiMullerian hormone(AMH),sex hormones,and the Endometriosis Health Profile-5(EHP-5).Outcomes will be collected at baseline,the end of treatment,and follow-up visits at 3,6,and 12 menstrual cycles.All data,including major adverse events,will be recorded in electronic case report forms and analyzed using SPSS V.25.0.Discussion:This study will help to evaluate whether acupuncture is effective in increasing the pregnancy rate of infertile women with endometriosis.
基金the National Natural Science Foundation of China (Grant No. 11534009, 11974285) to provide fund for conducting this research
文摘In the underwater waveguide,the conventional adaptive subspace detector(ASD),derived by using the generalized likelihood ratio test(GLRT)theory,suffers from a significant degradation in detection performance when the samplings of training data are deficient.This paper proposes a dimension-reduced approach to alleviate this problem.The dimension reduction includes two steps:firstly,the full array is divided into several subarrays;secondly,the test data and the training data at each subarray are transformed into the modal domain from the hydrophone domain.Then the modal-domain test data and training data at each subarray are processed to formulate the subarray statistic by using the GLRT theory.The final test statistic of the dimension-reduced ASD(DR-ASD)is obtained by summing all the subarray statistics.After the dimension reduction,the unknown parameters can be estimated more accurately so the DR-ASD achieves a better detection performance than the ASD.In order to achieve the optimal detection performance,the processing gain of the DR-ASD is deduced to choose a proper number of subarrays.Simulation experiments verify the improved detection performance of the DR-ASD compared with the ASD.
