Tinospora cordifolia (Wild) Hook, local name: Guduchi/Amrita;English: Indian Tinospora, Hindi: Giloya/Gulancha, belongs to the family of Menispermaceae and is found in abundance in Bangladesh, Myanmar, Sri Lanka, and ...Tinospora cordifolia (Wild) Hook, local name: Guduchi/Amrita;English: Indian Tinospora, Hindi: Giloya/Gulancha, belongs to the family of Menispermaceae and is found in abundance in Bangladesh, Myanmar, Sri Lanka, and China, the plant is a spreading and mounting shrub with a lot twisting branches. T. cordifolia is used in Ayurveda medicinal system and has numerous therapeutic properties. This article summarizes the chemical constituents and pharmacological properties found within the plant. The review will provide a scientific basis of its use in Ayurveda and is an informative database on an ethno-pharmacologically important medicinal plant for future researchers.展开更多
<span style="font-family:Verdana;">The objective of this study is </span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="...<span style="font-family:Verdana;">The objective of this study is </span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">t</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">o isolate, identify and investigate the pharmacological activities of the</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> endophytic fungi from an aquatic plant </span><i><span style="font-family:Verdana;">Aponogeton undulatus </span></i><span style="font-family:Verdana;">Roxb. (</span><i><span style="font-family:Verdana;">A. undulatus</span></i><span style="font-family:Verdana;">). </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Endophytic fungi were isolated and identified based on morphological characters.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The molecular identification of the fungal isolates was performed</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">using by analyzing the DNA sequence based on mega BLAST program. Spectrums of antibacterial and antifungal activities </span><span style="font-family:Verdana;">were studied by Agar diffusion methods. Extracts of the endophytic funga</span><span style="font-family:Verdana;">l strains isolated from the plant </span><i><span style="font-family:Verdana;">A. undulatus</span></i><span style="font-family:Verdana;"> were screened for probable cytotoxic activities using brine shrimp </span><span style="font-family:Verdana;">lethality bioassay. Six</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="fon展开更多
Counterfeit and substandard drugs possess serious health risks. Regular quality screening is very important to ensure the standard and efficacy of pharmaceutical products. The study aimed to compare the quality of aml...Counterfeit and substandard drugs possess serious health risks. Regular quality screening is very important to ensure the standard and efficacy of pharmaceutical products. The study aimed to compare the quality of amlodipine besylate tablets available in the Bangladesh drug market and examine their physical and pharmaceutical equivalence. The various physico-chemical parameters such as diameter, shape, size, weight variation, thickness, hardness, loss on drying (LOD), friability, disintegration, dissolution, and assay have been determined according to the methods mentioned in the United States Pharmacopoeia (USP) and British Pharmacopoeia (BP). Four brands of amlodipine besylate were purchased from different local retail stores and coded as ALT<sub>1</sub>, AMT<sub>2</sub>, AMT<sub>3</sub>, and AST<sub>4</sub> on the basis of their market share. All four brands met official USP specifications. Pharmaceutical equivalence was determined from the dissolution profile which gives acceptable difference (f<sub>1</sub>) and similarity (f<sub>2</sub>) factor values for all the brands compared with the benchmark brand for its highest market share. All the brands also met the USP criteria for assay of not less than 90.0% and not more than 110.0% of the labeled amount of amlodipine (C<sub>20</sub>H<sub>25</sub>N<sub>2</sub>O<sub>5</sub>Cl).展开更多
文摘Tinospora cordifolia (Wild) Hook, local name: Guduchi/Amrita;English: Indian Tinospora, Hindi: Giloya/Gulancha, belongs to the family of Menispermaceae and is found in abundance in Bangladesh, Myanmar, Sri Lanka, and China, the plant is a spreading and mounting shrub with a lot twisting branches. T. cordifolia is used in Ayurveda medicinal system and has numerous therapeutic properties. This article summarizes the chemical constituents and pharmacological properties found within the plant. The review will provide a scientific basis of its use in Ayurveda and is an informative database on an ethno-pharmacologically important medicinal plant for future researchers.
文摘<span style="font-family:Verdana;">The objective of this study is </span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">t</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">o isolate, identify and investigate the pharmacological activities of the</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> endophytic fungi from an aquatic plant </span><i><span style="font-family:Verdana;">Aponogeton undulatus </span></i><span style="font-family:Verdana;">Roxb. (</span><i><span style="font-family:Verdana;">A. undulatus</span></i><span style="font-family:Verdana;">). </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Endophytic fungi were isolated and identified based on morphological characters.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">The molecular identification of the fungal isolates was performed</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">using by analyzing the DNA sequence based on mega BLAST program. Spectrums of antibacterial and antifungal activities </span><span style="font-family:Verdana;">were studied by Agar diffusion methods. Extracts of the endophytic funga</span><span style="font-family:Verdana;">l strains isolated from the plant </span><i><span style="font-family:Verdana;">A. undulatus</span></i><span style="font-family:Verdana;"> were screened for probable cytotoxic activities using brine shrimp </span><span style="font-family:Verdana;">lethality bioassay. Six</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="fon
文摘Counterfeit and substandard drugs possess serious health risks. Regular quality screening is very important to ensure the standard and efficacy of pharmaceutical products. The study aimed to compare the quality of amlodipine besylate tablets available in the Bangladesh drug market and examine their physical and pharmaceutical equivalence. The various physico-chemical parameters such as diameter, shape, size, weight variation, thickness, hardness, loss on drying (LOD), friability, disintegration, dissolution, and assay have been determined according to the methods mentioned in the United States Pharmacopoeia (USP) and British Pharmacopoeia (BP). Four brands of amlodipine besylate were purchased from different local retail stores and coded as ALT<sub>1</sub>, AMT<sub>2</sub>, AMT<sub>3</sub>, and AST<sub>4</sub> on the basis of their market share. All four brands met official USP specifications. Pharmaceutical equivalence was determined from the dissolution profile which gives acceptable difference (f<sub>1</sub>) and similarity (f<sub>2</sub>) factor values for all the brands compared with the benchmark brand for its highest market share. All the brands also met the USP criteria for assay of not less than 90.0% and not more than 110.0% of the labeled amount of amlodipine (C<sub>20</sub>H<sub>25</sub>N<sub>2</sub>O<sub>5</sub>Cl).
