Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ven...Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.展开更多
<strong>Background:</strong><span style="font-family:Verdana;"> Post-operative breast radiotherapy is used to reduce recurrence</span><span style="font-family:"">...<strong>Background:</strong><span style="font-family:Verdana;"> Post-operative breast radiotherapy is used to reduce recurrence</span><span style="font-family:""><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">The aim of this study was</span><span style="font-family:Verdana;"> to investigate the outcomes of </span><span style="font-family:Verdana;">Deep</span><span style="font-family:Verdana;"> Inspiration Breath-Hold (DIBH) technique with indigenous </span><span style="font-family:Verdana;">breath holding</span><span style="font-family:Verdana;"> indicator scale in 3DCRT for breast cancer radiotherapy over </span><span style="font-family:Verdana;">Free</span><span style="font-family:Verdana;"> Breathing (FB) technique. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> An observational study </span><span style="font-family:Verdana;">conducted</span> </span><span style="font-family:""><span style="font-family:Verdana;">at the </span><span style="font-family:Verdana;">Department</span><span style="font-family:Verdana;"> of Radiation Oncology </span></span><span style="font-family:""><span style="font-family:Verdana;">at </span><span style="font-family:Verdana;">National</span><span style="font-family:Verdana;"> Institute of Cancer Research and Hospital, Dhaka and Square Hospital Limited, Dhaka, Bangladesh from June 2015 to May 2016. A total of 60</span></span><span style="font-family:""><span style="font-family:Verdana;"> confirmed breast cancer patients who underwent adjuvant radiotherapy were included. An indigenous reproducible plastic tool (Perspex) was used as </span><span style="font-family:Verdana;">breath holding</span><span style="font-family:Verdana;"> indicator scale with </span></span><span style="font-family:Verdana;">DIBH</span><span style="font-family:""><span style="font-family:Verdana;"> technique in 3DCRT</span><i><span style="font-family:Verdana;">. </span></i><span><span style="font-family:Verdana;">Paired sample t-展开更多
文摘Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.
文摘<strong>Background:</strong><span style="font-family:Verdana;"> Post-operative breast radiotherapy is used to reduce recurrence</span><span style="font-family:""><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">The aim of this study was</span><span style="font-family:Verdana;"> to investigate the outcomes of </span><span style="font-family:Verdana;">Deep</span><span style="font-family:Verdana;"> Inspiration Breath-Hold (DIBH) technique with indigenous </span><span style="font-family:Verdana;">breath holding</span><span style="font-family:Verdana;"> indicator scale in 3DCRT for breast cancer radiotherapy over </span><span style="font-family:Verdana;">Free</span><span style="font-family:Verdana;"> Breathing (FB) technique. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> An observational study </span><span style="font-family:Verdana;">conducted</span> </span><span style="font-family:""><span style="font-family:Verdana;">at the </span><span style="font-family:Verdana;">Department</span><span style="font-family:Verdana;"> of Radiation Oncology </span></span><span style="font-family:""><span style="font-family:Verdana;">at </span><span style="font-family:Verdana;">National</span><span style="font-family:Verdana;"> Institute of Cancer Research and Hospital, Dhaka and Square Hospital Limited, Dhaka, Bangladesh from June 2015 to May 2016. A total of 60</span></span><span style="font-family:""><span style="font-family:Verdana;"> confirmed breast cancer patients who underwent adjuvant radiotherapy were included. An indigenous reproducible plastic tool (Perspex) was used as </span><span style="font-family:Verdana;">breath holding</span><span style="font-family:Verdana;"> indicator scale with </span></span><span style="font-family:Verdana;">DIBH</span><span style="font-family:""><span style="font-family:Verdana;"> technique in 3DCRT</span><i><span style="font-family:Verdana;">. </span></i><span><span style="font-family:Verdana;">Paired sample t-
