A methodology has been developed to generate a non-uniform/distoited inlet flow field to test a gas turbine engine in ground test facilities.The distorted flow field is generated by positioning radial and circumferent...A methodology has been developed to generate a non-uniform/distoited inlet flow field to test a gas turbine engine in ground test facilities.The distorted flow field is generated by positioning radial and circumferential strips of varying widths upstream of the Aerodynamic Interface Plane.The interacting wakes from these strips are used to generate a given target flow field.The approximate superposition of these wakes is investigated and used to construct the strip arrangement which is subsequently validated by computing the flow field by solving the Navier-Stokes equations.The strip geometry designed using the present methodology is able to produce the target Mach number distribution with a root-mean-square error of 5.06%.展开更多
Objective: To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. Methods: This study examined the effects of three parts(aerial, l...Objective: To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. Methods: This study examined the effects of three parts(aerial, leaf, stem) of whole plant on HT-29 colon cancer cell lines. Three different extracts from the plant parts were prepared by maceration technique using 80% ethanol. The anticancer activities were determined using MTT, clonogenic, cell motility and AOPI assay. The chemical composition profiling was analyzed by GC-MS. Results: Among three plant part extracts, leaf extract greatly suppressed the growth of colon cancer cells in time and dosage-dependent manner, followed by aerial and stem. The cytotoxicity results were rationalized with clonogenic, cell motility and AO/PI assay, where extract showed the most active activity compared to aerial and stem extracts. GC-MS analysis of leaf extract showed there were various recognized anti-cancer, anti-oxidant and anti-inflammatory compounds. Conclusions: Amid the screened extracts, the leaf extract exhibits the credible cytotoxic, anti-proliferative and apoptotic activity and hence, our findings call for additional research to conclude the active compounds and their mechanisms determining the apoptotic activity.展开更多
文摘A methodology has been developed to generate a non-uniform/distoited inlet flow field to test a gas turbine engine in ground test facilities.The distorted flow field is generated by positioning radial and circumferential strips of varying widths upstream of the Aerodynamic Interface Plane.The interacting wakes from these strips are used to generate a given target flow field.The approximate superposition of these wakes is investigated and used to construct the strip arrangement which is subsequently validated by computing the flow field by solving the Navier-Stokes equations.The strip geometry designed using the present methodology is able to produce the target Mach number distribution with a root-mean-square error of 5.06%.
文摘Objective: To identify the bioactive extracts from Alternanthera sessilis and investigate its cytotoxicity potential against colon cancer cells, HT-29. Methods: This study examined the effects of three parts(aerial, leaf, stem) of whole plant on HT-29 colon cancer cell lines. Three different extracts from the plant parts were prepared by maceration technique using 80% ethanol. The anticancer activities were determined using MTT, clonogenic, cell motility and AOPI assay. The chemical composition profiling was analyzed by GC-MS. Results: Among three plant part extracts, leaf extract greatly suppressed the growth of colon cancer cells in time and dosage-dependent manner, followed by aerial and stem. The cytotoxicity results were rationalized with clonogenic, cell motility and AO/PI assay, where extract showed the most active activity compared to aerial and stem extracts. GC-MS analysis of leaf extract showed there were various recognized anti-cancer, anti-oxidant and anti-inflammatory compounds. Conclusions: Amid the screened extracts, the leaf extract exhibits the credible cytotoxic, anti-proliferative and apoptotic activity and hence, our findings call for additional research to conclude the active compounds and their mechanisms determining the apoptotic activity.
