Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology. Social deficits represent one of the core symptoms of the diagnosis. The aim was to reveal possible correlations among peripheral le...Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology. Social deficits represent one of the core symptoms of the diagnosis. The aim was to reveal possible correlations among peripheral levels of oxytocin and testosterone with behavioral and symptom characteristics in patients with ASD. 8 children with ASD were recruited and underwent psychological profiling. Blood oxytocin and testosterone levels were analyzed using ELISA method. Oxytocin levels positively correlated with Adaptation to change category of CARS-2 (P = 0.008, R = 0.848) and Vineland-II maladaptive behavior scores (P = 0.004, R = 0.884). No significant correlations were found among testosterone levels and behavioral parameters. Higher oxytocin levels were connected with more severe adaptive behavior in ASD patients. Increased oxytocin levels in children with more severe phenotype could be a result of compensatory mechanism of impaired oxytocin signaling. Oxytocin seems to employ distinct mechanisms in regulating social behavior in autism and healthy population.展开更多
The study aims to determine a mathematical formula that correlates the vertical stiffness of the principal elements of a high speed railway. To do this, beginning on the traditional formulations, a new mathematical mo...The study aims to determine a mathematical formula that correlates the vertical stiffness of the principal elements of a high speed railway. To do this, beginning on the traditional formulations, a new mathematical model has been proposed, and has been verified and confirmed with the real information of high speed railways. Finally, there has been obtained a simple expression that correlates simply the vertical stiffness of the railway with the vertical stiffness of the elements that compound it, essentially with the base plate and the ballast system set. On the other hand, also the accuracy of the model has been verified to select the stiffness of the base plate and the ballast system depending on one of this stiffness and the total vertical stiffness that it is wanted. With this simplified formula, it is possible to optimize the vertical stiffness of the railway to obtain the best behavior in each zone and to reduce the final cost of the use of the via, taking in consideration the energy needed to move the trains, the maintenance cost, the useful life, etc.. The process to optimize the railway stiffness in each point depends on the vertical stiffness of the ballast and the sub-ballast, and it is possible to use different plate bases with different stiffness to obtain the optimal stiffness that has been previously obtained with a cost and maintenance analysis.展开更多
The economy of the equestrian sector encompasses all the activities related to the equine world. All activities revolving around the use of a horse as entertainment, sport or business play a role in the ＂horse indus...The economy of the equestrian sector encompasses all the activities related to the equine world. All activities revolving around the use of a horse as entertainment, sport or business play a role in the ＂horse industry＂. These activities take place due to the existence of people demanding horses and a variety of goods and services associated with them Previous studies reveal that as income per capita becomes larger, the equestrian demand increases and, consequently, the global expenditure incurred by those individuals interested in horses. More than 500,000 horse, 9,000 breeders and 50,000 equestrian businesses, show the economic importance of the equestrian sector in Spain. That part of global expenditure that adds to the GDP of a country is what is generally defined as economic impact of the sector. Its relation will depend mostly on： the percentage of the expenditure that adds to national production and the participation in the country＇s global expenditure of those domestic goods and services associated with the equestrian demand. The activities related to sports are those with most economic impact, about 8,000 ∈ per horse, measured as total expenditure or with respect to the employment that they generate in the economy.展开更多
Purpose: To evaluate the topographic concordance between sensibility values of short wave automated perimetry (SWAP) and frequency doubling technology (FDT) in ocular hypertension. Methods: 22 eyes of 22 patients diag...Purpose: To evaluate the topographic concordance between sensibility values of short wave automated perimetry (SWAP) and frequency doubling technology (FDT) in ocular hypertension. Methods: 22 eyes of 22 patients diagnosed of ocular hypertension underwent SWAP (24-2 test, Humphrey analyser) and FDT (C-20 threshold test). According the 17 points examined展开更多
文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder of unknown etiology. Social deficits represent one of the core symptoms of the diagnosis. The aim was to reveal possible correlations among peripheral levels of oxytocin and testosterone with behavioral and symptom characteristics in patients with ASD. 8 children with ASD were recruited and underwent psychological profiling. Blood oxytocin and testosterone levels were analyzed using ELISA method. Oxytocin levels positively correlated with Adaptation to change category of CARS-2 (P = 0.008, R = 0.848) and Vineland-II maladaptive behavior scores (P = 0.004, R = 0.884). No significant correlations were found among testosterone levels and behavioral parameters. Higher oxytocin levels were connected with more severe adaptive behavior in ASD patients. Increased oxytocin levels in children with more severe phenotype could be a result of compensatory mechanism of impaired oxytocin signaling. Oxytocin seems to employ distinct mechanisms in regulating social behavior in autism and healthy population.
文摘The study aims to determine a mathematical formula that correlates the vertical stiffness of the principal elements of a high speed railway. To do this, beginning on the traditional formulations, a new mathematical model has been proposed, and has been verified and confirmed with the real information of high speed railways. Finally, there has been obtained a simple expression that correlates simply the vertical stiffness of the railway with the vertical stiffness of the elements that compound it, essentially with the base plate and the ballast system set. On the other hand, also the accuracy of the model has been verified to select the stiffness of the base plate and the ballast system depending on one of this stiffness and the total vertical stiffness that it is wanted. With this simplified formula, it is possible to optimize the vertical stiffness of the railway to obtain the best behavior in each zone and to reduce the final cost of the use of the via, taking in consideration the energy needed to move the trains, the maintenance cost, the useful life, etc.. The process to optimize the railway stiffness in each point depends on the vertical stiffness of the ballast and the sub-ballast, and it is possible to use different plate bases with different stiffness to obtain the optimal stiffness that has been previously obtained with a cost and maintenance analysis.
文摘The economy of the equestrian sector encompasses all the activities related to the equine world. All activities revolving around the use of a horse as entertainment, sport or business play a role in the ＂horse industry＂. These activities take place due to the existence of people demanding horses and a variety of goods and services associated with them Previous studies reveal that as income per capita becomes larger, the equestrian demand increases and, consequently, the global expenditure incurred by those individuals interested in horses. More than 500,000 horse, 9,000 breeders and 50,000 equestrian businesses, show the economic importance of the equestrian sector in Spain. That part of global expenditure that adds to the GDP of a country is what is generally defined as economic impact of the sector. Its relation will depend mostly on： the percentage of the expenditure that adds to national production and the participation in the country＇s global expenditure of those domestic goods and services associated with the equestrian demand. The activities related to sports are those with most economic impact, about 8,000 ∈ per horse, measured as total expenditure or with respect to the employment that they generate in the economy.
文摘Purpose: To evaluate the topographic concordance between sensibility values of short wave automated perimetry (SWAP) and frequency doubling technology (FDT) in ocular hypertension. Methods: 22 eyes of 22 patients diagnosed of ocular hypertension underwent SWAP (24-2 test, Humphrey analyser) and FDT (C-20 threshold test). According the 17 points examined
