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Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations 被引量:8
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作者 Yuichi Matsuno Junji umeno +19 位作者 Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto 《World Journal of Gastroenterology》 SCIE CAS 2019年第14期1753-1763,共11页
BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(C... BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. 展开更多
关键词 CHRONIC enteropathy associated with SLCO2A1 gene PROSTAGLANDIN E major urinary METABOLITES CHRONIC nonspecific multiple ulcers of the SMALL INTESTINE Crohn's disease SMALL INTESTINE
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Catalyst-Free Growth of Graphene by Microwave Surface Wave Plasma Chemical Vapor Deposition at Low Temperature 被引量:2
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作者 Sudip Adhikari Hare Ram Aryal +1 位作者 Hideo Uchida Masayoshi umeno 《Journal of Materials Science and Chemical Engineering》 2016年第3期10-14,共5页
Catalyst-free graphene films has been synthesized by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) using hydrogenated carbon source on silicon substrates at low temperature (500℃). The synt... Catalyst-free graphene films has been synthesized by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) using hydrogenated carbon source on silicon substrates at low temperature (500℃). The synthesized process is simple, low-cost and possible for application on transparent electrodes, gas sensors and thin film resistors. Analytical methods such as Raman spectroscopy, transmission electron microscopy (TEM) and four points prove resistivity measurement and UV-VIS-NIR spectroscopy were employed to characterize properties of the graphene films. The formation of multilayer of graphene on silicon substrate was confirmed by Raman spectroscopy and TEM. It is possible to grow graphene directly on silicon substrate (without using catalyst) due to high radical density of MW SWP CVD. In addition, we also observed that the hydrogen had significant role for quality of graphene. 展开更多
关键词 Graphene Films Direct Synthesis H2 Flow Rate Silicon Substrate Microwave Surface Wave Plasma CVD
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Capability of TEC correlation Analysis and Deceleration at Propagation Velocities of Medium-Scale Traveling Ionospheric Disturbances: Preseismic Anomalies before the Large Earthquakes
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作者 Ken umeno Ryo Nakabayashi +1 位作者 Takuya Iwata Minghui Kao 《Open Journal of Earthquake Research》 2021年第4期105-137,共33页
Data analysis method (CRA, hereafter) to correlate multiple TEC anomaly signals has detected pre-seismic anomalies before the 2011 Tohoku-Oki earthquake (Iwata & Umeno 2016), the 2016 Kumamoto earthquake (Iwata &a... Data analysis method (CRA, hereafter) to correlate multiple TEC anomaly signals has detected pre-seismic anomalies before the 2011 Tohoku-Oki earthquake (Iwata & Umeno 2016), the 2016 Kumamoto earthquake (Iwata & Umeno 2017) and the 2016 Tainan earthquake (Goto <i><span style="font-family:Verdana;">et al</span></i><span style="font-family:Verdana;">. 2019). However, a critical argument said that those anomalies detected by CRA would not </span><span style="font-family:Verdana;">be pre-seismic anomalies published by Journal of Geophysical Re</span><span style="font-family:Verdana;">search-Space Physics (126), 2021 (JGR-SP (126), hereafter). In this paper, we would point out its incorrect use of statistical anomalies in evaluating CRA as the following points: CRA is shown to increase the signal-to-noise ratio (SNR) to amplify pre-seismic TEC’s small anomaly signals with synchronizing and correlating multiple GNSS receivers’ data. We proved again that pre-seismic anomalies certainly exist before the 2011 Tohoku-Oki earthquake and the 2016 Kumamoto earthquake with additional data analysis. In particular, </span><span style="font-family:Verdana;">a</span><span style="font-family:Verdana;">s </span><span style="font-family:Verdana;">a</span><span style="font-family:Verdana;"> temporal anomaly, deceleration at propagation velocities of medium-scale traveling ionospheric disturbances (MSTID, hereafter) before the 2016 Kumamoto earthquake captured by CRA (Iwata & Umeno 2017) is elucidated as pre-seismic anomalies. Furthermore, we proposed a physical model to predict that 35 m/s change at MSTID propagation velocities estimated by TEC’s CRA requires 0.58</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">×</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">10</span><sup><span style="font-family:Verdana;"><span style="white-space:nowrap;">&#45;</span>3</span></sup><span style="font-family:Verdana;"> V/m electric field in the F Layer ionosphere. Contrary to 展开更多
关键词 CRA TEC MSTID Preseismic Ionospheric Anomaly The 2016 Kumamoto Earthquake The 2011 Tohoku-Oki Earthquake
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Direct Synthesis of Graphene on Silicon at Low Temperature for Schottky Junction Solar Cells
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作者 Sudip Adhikari Rucheng Zhu Masayoshi umeno 《Journal of Materials Science and Chemical Engineering》 2021年第10期1-9,共9页
Graphene thin films synthesized directly at low temperature (550˚C) on silicon substrate by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) using the cover on substrates for avoiding plasma em... Graphene thin films synthesized directly at low temperature (550˚C) on silicon substrate by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) using the cover on substrates for avoiding plasma emission ultraviolet ray’s effect during film deposition. Analytical methods such as Raman spectroscopy, Transmission electron microscopy (TEM) and Scanning electron microscopy (SEM), four-point probe method, and JASCO V-570 UV/VIS/NIR spectrophotometer were employed to characterize the properties of the graphene films. Here, we report that it is possible to grow graphene directly on the silicon substrate (without using catalyst) due to the high radical density of MW SWP CVD. Furthermore, we fabricated graphene/silicon Schottky junction solar cells with an efficiency of up to 6.39%. Compared to conventional silicon solar cells, the fabrication process is greatly simplified;just graphene is synthesized directly on n-type crystalline Si substrate at low temperate. 展开更多
关键词 GRAPHENE Direct Synthesis Microwave Plasma CVD Photovoltaics
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Genetic analysis is helpful for the diagnosis of small bowel ulceration 被引量:2
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作者 Junji umeno Takayuki Matsumoto +2 位作者 Atsushi Hirano Yuta Fuyuno Motohiro Esaki 《World Journal of Gastroenterology》 SCIE CAS 2018年第28期3198-3200,共3页
The widespread use of capsule endoscopy and balloonassisted endoscopy has provided easy access for detailed mucosal assessment of the small intestine. However, the diagnosis of rare small bowel diseases, such as crypt... The widespread use of capsule endoscopy and balloonassisted endoscopy has provided easy access for detailed mucosal assessment of the small intestine. However, the diagnosis of rare small bowel diseases, such as cryptogenic multifocal ulcerous stenosing enteritis(CMUSE), remains difficult because clinical and morphological features of these diseases are obscure even for gastroenterologists. In an issue of this journal in 2017, Hwang et al reviewed and summarized clinical and radiographic features of 20 patients with an established diagnosis of CMUSE. Recently, recessive mutations in the PLA2G4A and SLCO2A1 genes have been shown to cause small intestinal diseases. The small bowel ulcers in each disease mimic those in the other and furthermore those found in nonsteroidal anti-inflammatory drug-induced enteropathy. These recent and novel findings suggest that a clinical diagnosis exclusively based on the characteristics of small bowel lesions is possibly imprecise. Genetic analyses seem to be inevitable for the diagnosis of rare small bowel disorders such as CMUSE. 展开更多
关键词 CRYPTOGENIC multifocal ulcerous stenosing ENTERITIS CHRONIC NONSPECIFIC multiple ulcers of the small intestine CHRONIC ENTEROPATHY associated with SLCO2A1 gene Crohn’s disease
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Low Temperature Plasma CVD Grown Graphene by Microwave Surface-Wave Plasma CVD Using Camphor Precursor 被引量:1
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作者 Hideo Uchida Hare Ram Aryal +1 位作者 Sudip Adhikari Masayoshi umeno 《Journal of Physical Science and Application》 2016年第2期34-38,共5页
Hydrocarbon precursor such as methane has been widely used to grow graphene films and the methods of growing quality graphene films are dominated by thermal CVD (chemical vapor deposition) system. Graphene films gro... Hydrocarbon precursor such as methane has been widely used to grow graphene films and the methods of growing quality graphene films are dominated by thermal CVD (chemical vapor deposition) system. Graphene films grown by plasma process are generally highly defective which in turns degrade the quality of the films. Here, using a green precursor, camphor we demonstrate a simple and economical method to get high-quality graphene film on copper substrate by micro wave surface-wave plasma CVD at relatively low temperature 550℃. Graphene film grown using camphor shows superior quality than that of the film grown using methane. Results revealed that camphor precursor is a good alternative to hydrocarbon precursors for graphene research. 展开更多
关键词 CAMPHOR plasma CVD quality graphene plasma induced defects.
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Law Education in Japan and China:Comparative Analysis Focusing on Law-Related Materials
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作者 Masanobu umeno Yoshihiko Fukuda Naho Inoue 《ECNU Review of Education》 2023年第2期261-279,共19页
Purpose:This study examines law-related education in Japan and China to reveal the current state of research and identify the roles,possibilities,and challenges facing such teaching at the elementary,junior high,and s... Purpose:This study examines law-related education in Japan and China to reveal the current state of research and identify the roles,possibilities,and challenges facing such teaching at the elementary,junior high,and senior high school levels.This study conducts a comparative review of research on perspectives toward law education in both countries,as well as the characteristics of and issues facing law education in Japan.Design/Approach/Methods:This study examines trends in research and educational reform related to law education in Japan.In doing so,it evaluates how the characteristics of and issues facing law education in Japan are related to law education in China.Findings:Results show no evidence of a systematic study of law in Japan.Reforming subjects to engage in collaborative learning is a more realistic strategy than attempting to design wholly new subjects.Accordingly,exploring what kind of learning activities are linked to law-abiding education in China offers insights and references for Japan.Adapting these strategies to the Japanese context and law material can help create a more systematic form of learning.Originality/Value:Through joint research by researchers and educators from East Asian countries,we intend to conduct further research on the development of curricula,textbooks,and class models suited to specific subjects.Employing the joint research learning approach discussed in this study in Japan and China may result in further learning possibilities. 展开更多
关键词 Curriculum East Asia law-related education normative awareness social studies
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Characteristics of Anomalous Radio Propagation before and after the 2011 Tohoku-Oki Earthquake as Seen by Oblique Ionograms 被引量:1
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作者 Kiyoshi Igarashi Toshio Tsuchiya Ken umeno 《Open Journal of Earthquake Research》 2020年第2期100-112,共13页
The characteristics of anomalous radio propagation in the frequency 1 - 30 MHz before and after the 2011 Tohoku-Oki earthquake are firstly revealed by using oblique ionograms for the pass from Wakkanai to Kokubunji wh... The characteristics of anomalous radio propagation in the frequency 1 - 30 MHz before and after the 2011 Tohoku-Oki earthquake are firstly revealed by using oblique ionograms for the pass from Wakkanai to Kokubunji which is closest to the epicenter. An oblique ionogram with a wavy-shape-trace was observed at 06:30 UTC on 11 March 2011 after the 2011 Tohoku-Oki earthquake. The velocity of northward-propagating disturbance caused this wavy-shape-trace is estimated to be 130 m/s. This wave-shape-trace shows very clear signature appearing in the oblique ionograms as the characteristic of strong ionospheric disturbances triggered by the earthquake. An oblique ionogram with a steep slopy-shape-trace was observed at 04:45 UTC on 11 March 2011 one hour before the 2011 Tohoku-Oki earthquake. This slopy-shape-trace is investigated as the signatures of preseismic ionospheric anomaly. This anomalous oblique ionogram with a slopy-shape-trace is examined with the slope ratio of virtual height to sweep-frequency, and the difference between monthly median foF2 and hourly value foF2 at Wakkanai and Kokubunji. These features appearing in oblique ionograms suggest that it is useful for studying the signatures of preseismic ionospheric anomaly. 展开更多
关键词 IONOSPHERIC Disturbances OBLIQUE IONOGRAM ANOMALOUS Radio Propagation Atmospheric GRAVITY Waves
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Influence of automated driving on driver’s own localization:a driving simulator study
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作者 Ryuichi umeno Makoto Itoh Satoshi Kitazaki 《Journal of Intelligent and Connected Vehicles》 2018年第3期99-106,共8页
Purpose–Level 3 automated driving,which has been defined by the Society of Automotive Engineers,may cause driver drowsiness or lack of situation awareness,which can make it difficult for the driver to recognize where... Purpose–Level 3 automated driving,which has been defined by the Society of Automotive Engineers,may cause driver drowsiness or lack of situation awareness,which can make it difficult for the driver to recognize where he/she is.Therefore,the purpose of this study was to conduct an experimental study with a driving simulator to investigate whether automated driving affects the driver’s own localization compared to manual driving.Design/methodology/approach–Seventeen drivers were divided into the automated operation group and manual operation group.Drivers in each group were instructed to travel along the expressway and proceed to the specified destinations.The automated operation group was forced to select a course after receiving a Request to Intervene(RtI)from an automated driving system.Findings–A driver who used the automated operation system tended to not take over the driving operation correctly when a lane change is immediately required after the RtI.Originality/value–This is a fundamental research that examined how the automated driving operation affects the driver's own localization.The experimental results suggest that it is not enough to simply issue an RtI,and it is necessary to tell the driver what kind of circumstances he/she is in and what they should do next through the HMI.This conclusion can be taken into consideration for engineers who design automatic driving vehicles. 展开更多
关键词 Automated vehicles Autonomous driving Advanced driver assistant systems Driver behaviors and assistance Human-machine interfaces Request to intervene
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Nitrogen Plasma Treatment Effect on Graphene Sheeted Vertically Aligned Carbon Nanofibers
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作者 Dilip Chandra Ghimire M. Matsushima M. umeno 《Journal of Chemistry and Chemical Engineering》 2013年第9期842-846,共5页
Nitrogen plasma treatment effect on GS-CNFs (graphene seeted vertically aligned carbon nanofibers) has been studied. GS-CNFs were grown on nickel coated cupper substrates by DC-plasma CVD (chemical vapor deposition... Nitrogen plasma treatment effect on GS-CNFs (graphene seeted vertically aligned carbon nanofibers) has been studied. GS-CNFs were grown on nickel coated cupper substrates by DC-plasma CVD (chemical vapor deposition) at relatively low temperature. GS-CNFs were studied by SEM (scanning electron microscopy), HR-TEM (high-resolution transmission electron microscopy), XPS and Raman measurements. GS-CNFs are composed of cylindrical shaped having pure graphite sheets with about 5 μm length and nanometer size tips and roots diameter. Nitrogen plasma treatment causes nitrogen chemical etching on the graphene seeted carbon nanofibers were disordered its fine shape and increase the graphetization due to nitrogen incorporation. 展开更多
关键词 DC-plasma CVD graphene seeted carbon nanofibers nitrogen plasma treatment effect.
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二维自由度刚性伺服系统的设计
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作者 umeno,T 方勇 《科技译丛(重庆)》 1996年第1期78-95,共18页
关键词 控制器 二维 自由度 刚性系统 伺服系统 设计
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Improved Photovoltaic Properties of Heterojunction Carbon Based Solar Cell 被引量:1
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作者 Sudip Adhikari M. S. Kayastha +8 位作者 D. C. Ghimire H. R. Aryal S. Adhikary T. Takeuchi K. Murakami Y. Kawashimo H. Uchida K. Wakita M. umeno 《Journal of Surface Engineered Materials and Advanced Technology》 2013年第3期178-183,共6页
Amorphous carbon (a-C) thin films have been synthesized by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) on n-type silicon and quartz substrates, aiming at the application of the films for p... Amorphous carbon (a-C) thin films have been synthesized by microwave (MW) surface wave plasma (SWP) chemical vapor deposition (CVD) on n-type silicon and quartz substrates, aiming at the application of the films for photovoltaic solar cells. Argon, acetylene and trimethylboron were used as a carrier, source and dopant gases. Analytical methods such as X-ray photoelectron spectroscopy (XPS), Hall Effect measurement, JASCO V-570 UV/VIS/NIR spectroscopy, Raman spectroscopy, Transmission electron microscopy (TEM) and Solar simulator were employed to investigate chemical, optical, structural and electrical properties of the a-C films. Two types of solar cells of configuration p-C/n-Si and p-C/i-C/n-Si have been fabricated and their current-voltage characteristics under dark and illumination (AM 1.5, 100 mW/cm2) have been studied. The two solar cells showed rectifying curves under the dark condition confirming the heterojunction carbon based solar cell between p-C and n-Si. When illuminated by the solar simulator light the devices showed photovoltaic behavior. The heterojunction device (p-C/i-C/n-Si) having inserted intrinsic carbon film between p-C and n-Si exhibited significant enhancement of the conversation efficiency (0.167% to 2.349%) over the device (p-C/n-Si). 展开更多
关键词 CARBON PHOTOVOLTAIC Properties HETEROJUNCTION SOLAR CELL
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Carbon Nanotube-Conducting Polymer Composites Based Solar Cells
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作者 Prakash R.Somani M.umeno 《复旦学报(自然科学版)》 CAS CSCD 北大核心 2007年第5期656-,共1页
1 Results Combination of carbon nanotubes (CN) with polymers is important for application towards value added composites,solar cells,fuel cells etc.Especially interesting is the combination of CN with π-conjugated po... 1 Results Combination of carbon nanotubes (CN) with polymers is important for application towards value added composites,solar cells,fuel cells etc.Especially interesting is the combination of CN with π-conjugated polymers because of the potential interaction between the highly delocalized π-electrons of the CN and the π-electrons correlated with the lattice of polymer skeleton.Efficient exciton dissociation due to electron transfer from the photoexcited polymer to CN is of interest for photovoltaic app... 展开更多
关键词 carbon nanotube conjugated polymers solar cell
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