This paper presents a comparative study of a meshless level-set method in the simulation of sloshing flows. The numerical moving particle semi-implicit （MPS） method and a grid based schemes of the MPS and level-set ...This paper presents a comparative study of a meshless level-set method in the simulation of sloshing flows. The numerical moving particle semi-implicit （MPS） method and a grid based schemes of the MPS and level-set methods are outlined and two violent sloshing cases are considered. The computed results are compared with the corresponding experimental data for validation. The impact pressure and the deformations of free surface induced by sloshing are comparatively analyzed, and are in good agreement with experimental ones. Results show that both the MPS and level-set methods are good tools for simulation of violent sloshing flows. However, the second pressure peaks as well as breaking and splashing of free surface by the MPS method are captured better than by the level-set method.展开更多
The effects of alloying elements on zincate treatment and adhesion of electroless Ni-P coating onto various aluminum alloy substrates were examined.Surface morphology of zinc deposits in the 1st zincate treatment and ...The effects of alloying elements on zincate treatment and adhesion of electroless Ni-P coating onto various aluminum alloy substrates were examined.Surface morphology of zinc deposits in the 1st zincate treatment and its adhesion were changed depending on the alloying element.The zinc deposits in the 2nd zincate treatment became thinly uniform,and the adhesion between aluminum alloy substrate and Ni-P coating was improved irrespective of the alloying element.XPS analysis revealed the existence of zinc on the surface of each aluminum alloy substrate after the pickling in 5% nitric acid.This zinc on the surface should be an important factor influencing the morphology of zinc deposit at the 2nd zincate treatment and its adhesion.展开更多
The monomer agglomeration of nonmetallic inclusions was simulated with a diffusion limited aggregation （DLA） model of the fractal theory. The simulation study with a random two-dimensional diffusion was carried out....The monomer agglomeration of nonmetallic inclusions was simulated with a diffusion limited aggregation （DLA） model of the fractal theory. The simulation study with a random two-dimensional diffusion was carried out. The results indicate that the DLA model can be used for the simulation of agglomeration behavior of the cluster-type inclusions. The morphology of clusters was observed with SEM and compared with the simulated agglomerates. The modelling procedure of the DLA model is applicable for the agglomeration process. The uncertainty of agglomeration process and the persuasive average agglomerative ratio was analyzed. The factors about the agglomerative ratio with the collision path distance and the size of particles or seed were discussed. The adherence of the nonmetallic inclusions on the dam, the weir and the walls of a tundish, and the absorption of inclusions by stopper or nozzle were also discussed.展开更多
Spectroscopy is a widely used experimental technique,and enhancing its efficiency can have a strong impact on materials research.We propose an adaptive design for spectroscopy experiments that uses a machine learning ...Spectroscopy is a widely used experimental technique,and enhancing its efficiency can have a strong impact on materials research.We propose an adaptive design for spectroscopy experiments that uses a machine learning technique to improve efficiency.We examined X-ray magnetic circular dichroism(XMCD)spectroscopy for the applicability of a machine learning technique to spectroscopy.An XMCD spectrum was predicted by Gaussian process modelling with learning of an experimental spectrum using a limited number of observed data points.Adaptive sampling of data points with maximum variance of the predicted spectrum successfully reduced the total data points for the evaluation of magnetic moments while providing the required accuracy.The present method reduces the time and cost for XMCD spectroscopy and has potential applicability to various spectroscopies.展开更多
Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpress...Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy.展开更多
An environmental friendly anodizing treatment (Anomag) from a phosphate-based so lution without heavy metals on AZ91D magnesium alloy was studied. The characteri stics of the coatings, such as structure, composition a...An environmental friendly anodizing treatment (Anomag) from a phosphate-based so lution without heavy metals on AZ91D magnesium alloy was studied. The characteri stics of the coatings, such as structure, composition and corrosion resistance w ere investigated. The effects of this anodizing treatment on the mechanical prop erties were examined. X-ray diffraction (XRD) analysis revealed that the structu re of the coatings is amorphous or glassy. In salt spray tests coatings with an average thickness of 10μm had an anticorrosive performance of over 1000 hours. Fatigue tests revealed that anodizing onto AZ91D magnesium alloy does not affect the fatigue strength. These results demonstrate the utility of this anodizing t reatment on magnesium alloy for application as a structural material, such as in the automotive field.展开更多
The fixing of a silane coupling agent to Zn-Ni-silica(SiO_(2))composite coatings was studied for the purpose of developing a coating process as an alternative to chromating.The corrosion resistance of Zn-Ni-silica com...The fixing of a silane coupling agent to Zn-Ni-silica(SiO_(2))composite coatings was studied for the purpose of developing a coating process as an alternative to chromating.The corrosion resistance of Zn-Ni-silica composite coatings was rem arkably improved by the silica nanoparticles in the composite,which were disper sed in the surface of this film.The silane coupling agent formed chemical bonds with the inorganic silica particles during the silane coupling treatment on the se composite coatings.The treatment suppressed the formation of white corrosion products to the same extent as chromating,as measured in salt spray tests.It is concluded that treating Zn-Ni-silica composite coatings with silane coupling agents is a viable alternative technique to chromating.展开更多
Background: Hiccups are common somatic side effects of medication. Our previous analysis of the clinical risk factors for hiccups identified chemotherapy as a factor related to hiccup risk. Therefore, in the present s...Background: Hiccups are common somatic side effects of medication. Our previous analysis of the clinical risk factors for hiccups identified chemotherapy as a factor related to hiccup risk. Therefore, in the present study, we investigated the risk factors for hiccups associated with chemotherapy. Methods: We included all patients who received cancer chemotherapy and were hospitalized at the Musashino Red Cross Hospital between April 2014 and December 2014. We investigated patient demographics, physical characteristics, and other clinical factors to identify the risk factors for chemotherapy-induced hiccups (CIH). We conducted univariate and multivariable analysis to compare the CIH group and the non-CIH and determined risk factors of CIH. Results: Hiccups were identified in 48 of 292 patients with an incidence rate of 16.4%. Univariate analysis revealed that the male gender, pain, and nausea and vomiting were related to CIH. It also showed that cisplatin, pemetrexed, gemcitabine, etoposide, dexamethasone, and metoclopramide were related to CIH.A correlation which was found with doses of cisplatin, pemetrexed, gemcitabine, and etoposide. Multivariable analysis identified male gender (OR, 72.69;95% CI, 6.95 - 757.64), nausea and vomiting (OR, 52.01;95% CI, 3.93 - 447.13), dexamethasone (OR, 4.55;95% CI, 1.12 - 16.91), cisplatin (OR, 3.84;95% CI, 1.52 - 9.70), and etoposide (OR, 3.72;95% CI, 1.14 - 12.11) as independent risk factors for hiccups. Conclusions: The present study is the first one to report risk factors for the development of CIH. Our results suggest that male gender, having nausea, and the drugs dexamethasone, cisplatin, and etoposide are important risk factors for CIH. These results may assist in elucidation of the underlying mechanisms and guide therapy to reduce hiccup risk.展开更多
The effect of pore water chemistry on anisotropic behavior of consolidation and shear strength of reconstituted Ariake clay has been investigated experimentally.Two types of chemicals added into the pore water of the ...The effect of pore water chemistry on anisotropic behavior of consolidation and shear strength of reconstituted Ariake clay has been investigated experimentally.Two types of chemicals added into the pore water of the soil for enhancing flocculation microstructure of soil particles are sodium chloride(salt)(NaCl),and calcium chloride(CaCl_(2));and two dispersants added are sodium triphosphate(Na_(5)-P_(3)O_(10))and sodium hexametaphosphate(Na_(6)P_(6)O_(18)),respectively.The concentrations of these chemicals in pore water were 2-3%.Degrees of anisotropy of the coefficient of consolidation and undrained shear strength decreased with adding NaCl and CaCl_(2),but increased with adding the dispersants.Degree of anisotropy also increased with one-dimensional(1D)deformation and the samples with dispersive additives had higher increase rate.It has been confirmed qualitatively by scanning electron microscopy(SEM)images that adding dispersive chemicals promoted the formation of dispersive microstructure and increased the degree of anisotropy,and the chemicals enhancing flocculent microstructure had an inverse effect.The possible application of the findings to underground construction has been discussed also.展开更多
A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was performed.Ni or Cu atoms were shown to adopt the corresponding position ...A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was performed.Ni or Cu atoms were shown to adopt the corresponding position to the bcc structure of the Fe(100) substrate.Other calculations showed that the interfaces of Ni(5 atomic layers)/Fe(100)(5 layers) or Cu(5 atomic layers)/Fe(100)(5 layers) had square lattices.The orientation relationship of Ni/Fe(100) interface corresponds to fcc-Ni(100)//bcc-Fe(100),Ni[011]//Fe[010],and Ni[011]//Fe[001].Similar results were obtained for Cu/Fe(100) interfaces.This structure was supported by TEM analysis of plated Ni layer on Fe(100) surfaces.The adhesion strength of the Ni/Fe(100) interface evaluated by first principles calculation was higher than that of the Cu/Fe(100) interface.The experimental results of Hull cell iron plated with Ni or Cu supported the results of the calculation.These results indicate that the first principles calculation,which deals with the ideal interface at the atomic scale,has the potential to evaluate the adhesion strength of metallic material interfaces.展开更多
Methods for estimating the overconsolidation ratio(OCR)of soil deposits from piezocone sounding results have been investigated.Three existing methods have been briefly reviewed and a new method has been proposed.The p...Methods for estimating the overconsolidation ratio(OCR)of soil deposits from piezocone sounding results have been investigated.Three existing methods have been briefly reviewed and a new method has been proposed.The proposed method can be applied to both normally consolidated/overconsolidated and underconsolidated deposits.Furthermore,existing methods have been modified so that they can be applied to underconsolidated deposits.Then,all the methods have been applied to 12 case histories collected from 6 different countries.The estimated values of OCR have been compared with the measured data.It has been shown that if the parameters(soil properties and empirical parameters)can be determined appropriately,then all the methods can achieve a reasonable prediction.It has also been shown that the proposed method exhibits a relatively better performance and results in less scattered data than the other methods.展开更多
The automated stopping of a spectral measurement with active learning is proposed.The optimal stopping of the measurement is realised with a stopping criterion based on the upper bound of the posterior average of the ...The automated stopping of a spectral measurement with active learning is proposed.The optimal stopping of the measurement is realised with a stopping criterion based on the upper bound of the posterior average of the generalisation error of the Gaussian process regression.It is revealed that the automated stopping criterion of the spectral measurement gives an approximated X-ray absorption spectrum with sufficient accuracy and reduced data size.The proposed method is not only a proof-of-concept of the optimal stopping problem in active learning but also the key to enhancing the efficiency of spectral measurements for highthroughput experiments in the era of materials informatics.展开更多
Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme...Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the MHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.展开更多
This study focuses on the use of heavy fuel oil in construction in Burkina Faso.Mixed with silty and/or clay soil,it is used as a coating to reinforce the walls of raw soil constructions which are very sensitive to wa...This study focuses on the use of heavy fuel oil in construction in Burkina Faso.Mixed with silty and/or clay soil,it is used as a coating to reinforce the walls of raw soil constructions which are very sensitive to water.The interest of this paper is to shed light on the thermomechanical and above all water effects of heavy fuel oil on a sample of silty clayey soil.To achieve this,we used heavy fuel oil added in different proportions to silty clayey soil,to make sample of bricks on which tests were carried out.At the end of the experimental tests carried out on materials made(bricks)with our soil sample,it appears that heavy fuel oil moderately reduces the mechanical resistance of bricks and slightly increases thermal diffusion through them.On the contrary,we note a very good water resistance of the bricks thanks to the heavy fuel oil,in particular their water absorption by capillarity.This confirms that the mixture of heavy fuel oil and a silty-clayey soil used as a coating makes it possible to prevent the infiltration of water into the walls of raw soil constructions.However,its use as a construction material does not guarantee very good mechanical resistance,and slightly increases thermal diffusion.展开更多
This paper aims to derive the optimal switching strategy for production system considering efficiency, delivery time and green evaluation. Nowadays more and more manufacturing and logistics systems not only pursue bet...This paper aims to derive the optimal switching strategy for production system considering efficiency, delivery time and green evaluation. Nowadays more and more manufacturing and logistics systems not only pursue better work efficiency, but also focus on green energy evaluation issues. Cost reduction and shortening of delivery time are always important management issues in pursuit of efficiency and optimization of the entire production system because of global production competition. In a market situation where customer needs change in various ways, in particular, due to inadequate quality, changes in the local environment, natural disasters and so on. Therefore, prompt planning of management measures such as switching work processes and changing production methods has become an important issue. On the other hand, since the Paris Agreement came into effect, the construction of an environment-friendly production system has been required as an approach to environmental problems such as global warming. In this paper, we propose an optimum switching model of production systems considering efficiency, delivery time and green evaluation using a green evaluation index (GEC: Green Energy Coefficient). We also discuss the optimal switching strategy by numerical observation.展开更多
There is a close relation between the characteristics of products and the chemical composition control of inclusions in steelmaking process. Therefore, it is very important for a warranty of product’s characteristics...There is a close relation between the characteristics of products and the chemical composition control of inclusions in steelmaking process. Therefore, it is very important for a warranty of product’s characteristics to improve inclusion quality resulting in defective products. In the present work, the control technique of inclusions’ chemical composition is discussed thermodynamically based on the Redlich-Kister type polynomial to metallic solution and regular solution model to molten oxide solution. It is very effective for the precise chemical composition control of oxides to determine the concentration of deoxidizers based on the thermodynamic relation among dissolved deoxidizers and oxygen, because it is known that oxide inclusions are equilibrated with them in molten steel in the steel making process. High alloy steel production process was focused in the present work.展开更多
Vanadium alloy is proposed as an attractive candidate for first wall and blanket structural material of fusion reactors. The retention and release behaviors of hydrogen and helium in vanadium alloy may be an important...Vanadium alloy is proposed as an attractive candidate for first wall and blanket structural material of fusion reactors. The retention and release behaviors of hydrogen and helium in vanadium alloy may be an important issue. In the present work, 1.7 keV deuterium and 5 keV helium ions are respectively implanted into V-4Cr-4Ti and V-4Ti at room temperature. The retention and release of deuterium and helium are measured with thermal desorption spectroscopy (TDS). When the helium ion fluence is larger than 3 × 1017 He/cm2, the retained helium saturates with a value of approximately 2.5 ×1017 He/cm2. However, when the ion fluence is 1×1019 D/cm2, the hydrogen saturation in vanadium alloy does not take place. Experimental results indicates that hydrogen and helium retention in vanadium alloy may lead to serious problems and special attention should be paid when it is applied to fusion reactors.展开更多
Materials informatics has significantly accelerated the discovery and analysis of materials in the past decade.One of the key contributors to accelerated materials discovery is the use of on-the-fly data analysis with...Materials informatics has significantly accelerated the discovery and analysis of materials in the past decade.One of the key contributors to accelerated materials discovery is the use of on-the-fly data analysis with high-throughput experiments,which has given rise to the need for accelerated and accurate automated estimation of the properties of materials.In this regard,spectroscopic data are widely used for materials discovery because these data include essential information about materials.An important requirement for the realisation of the automated estimation of materials parameters is the selection of a similarity measure,or kernel function.The required measure should be robust in terms of peak shifting,peak broadening,and noise.However,the determination of appropriate similarity measures for spectra and the automated estimation of materials parameters from these spectra currently remain unresolved.We examined major similarity measures to evaluate the similarity of both X-ray absorption and electron energy-loss spectra.The similarity measures show good correspondence with the materials parameter,that is,the crystal-field parameter,in all measures.The Pearson's correlation coefficient was the highest for the robustness against noise and peak broadening.We obtained the regression model for the crystal-field parameter 10 Dq from the similarity of the spectra.The regression model enabled the materials parameter,that is,10 Dq,to be automatically estimated from the spectra.With regard to research progress in similarity measures,this methodology would make it possible to extract the materials parameter from a large-scale dataset of experimental data.展开更多
The field strengths of cement/lime treated clays were investigated in the Ariake Sea costal lowlands.The deposition environment of the investigation location is reconstructed and compared to the present ground environ...The field strengths of cement/lime treated clays were investigated in the Ariake Sea costal lowlands.The deposition environment of the investigation location is reconstructed and compared to the present ground environment.The mechanism of the ground environment change and its effect on the strength of cement/lime treated soil are discussed.The strength development of improved soil using cement and lime in different curing environments was investigated in the laboratory for studying the effect of environment change on the strength also.It has been found that the strength deterioration of improved soil in deep mixing method is due to 1)the ground environment change due to the secondary oxidation which results in low pH value and high organic content,and 2)the formations of the porous structures result from the elution of the calcium ions.Also,it has been found that the initial strength increase of the improved soil is related to the dissolved silica and that the dissolution of the silica in clay minerals needs long time.When examining the longterm strength for preventing strength degradation,the effect of environmental change has to be considered.The importance of measuring pH and oxidation-reduction potential(ORP)of the ground for cement/lime solidification method is explained.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.51379125,51411130131 and 11272120)the National Key Basic Research Development of China(973 Program,Grant No.2013CB036103)+1 种基金the High Te-chnology of Marine Research Project of the Ministry of Indu-stry and the Information Technology of Chinathe Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(Grant No.2013022)
文摘This paper presents a comparative study of a meshless level-set method in the simulation of sloshing flows. The numerical moving particle semi-implicit （MPS） method and a grid based schemes of the MPS and level-set methods are outlined and two violent sloshing cases are considered. The computed results are compared with the corresponding experimental data for validation. The impact pressure and the deformations of free surface induced by sloshing are comparatively analyzed, and are in good agreement with experimental ones. Results show that both the MPS and level-set methods are good tools for simulation of violent sloshing flows. However, the second pressure peaks as well as breaking and splashing of free surface by the MPS method are captured better than by the level-set method.
文摘The effects of alloying elements on zincate treatment and adhesion of electroless Ni-P coating onto various aluminum alloy substrates were examined.Surface morphology of zinc deposits in the 1st zincate treatment and its adhesion were changed depending on the alloying element.The zinc deposits in the 2nd zincate treatment became thinly uniform,and the adhesion between aluminum alloy substrate and Ni-P coating was improved irrespective of the alloying element.XPS analysis revealed the existence of zinc on the surface of each aluminum alloy substrate after the pickling in 5% nitric acid.This zinc on the surface should be an important factor influencing the morphology of zinc deposit at the 2nd zincate treatment and its adhesion.
文摘The monomer agglomeration of nonmetallic inclusions was simulated with a diffusion limited aggregation （DLA） model of the fractal theory. The simulation study with a random two-dimensional diffusion was carried out. The results indicate that the DLA model can be used for the simulation of agglomeration behavior of the cluster-type inclusions. The morphology of clusters was observed with SEM and compared with the simulated agglomerates. The modelling procedure of the DLA model is applicable for the agglomeration process. The uncertainty of agglomeration process and the persuasive average agglomerative ratio was analyzed. The factors about the agglomerative ratio with the collision path distance and the size of particles or seed were discussed. The adherence of the nonmetallic inclusions on the dam, the weir and the walls of a tundish, and the absorption of inclusions by stopper or nozzle were also discussed.
基金The STXM experiment was performed with the approval of the Photon Factory Program Advisory Committee(Proposal No.2015MP004)The XAS and XMCD experiments were performed at HSRC with the approval of the Proposal Assessing Committee(Proposal No.11-B-14)T.U.acknowledges the support of JSPS KAKENHI Grant Number 15K17458.H.H.is supported by JSPS KAKENHI Grant Numbers 16K16108 and 25120011.
文摘Spectroscopy is a widely used experimental technique,and enhancing its efficiency can have a strong impact on materials research.We propose an adaptive design for spectroscopy experiments that uses a machine learning technique to improve efficiency.We examined X-ray magnetic circular dichroism(XMCD)spectroscopy for the applicability of a machine learning technique to spectroscopy.An XMCD spectrum was predicted by Gaussian process modelling with learning of an experimental spectrum using a limited number of observed data points.Adaptive sampling of data points with maximum variance of the predicted spectrum successfully reduced the total data points for the evaluation of magnetic moments while providing the required accuracy.The present method reduces the time and cost for XMCD spectroscopy and has potential applicability to various spectroscopies.
文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy.
文摘An environmental friendly anodizing treatment (Anomag) from a phosphate-based so lution without heavy metals on AZ91D magnesium alloy was studied. The characteri stics of the coatings, such as structure, composition and corrosion resistance w ere investigated. The effects of this anodizing treatment on the mechanical prop erties were examined. X-ray diffraction (XRD) analysis revealed that the structu re of the coatings is amorphous or glassy. In salt spray tests coatings with an average thickness of 10μm had an anticorrosive performance of over 1000 hours. Fatigue tests revealed that anodizing onto AZ91D magnesium alloy does not affect the fatigue strength. These results demonstrate the utility of this anodizing t reatment on magnesium alloy for application as a structural material, such as in the automotive field.
文摘The fixing of a silane coupling agent to Zn-Ni-silica(SiO_(2))composite coatings was studied for the purpose of developing a coating process as an alternative to chromating.The corrosion resistance of Zn-Ni-silica composite coatings was rem arkably improved by the silica nanoparticles in the composite,which were disper sed in the surface of this film.The silane coupling agent formed chemical bonds with the inorganic silica particles during the silane coupling treatment on the se composite coatings.The treatment suppressed the formation of white corrosion products to the same extent as chromating,as measured in salt spray tests.It is concluded that treating Zn-Ni-silica composite coatings with silane coupling agents is a viable alternative technique to chromating.
文摘Background: Hiccups are common somatic side effects of medication. Our previous analysis of the clinical risk factors for hiccups identified chemotherapy as a factor related to hiccup risk. Therefore, in the present study, we investigated the risk factors for hiccups associated with chemotherapy. Methods: We included all patients who received cancer chemotherapy and were hospitalized at the Musashino Red Cross Hospital between April 2014 and December 2014. We investigated patient demographics, physical characteristics, and other clinical factors to identify the risk factors for chemotherapy-induced hiccups (CIH). We conducted univariate and multivariable analysis to compare the CIH group and the non-CIH and determined risk factors of CIH. Results: Hiccups were identified in 48 of 292 patients with an incidence rate of 16.4%. Univariate analysis revealed that the male gender, pain, and nausea and vomiting were related to CIH. It also showed that cisplatin, pemetrexed, gemcitabine, etoposide, dexamethasone, and metoclopramide were related to CIH.A correlation which was found with doses of cisplatin, pemetrexed, gemcitabine, and etoposide. Multivariable analysis identified male gender (OR, 72.69;95% CI, 6.95 - 757.64), nausea and vomiting (OR, 52.01;95% CI, 3.93 - 447.13), dexamethasone (OR, 4.55;95% CI, 1.12 - 16.91), cisplatin (OR, 3.84;95% CI, 1.52 - 9.70), and etoposide (OR, 3.72;95% CI, 1.14 - 12.11) as independent risk factors for hiccups. Conclusions: The present study is the first one to report risk factors for the development of CIH. Our results suggest that male gender, having nausea, and the drugs dexamethasone, cisplatin, and etoposide are important risk factors for CIH. These results may assist in elucidation of the underlying mechanisms and guide therapy to reduce hiccup risk.
基金Mr.A.Saito,technician at the Graduate School of Science and Engineering,Saga University,Japan and Mr.T.Shimizu,graduate of the Faculty of Science and Engineering,Saga University conducted the direct shear tests reported in this study.This work has been supported by the National Natural Science Foundation of China(NSFC)with a grant No.51578333the Grants-in-Aid for Scientific Research(KAKENHI)of the Japanese Society for the Promotion of Science(JSPS)with a grant number of 15K06212.
文摘The effect of pore water chemistry on anisotropic behavior of consolidation and shear strength of reconstituted Ariake clay has been investigated experimentally.Two types of chemicals added into the pore water of the soil for enhancing flocculation microstructure of soil particles are sodium chloride(salt)(NaCl),and calcium chloride(CaCl_(2));and two dispersants added are sodium triphosphate(Na_(5)-P_(3)O_(10))and sodium hexametaphosphate(Na_(6)P_(6)O_(18)),respectively.The concentrations of these chemicals in pore water were 2-3%.Degrees of anisotropy of the coefficient of consolidation and undrained shear strength decreased with adding NaCl and CaCl_(2),but increased with adding the dispersants.Degree of anisotropy also increased with one-dimensional(1D)deformation and the samples with dispersive additives had higher increase rate.It has been confirmed qualitatively by scanning electron microscopy(SEM)images that adding dispersive chemicals promoted the formation of dispersive microstructure and increased the degree of anisotropy,and the chemicals enhancing flocculent microstructure had an inverse effect.The possible application of the findings to underground construction has been discussed also.
文摘A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was performed.Ni or Cu atoms were shown to adopt the corresponding position to the bcc structure of the Fe(100) substrate.Other calculations showed that the interfaces of Ni(5 atomic layers)/Fe(100)(5 layers) or Cu(5 atomic layers)/Fe(100)(5 layers) had square lattices.The orientation relationship of Ni/Fe(100) interface corresponds to fcc-Ni(100)//bcc-Fe(100),Ni[011]//Fe[010],and Ni[011]//Fe[001].Similar results were obtained for Cu/Fe(100) interfaces.This structure was supported by TEM analysis of plated Ni layer on Fe(100) surfaces.The adhesion strength of the Ni/Fe(100) interface evaluated by first principles calculation was higher than that of the Cu/Fe(100) interface.The experimental results of Hull cell iron plated with Ni or Cu supported the results of the calculation.These results indicate that the first principles calculation,which deals with the ideal interface at the atomic scale,has the potential to evaluate the adhesion strength of metallic material interfaces.
基金The field data of Saga site have been provided by the Ariake Sea Coastal Road Development Office(ASCRDO),Saga Prefecture,Japan.This research is partially funded by the International Science and Technology Cooperation Program of China,with a grant number of 2015DFA71550Grants-in-Aid for Scientific Research(KAKENHI)of Japan Society for the Promotion of Science(JSPS)with grant number of 15K06212.
文摘Methods for estimating the overconsolidation ratio(OCR)of soil deposits from piezocone sounding results have been investigated.Three existing methods have been briefly reviewed and a new method has been proposed.The proposed method can be applied to both normally consolidated/overconsolidated and underconsolidated deposits.Furthermore,existing methods have been modified so that they can be applied to underconsolidated deposits.Then,all the methods have been applied to 12 case histories collected from 6 different countries.The estimated values of OCR have been compared with the measured data.It has been shown that if the parameters(soil properties and empirical parameters)can be determined appropriately,then all the methods can achieve a reasonable prediction.It has also been shown that the proposed method exhibits a relatively better performance and results in less scattered data than the other methods.
基金This work was supported by JST-Mirai Program Grant Numbers JPMJMI19G1 and JPMJMI21G2T.U.acknowledges the support of JSPS KAKENHI Grant Number JP18K13984 and QST President’s Strategic Grant(Exploratory Research).H.H.acknowledges the support of NEDO Grant Number JPNP18002 and JST CREST Grant Number JPMJCR1761+2 种基金This work was carried out under the ISM Cooperative Research Program(H30-J-4302 and 2019-ISMCRP-4206)The XAS experiment was performed under the approval of the Photon Factory Program Advisory Committee(Proposal No.2018MP001)The authors thank Dr.Yasuo Takeichi for the support of the experiments at the Photon Factory.
文摘The automated stopping of a spectral measurement with active learning is proposed.The optimal stopping of the measurement is realised with a stopping criterion based on the upper bound of the posterior average of the generalisation error of the Gaussian process regression.It is revealed that the automated stopping criterion of the spectral measurement gives an approximated X-ray absorption spectrum with sufficient accuracy and reduced data size.The proposed method is not only a proof-of-concept of the optimal stopping problem in active learning but also the key to enhancing the efficiency of spectral measurements for highthroughput experiments in the era of materials informatics.
文摘Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the MHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.
文摘This study focuses on the use of heavy fuel oil in construction in Burkina Faso.Mixed with silty and/or clay soil,it is used as a coating to reinforce the walls of raw soil constructions which are very sensitive to water.The interest of this paper is to shed light on the thermomechanical and above all water effects of heavy fuel oil on a sample of silty clayey soil.To achieve this,we used heavy fuel oil added in different proportions to silty clayey soil,to make sample of bricks on which tests were carried out.At the end of the experimental tests carried out on materials made(bricks)with our soil sample,it appears that heavy fuel oil moderately reduces the mechanical resistance of bricks and slightly increases thermal diffusion through them.On the contrary,we note a very good water resistance of the bricks thanks to the heavy fuel oil,in particular their water absorption by capillarity.This confirms that the mixture of heavy fuel oil and a silty-clayey soil used as a coating makes it possible to prevent the infiltration of water into the walls of raw soil constructions.However,its use as a construction material does not guarantee very good mechanical resistance,and slightly increases thermal diffusion.
文摘This paper aims to derive the optimal switching strategy for production system considering efficiency, delivery time and green evaluation. Nowadays more and more manufacturing and logistics systems not only pursue better work efficiency, but also focus on green energy evaluation issues. Cost reduction and shortening of delivery time are always important management issues in pursuit of efficiency and optimization of the entire production system because of global production competition. In a market situation where customer needs change in various ways, in particular, due to inadequate quality, changes in the local environment, natural disasters and so on. Therefore, prompt planning of management measures such as switching work processes and changing production methods has become an important issue. On the other hand, since the Paris Agreement came into effect, the construction of an environment-friendly production system has been required as an approach to environmental problems such as global warming. In this paper, we propose an optimum switching model of production systems considering efficiency, delivery time and green evaluation using a green evaluation index (GEC: Green Energy Coefficient). We also discuss the optimal switching strategy by numerical observation.
文摘There is a close relation between the characteristics of products and the chemical composition control of inclusions in steelmaking process. Therefore, it is very important for a warranty of product’s characteristics to improve inclusion quality resulting in defective products. In the present work, the control technique of inclusions’ chemical composition is discussed thermodynamically based on the Redlich-Kister type polynomial to metallic solution and regular solution model to molten oxide solution. It is very effective for the precise chemical composition control of oxides to determine the concentration of deoxidizers based on the thermodynamic relation among dissolved deoxidizers and oxygen, because it is known that oxide inclusions are equilibrated with them in molten steel in the steel making process. High alloy steel production process was focused in the present work.
基金The project supported by China-Japan Core University Program (Taskl-2A)
文摘Vanadium alloy is proposed as an attractive candidate for first wall and blanket structural material of fusion reactors. The retention and release behaviors of hydrogen and helium in vanadium alloy may be an important issue. In the present work, 1.7 keV deuterium and 5 keV helium ions are respectively implanted into V-4Cr-4Ti and V-4Ti at room temperature. The retention and release of deuterium and helium are measured with thermal desorption spectroscopy (TDS). When the helium ion fluence is larger than 3 × 1017 He/cm2, the retained helium saturates with a value of approximately 2.5 ×1017 He/cm2. However, when the ion fluence is 1×1019 D/cm2, the hydrogen saturation in vanadium alloy does not take place. Experimental results indicates that hydrogen and helium retention in vanadium alloy may lead to serious problems and special attention should be paid when it is applied to fusion reactors.
基金This work is partly supported by the Elements Strategy Initiative Centre for Magnetic Materials(ESICMM)under the outsourcing project of the Ministry of Education,Culture,Sports,Science,Technology(MEXT)This work is partly supported in part by‘Materials Research by Information Integration’Initiative(MI2I)project of the Support Program for Starting Up Innovation Hub from Japan Science and Technology Agency(JST)+1 种基金H.H.is partly supported by JST CREST grant number JPMJCR1761.Y.S.is supported by JST,ACT-I,grant Number JPMJPR18UEK.O.gratefully acknowledges the financial support by Toyota Motor Corporation.
文摘Materials informatics has significantly accelerated the discovery and analysis of materials in the past decade.One of the key contributors to accelerated materials discovery is the use of on-the-fly data analysis with high-throughput experiments,which has given rise to the need for accelerated and accurate automated estimation of the properties of materials.In this regard,spectroscopic data are widely used for materials discovery because these data include essential information about materials.An important requirement for the realisation of the automated estimation of materials parameters is the selection of a similarity measure,or kernel function.The required measure should be robust in terms of peak shifting,peak broadening,and noise.However,the determination of appropriate similarity measures for spectra and the automated estimation of materials parameters from these spectra currently remain unresolved.We examined major similarity measures to evaluate the similarity of both X-ray absorption and electron energy-loss spectra.The similarity measures show good correspondence with the materials parameter,that is,the crystal-field parameter,in all measures.The Pearson's correlation coefficient was the highest for the robustness against noise and peak broadening.We obtained the regression model for the crystal-field parameter 10 Dq from the similarity of the spectra.The regression model enabled the materials parameter,that is,10 Dq,to be automatically estimated from the spectra.With regard to research progress in similarity measures,this methodology would make it possible to extract the materials parameter from a large-scale dataset of experimental data.
基金The authors are grateful to the Japan Society for the Promotion of Science for funding the present research work under Grant-in-Aid for Scientific Research$Scientific Research B,23360204(Principal Investigator:Takenori Hino)Grant-in-Aid for Scientific Research·Challenging Exploratory Research,23656300(Principal Investigator:Takenori Hino).
文摘The field strengths of cement/lime treated clays were investigated in the Ariake Sea costal lowlands.The deposition environment of the investigation location is reconstructed and compared to the present ground environment.The mechanism of the ground environment change and its effect on the strength of cement/lime treated soil are discussed.The strength development of improved soil using cement and lime in different curing environments was investigated in the laboratory for studying the effect of environment change on the strength also.It has been found that the strength deterioration of improved soil in deep mixing method is due to 1)the ground environment change due to the secondary oxidation which results in low pH value and high organic content,and 2)the formations of the porous structures result from the elution of the calcium ions.Also,it has been found that the initial strength increase of the improved soil is related to the dissolved silica and that the dissolution of the silica in clay minerals needs long time.When examining the longterm strength for preventing strength degradation,the effect of environmental change has to be considered.The importance of measuring pH and oxidation-reduction potential(ORP)of the ground for cement/lime solidification method is explained.
