Colitis-associated colorectal cancer(CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease(IBD) patients. CA-CRC results from the accumulation of mutations in intestinal epithelial cells and progresse...Colitis-associated colorectal cancer(CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease(IBD) patients. CA-CRC results from the accumulation of mutations in intestinal epithelial cells and progresses through a well-characterized inflammation to dysplasia to carcinoma sequence. Quantitative estimates of overall CA-CRC risks are highly variable ranging from 2% to 40% depending on IBD severity, duration and location, with IBD duration being the most significant risk factor associated with CA-CRC development. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. One suggestion is that select IBD patients carry polymorphisms in various low penetrance disease susceptibility genes, which predispose them to CA-CRC development, although these loci have proven difficult to identify in human genomewide association studies. Mouse models of CA-CRC have provided a viable alternative for the discovery, validation and study of individual genes in CA-CRC pathology. In this review, we summarize the current CA-CRC literature with a strong focus on genetic predisposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles.展开更多
BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors ap...BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory complaints.METHODS We conducted a prospective case control study from March 2020 to May 2021.Patients recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by serology.Post-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology department.Psychiatric medical histories were collected by a psychiatrist during the assessments.RESULTS Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the study.Fifty percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 years.The control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 years.The rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent anosmia.It therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk patients.Further prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.展开更多
Significant efforts have been made to identify modifiable risk factors of non-contact anterior cruciate ligament(ACL)injuries in male and female athletes.However,current literature on the risk factors for ACL injury a...Significant efforts have been made to identify modifiable risk factors of non-contact anterior cruciate ligament(ACL)injuries in male and female athletes.However,current literature on the risk factors for ACL injury are purely descriptive.An understanding of biomechanical relationship between risk and risk factors of the non-contact ACL injury is necessary to develop effective prevention programs.Purpose:To compare lower extremity kinematics and kinetics between trials with and without non-contact ACL injuries and to determine if any difference exists between male and female trials with non-contact ACL injuries regarding the lower extremity motion patterns.Methods:In this computer simulation study,a stochastic biomechanical model was used to estimate the ACL loading at the time of peak posterior ground reaction force(GRF)during landing of the stop-jump task.Monte Carlo simulations were performed to simulate the ACL injuries with repeated random samples of independent variables.The distributions of independent variables were determined from in vivo laboratory data of 40 male and 40 female recreational athletes.Results:In the simulated injured trials,both male and female athletes had significantly smaller knee flexion angles,greater normalized peak posterior and vertical GRF,greater knee valgus moment,greater patella tendon force,greater quadriceps force,greater knee extension moment,and greater proximal tibia anterior shear force in comparison to the simulated uninjured trials.No significant difference was found between genders in any of the selected biomechanical variables in the trials with simulated non-contact ACL injuries.Conclusion:Small knee flexion angle,large posterior GRF,and large knee valgus moment are risk factors of non-contact ACL injury determined by a stochastic biomechanical model with a cause-and-effect relationship.Copyright(c)2012,Shanghai University of Sport.Production and hosting by Elsevier B.V.All rights reserved.展开更多
Sexual dimorphism is a widespread phenomenon in Lepidoptera.It is reflected in differences in life history,behavior and morphology.Analyses of differences in behavior are mostly difficult and time-consuming,especially...Sexual dimorphism is a widespread phenomenon in Lepidoptera.It is reflected in differences in life history,behavior and morphology.Analyses of differences in behavior are mostly difficult and time-consuming,especially in high mountain ecosystems.To enhance our knowledge on sexual dimorphisms of alpine butterflies,we performed a mark-release-recapture study on 2 species common in the Alps:Boloriapales and Boloria napaea.We analysed movement and foraging behavior to investigate differences between sexes.Both sexes were mostly sedentary and the movement distances of males and females similar.However,obvious differences in dispersal behavior between the sexes were found in the movement patterns.Three different patterns were distinguished.Most males showed intensive flight activity,but mostly flew only in a limited part of the entire habitat (i.e.,their individual home range)searching for females,whereas females were less flight active and flew only to find places for oviposition or feeding.The third pattern,where individuals flew larger distances,was only observed in a small number of males,which always returned to their home range.Nearly all feeding was observed on Asteraceae.However,males preferred the genera Leontodon and Crepis,while females preferred Leontodon and Carduus.Apart from this sexual difference in foraging,individuals of both sexes were found to be more or less specialised on nectar sources.Flight activity was generally greater in males than females.Therefore,we think that sex-specific requirements in nectar ingredients exist,that is,sugar for the intensive flight activity of males and amino acids for egg production of females.展开更多
We present ultra low energy results taken with the novel Spherical Proportional Counter. The energy threshold has been pushed down to about 25 eV and single electrons are clearly collected and detected. To reach such ...We present ultra low energy results taken with the novel Spherical Proportional Counter. The energy threshold has been pushed down to about 25 eV and single electrons are clearly collected and detected. To reach such a performance two low energy calibration systems have been successfully developed: a pulsed UV lamp extracting photoelectrons from the inner surface of the detector and various radioactive sources allowing low energy peaks through fluorescence processes. The bench mark result is the observation of a well resolved peak at 270 eV due to carbon fluorescence, which is a unique performance for such large massive detector. It opens up a new window in dark matter and low energy neutrino searches and it may allow the detection of neutrinos from a nuclear reactor or from supernova via neutrino-nucleus elastic scattering.展开更多
本试验的目的是评价抗坏血酸(AA)和环境应激之间的相互作用对鸡抗大肠杆菌攻击感染的影响.材料和方法试验用鸡、攻击感染、应激评价:(这几项所用方法与前一篇文章所述相似——本刊编者注)试验1 LA 和 HA 系鸡〔即对绵羊红血球具有低(LA...本试验的目的是评价抗坏血酸(AA)和环境应激之间的相互作用对鸡抗大肠杆菌攻击感染的影响.材料和方法试验用鸡、攻击感染、应激评价:(这几项所用方法与前一篇文章所述相似——本刊编者注)试验1 LA 和 HA 系鸡〔即对绵羊红血球具有低(LA)和高(LA)抗体应答的鸡〕在用大肠杆菌攻击前一天在10℃房间中待2小时.从攻击前一天开始一直到试验结束,每千克饲料中添加0、220、330或440毫克 AA.在应激作用前和攻击时,采血测定 H/L比值.每个鸡系分4个不同剂量组,共为8组,每组11只鸡,共88只.展开更多
有证据表明,抗坏血酸(即维生素 C,简称为AA)和吞噬作用之间有一定的关系.感染禽伤寒的鸡,其血浆中的 AA 水平降低,而在饲料中添加 AA(每千克饲料添加1000毫升)后,虽不能完全控制禽霍乱引起的死亡.但能减少早期死亡(Satterfield,1940)....有证据表明,抗坏血酸(即维生素 C,简称为AA)和吞噬作用之间有一定的关系.感染禽伤寒的鸡,其血浆中的 AA 水平降低,而在饲料中添加 AA(每千克饲料添加1000毫升)后,虽不能完全控制禽霍乱引起的死亡.但能减少早期死亡(Satterfield,1940).适量水平的 AA 可增加吞噬细胞中过氧化物基团的数量,而且 AA 水平进一步提高可增加过氧化物基团的降解.本试验的目的是评价在饲料中添加 AA 是否会影响鸡体对大肠杆菌攻击的应答。展开更多
基金Supported by The Cancer Research Society,No.19490(to Beauchemin N and Gros P).Van Der Kraak L is the recipient of a Canadian Institute of Health Research Doctoral Award(PA-Digestive Health)and a Mc Gill Integrated Cancer Research Training Program studentship
文摘Colitis-associated colorectal cancer(CA-CRC) is the cause of death in 10%-15% of inflammatory bowel disease(IBD) patients. CA-CRC results from the accumulation of mutations in intestinal epithelial cells and progresses through a well-characterized inflammation to dysplasia to carcinoma sequence. Quantitative estimates of overall CA-CRC risks are highly variable ranging from 2% to 40% depending on IBD severity, duration and location, with IBD duration being the most significant risk factor associated with CA-CRC development. Recently, studies have identified IBD patients with similar patterns of colonic inflammation, but that differ with respect to CA-CRC development, suggesting a role for additional non-inflammatory risk factors in CA-CRC development. One suggestion is that select IBD patients carry polymorphisms in various low penetrance disease susceptibility genes, which predispose them to CA-CRC development, although these loci have proven difficult to identify in human genomewide association studies. Mouse models of CA-CRC have provided a viable alternative for the discovery, validation and study of individual genes in CA-CRC pathology. In this review, we summarize the current CA-CRC literature with a strong focus on genetic predisposition and highlight an emerging role for mouse models in the search for CA-CRC risk alleles.
文摘BACKGROUND Anosmia was one of the main symptoms of coronavirus disease 2019(COVID-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVID-19 diagnosis,and COVID-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVID patients without anosmia vs patients with persistent olfactory complaints.METHODS We conducted a prospective case control study from March 2020 to May 2021.Patients recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by serology.Post-COVID patients without persistent olfactory disorders were recruited at the university hospital infectiology department.Psychiatric medical histories were collected by a psychiatrist during the assessments.RESULTS Thirty-four patients with post-COVID-19 olfactory complaints were included in the first group of the study.Fifty percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 years.The control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 years.The rate of psychiatric disorder among post-COVID patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVID due to persistent anosmia.It therefore seems important to establish reinforced health monitoring after a COVID 19 infection in at-risk patients.Further prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.
文摘Significant efforts have been made to identify modifiable risk factors of non-contact anterior cruciate ligament(ACL)injuries in male and female athletes.However,current literature on the risk factors for ACL injury are purely descriptive.An understanding of biomechanical relationship between risk and risk factors of the non-contact ACL injury is necessary to develop effective prevention programs.Purpose:To compare lower extremity kinematics and kinetics between trials with and without non-contact ACL injuries and to determine if any difference exists between male and female trials with non-contact ACL injuries regarding the lower extremity motion patterns.Methods:In this computer simulation study,a stochastic biomechanical model was used to estimate the ACL loading at the time of peak posterior ground reaction force(GRF)during landing of the stop-jump task.Monte Carlo simulations were performed to simulate the ACL injuries with repeated random samples of independent variables.The distributions of independent variables were determined from in vivo laboratory data of 40 male and 40 female recreational athletes.Results:In the simulated injured trials,both male and female athletes had significantly smaller knee flexion angles,greater normalized peak posterior and vertical GRF,greater knee valgus moment,greater patella tendon force,greater quadriceps force,greater knee extension moment,and greater proximal tibia anterior shear force in comparison to the simulated uninjured trials.No significant difference was found between genders in any of the selected biomechanical variables in the trials with simulated non-contact ACL injuries.Conclusion:Small knee flexion angle,large posterior GRF,and large knee valgus moment are risk factors of non-contact ACL injury determined by a stochastic biomechanical model with a cause-and-effect relationship.Copyright(c)2012,Shanghai University of Sport.Production and hosting by Elsevier B.V.All rights reserved.
文摘Sexual dimorphism is a widespread phenomenon in Lepidoptera.It is reflected in differences in life history,behavior and morphology.Analyses of differences in behavior are mostly difficult and time-consuming,especially in high mountain ecosystems.To enhance our knowledge on sexual dimorphisms of alpine butterflies,we performed a mark-release-recapture study on 2 species common in the Alps:Boloriapales and Boloria napaea.We analysed movement and foraging behavior to investigate differences between sexes.Both sexes were mostly sedentary and the movement distances of males and females similar.However,obvious differences in dispersal behavior between the sexes were found in the movement patterns.Three different patterns were distinguished.Most males showed intensive flight activity,but mostly flew only in a limited part of the entire habitat (i.e.,their individual home range)searching for females,whereas females were less flight active and flew only to find places for oviposition or feeding.The third pattern,where individuals flew larger distances,was only observed in a small number of males,which always returned to their home range.Nearly all feeding was observed on Asteraceae.However,males preferred the genera Leontodon and Crepis,while females preferred Leontodon and Carduus.Apart from this sexual difference in foraging,individuals of both sexes were found to be more or less specialised on nectar sources.Flight activity was generally greater in males than females.Therefore,we think that sex-specific requirements in nectar ingredients exist,that is,sugar for the intensive flight activity of males and amino acids for egg production of females.
文摘We present ultra low energy results taken with the novel Spherical Proportional Counter. The energy threshold has been pushed down to about 25 eV and single electrons are clearly collected and detected. To reach such a performance two low energy calibration systems have been successfully developed: a pulsed UV lamp extracting photoelectrons from the inner surface of the detector and various radioactive sources allowing low energy peaks through fluorescence processes. The bench mark result is the observation of a well resolved peak at 270 eV due to carbon fluorescence, which is a unique performance for such large massive detector. It opens up a new window in dark matter and low energy neutrino searches and it may allow the detection of neutrinos from a nuclear reactor or from supernova via neutrino-nucleus elastic scattering.
文摘本试验的目的是评价抗坏血酸(AA)和环境应激之间的相互作用对鸡抗大肠杆菌攻击感染的影响.材料和方法试验用鸡、攻击感染、应激评价:(这几项所用方法与前一篇文章所述相似——本刊编者注)试验1 LA 和 HA 系鸡〔即对绵羊红血球具有低(LA)和高(LA)抗体应答的鸡〕在用大肠杆菌攻击前一天在10℃房间中待2小时.从攻击前一天开始一直到试验结束,每千克饲料中添加0、220、330或440毫克 AA.在应激作用前和攻击时,采血测定 H/L比值.每个鸡系分4个不同剂量组,共为8组,每组11只鸡,共88只.
文摘有证据表明,抗坏血酸(即维生素 C,简称为AA)和吞噬作用之间有一定的关系.感染禽伤寒的鸡,其血浆中的 AA 水平降低,而在饲料中添加 AA(每千克饲料添加1000毫升)后,虽不能完全控制禽霍乱引起的死亡.但能减少早期死亡(Satterfield,1940).适量水平的 AA 可增加吞噬细胞中过氧化物基团的数量,而且 AA 水平进一步提高可增加过氧化物基团的降解.本试验的目的是评价在饲料中添加 AA 是否会影响鸡体对大肠杆菌攻击的应答。
