Dutch housing associations are dealing with a growing number of tenants who are ageing in place.Meanwhile,there is a lack of suitable housing that meets the(social)needs of this target group.Clustered housing,which of...Dutch housing associations are dealing with a growing number of tenants who are ageing in place.Meanwhile,there is a lack of suitable housing that meets the(social)needs of this target group.Clustered housing,which offers a socio-spatial context that facilitates encounters between residents,is considered a promising housing concept to(partly)fill this gap.However,clustered housing is a broad concept consisting of a variety of housing types that differ from each other in the extent to which people“live together”.Still little is known about which types of clustered housing can be distinguished in relation to the potential for social interaction.Therefore,in this article we distinguish between types of clustered housing based on social,organizational,and spatial building characteristics.We have mapped these characteristics by combining real estate data of housing association Woonzorg Nederland with survey data collected among their building managers.Based on this dataset,an explorative cluster analysis was performed,resulting in four types of clustered housing.Finally,further exploration of the data shows that,from the perspective of building managers,residents of certain types of clustered housing interact more often and feel more connected with each other than residents of non-clustered housing types.展开更多
<strong>Background:</strong> The presence of the angiotensin-converting enzyme 2 (ACE2) receptor, the main entry receptor for SARS-CoV-2 in lung alveolar tissue, in Sertoli and Leydig cells of the adult te...<strong>Background:</strong> The presence of the angiotensin-converting enzyme 2 (ACE2) receptor, the main entry receptor for SARS-CoV-2 in lung alveolar tissue, in Sertoli and Leydig cells of the adult testis, may suggest possible testicular involvement during SARS-CoV-2 infection. Our aim was to investigate the impact of COVID-19 on gonadal function in men. <strong>Methods:</strong> This was a cross-sectional descriptive and analytical study in a population of men aged below 65 years of age with SARS-CoV-2. Not included in the study were any subjects on testosterone replacement therapy or with a known condition that could create hypogonadism. We recruited patients through a questionnaire and then performed total testosterone and SHBG analysis at 8 hours and 2 months post infection by ELISA. We used the Spearman Rho test for statistical analysis of correlations. The significance level was set at 0.05. <strong>Results:</strong> The sample consisted of 40 male COVID positive patients with a mean age of 46.4 ± 11.8 years. Eight patients were reviewed after infection. The mean total testosterone was 11 ng/ml ± 2.4 and the SHBG was 113 nmol/l ± 66.9 during infection. In the 8 patients reviewed after infection, median total testosterone decreased during infection (11 ng/ml) and increased after infection (12.7 ng/ml), this result was statistically significant (P = 0.028). Median SHBG during infection was increased (115.7 nmol/l) and after infection was decreased (82 nmol/l). There was a statistically significant (P = 0.04) and positive correlation between serum testosterone and SHBG levels in patients with severe infection. <strong>Conclusion:</strong> There could be a transient relative hypogonadism during SARS-CoV-2 infection, more marked in the severe forms of the disease with a tendency to improve after infection.展开更多
<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""> Various thyroid abnormalities have been reported during heart failure (HF). The present ...<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""> Various thyroid abnormalities have been reported during heart failure (HF). The present study aimed to evaluate the burden, type, and associated factors of thyroid disorders in Cameroonian patients with heart failure. <b>Materials and Methods:</b> We conducted a cross-sectional study from January to May 2020, involving volunteer adults followed for heart failure at the Yaoundé Central Hospital. Those receiving treatment that could cause thyroid dysfunction were excluded. Thyroid hormone levels (TSH, free T3, and free T4) were measured by enzyme-linked immunosorbent assay. <b>Results: </b>A total of 63 patients (30 women;47.6%) were included. The median age was 65 (IQR: 56 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 70) years. The main etiology of heart failure was hypertension</span><span style="white-space:normal;font-family:;" "=""> (52.4%) followed by valvular heart disease (14.3%). Thyroid dysfunction was seen in 38 (60.3%, [95% CI: 47.2 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 72.4]) patients, of which 30 (79%) had hypothyroidism and 8 (21%) had hyperthyroidism. The most frequent thyroid dysfunction was Low T3 syndrome in 27% (95% CI: 16.6 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 39.7) of the study population followed sub-clinical hypothyroidism in 19.1% (95% CI: 10.3 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 30.9) of patients. Patients with HF and reduced ejection fraction (HFrEF) were more likely to have hypothyroidism than those with preserved ejection fraction (OR: 3.5, [95% CI: 1.2 - 9.9], p = 0.016). Also, patients with more than one hospital admission in the past 12 months were more likely to have hypothyroi展开更多
Objectives. This study investigated the role of religion/spirituality (R/S) and coping in quality of life (QOL) in 129 women immediately prior to a course of adjuvant chemotherapy for ovarian cancer. Methods. Particip...Objectives. This study investigated the role of religion/spirituality (R/S) and coping in quality of life (QOL) in 129 women immediately prior to a course of adjuvant chemotherapy for ovarian cancer. Methods. Participants completed the COPE, the Functional Assessment of Cancer Therapy- Ovarian (FACT- O), and the Systems of Belief Inventory- 15R (SBI- 15R).Women averaged 58.9 years of age (SD = 11.5) and were primarily Caucasian (86% ), married (74% ), and had received at least some college education (67% ). Eighty- five percent of the participants had stage III or IV ovarian cancer at study entry. Results. Correlational analyses revealed that R/S was associated with active coping (r = 0.23, P = 0.022), overall QOL (r = 0.25, P = 0.012), emotional and functional well- being (r = 0.24, P = 0.014 and r = 0.28, P = 0.004), and fewer ovarian cancer- specific concerns (r = 0.27, P = 0.006). In addition, active coping was related to overall QOL (r = 0.22, P = 0.029)- and social and functional well- being (r = 0.20, P = 0.042 and r = 0.33, P = 0.001). Tests of mediation between these variables suggested that the positive associations between R/S and functional well- being and R/S and overall QOL were mediated through the use of active coping. Conclusion. Future studies are needed to better understand the complex relationships between R/S, coping, and QOL throughout the ovarian cancer treatment experience.展开更多
In this paper we use the auxiliary principle technique to suggest and analyze novel and innovative iterative algorithms for a class of nonlinear variational inequalities. Several special cases, which can be obtained ... In this paper we use the auxiliary principle technique to suggest and analyze novel and innovative iterative algorithms for a class of nonlinear variational inequalities. Several special cases, which can be obtained from our main results, are also discussed.展开更多
基金This article was written as part of a collaborative research project between the housing association Woonzorg Nederland(contributes financially),HAN University of Applied Sciences(Research Group Architecture in Health),and Eindhoven University of Technology(Chair Smart Architectural Technologies).The data presented was collected in collaboration with Woonzorg Nederland.Our special thanks go to our colleagues at Woonzorg Nederland,including all building managers of Woonzorg Nederland,who contributed to the research.
文摘Dutch housing associations are dealing with a growing number of tenants who are ageing in place.Meanwhile,there is a lack of suitable housing that meets the(social)needs of this target group.Clustered housing,which offers a socio-spatial context that facilitates encounters between residents,is considered a promising housing concept to(partly)fill this gap.However,clustered housing is a broad concept consisting of a variety of housing types that differ from each other in the extent to which people“live together”.Still little is known about which types of clustered housing can be distinguished in relation to the potential for social interaction.Therefore,in this article we distinguish between types of clustered housing based on social,organizational,and spatial building characteristics.We have mapped these characteristics by combining real estate data of housing association Woonzorg Nederland with survey data collected among their building managers.Based on this dataset,an explorative cluster analysis was performed,resulting in four types of clustered housing.Finally,further exploration of the data shows that,from the perspective of building managers,residents of certain types of clustered housing interact more often and feel more connected with each other than residents of non-clustered housing types.
文摘<strong>Background:</strong> The presence of the angiotensin-converting enzyme 2 (ACE2) receptor, the main entry receptor for SARS-CoV-2 in lung alveolar tissue, in Sertoli and Leydig cells of the adult testis, may suggest possible testicular involvement during SARS-CoV-2 infection. Our aim was to investigate the impact of COVID-19 on gonadal function in men. <strong>Methods:</strong> This was a cross-sectional descriptive and analytical study in a population of men aged below 65 years of age with SARS-CoV-2. Not included in the study were any subjects on testosterone replacement therapy or with a known condition that could create hypogonadism. We recruited patients through a questionnaire and then performed total testosterone and SHBG analysis at 8 hours and 2 months post infection by ELISA. We used the Spearman Rho test for statistical analysis of correlations. The significance level was set at 0.05. <strong>Results:</strong> The sample consisted of 40 male COVID positive patients with a mean age of 46.4 ± 11.8 years. Eight patients were reviewed after infection. The mean total testosterone was 11 ng/ml ± 2.4 and the SHBG was 113 nmol/l ± 66.9 during infection. In the 8 patients reviewed after infection, median total testosterone decreased during infection (11 ng/ml) and increased after infection (12.7 ng/ml), this result was statistically significant (P = 0.028). Median SHBG during infection was increased (115.7 nmol/l) and after infection was decreased (82 nmol/l). There was a statistically significant (P = 0.04) and positive correlation between serum testosterone and SHBG levels in patients with severe infection. <strong>Conclusion:</strong> There could be a transient relative hypogonadism during SARS-CoV-2 infection, more marked in the severe forms of the disease with a tendency to improve after infection.
文摘<strong>Background:</strong><span style="white-space:normal;font-family:;" "=""> Various thyroid abnormalities have been reported during heart failure (HF). The present study aimed to evaluate the burden, type, and associated factors of thyroid disorders in Cameroonian patients with heart failure. <b>Materials and Methods:</b> We conducted a cross-sectional study from January to May 2020, involving volunteer adults followed for heart failure at the Yaoundé Central Hospital. Those receiving treatment that could cause thyroid dysfunction were excluded. Thyroid hormone levels (TSH, free T3, and free T4) were measured by enzyme-linked immunosorbent assay. <b>Results: </b>A total of 63 patients (30 women;47.6%) were included. The median age was 65 (IQR: 56 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 70) years. The main etiology of heart failure was hypertension</span><span style="white-space:normal;font-family:;" "=""> (52.4%) followed by valvular heart disease (14.3%). Thyroid dysfunction was seen in 38 (60.3%, [95% CI: 47.2 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 72.4]) patients, of which 30 (79%) had hypothyroidism and 8 (21%) had hyperthyroidism. The most frequent thyroid dysfunction was Low T3 syndrome in 27% (95% CI: 16.6 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 39.7) of the study population followed sub-clinical hypothyroidism in 19.1% (95% CI: 10.3 </span><span style="white-space:normal;font-family:;" "="">-</span><span style="white-space:normal;font-family:;" "=""> 30.9) of patients. Patients with HF and reduced ejection fraction (HFrEF) were more likely to have hypothyroidism than those with preserved ejection fraction (OR: 3.5, [95% CI: 1.2 - 9.9], p = 0.016). Also, patients with more than one hospital admission in the past 12 months were more likely to have hypothyroi
文摘Objectives. This study investigated the role of religion/spirituality (R/S) and coping in quality of life (QOL) in 129 women immediately prior to a course of adjuvant chemotherapy for ovarian cancer. Methods. Participants completed the COPE, the Functional Assessment of Cancer Therapy- Ovarian (FACT- O), and the Systems of Belief Inventory- 15R (SBI- 15R).Women averaged 58.9 years of age (SD = 11.5) and were primarily Caucasian (86% ), married (74% ), and had received at least some college education (67% ). Eighty- five percent of the participants had stage III or IV ovarian cancer at study entry. Results. Correlational analyses revealed that R/S was associated with active coping (r = 0.23, P = 0.022), overall QOL (r = 0.25, P = 0.012), emotional and functional well- being (r = 0.24, P = 0.014 and r = 0.28, P = 0.004), and fewer ovarian cancer- specific concerns (r = 0.27, P = 0.006). In addition, active coping was related to overall QOL (r = 0.22, P = 0.029)- and social and functional well- being (r = 0.20, P = 0.042 and r = 0.33, P = 0.001). Tests of mediation between these variables suggested that the positive associations between R/S and functional well- being and R/S and overall QOL were mediated through the use of active coping. Conclusion. Future studies are needed to better understand the complex relationships between R/S, coping, and QOL throughout the ovarian cancer treatment experience.
文摘 In this paper we use the auxiliary principle technique to suggest and analyze novel and innovative iterative algorithms for a class of nonlinear variational inequalities. Several special cases, which can be obtained from our main results, are also discussed.
