The fission yield data in the 14 MeV energy neutron induced fission of^(238)U play an important role in decay heat calculations and generation-Ⅳ reactor designs.In order to accurately measure fission product yields(F...The fission yield data in the 14 MeV energy neutron induced fission of^(238)U play an important role in decay heat calculations and generation-Ⅳ reactor designs.In order to accurately measure fission product yields(FPYs)of^(238)U induced by 14 MeV neutrons,the cumulative yields of fission products ranging from^(92)Sr to^(147)Nd in the^(239)U(n,f) reaction with a 14.7 MeV neutron were determined using an off-line γ-ray spectrometric technique.The14.7 MeV quasi-monoenergetic neutron beam was provided by the K-400 D-T neutron generator at China Academy of Engineering Physics(CAEP).Fission products were measured by a low background high purity germanium gamma spectrometer.The neutron flux was obtained from the^(93)Nb(n.2n)^(92m)Nb reaction,and the mean neutron energy was calculated using the cross-section ratios for the^(90)Zr(n,2n)^(89)Zr and^(93)Nb(n,2n)^(92m)Nb reactions.With a series of corrections,high precision cumulative yields of 20 fission products were obtained.Our FPYs for the^(238)U(n,f) reaction at 14.7 MeV were compared with the existing experimental nuclear reaction data and evaluated nuclear data,respectively.The results will be helpful in the design of a generation-Ⅳ reactor and the construction of evaluated fission yield databases.展开更多
Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical rol...Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.展开更多
Increasing air movement by utilizing electric fans is among the common approaches for comfort and energy savings in buildings in summer;however,the use of electric fans is usually the forced constant airflow.This stud...Increasing air movement by utilizing electric fans is among the common approaches for comfort and energy savings in buildings in summer;however,the use of electric fans is usually the forced constant airflow.This study reformed the one-chip computer program of a floor fan motor and simulated dynamic airflow through controlling the rotating frequency only.The flow field characteristics of constant,oscillated,sinusoidal airflows with periods of 10 s,30 s,60 s,100 s were measured.The comfort performance was evaluated by chamber experiments,with 20 subjects exposed to six airflow patterns under 30℃,70%RH.The results showed that the simulated sinusoidal airflows had relatively higher turbulence intensity(32%–37%)andβvalues(>0.4).While subjects’thermal sensations were not statistically significant among six airflows,their reported discomfort symptoms during 60 min exposure were reduced under sinusoidal airflows.The calculated convective heat transfer shared similar variations to instantaneous air velocity and skin temperature.A large fluctuation of 10–50 W/m^(2)and higher total convective heat loss(3000–3500 W/m^(2))were found for sinusoidal period 30 s.This study develops a new method to simulate varying air velocities through conveniently controlling the fan motor amplitude and frequency,and verifies the comfortable feelings to dynamic sinusoidal airflows.The work benefits to improve the performance of the current electric fans with lower costs and promote the applications of personal ventilation devices in buildings,thus optimizing human thermal comfort,reducing dependences on air conditionings and achieving building energy efficiency.展开更多
The 13C(, n)16O reaction is the key neutron source reaction for the main s-process nucleosynthesis[1]. Theimportant energy range (Gamow window) for the 13C( , n)16O reaction during the s-process spans from 140 to230 k...The 13C(, n)16O reaction is the key neutron source reaction for the main s-process nucleosynthesis[1]. Theimportant energy range (Gamow window) for the 13C( , n)16O reaction during the s-process spans from 140 to230 keV in the center of mass frame. Because of the Coulomb barrier, the cross sections drop exponentially asmeasurement approaches the Gamow window energies. Limited by cosmic ray background and the available beamintensity, the ground-based measurements are limited to energies above 280 keV. Therefore, the extrapolationbased on R-matrix calculation and/or in-direct measurement is the current method to estimate the cross sectionsfor astrophysical interest with limited precision. Moreover, due to the existence of sub-threshold resonances, thereare rather large uncertainties associated with the extrapolated cross sections which limit the precision of the currentreaction rate and thus prevent us from a complete understanding of the nucleosynthesis of heavy elements.展开更多
基金Supported by the National Natural Science Foundation of China (11975113)。
文摘The fission yield data in the 14 MeV energy neutron induced fission of^(238)U play an important role in decay heat calculations and generation-Ⅳ reactor designs.In order to accurately measure fission product yields(FPYs)of^(238)U induced by 14 MeV neutrons,the cumulative yields of fission products ranging from^(92)Sr to^(147)Nd in the^(239)U(n,f) reaction with a 14.7 MeV neutron were determined using an off-line γ-ray spectrometric technique.The14.7 MeV quasi-monoenergetic neutron beam was provided by the K-400 D-T neutron generator at China Academy of Engineering Physics(CAEP).Fission products were measured by a low background high purity germanium gamma spectrometer.The neutron flux was obtained from the^(93)Nb(n.2n)^(92m)Nb reaction,and the mean neutron energy was calculated using the cross-section ratios for the^(90)Zr(n,2n)^(89)Zr and^(93)Nb(n,2n)^(92m)Nb reactions.With a series of corrections,high precision cumulative yields of 20 fission products were obtained.Our FPYs for the^(238)U(n,f) reaction at 14.7 MeV were compared with the existing experimental nuclear reaction data and evaluated nuclear data,respectively.The results will be helpful in the design of a generation-Ⅳ reactor and the construction of evaluated fission yield databases.
基金supported by the Zhejiang Provincial Natural Science Foundation of China (No. LQ12H01001)the Zhejiang Provincial Medicine & Health Scientific Foundation of China (No. 2012KYA143)
文摘Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.
基金supported by the National Natural Science Foundation of China(No.51908079)associated with the projects supported by the Fundamental Research Funds for the Central Universities(No.2021CDJCGJ015)。
文摘Increasing air movement by utilizing electric fans is among the common approaches for comfort and energy savings in buildings in summer;however,the use of electric fans is usually the forced constant airflow.This study reformed the one-chip computer program of a floor fan motor and simulated dynamic airflow through controlling the rotating frequency only.The flow field characteristics of constant,oscillated,sinusoidal airflows with periods of 10 s,30 s,60 s,100 s were measured.The comfort performance was evaluated by chamber experiments,with 20 subjects exposed to six airflow patterns under 30℃,70%RH.The results showed that the simulated sinusoidal airflows had relatively higher turbulence intensity(32%–37%)andβvalues(>0.4).While subjects’thermal sensations were not statistically significant among six airflows,their reported discomfort symptoms during 60 min exposure were reduced under sinusoidal airflows.The calculated convective heat transfer shared similar variations to instantaneous air velocity and skin temperature.A large fluctuation of 10–50 W/m^(2)and higher total convective heat loss(3000–3500 W/m^(2))were found for sinusoidal period 30 s.This study develops a new method to simulate varying air velocities through conveniently controlling the fan motor amplitude and frequency,and verifies the comfortable feelings to dynamic sinusoidal airflows.The work benefits to improve the performance of the current electric fans with lower costs and promote the applications of personal ventilation devices in buildings,thus optimizing human thermal comfort,reducing dependences on air conditionings and achieving building energy efficiency.
文摘The 13C(, n)16O reaction is the key neutron source reaction for the main s-process nucleosynthesis[1]. Theimportant energy range (Gamow window) for the 13C( , n)16O reaction during the s-process spans from 140 to230 keV in the center of mass frame. Because of the Coulomb barrier, the cross sections drop exponentially asmeasurement approaches the Gamow window energies. Limited by cosmic ray background and the available beamintensity, the ground-based measurements are limited to energies above 280 keV. Therefore, the extrapolationbased on R-matrix calculation and/or in-direct measurement is the current method to estimate the cross sectionsfor astrophysical interest with limited precision. Moreover, due to the existence of sub-threshold resonances, thereare rather large uncertainties associated with the extrapolated cross sections which limit the precision of the currentreaction rate and thus prevent us from a complete understanding of the nucleosynthesis of heavy elements.
