Background Emerging evidence suggests that stem cells can be used to improvecardiac function in patients after acute myocardial infarction. In this randomized trial, we aimedto use Doppler tissue tracking and strain i...Background Emerging evidence suggests that stem cells can be used to improvecardiac function in patients after acute myocardial infarction. In this randomized trial, we aimedto use Doppler tissue tracking and strain imaging to assess left ventricular segmental functionafter intracoronary transfer of autologous bone-marrow stem cells ( BMCs) for 6 months' follow up.Methods Twenty patients with acute myocardial infarction and anterior descending coronary arteryocclusion proven by angiography were double-blindedly randomized into intracoronary injection ofbone-marrow cell (treated, n = 9 ) or diluted serum ( control, n = 11) groups. GE vivid 7 andQ-analyze software were used to perform echocardiogram in both groups 1 week, 3 months and 6 monthsafter treatment. Three apical views of tissue Doppler imaging were acquired to measure peak systolicdisplacement ( D_s) and peak systolic strain (ε_(peak)) from 12 segments of LV walls. Leftventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume ( ESV) wereobtained by Simposon's biplane method. Results (1) 3 months later, D_a and ε_(peak) over theinfract-related region clearly increased in the BMCs group [D_8: (4.49 ±2.71) mm vs (7.56 ±2.95)mm, P < 0. 01; ε_(peak): ( - 13.40 ±6.00)% vs ( - 17.06 ± 6.05)% , P<0.01] , but not in thecontrol group [ D_8: (4.74 ±2.67) mm vs (5.01 ±3.23) mm, P >0.05; ε_(peak): ( - 13.84 ± 6.05) %vs ( - 15.04 ± 6.75) % , P > 0.05 ]. At the same time, D_s over the normal region also increased,but the D_8 enhancement was markedly higher in the BMCs group than that in the control group [ (3.21±3.17) mm vs (0.76 ± 1.94) mm, P <0.01 ]. Parameters remained steady from the 3rd to 6th month ineither group (P >0.05). (2) LVEF in treated and control groups were almost the same at baseline (1st week after PCI) [ (53.37 ± 8.92) % vs (53.51 ± 5.84) % , P > 0.05 ]. But 6 months later, LVEFin the BMCs group were clearly higher than that in the control group [(59.33 ± 12.91)% vs (50.30 ±8.30)%, P < 0.05 ]. (3) There展开更多
文摘Background Emerging evidence suggests that stem cells can be used to improvecardiac function in patients after acute myocardial infarction. In this randomized trial, we aimedto use Doppler tissue tracking and strain imaging to assess left ventricular segmental functionafter intracoronary transfer of autologous bone-marrow stem cells ( BMCs) for 6 months' follow up.Methods Twenty patients with acute myocardial infarction and anterior descending coronary arteryocclusion proven by angiography were double-blindedly randomized into intracoronary injection ofbone-marrow cell (treated, n = 9 ) or diluted serum ( control, n = 11) groups. GE vivid 7 andQ-analyze software were used to perform echocardiogram in both groups 1 week, 3 months and 6 monthsafter treatment. Three apical views of tissue Doppler imaging were acquired to measure peak systolicdisplacement ( D_s) and peak systolic strain (ε_(peak)) from 12 segments of LV walls. Leftventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume ( ESV) wereobtained by Simposon's biplane method. Results (1) 3 months later, D_a and ε_(peak) over theinfract-related region clearly increased in the BMCs group [D_8: (4.49 ±2.71) mm vs (7.56 ±2.95)mm, P < 0. 01; ε_(peak): ( - 13.40 ±6.00)% vs ( - 17.06 ± 6.05)% , P<0.01] , but not in thecontrol group [ D_8: (4.74 ±2.67) mm vs (5.01 ±3.23) mm, P >0.05; ε_(peak): ( - 13.84 ± 6.05) %vs ( - 15.04 ± 6.75) % , P > 0.05 ]. At the same time, D_s over the normal region also increased,but the D_8 enhancement was markedly higher in the BMCs group than that in the control group [ (3.21±3.17) mm vs (0.76 ± 1.94) mm, P <0.01 ]. Parameters remained steady from the 3rd to 6th month ineither group (P >0.05). (2) LVEF in treated and control groups were almost the same at baseline (1st week after PCI) [ (53.37 ± 8.92) % vs (53.51 ± 5.84) % , P > 0.05 ]. But 6 months later, LVEFin the BMCs group were clearly higher than that in the control group [(59.33 ± 12.91)% vs (50.30 ±8.30)%, P < 0.05 ]. (3) There
